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UniProtKB - A0A3Q2HCE8 (A0A3Q2HCE8_HORSE)

Entry version 9 (07 Oct 2020)
Sequence version 1 (10 Apr 2019)
Previous versions | rss
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Protein
Submitted name:

Uncharacterized protein

Gene

ANK2

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANK2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A0A3Q2HCE8, baseline

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 828ANK_REP_REGIONInterPro annotationAdd BLAST784
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati78 – 110ANKPROSITE-ProRule annotationAdd BLAST33
Repeati111 – 143ANKPROSITE-ProRule annotationAdd BLAST33
Repeati144 – 176ANKPROSITE-ProRule annotationAdd BLAST33
Repeati247 – 279ANKPROSITE-ProRule annotationAdd BLAST33
Repeati280 – 312ANKPROSITE-ProRule annotationAdd BLAST33
Repeati313 – 345ANKPROSITE-ProRule annotationAdd BLAST33
Repeati346 – 378ANKPROSITE-ProRule annotationAdd BLAST33
Repeati379 – 411ANKPROSITE-ProRule annotationAdd BLAST33
Repeati412 – 444ANKPROSITE-ProRule annotationAdd BLAST33
Repeati445 – 477ANKPROSITE-ProRule annotationAdd BLAST33
Repeati478 – 510ANKPROSITE-ProRule annotationAdd BLAST33
Repeati511 – 543ANKPROSITE-ProRule annotationAdd BLAST33
Repeati544 – 576ANKPROSITE-ProRule annotationAdd BLAST33
Repeati577 – 609ANKPROSITE-ProRule annotationAdd BLAST33
Repeati610 – 642ANKPROSITE-ProRule annotationAdd BLAST33
Repeati643 – 675ANKPROSITE-ProRule annotationAdd BLAST33
Repeati676 – 708ANKPROSITE-ProRule annotationAdd BLAST33
Repeati709 – 741ANKPROSITE-ProRule annotationAdd BLAST33
Repeati742 – 774ANKPROSITE-ProRule annotationAdd BLAST33
Repeati775 – 807ANKPROSITE-ProRule annotationAdd BLAST33
Domaini987 – 1175ZU5InterPro annotationAdd BLAST189
Domaini1177 – 1323ZU5InterPro annotationAdd BLAST147
Domaini3589 – 3673DeathInterPro annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 49DisorderedSequence analysisAdd BLAST49
Regioni1476 – 1505DisorderedSequence analysisAdd BLAST30
Regioni1668 – 1775DisorderedSequence analysisAdd BLAST108
Regioni1794 – 2160DisorderedSequence analysisAdd BLAST367
Regioni2212 – 2499DisorderedSequence analysisAdd BLAST288
Regioni2532 – 2817DisorderedSequence analysisAdd BLAST286
Regioni2831 – 2977DisorderedSequence analysisAdd BLAST147
Regioni2995 – 3040DisorderedSequence analysisAdd BLAST46
Regioni3088 – 3126DisorderedSequence analysisAdd BLAST39
Regioni3155 – 3484DisorderedSequence analysisAdd BLAST330
Regioni3569 – 3588DisorderedSequence analysisAdd BLAST20
Regioni3714 – 3733DisorderedSequence analysisAdd BLAST20
Regioni3746 – 3875DisorderedSequence analysisAdd BLAST130

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3498 – 3518Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 48PolyampholyteSequence analysisAdd BLAST48
Compositional biasi1668 – 1692PolarSequence analysisAdd BLAST25
Compositional biasi1729 – 1756PolyampholyteSequence analysisAdd BLAST28
Compositional biasi1794 – 1822PolyampholyteSequence analysisAdd BLAST29
Compositional biasi1844 – 1923PolarSequence analysisAdd BLAST80
Compositional biasi1989 – 2003PolarSequence analysisAdd BLAST15
Compositional biasi2026 – 2059PolyampholyteSequence analysisAdd BLAST34
Compositional biasi2060 – 2075PolarSequence analysisAdd BLAST16
Compositional biasi2090 – 2145PolyampholyteSequence analysisAdd BLAST56
Compositional biasi2272 – 2306PolyampholyteSequence analysisAdd BLAST35
Compositional biasi2372 – 2401PolarSequence analysisAdd BLAST30
Compositional biasi2408 – 2422PolarSequence analysisAdd BLAST15
Compositional biasi2542 – 2576PolarSequence analysisAdd BLAST35
Compositional biasi2587 – 2645PolyampholyteSequence analysisAdd BLAST59
Compositional biasi2653 – 2668PolyampholyteSequence analysisAdd BLAST16
Compositional biasi2676 – 2692PolarSequence analysisAdd BLAST17
Compositional biasi2716 – 2743PolarSequence analysisAdd BLAST28
Compositional biasi2744 – 2765PolyampholyteSequence analysisAdd BLAST22
Compositional biasi2779 – 2796PolyampholyteSequence analysisAdd BLAST18
Compositional biasi2834 – 2849PolyampholyteSequence analysisAdd BLAST16
Compositional biasi2857 – 2873PolarSequence analysisAdd BLAST17
Compositional biasi2891 – 2926PolarSequence analysisAdd BLAST36
Compositional biasi2938 – 2977PolarSequence analysisAdd BLAST40
Compositional biasi3017 – 3040PolarSequence analysisAdd BLAST24
Compositional biasi3091 – 3122PolarSequence analysisAdd BLAST32
Compositional biasi3175 – 3189PolarSequence analysisAdd BLAST15
Compositional biasi3198 – 3212AcidicSequence analysisAdd BLAST15
Compositional biasi3214 – 3268PolarSequence analysisAdd BLAST55
Compositional biasi3284 – 3299PolyampholyteSequence analysisAdd BLAST16
Compositional biasi3313 – 3340PolarSequence analysisAdd BLAST28
Compositional biasi3380 – 3398PolarSequence analysisAdd BLAST19
Compositional biasi3400 – 3437PolyampholyteSequence analysisAdd BLAST38
Compositional biasi3462 – 3476PolarSequence analysisAdd BLAST15
Compositional biasi3746 – 3765PolarSequence analysisAdd BLAST20
Compositional biasi3790 – 3821PolarSequence analysisAdd BLAST32

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis, RepeatARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155279

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00023, Ank, 2 hits
PF12796, Ank_2, 6 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 23 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 20 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

A0A3Q2HCE8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHAAASIKK VREAELDEKE KTLERERKKQ RKIPRERMER KRKSDSNASF 
        60         70         80         90        100
LRAARAGNLD KVVEYLKGGI DINTCNQNGL NALHLAAKEG HVGLVQELLG 
       110        120        130        140        150
RGSSVDSATK KGNTALHIAS LAGQAEVVKV LVKEGANINA QSQNGFTPLY 
       160        170        180        190        200
MAAQENHIDV VKYLLENGAN QSTATEDGFT PLAVALQQGH NQAVAILLEN 
       210        220        230        240        250
DTKGKVRLPA LHIAARKDDT KSAALLLQND HNADVQSKMM VNRTTESGFT 
       260        270        280        290        300
PLHIAAHYGN VNVATLLLNR GAAVDFTARN GITPLHVASK RGNTNMVKLL 
       310        320        330        340        350
LDRGGQIDAK TRDGLTPLHC AARSGHDQVV ELLLERGAPL LARTKNGLSP 
       360        370        380        390        400
LHMAAQGDHV ECVKHLLQHK APVDDVTLDY LTALHVAAHC GHYRVTKLLL 
       410        420        430        440        450
DKRANPNARA LNGFTPLHIA CKKNRIKVME LLVKYGASIQ AITESGLTPI 
       460        470        480        490        500
HVAAFMGHLN IVLLLLQNGA SPDVTNIRGE TALHMAARAG QVEVVRCLLR 
       510        520        530        540        550
NGALVDARAR EEQTPLHIAS RLGKTEIVQL LLQHMAHPDA ATTNGYTPLH 
       560        570        580        590        600
ISAREGQVDV ASVLLEAGAA HSLATKKGFT PLHVAAKYGS LDVAKLLLQR 
       610        620        630        640        650
RAAADSAGKN GLTPLHVAAH YDNQKVALLL LEKGASPHAT AKNGYTPLHI 
       660        670        680        690        700
AAKKNQMQIA STLLNYGAET NIVTKQGVTP LHLASQEGHT DMVTLLLDKG 
       710        720        730        740        750
ANIHMSTKSG LTSLHLAAQE DKVNVADILT KNGADQDAHT KLGYTPLIVA 
       760        770        780        790        800
CHYGNVKMVN FLLKQGADVN AKTKNGYTPL HQAAQQGHTH IINVLLQHGA 
       810        820        830        840        850
KPNATTANGN TALAIAKRLG YISVVDTLKV VTEEVTTTTT TITEKHKLNV 
       860        870        880        890        900
PETMTEVLDV SDEEGDDTMT GDGGEYLRPE DLKELGDDSL PSSQFLDGMN 
       910        920        930        940        950
YLRYSLEGGR SDSTMPSLRS FSSDRSHTLS HASYLRDSAM IDDTVVIPSH 
       960        970        980        990       1000
QVSALAKEAE RNSYRLSWGT ENLDNVALSS SPIHSGFLVS FMVDARGGAM 
      1010       1020       1030       1040       1050
RGCRHNGLRI IIPPRKCTAP TRVTCRLVKR HRLATMPPMV EGEGLASRLI 
      1060       1070       1080       1090       1100
EVGPSGAQFL GKLHLPTAPP PLNEGESLVS RILQLGPPGT KFLGPVIVEI 
      1110       1120       1130       1140       1150
PHFAALRGKE RELVVLRSEN GDSWKEHYCE YTEDELNEIL NGMDEVLDSP 
      1160       1170       1180       1190       1200
EDLEKKRICR IVTRDFPQYF AVVSRIKQDS NLIGPEGGVL SSTVVPQVQA 
      1210       1220       1230       1240       1250
VFPEGALTKR IRVGLQAQPM HSELVKKILG NKATFSPIVT LEPRRRKFHK 
      1260       1270       1280       1290       1300
PITMTIPVPK ASSDVMLNGF GGDAPTLRLL CSITGGTTPA QWEDITGTTP 
      1310       1320       1330       1340       1350
LTFVNECVSF TTNVSARFWL IDCRQIQESV TFASQVYREI ICVPYMAKFV 
      1360       1370       1380       1390       1400
VFAKSHDPIE ARLRCFCMTD DKVDKTLEQQ ENFAEVARSR DVEVLEGKPI 
      1410       1420       1430       1440       1450
YVDCFGNLVP LTKSGQHHIF SFFAFKENRL PLFVKVRDTT QEPCGRLSFM 
      1460       1470       1480       1490       1500
KEPKSTRGLV HQAICNLNIT LPVYTKESES DQEQEEEIDM TSEKNDETES 
      1510       1520       1530       1540       1550
TETSVLKSHL VNEVPVLASP DLLSEVSEMK QDLIKMTAIL TTDVSERAGS 
      1560       1570       1580       1590       1600
IKVKELVKAA EEEPGEPFEI VERVKEDLEK VNEILRSGTC TRDEASAPRA 
      1610       1620       1630       1640       1650
RSERELVEEE WVIISDEEIE EARQKAPLEI TEYPCVEVRI DKETKEEVEK 
      1660       1670       1680       1690       1700
DSTGLVNYLT EDLNSYVSPH GEQLQPAQEM AGETSQAPAV GRSSENEGKD 
      1710       1720       1730       1740       1750
AHPDETQIPQ KQQKPSLGIK KPVRRKLKEK QKQKEESLQA STEKTELTKG 
      1760       1770       1780       1790       1800
SSEESLDEDL GLAPEPVPAV KATSPLIEET PIGSIKDKVK ALQKRVEDEQ 
      1810       1820       1830       1840       1850
KGRSKLPIRV KGKEDVPKKI VHRTHPAVSP SLKAEKHTPA SPASKTERHS 
      1860       1870       1880       1890       1900
SLSSSAKTER HPPVSPSSKT EKHSPVSPSA KTERHSPVSS SSKTEKHSPV 
      1910       1920       1930       1940       1950
SPSTKTERHS PVSSSTKTER HPPVSPSGKT DKRPPISPSG RPEKHSPVSP 
      1960       1970       1980       1990       2000
GRTEKRSPVS PAGRIERHPP VSALGKTEKH LPVSPSGKTE KQPPVSPTSK 
      2010       2020       2030       2040       2050
TERIEETMSV RELMKAFQSG QDPSKHKAGL FEHKSAKQKQ PQEKGKVRVE 
      2060       2070       2080       2090       2100
KEKGQMLTQR ETQRTESQTI KRGQKILVTG ASESKRGVRA SSLGFKKEET 
      2110       2120       2130       2140       2150
VGEKEKGVSH KTPEPVRSAP EEESHKENEV PKEKPAEEQG DMDLQISPDR 
      2160       2170       2180       2190       2200
KASTDFSDVI KQELEDNEKY QQFRLSEEPE KAQLHLDQVL TSPFNTTFPL 
      2210       2220       2230       2240       2250
DYVKDEFLPA LSLPSGALDG SSESPKHEGV AGSPCGSLME GTPQISSEES 
      2260       2270       2280       2290       2300
YKHEGLAETP ETSPESLSFS PKKSEEPVRE ENETTKLETP REIHLEKEHP 
      2310       2320       2330       2340       2350
STKDVPDGSE EPGAAVTEGT EPSAECLLKE ATLDPSKDTS SKQEGDYLDS 
      2360       2370       2380       2390       2400
NSVSLAKETP KGLAEEASCD EGQPTYVSSA LKAQTDTEAQ GSTTTKPSDE 
      2410       2420       2430       2440       2450
TKASPLPDVS VKTGTGTEPK PQGVVRSPQG LELALPSRDS EVFSPGADES 
      2460       2470       2480       2490       2500
FAVSHKDSLE ASPVLEDNSS HKTPDSLEPS PLKESPCRDS LESSPVEPKM 
      2510       2520       2530       2540       2550
KAGILSSHFP LPAAVAKTEL FTEVASMRSR LLRDPDGSAE DDSLEQTSLM 
      2560       2570       2580       2590       2600
ESSGKSPLSP DTPSSEEISY EVTPKATDAS TPKPAVIHEC AEEDDLENGE 
      2610       2620       2630       2640       2650
KKRFTPEEEM FKMVTKIKTF DELEQEAKQK RDYRKEPKQE ESSSSSEPDA 
      2660       2670       2680       2690       2700
DSSADVDEPK HMESAEEESE VPVAVTSESR KASSSSESEP ELTQLKKGAD 
      2710       2720       2730       2740       2750
SGLLPEPVIR VQPPSPLPSS IDSNSSPEEV QFQPIVSKQY TFKMNEDTQE 
      2760       2770       2780       2790       2800
ESGKSEEEKV CESHLPEDSQ TVSTEGPDMS YDDLKRDDDQ PKIYDDHGCE 
      2810       2820       2830       2840       2850
AGSPSSPATP ISSGLHSSCA HDISEQLVIH KEALPLQDAE EKDTEGELDV 
      2860       2870       2880       2890       2900
SGLESPQVEG PSESSSSPSS LPRCLASERK ELDEDLVSPS SPTKVEATKT 
      2910       2920       2930       2940       2950
DQAFESLPKD CSTEDSSITP QTDRLSVDVP VSDPAETDEI SDPQTISPYE 
      2960       2970       2980       2990       3000
NVPSQSFFSS EESKTQTDAS HTSFHSSEVC SVTVTSSVAE VAVESSSSRT 
      3010       3020       3030       3040       3050
VSSKESNFED QNMELESKQE STLWEMQSDG APSSVESTIP NTSAVVGEKI 
      3060       3070       3080       3090       3100
SKVIITKTDV DSDSWSEIRE DDEAFEARVK EEEQKIFGLM VDRQSQGTTP 
      3110       3120       3130       3140       3150
DTTPARTPTE EGTPTSEQNP FLFQEGKLFE MTRSGAIDMT KRSYADESFH 
      3160       3170       3180       3190       3200
FFQIGQESSE ETLSEDMKGV STGAEPPQLE TSAESLALSQ SKEPVDDEAD 
      3210       3220       3230       3240       3250
LLPDDLSEEV EEIPSSDAQL NSQMEISASA ETSTEDATSA EPEDLPTTQV 
      3260       3270       3280       3290       3300
SDTPPKSSVK QTSCPDSPEP AVQVHLDFST VTRSVYSDRE DDSPDSSPEE 
      3310       3320       3330       3340       3350
QKSVIEIPTA PMESVPSTES KSKIPIRTIP TSTPAPPSAE DENSLSEDVP 
      3360       3370       3380       3390       3400
PSLDEESKED ETKPKSKIPV KAPVQRVEQQ LLVLDSSLQK TVAPQGQDVT 
      3410       3420       3430       3440       3450
SRARDDRSKS ESDADPLDSK AKSPVKTRSY TETETESGEK AEELELESEE 
      3460       3470       3480       3490       3500
GATRTKIFAS RLPVKSKSTT SSCREDTSPT KDSKEHFLDL YRNSIEFFEE 
      3510       3520       3530       3540       3550
ISDEASKLVD RLTQSEREQE LVSDDESSSA LEVSVIENLP PVETEHSIPE 
      3560       3570       3580       3590       3600
DIFDTRPIWD ESIETLIERI PDENGHDHAE DQQDEQERTE ERLAYIADHL 
      3610       3620       3630       3640       3650
GFSWTELARE LDFTEEQIHQ IRIENPNSLQ DQSHALLKYW LERDGKHATD 
      3660       3670       3680       3690       3700
TSLIECLTKI NRMDIVHLLE TSTEPLQEHM SHSYAEIEQT ITLDHSEGFS 
      3710       3720       3730       3740       3750
VLQEELCLAQ QKQKEEEQAA SKEGEPCDQP PIVSEEDISV GYSTFQDYIP 
      3760       3770       3780       3790       3800
KTDGDSSTTE LLPQTHKEEV QQDFSGKMQD LPEKSPPDHQ QEYFVTTPGT 
      3810       3820       3830       3840       3850
EVSETQKATA ASGSPSKTPE EITTPPEEER PYLQTPTPSE QGDSPIVQEP 
      3860       3870       3880       3890       3900
EEPLAQREES PRKTSLVIVE SADDQPQAFE RLEEDAAFQK ELTEELGELE 
      3910       3920       3930       3940       3950
ASSDDEATVT TRVVRRRVII QGDDMPDIPP ESVTEEEYID EHGHTVVKKV 
      3960       3970       3980       3990       4000
TRKIIKRYVS SDGTEKEEIT VQGLPQDPVD VEEGDGYSKV IKRVVLKSDT 
      4010       4020       4030       4040       4050
ALSEVTLSEP SILSSSSQFE AEPVEGRRVS KVVKTTMVHG ERMEKHLGDS 
      4060       4070       4080       4090       4100
SLATDLPSAK DDFEEALSYT GSHMKVHSPS LVEREILKED GSVIKRTVMS 
      4110       4120       4130       4140       4150
KASTRSRAVV KDQHGKHIHL EHLEDVPEAL DQGDLQRDLQ QLLQHFCKEH 

LKQEAK
Length:4,156
Mass (Da):456,226
Last modified:April 10, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4F7CEAB66B71830D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6SQK7F6SQK7_HORSE
Uncharacterized protein
ANK2
3,958Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6SQP2F6SQP2_HORSE
Uncharacterized protein
ANK2
4,137Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2GU11A0A3Q2GU11_HORSE
Uncharacterized protein
ANK2
4,077Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2GZG4A0A3Q2GZG4_HORSE
Uncharacterized protein
ANK2
4,164Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2H3M0A0A3Q2H3M0_HORSE
Uncharacterized protein
ANK2
4,143Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HHV3A0A3Q2HHV3_HORSE
Uncharacterized protein
ANK2
4,141Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HPB7A0A3Q2HPB7_HORSE
Uncharacterized protein
ANK2
4,069Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2I396A0A3Q2I396_HORSE
Uncharacterized protein
ANK2
4,098Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSECAT00000041783; ENSECAP00000031873; ENSECAG00000024436

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENSECAT00000041783; ENSECAP00000031873; ENSECAG00000024436

Phylogenomic databases

GeneTreeiENSGT00940000155279

Gene expression databases

ExpressionAtlasiA0A3Q2HCE8, baseline

Family and domain databases

Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom
PfamiView protein in Pfam
PF00023, Ank, 2 hits
PF12796, Ank_2, 6 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 2 hits
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 23 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 20 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3Q2HCE8_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3Q2HCE8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 10, 2019
Last sequence update: April 10, 2019
Last modified: October 7, 2020
This is version 9 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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