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Entry version 9 (07 Oct 2020)
Sequence version 1 (10 Apr 2019)
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Protein
Submitted name:

Uncharacterized protein

Gene

ANK2

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANK2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A3Q2HCE8, baseline

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 828ANK_REP_REGIONInterPro annotationAdd BLAST784
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati78 – 110ANKPROSITE-ProRule annotationAdd BLAST33
Repeati111 – 143ANKPROSITE-ProRule annotationAdd BLAST33
Repeati144 – 176ANKPROSITE-ProRule annotationAdd BLAST33
Repeati247 – 279ANKPROSITE-ProRule annotationAdd BLAST33
Repeati280 – 312ANKPROSITE-ProRule annotationAdd BLAST33
Repeati313 – 345ANKPROSITE-ProRule annotationAdd BLAST33
Repeati346 – 378ANKPROSITE-ProRule annotationAdd BLAST33
Repeati379 – 411ANKPROSITE-ProRule annotationAdd BLAST33
Repeati412 – 444ANKPROSITE-ProRule annotationAdd BLAST33
Repeati445 – 477ANKPROSITE-ProRule annotationAdd BLAST33
Repeati478 – 510ANKPROSITE-ProRule annotationAdd BLAST33
Repeati511 – 543ANKPROSITE-ProRule annotationAdd BLAST33
Repeati544 – 576ANKPROSITE-ProRule annotationAdd BLAST33
Repeati577 – 609ANKPROSITE-ProRule annotationAdd BLAST33
Repeati610 – 642ANKPROSITE-ProRule annotationAdd BLAST33
Repeati643 – 675ANKPROSITE-ProRule annotationAdd BLAST33
Repeati676 – 708ANKPROSITE-ProRule annotationAdd BLAST33
Repeati709 – 741ANKPROSITE-ProRule annotationAdd BLAST33
Repeati742 – 774ANKPROSITE-ProRule annotationAdd BLAST33
Repeati775 – 807ANKPROSITE-ProRule annotationAdd BLAST33
Domaini987 – 1175ZU5InterPro annotationAdd BLAST189
Domaini1177 – 1323ZU5InterPro annotationAdd BLAST147
Domaini3589 – 3673DeathInterPro annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 49DisorderedSequence analysisAdd BLAST49
Regioni1476 – 1505DisorderedSequence analysisAdd BLAST30
Regioni1668 – 1775DisorderedSequence analysisAdd BLAST108
Regioni1794 – 2160DisorderedSequence analysisAdd BLAST367
Regioni2212 – 2499DisorderedSequence analysisAdd BLAST288
Regioni2532 – 2817DisorderedSequence analysisAdd BLAST286
Regioni2831 – 2977DisorderedSequence analysisAdd BLAST147
Regioni2995 – 3040DisorderedSequence analysisAdd BLAST46
Regioni3088 – 3126DisorderedSequence analysisAdd BLAST39
Regioni3155 – 3484DisorderedSequence analysisAdd BLAST330
Regioni3569 – 3588DisorderedSequence analysisAdd BLAST20
Regioni3714 – 3733DisorderedSequence analysisAdd BLAST20
Regioni3746 – 3875DisorderedSequence analysisAdd BLAST130

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3498 – 3518Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 48PolyampholyteSequence analysisAdd BLAST48
Compositional biasi1668 – 1692PolarSequence analysisAdd BLAST25
Compositional biasi1729 – 1756PolyampholyteSequence analysisAdd BLAST28
Compositional biasi1794 – 1822PolyampholyteSequence analysisAdd BLAST29
Compositional biasi1844 – 1923PolarSequence analysisAdd BLAST80
Compositional biasi1989 – 2003PolarSequence analysisAdd BLAST15
Compositional biasi2026 – 2059PolyampholyteSequence analysisAdd BLAST34
Compositional biasi2060 – 2075PolarSequence analysisAdd BLAST16
Compositional biasi2090 – 2145PolyampholyteSequence analysisAdd BLAST56
Compositional biasi2272 – 2306PolyampholyteSequence analysisAdd BLAST35
Compositional biasi2372 – 2401PolarSequence analysisAdd BLAST30
Compositional biasi2408 – 2422PolarSequence analysisAdd BLAST15
Compositional biasi2542 – 2576PolarSequence analysisAdd BLAST35
Compositional biasi2587 – 2645PolyampholyteSequence analysisAdd BLAST59
Compositional biasi2653 – 2668PolyampholyteSequence analysisAdd BLAST16
Compositional biasi2676 – 2692PolarSequence analysisAdd BLAST17
Compositional biasi2716 – 2743PolarSequence analysisAdd BLAST28
Compositional biasi2744 – 2765PolyampholyteSequence analysisAdd BLAST22
Compositional biasi2779 – 2796PolyampholyteSequence analysisAdd BLAST18
Compositional biasi2834 – 2849PolyampholyteSequence analysisAdd BLAST16
Compositional biasi2857 – 2873PolarSequence analysisAdd BLAST17
Compositional biasi2891 – 2926PolarSequence analysisAdd BLAST36
Compositional biasi2938 – 2977PolarSequence analysisAdd BLAST40
Compositional biasi3017 – 3040PolarSequence analysisAdd BLAST24
Compositional biasi3091 – 3122PolarSequence analysisAdd BLAST32
Compositional biasi3175 – 3189PolarSequence analysisAdd BLAST15
Compositional biasi3198 – 3212AcidicSequence analysisAdd BLAST15
Compositional biasi3214 – 3268PolarSequence analysisAdd BLAST55
Compositional biasi3284 – 3299PolyampholyteSequence analysisAdd BLAST16
Compositional biasi3313 – 3340PolarSequence analysisAdd BLAST28
Compositional biasi3380 – 3398PolarSequence analysisAdd BLAST19
Compositional biasi3400 – 3437PolyampholyteSequence analysisAdd BLAST38
Compositional biasi3462 – 3476PolarSequence analysisAdd BLAST15
Compositional biasi3746 – 3765PolarSequence analysisAdd BLAST20
Compositional biasi3790 – 3821PolarSequence analysisAdd BLAST32

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis, RepeatARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155279

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023, Ank, 2 hits
PF12796, Ank_2, 6 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 23 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 20 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

A0A3Q2HCE8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHAAASIKK VREAELDEKE KTLERERKKQ RKIPRERMER KRKSDSNASF
60 70 80 90 100
LRAARAGNLD KVVEYLKGGI DINTCNQNGL NALHLAAKEG HVGLVQELLG
110 120 130 140 150
RGSSVDSATK KGNTALHIAS LAGQAEVVKV LVKEGANINA QSQNGFTPLY
160 170 180 190 200
MAAQENHIDV VKYLLENGAN QSTATEDGFT PLAVALQQGH NQAVAILLEN
210 220 230 240 250
DTKGKVRLPA LHIAARKDDT KSAALLLQND HNADVQSKMM VNRTTESGFT
260 270 280 290 300
PLHIAAHYGN VNVATLLLNR GAAVDFTARN GITPLHVASK RGNTNMVKLL
310 320 330 340 350
LDRGGQIDAK TRDGLTPLHC AARSGHDQVV ELLLERGAPL LARTKNGLSP
360 370 380 390 400
LHMAAQGDHV ECVKHLLQHK APVDDVTLDY LTALHVAAHC GHYRVTKLLL
410 420 430 440 450
DKRANPNARA LNGFTPLHIA CKKNRIKVME LLVKYGASIQ AITESGLTPI
460 470 480 490 500
HVAAFMGHLN IVLLLLQNGA SPDVTNIRGE TALHMAARAG QVEVVRCLLR
510 520 530 540 550
NGALVDARAR EEQTPLHIAS RLGKTEIVQL LLQHMAHPDA ATTNGYTPLH
560 570 580 590 600
ISAREGQVDV ASVLLEAGAA HSLATKKGFT PLHVAAKYGS LDVAKLLLQR
610 620 630 640 650
RAAADSAGKN GLTPLHVAAH YDNQKVALLL LEKGASPHAT AKNGYTPLHI
660 670 680 690 700
AAKKNQMQIA STLLNYGAET NIVTKQGVTP LHLASQEGHT DMVTLLLDKG
710 720 730 740 750
ANIHMSTKSG LTSLHLAAQE DKVNVADILT KNGADQDAHT KLGYTPLIVA
760 770 780 790 800
CHYGNVKMVN FLLKQGADVN AKTKNGYTPL HQAAQQGHTH IINVLLQHGA
810 820 830 840 850
KPNATTANGN TALAIAKRLG YISVVDTLKV VTEEVTTTTT TITEKHKLNV
860 870 880 890 900
PETMTEVLDV SDEEGDDTMT GDGGEYLRPE DLKELGDDSL PSSQFLDGMN
910 920 930 940 950
YLRYSLEGGR SDSTMPSLRS FSSDRSHTLS HASYLRDSAM IDDTVVIPSH
960 970 980 990 1000
QVSALAKEAE RNSYRLSWGT ENLDNVALSS SPIHSGFLVS FMVDARGGAM
1010 1020 1030 1040 1050
RGCRHNGLRI IIPPRKCTAP TRVTCRLVKR HRLATMPPMV EGEGLASRLI
1060 1070 1080 1090 1100
EVGPSGAQFL GKLHLPTAPP PLNEGESLVS RILQLGPPGT KFLGPVIVEI
1110 1120 1130 1140 1150
PHFAALRGKE RELVVLRSEN GDSWKEHYCE YTEDELNEIL NGMDEVLDSP
1160 1170 1180 1190 1200
EDLEKKRICR IVTRDFPQYF AVVSRIKQDS NLIGPEGGVL SSTVVPQVQA
1210 1220 1230 1240 1250
VFPEGALTKR IRVGLQAQPM HSELVKKILG NKATFSPIVT LEPRRRKFHK
1260 1270 1280 1290 1300
PITMTIPVPK ASSDVMLNGF GGDAPTLRLL CSITGGTTPA QWEDITGTTP
1310 1320 1330 1340 1350
LTFVNECVSF TTNVSARFWL IDCRQIQESV TFASQVYREI ICVPYMAKFV
1360 1370 1380 1390 1400
VFAKSHDPIE ARLRCFCMTD DKVDKTLEQQ ENFAEVARSR DVEVLEGKPI
1410 1420 1430 1440 1450
YVDCFGNLVP LTKSGQHHIF SFFAFKENRL PLFVKVRDTT QEPCGRLSFM
1460 1470 1480 1490 1500
KEPKSTRGLV HQAICNLNIT LPVYTKESES DQEQEEEIDM TSEKNDETES
1510 1520 1530 1540 1550
TETSVLKSHL VNEVPVLASP DLLSEVSEMK QDLIKMTAIL TTDVSERAGS
1560 1570 1580 1590 1600
IKVKELVKAA EEEPGEPFEI VERVKEDLEK VNEILRSGTC TRDEASAPRA
1610 1620 1630 1640 1650
RSERELVEEE WVIISDEEIE EARQKAPLEI TEYPCVEVRI DKETKEEVEK
1660 1670 1680 1690 1700
DSTGLVNYLT EDLNSYVSPH GEQLQPAQEM AGETSQAPAV GRSSENEGKD
1710 1720 1730 1740 1750
AHPDETQIPQ KQQKPSLGIK KPVRRKLKEK QKQKEESLQA STEKTELTKG
1760 1770 1780 1790 1800
SSEESLDEDL GLAPEPVPAV KATSPLIEET PIGSIKDKVK ALQKRVEDEQ
1810 1820 1830 1840 1850
KGRSKLPIRV KGKEDVPKKI VHRTHPAVSP SLKAEKHTPA SPASKTERHS
1860 1870 1880 1890 1900
SLSSSAKTER HPPVSPSSKT EKHSPVSPSA KTERHSPVSS SSKTEKHSPV
1910 1920 1930 1940 1950
SPSTKTERHS PVSSSTKTER HPPVSPSGKT DKRPPISPSG RPEKHSPVSP
1960 1970 1980 1990 2000
GRTEKRSPVS PAGRIERHPP VSALGKTEKH LPVSPSGKTE KQPPVSPTSK
2010 2020 2030 2040 2050
TERIEETMSV RELMKAFQSG QDPSKHKAGL FEHKSAKQKQ PQEKGKVRVE
2060 2070 2080 2090 2100
KEKGQMLTQR ETQRTESQTI KRGQKILVTG ASESKRGVRA SSLGFKKEET
2110 2120 2130 2140 2150
VGEKEKGVSH KTPEPVRSAP EEESHKENEV PKEKPAEEQG DMDLQISPDR
2160 2170 2180 2190 2200
KASTDFSDVI KQELEDNEKY QQFRLSEEPE KAQLHLDQVL TSPFNTTFPL
2210 2220 2230 2240 2250
DYVKDEFLPA LSLPSGALDG SSESPKHEGV AGSPCGSLME GTPQISSEES
2260 2270 2280 2290 2300
YKHEGLAETP ETSPESLSFS PKKSEEPVRE ENETTKLETP REIHLEKEHP
2310 2320 2330 2340 2350
STKDVPDGSE EPGAAVTEGT EPSAECLLKE ATLDPSKDTS SKQEGDYLDS
2360 2370 2380 2390 2400
NSVSLAKETP KGLAEEASCD EGQPTYVSSA LKAQTDTEAQ GSTTTKPSDE
2410 2420 2430 2440 2450
TKASPLPDVS VKTGTGTEPK PQGVVRSPQG LELALPSRDS EVFSPGADES
2460 2470 2480 2490 2500
FAVSHKDSLE ASPVLEDNSS HKTPDSLEPS PLKESPCRDS LESSPVEPKM
2510 2520 2530 2540 2550
KAGILSSHFP LPAAVAKTEL FTEVASMRSR LLRDPDGSAE DDSLEQTSLM
2560 2570 2580 2590 2600
ESSGKSPLSP DTPSSEEISY EVTPKATDAS TPKPAVIHEC AEEDDLENGE
2610 2620 2630 2640 2650
KKRFTPEEEM FKMVTKIKTF DELEQEAKQK RDYRKEPKQE ESSSSSEPDA
2660 2670 2680 2690 2700
DSSADVDEPK HMESAEEESE VPVAVTSESR KASSSSESEP ELTQLKKGAD
2710 2720 2730 2740 2750
SGLLPEPVIR VQPPSPLPSS IDSNSSPEEV QFQPIVSKQY TFKMNEDTQE
2760 2770 2780 2790 2800
ESGKSEEEKV CESHLPEDSQ TVSTEGPDMS YDDLKRDDDQ PKIYDDHGCE
2810 2820 2830 2840 2850
AGSPSSPATP ISSGLHSSCA HDISEQLVIH KEALPLQDAE EKDTEGELDV
2860 2870 2880 2890 2900
SGLESPQVEG PSESSSSPSS LPRCLASERK ELDEDLVSPS SPTKVEATKT
2910 2920 2930 2940 2950
DQAFESLPKD CSTEDSSITP QTDRLSVDVP VSDPAETDEI SDPQTISPYE
2960 2970 2980 2990 3000
NVPSQSFFSS EESKTQTDAS HTSFHSSEVC SVTVTSSVAE VAVESSSSRT
3010 3020 3030 3040 3050
VSSKESNFED QNMELESKQE STLWEMQSDG APSSVESTIP NTSAVVGEKI
3060 3070 3080 3090 3100
SKVIITKTDV DSDSWSEIRE DDEAFEARVK EEEQKIFGLM VDRQSQGTTP
3110 3120 3130 3140 3150
DTTPARTPTE EGTPTSEQNP FLFQEGKLFE MTRSGAIDMT KRSYADESFH
3160 3170 3180 3190 3200
FFQIGQESSE ETLSEDMKGV STGAEPPQLE TSAESLALSQ SKEPVDDEAD
3210 3220 3230 3240 3250
LLPDDLSEEV EEIPSSDAQL NSQMEISASA ETSTEDATSA EPEDLPTTQV
3260 3270 3280 3290 3300
SDTPPKSSVK QTSCPDSPEP AVQVHLDFST VTRSVYSDRE DDSPDSSPEE
3310 3320 3330 3340 3350
QKSVIEIPTA PMESVPSTES KSKIPIRTIP TSTPAPPSAE DENSLSEDVP
3360 3370 3380 3390 3400
PSLDEESKED ETKPKSKIPV KAPVQRVEQQ LLVLDSSLQK TVAPQGQDVT
3410 3420 3430 3440 3450
SRARDDRSKS ESDADPLDSK AKSPVKTRSY TETETESGEK AEELELESEE
3460 3470 3480 3490 3500
GATRTKIFAS RLPVKSKSTT SSCREDTSPT KDSKEHFLDL YRNSIEFFEE
3510 3520 3530 3540 3550
ISDEASKLVD RLTQSEREQE LVSDDESSSA LEVSVIENLP PVETEHSIPE
3560 3570 3580 3590 3600
DIFDTRPIWD ESIETLIERI PDENGHDHAE DQQDEQERTE ERLAYIADHL
3610 3620 3630 3640 3650
GFSWTELARE LDFTEEQIHQ IRIENPNSLQ DQSHALLKYW LERDGKHATD
3660 3670 3680 3690 3700
TSLIECLTKI NRMDIVHLLE TSTEPLQEHM SHSYAEIEQT ITLDHSEGFS
3710 3720 3730 3740 3750
VLQEELCLAQ QKQKEEEQAA SKEGEPCDQP PIVSEEDISV GYSTFQDYIP
3760 3770 3780 3790 3800
KTDGDSSTTE LLPQTHKEEV QQDFSGKMQD LPEKSPPDHQ QEYFVTTPGT
3810 3820 3830 3840 3850
EVSETQKATA ASGSPSKTPE EITTPPEEER PYLQTPTPSE QGDSPIVQEP
3860 3870 3880 3890 3900
EEPLAQREES PRKTSLVIVE SADDQPQAFE RLEEDAAFQK ELTEELGELE
3910 3920 3930 3940 3950
ASSDDEATVT TRVVRRRVII QGDDMPDIPP ESVTEEEYID EHGHTVVKKV
3960 3970 3980 3990 4000
TRKIIKRYVS SDGTEKEEIT VQGLPQDPVD VEEGDGYSKV IKRVVLKSDT
4010 4020 4030 4040 4050
ALSEVTLSEP SILSSSSQFE AEPVEGRRVS KVVKTTMVHG ERMEKHLGDS
4060 4070 4080 4090 4100
SLATDLPSAK DDFEEALSYT GSHMKVHSPS LVEREILKED GSVIKRTVMS
4110 4120 4130 4140 4150
KASTRSRAVV KDQHGKHIHL EHLEDVPEAL DQGDLQRDLQ QLLQHFCKEH

LKQEAK
Length:4,156
Mass (Da):456,226
Last modified:April 10, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4F7CEAB66B71830D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6SQK7F6SQK7_HORSE
Uncharacterized protein
ANK2
3,958Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6SQP2F6SQP2_HORSE
Uncharacterized protein
ANK2
4,137Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2GU11A0A3Q2GU11_HORSE
Uncharacterized protein
ANK2
4,077Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2GZG4A0A3Q2GZG4_HORSE
Uncharacterized protein
ANK2
4,164Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2H3M0A0A3Q2H3M0_HORSE
Uncharacterized protein
ANK2
4,143Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HHV3A0A3Q2HHV3_HORSE
Uncharacterized protein
ANK2
4,141Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HPB7A0A3Q2HPB7_HORSE
Uncharacterized protein
ANK2
4,069Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2I396A0A3Q2I396_HORSE
Uncharacterized protein
ANK2
4,098Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSECAT00000041783; ENSECAP00000031873; ENSECAG00000024436

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSECAT00000041783; ENSECAP00000031873; ENSECAG00000024436

Phylogenomic databases

GeneTreeiENSGT00940000155279

Gene expression databases

ExpressionAtlasiA0A3Q2HCE8, baseline

Family and domain databases

Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom
PfamiView protein in Pfam
PF00023, Ank, 2 hits
PF12796, Ank_2, 6 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 2 hits
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 23 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 20 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3Q2HCE8_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3Q2HCE8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 10, 2019
Last sequence update: April 10, 2019
Last modified: October 7, 2020
This is version 9 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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