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Entry version 11 (10 Feb 2021)
Sequence version 1 (10 Apr 2019)
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Protein
Submitted name:

Uncharacterized protein

Gene

ANK2

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANK2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A3Q2GZG4, baseline

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 828ANK_REP_REGIONInterPro annotationAdd BLAST784
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati78 – 110ANKPROSITE-ProRule annotationAdd BLAST33
Repeati111 – 143ANKPROSITE-ProRule annotationAdd BLAST33
Repeati144 – 176ANKPROSITE-ProRule annotationAdd BLAST33
Repeati247 – 279ANKPROSITE-ProRule annotationAdd BLAST33
Repeati280 – 312ANKPROSITE-ProRule annotationAdd BLAST33
Repeati313 – 345ANKPROSITE-ProRule annotationAdd BLAST33
Repeati346 – 378ANKPROSITE-ProRule annotationAdd BLAST33
Repeati379 – 411ANKPROSITE-ProRule annotationAdd BLAST33
Repeati412 – 444ANKPROSITE-ProRule annotationAdd BLAST33
Repeati445 – 477ANKPROSITE-ProRule annotationAdd BLAST33
Repeati478 – 510ANKPROSITE-ProRule annotationAdd BLAST33
Repeati511 – 543ANKPROSITE-ProRule annotationAdd BLAST33
Repeati544 – 576ANKPROSITE-ProRule annotationAdd BLAST33
Repeati577 – 609ANKPROSITE-ProRule annotationAdd BLAST33
Repeati610 – 642ANKPROSITE-ProRule annotationAdd BLAST33
Repeati643 – 675ANKPROSITE-ProRule annotationAdd BLAST33
Repeati676 – 708ANKPROSITE-ProRule annotationAdd BLAST33
Repeati709 – 741ANKPROSITE-ProRule annotationAdd BLAST33
Repeati742 – 774ANKPROSITE-ProRule annotationAdd BLAST33
Repeati775 – 807ANKPROSITE-ProRule annotationAdd BLAST33
Domaini995 – 1183ZU5InterPro annotationAdd BLAST189
Domaini1185 – 1331ZU5InterPro annotationAdd BLAST147
Domaini3597 – 3681DeathInterPro annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 49DisorderedSequence analysisAdd BLAST49
Regioni1484 – 1513DisorderedSequence analysisAdd BLAST30
Regioni1676 – 1783DisorderedSequence analysisAdd BLAST108
Regioni1802 – 2168DisorderedSequence analysisAdd BLAST367
Regioni2220 – 2507DisorderedSequence analysisAdd BLAST288
Regioni2540 – 2825DisorderedSequence analysisAdd BLAST286
Regioni2839 – 2985DisorderedSequence analysisAdd BLAST147
Regioni3003 – 3048DisorderedSequence analysisAdd BLAST46
Regioni3096 – 3134DisorderedSequence analysisAdd BLAST39
Regioni3163 – 3492DisorderedSequence analysisAdd BLAST330
Regioni3577 – 3596DisorderedSequence analysisAdd BLAST20
Regioni3722 – 3741DisorderedSequence analysisAdd BLAST20
Regioni3754 – 3883DisorderedSequence analysisAdd BLAST130

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3506 – 3526Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 48PolyampholyteSequence analysisAdd BLAST48
Compositional biasi1676 – 1700PolarSequence analysisAdd BLAST25
Compositional biasi1737 – 1764PolyampholyteSequence analysisAdd BLAST28
Compositional biasi1802 – 1830PolyampholyteSequence analysisAdd BLAST29
Compositional biasi1852 – 1931PolarSequence analysisAdd BLAST80
Compositional biasi1997 – 2011PolarSequence analysisAdd BLAST15
Compositional biasi2034 – 2067PolyampholyteSequence analysisAdd BLAST34
Compositional biasi2068 – 2083PolarSequence analysisAdd BLAST16
Compositional biasi2098 – 2153PolyampholyteSequence analysisAdd BLAST56
Compositional biasi2280 – 2314PolyampholyteSequence analysisAdd BLAST35
Compositional biasi2380 – 2409PolarSequence analysisAdd BLAST30
Compositional biasi2416 – 2430PolarSequence analysisAdd BLAST15
Compositional biasi2550 – 2584PolarSequence analysisAdd BLAST35
Compositional biasi2595 – 2653PolyampholyteSequence analysisAdd BLAST59
Compositional biasi2661 – 2676PolyampholyteSequence analysisAdd BLAST16
Compositional biasi2684 – 2700PolarSequence analysisAdd BLAST17
Compositional biasi2724 – 2751PolarSequence analysisAdd BLAST28
Compositional biasi2752 – 2773PolyampholyteSequence analysisAdd BLAST22
Compositional biasi2787 – 2804PolyampholyteSequence analysisAdd BLAST18
Compositional biasi2842 – 2857PolyampholyteSequence analysisAdd BLAST16
Compositional biasi2865 – 2881PolarSequence analysisAdd BLAST17
Compositional biasi2899 – 2934PolarSequence analysisAdd BLAST36
Compositional biasi2946 – 2985PolarSequence analysisAdd BLAST40
Compositional biasi3025 – 3048PolarSequence analysisAdd BLAST24
Compositional biasi3099 – 3130PolarSequence analysisAdd BLAST32
Compositional biasi3183 – 3197PolarSequence analysisAdd BLAST15
Compositional biasi3206 – 3220AcidicSequence analysisAdd BLAST15
Compositional biasi3222 – 3276PolarSequence analysisAdd BLAST55
Compositional biasi3292 – 3307PolyampholyteSequence analysisAdd BLAST16
Compositional biasi3321 – 3348PolarSequence analysisAdd BLAST28
Compositional biasi3388 – 3406PolarSequence analysisAdd BLAST19
Compositional biasi3408 – 3445PolyampholyteSequence analysisAdd BLAST38
Compositional biasi3470 – 3484PolarSequence analysisAdd BLAST15
Compositional biasi3754 – 3773PolarSequence analysisAdd BLAST20
Compositional biasi3798 – 3829PolarSequence analysisAdd BLAST32

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis, RepeatARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155279

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023, Ank, 2 hits
PF12796, Ank_2, 6 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 23 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 20 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

A0A3Q2GZG4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHAAASIKK VREAELDEKE KTLERERKKQ RKIPRERMER KRKSDSNASF
60 70 80 90 100
LRAARAGNLD KVVEYLKGGI DINTCNQNGL NALHLAAKEG HVGLVQELLG
110 120 130 140 150
RGSSVDSATK KGNTALHIAS LAGQAEVVKV LVKEGANINA QSQNGFTPLY
160 170 180 190 200
MAAQENHIDV VKYLLENGAN QSTATEDGFT PLAVALQQGH NQAVAILLEN
210 220 230 240 250
DTKGKVRLPA LHIAARKDDT KSAALLLQND HNADVQSKMM VNRTTESGFT
260 270 280 290 300
PLHIAAHYGN VNVATLLLNR GAAVDFTARN GITPLHVASK RGNTNMVKLL
310 320 330 340 350
LDRGGQIDAK TRDGLTPLHC AARSGHDQVV ELLLERGAPL LARTKNGLSP
360 370 380 390 400
LHMAAQGDHV ECVKHLLQHK APVDDVTLDY LTALHVAAHC GHYRVTKLLL
410 420 430 440 450
DKRANPNARA LNGFTPLHIA CKKNRIKVME LLVKYGASIQ AITESGLTPI
460 470 480 490 500
HVAAFMGHLN IVLLLLQNGA SPDVTNIRGE TALHMAARAG QVEVVRCLLR
510 520 530 540 550
NGALVDARAR EEQTPLHIAS RLGKTEIVQL LLQHMAHPDA ATTNGYTPLH
560 570 580 590 600
ISAREGQVDV ASVLLEAGAA HSLATKKGFT PLHVAAKYGS LDVAKLLLQR
610 620 630 640 650
RAAADSAGKN GLTPLHVAAH YDNQKVALLL LEKGASPHAT AKNGYTPLHI
660 670 680 690 700
AAKKNQMQIA STLLNYGAET NIVTKQGVTP LHLASQEGHT DMVTLLLDKG
710 720 730 740 750
ANIHMSTKSG LTSLHLAAQE DKVNVADILT KNGADQDAHT KLGYTPLIVA
760 770 780 790 800
CHYGNVKMVN FLLKQGADVN AKTKNGYTPL HQAAQQGHTH IINVLLQHGA
810 820 830 840 850
KPNATTANGN TALAIAKRLG YISVVDTLKV VTEEVTTTTT TITEKHKLNV
860 870 880 890 900
PETMTEVLDV SDEEGDDTMT GDGGEYLRPE DLKELGDDSL PSSQFLDGMN
910 920 930 940 950
YLRYSLEGGR SDSLRSFSSD RSHTLSHASY LRDSAMIDDT VVIPSHQVSA
960 970 980 990 1000
LAKEAERNSY RLSWGTENLD NVALSSSPIH SGRTSPCLDR DNSSFLVSFM
1010 1020 1030 1040 1050
VDARGGAMRG CRHNGLRIII PPRKCTAPTR VTCRLVKRHR LATMPPMVEG
1060 1070 1080 1090 1100
EGLASRLIEV GPSGAQFLGK LHLPTAPPPL NEGESLVSRI LQLGPPGTKF
1110 1120 1130 1140 1150
LGPVIVEIPH FAALRGKERE LVVLRSENGD SWKEHYCEYT EDELNEILNG
1160 1170 1180 1190 1200
MDEVLDSPED LEKKRICRIV TRDFPQYFAV VSRIKQDSNL IGPEGGVLSS
1210 1220 1230 1240 1250
TVVPQVQAVF PEGALTKRIR VGLQAQPMHS ELVKKILGNK ATFSPIVTLE
1260 1270 1280 1290 1300
PRRRKFHKPI TMTIPVPKAS SDVMLNGFGG DAPTLRLLCS ITGGTTPAQW
1310 1320 1330 1340 1350
EDITGTTPLT FVNECVSFTT NVSARFWLID CRQIQESVTF ASQVYREIIC
1360 1370 1380 1390 1400
VPYMAKFVVF AKSHDPIEAR LRCFCMTDDK VDKTLEQQEN FAEVARSRDV
1410 1420 1430 1440 1450
EVLEGKPIYV DCFGNLVPLT KSGQHHIFSF FAFKENRLPL FVKVRDTTQE
1460 1470 1480 1490 1500
PCGRLSFMKE PKSTRGLVHQ AICNLNITLP VYTKESESDQ EQEEEIDMTS
1510 1520 1530 1540 1550
EKNDETESTE TSVLKSHLVN EVPVLASPDL LSEVSEMKQD LIKMTAILTT
1560 1570 1580 1590 1600
DVSERAGSIK VKELVKAAEE EPGEPFEIVE RVKEDLEKVN EILRSGTCTR
1610 1620 1630 1640 1650
DEASAPRARS ERELVEEEWV IISDEEIEEA RQKAPLEITE YPCVEVRIDK
1660 1670 1680 1690 1700
ETKEEVEKDS TGLVNYLTED LNSYVSPHGE QLQPAQEMAG ETSQAPAVGR
1710 1720 1730 1740 1750
SSENEGKDAH PDETQIPQKQ QKPSLGIKKP VRRKLKEKQK QKEESLQAST
1760 1770 1780 1790 1800
EKTELTKGSS EESLDEDLGL APEPVPAVKA TSPLIEETPI GSIKDKVKAL
1810 1820 1830 1840 1850
QKRVEDEQKG RSKLPIRVKG KEDVPKKIVH RTHPAVSPSL KAEKHTPASP
1860 1870 1880 1890 1900
ASKTERHSSL SSSAKTERHP PVSPSSKTEK HSPVSPSAKT ERHSPVSSSS
1910 1920 1930 1940 1950
KTEKHSPVSP STKTERHSPV SSSTKTERHP PVSPSGKTDK RPPISPSGRP
1960 1970 1980 1990 2000
EKHSPVSPGR TEKRSPVSPA GRIERHPPVS ALGKTEKHLP VSPSGKTEKQ
2010 2020 2030 2040 2050
PPVSPTSKTE RIEETMSVRE LMKAFQSGQD PSKHKAGLFE HKSAKQKQPQ
2060 2070 2080 2090 2100
EKGKVRVEKE KGQMLTQRET QRTESQTIKR GQKILVTGAS ESKRGVRASS
2110 2120 2130 2140 2150
LGFKKEETVG EKEKGVSHKT PEPVRSAPEE ESHKENEVPK EKPAEEQGDM
2160 2170 2180 2190 2200
DLQISPDRKA STDFSDVIKQ ELEDNEKYQQ FRLSEEPEKA QLHLDQVLTS
2210 2220 2230 2240 2250
PFNTTFPLDY VKDEFLPALS LPSGALDGSS ESPKHEGVAG SPCGSLMEGT
2260 2270 2280 2290 2300
PQISSEESYK HEGLAETPET SPESLSFSPK KSEEPVREEN ETTKLETPRE
2310 2320 2330 2340 2350
IHLEKEHPST KDVPDGSEEP GAAVTEGTEP SAECLLKEAT LDPSKDTSSK
2360 2370 2380 2390 2400
QEGDYLDSNS VSLAKETPKG LAEEASCDEG QPTYVSSALK AQTDTEAQGS
2410 2420 2430 2440 2450
TTTKPSDETK ASPLPDVSVK TGTGTEPKPQ GVVRSPQGLE LALPSRDSEV
2460 2470 2480 2490 2500
FSPGADESFA VSHKDSLEAS PVLEDNSSHK TPDSLEPSPL KESPCRDSLE
2510 2520 2530 2540 2550
SSPVEPKMKA GILSSHFPLP AAVAKTELFT EVASMRSRLL RDPDGSAEDD
2560 2570 2580 2590 2600
SLEQTSLMES SGKSPLSPDT PSSEEISYEV TPKATDASTP KPAVIHECAE
2610 2620 2630 2640 2650
EDDLENGEKK RFTPEEEMFK MVTKIKTFDE LEQEAKQKRD YRKEPKQEES
2660 2670 2680 2690 2700
SSSSEPDADS SADVDEPKHM ESAEEESEVP VAVTSESRKA SSSSESEPEL
2710 2720 2730 2740 2750
TQLKKGADSG LLPEPVIRVQ PPSPLPSSID SNSSPEEVQF QPIVSKQYTF
2760 2770 2780 2790 2800
KMNEDTQEES GKSEEEKVCE SHLPEDSQTV STEGPDMSYD DLKRDDDQPK
2810 2820 2830 2840 2850
IYDDHGCEAG SPSSPATPIS SGLHSSCAHD ISEQLVIHKE ALPLQDAEEK
2860 2870 2880 2890 2900
DTEGELDVSG LESPQVEGPS ESSSSPSSLP RCLASERKEL DEDLVSPSSP
2910 2920 2930 2940 2950
TKVEATKTDQ AFESLPKDCS TEDSSITPQT DRLSVDVPVS DPAETDEISD
2960 2970 2980 2990 3000
PQTISPYENV PSQSFFSSEE SKTQTDASHT SFHSSEVCSV TVTSSVAEVA
3010 3020 3030 3040 3050
VESSSSRTVS SKESNFEDQN MELESKQEST LWEMQSDGAP SSVESTIPNT
3060 3070 3080 3090 3100
SAVVGEKISK VIITKTDVDS DSWSEIREDD EAFEARVKEE EQKIFGLMVD
3110 3120 3130 3140 3150
RQSQGTTPDT TPARTPTEEG TPTSEQNPFL FQEGKLFEMT RSGAIDMTKR
3160 3170 3180 3190 3200
SYADESFHFF QIGQESSEET LSEDMKGVST GAEPPQLETS AESLALSQSK
3210 3220 3230 3240 3250
EPVDDEADLL PDDLSEEVEE IPSSDAQLNS QMEISASAET STEDATSAEP
3260 3270 3280 3290 3300
EDLPTTQVSD TPPKSSVKQT SCPDSPEPAV QVHLDFSTVT RSVYSDREDD
3310 3320 3330 3340 3350
SPDSSPEEQK SVIEIPTAPM ESVPSTESKS KIPIRTIPTS TPAPPSAEDE
3360 3370 3380 3390 3400
NSLSEDVPPS LDEESKEDET KPKSKIPVKA PVQRVEQQLL VLDSSLQKTV
3410 3420 3430 3440 3450
APQGQDVTSR ARDDRSKSES DADPLDSKAK SPVKTRSYTE TETESGEKAE
3460 3470 3480 3490 3500
ELELESEEGA TRTKIFASRL PVKSKSTTSS CREDTSPTKD SKEHFLDLYR
3510 3520 3530 3540 3550
NSIEFFEEIS DEASKLVDRL TQSEREQELV SDDESSSALE VSVIENLPPV
3560 3570 3580 3590 3600
ETEHSIPEDI FDTRPIWDES IETLIERIPD ENGHDHAEDQ QDEQERTEER
3610 3620 3630 3640 3650
LAYIADHLGF SWTELARELD FTEEQIHQIR IENPNSLQDQ SHALLKYWLE
3660 3670 3680 3690 3700
RDGKHATDTS LIECLTKINR MDIVHLLETS TEPLQEHMSH SYAEIEQTIT
3710 3720 3730 3740 3750
LDHSEGFSVL QEELCLAQQK QKEEEQAASK EGEPCDQPPI VSEEDISVGY
3760 3770 3780 3790 3800
STFQDYIPKT DGDSSTTELL PQTHKEEVQQ DFSGKMQDLP EKSPPDHQQE
3810 3820 3830 3840 3850
YFVTTPGTEV SETQKATAAS GSPSKTPEEI TTPPEEERPY LQTPTPSEQG
3860 3870 3880 3890 3900
DSPIVQEPEE PLAQREESPR KTSLVIVESA DDQPQAFERL EEDAAFQKEL
3910 3920 3930 3940 3950
TEELGELEAS SDDEATVTTR VVRRRVIIQG DDMPDIPPES VTEEEYIDEH
3960 3970 3980 3990 4000
GHTVVKKVTR KIIKRYVSSD GTEKEEITVQ GLPQDPVDVE EGDGYSKVIK
4010 4020 4030 4040 4050
RVVLKSDTAL SEVTLSEPSI LSSSSQFEAE PVEGRRVSKV VKTTMVHGER
4060 4070 4080 4090 4100
MEKHLGDSSL ATDLPSAKDD FEEALSYTGS HMKVHSPSLV EREILKEDGS
4110 4120 4130 4140 4150
VIKRTVMSKA STRSRAVVKD QHGKHIHLEH LEDVPEALDQ GDLQRDLQQL
4160
LQHFCKEHLK QEAK
Length:4,164
Mass (Da):457,142
Last modified:April 10, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i40ABD5FDF65C48CF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6SQK7F6SQK7_HORSE
Uncharacterized protein
ANK2
3,958Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6SQP2F6SQP2_HORSE
Uncharacterized protein
ANK2
4,137Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2GU11A0A3Q2GU11_HORSE
Uncharacterized protein
ANK2
4,077Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2H3M0A0A3Q2H3M0_HORSE
Uncharacterized protein
ANK2
4,143Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HCE8A0A3Q2HCE8_HORSE
Uncharacterized protein
ANK2
4,156Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HHV3A0A3Q2HHV3_HORSE
Uncharacterized protein
ANK2
4,141Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HPB7A0A3Q2HPB7_HORSE
Uncharacterized protein
ANK2
4,069Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2I396A0A3Q2I396_HORSE
Uncharacterized protein
ANK2
4,098Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSECAT00000063393; ENSECAP00000026051; ENSECAG00000024436

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSECAT00000063393; ENSECAP00000026051; ENSECAG00000024436

Phylogenomic databases

GeneTreeiENSGT00940000155279

Gene expression databases

ExpressionAtlasiA0A3Q2GZG4, baseline

Family and domain databases

Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom
PfamiView protein in Pfam
PF00023, Ank, 2 hits
PF12796, Ank_2, 6 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 2 hits
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 23 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 20 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3Q2GZG4_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3Q2GZG4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 10, 2019
Last sequence update: April 10, 2019
Last modified: February 10, 2021
This is version 11 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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