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Entry version 13 (02 Jun 2021)
Sequence version 1 (10 Apr 2019)
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Protein
Submitted name:

Desmoplakin

Gene

DSP

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DesmoplakinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DSPImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 23

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:28225, DSP

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A3Q1MR22, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini468 – 525SH3InterPro annotationAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2063 – 2109DisorderedSequence analysisAdd BLAST47

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili145 – 165Sequence analysisAdd BLAST21
Coiled coili329 – 349Sequence analysisAdd BLAST21
Coiled coili421 – 451Sequence analysisAdd BLAST31
Coiled coili719 – 739Sequence analysisAdd BLAST21
Coiled coili1057 – 1164Sequence analysisAdd BLAST108

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2064 – 2109Polar residuesSequence analysisAdd BLAST46

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154843

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.1290.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028462, Desmoplakin
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin

The PANTHER Classification System

More...
PANTHERi
PTHR23169, PTHR23169, 2 hits
PTHR23169:SF26, PTHR23169:SF26, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00681, Plectin, 8 hits
PF17902, SH3_10, 1 hit
PF18373, Spectrin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00250, PLEC, 18 hits
SM00150, SPEC, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF75399, SSF75399, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A3Q1MR22-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSCNGGSHPR INTLGRMTRA ESGPDLRYEM TCGGVGGGGG GGGGGGTSRM
60 70 80 90 100
YYSRRCTVTD QNSDGYGQTG TMSRHQNQNT IQELLQNCSD CLMRAELIVQ
110 120 130 140 150
PELKYGDGIQ LARSRELDEC FAQANDQMEI TDSLIREMRQ MGQPCDAYQK
160 170 180 190 200
RLLQLQEQMR ALYKAISGPR VRRASSKGGG GYTCQSGSGW DEFTKRLTSE
210 220 230 240 250
CLGWMRQQRA EMDMMTWGVD LASVEQHISS HRSIHNTIGD YRWQLDKIKA
260 270 280 290 300
DLREKSAIYQ LEEEYENLLK ASFERMDHLR QLQNIIQATS REIMWINDCE
310 320 330 340 350
EEELLYDWSD RNTNIAQKQE AFSIRMSQLE VKEKELNKLK QESDQLVLNQ
360 370 380 390 400
HPASDKIEAY MDTLQTQWSW ILQITKCIDV HLKENAAYFQ FFEEAQSTEA
410 420 430 440 450
YLKGLQDSIR KKYPCDKNTP LQRLLEQIKE LEKEREKILE YKRQVQSLVN
460 470 480 490 500
KSKKIVQLKP RNPDYRSNKP IILRALCDYK QDQKIVHKGD ECILKDNNER
510 520 530 540 550
SKWYVTGPGG VDMLVPSVGL IIPPPNPLAV DLSSKIEQYY EAILALWNQL
560 570 580 590 600
YINMKSLVSW HYCMIDIEKI KAMTIAKLKT MRQEDYMKTI SDLELHYQEF
610 620 630 640 650
IRNSQGSEMF GDDDKRKMQT QFTDAQKHYQ TLVIQLPGHP QHQTVTTTEI
660 670 680 690 700
THLGTCQDVN HNKVIETNRE NDKQEAWMLI ELQKIRRQME LCESRMALKN
710 720 730 740 750
ILLADQGSSH HITVKINELK SVQNDAQAIA QVLNQLKDML ANFRGSEKYC
760 770 780 790 800
YLQNEVFGLF QKLENINGVT DGYLNSLCAV RALLQAILQT EDMLKVYEAR
810 820 830 840 850
LTEEETVCLD LDKVEAYRCG LKKIKNDLNL KKSLLATMKT ELQKAQQIHS
860 870 880 890 900
QTSQQYPLYD LDLGKFSEKV TQLTDRWQRI DKQIDYRLWD LEKQIKQLRN
910 920 930 940 950
YRDNYQTFCK WLYDAKRRQD SLESMKFGDS NTVMRFLNEQ KNLHSEISGK
960 970 980 990 1000
RDKSEEVQKI AELCANSIKD YELQLASYTS GLETLLSIPI KRTVIQSPSG
1010 1020 1030 1040 1050
VILQEAADMH ARYIELLTRS GDYYRFLSEM LKSLEDLKAS NRIQESKNQC
1060 1070 1080 1090 1100
TQVVQERESL LVKIKVLEQD KARLQRLEEE LSRAKTTLEA ESRLKQRLEC
1110 1120 1130 1140 1150
EKQQIQNDLN QWKTQYSRKE EAIRKIESER EKSEREKNSL RSEIERLQAE
1160 1170 1180 1190 1200
IKRIEERCRR KLEDSSRETQ SQLETERCRL QREIDRLKQR PYGSHRETQT
1210 1220 1230 1240 1250
EYEWSVDSSK LVFDGLRKKV TAMQLYECQL IDKATLDKLL KGKKSVEEVA
1260 1270 1280 1290 1300
SEIQPFLRGA GAIAGASASP KEKYSLVEAK RKKLITPEST VMLLEAQAAT
1310 1320 1330 1340 1350
GGIIDPHRNE KLTVDSAIAR DLIDFDDRQQ IYTAEKAITG FDDPFSGKTV
1360 1370 1380 1390 1400
SVSEAIKKNL IDRETGMRLL EAQIASGGVV DPVNSVFLPK DVALARGLID
1410 1420 1430 1440 1450
RDLYRSLNDP RDSQKNFVDP VTKKKVSYMQ LRERCRIEPH TGLLLLSVQK
1460 1470 1480 1490 1500
RSMSFQGIRQ PVTVSELVDS GILRPSTVNE LESGQISYDE VGERIKDFLQ
1510 1520 1530 1540 1550
GSSCIAGIYN ETTKQKLGIY EAMKIGLVRP GTALELLEAQ AATGFIVDPV
1560 1570 1580 1590 1600
SNLRLPVEEA YKRGLVGIEF KEKLLSAERA VTGYNDPETG NIISLFQAMN
1610 1620 1630 1640 1650
KELIEKGHGI RLLEAQIATG GIIDPKESHR LPVDIAYKRG YFNEELSEIL
1660 1670 1680 1690 1700
SDPSDDTKGF FDPNTEENLT YLQLKERCIK DEETGLCLLP LKEKKKQVQT
1710 1720 1730 1740 1750
SQKNTLRKRR VVIVDPETNK EMSVQEAYKK GLIDYDTFKE LCEQECEWEE
1760 1770 1780 1790 1800
ITITGSDGST RVVLVDRKTG SQYDIQDTID KGLIDRKFFE QYRSGSLSLT
1810 1820 1830 1840 1850
QFADMISLKN GVGGGVGGIV GGGSSTGGGL SDDVFGSSRQ ETVSKISTIS
1860 1870 1880 1890 1900
SIRNLTIRSS SLSEPLEESS PIAAIFDTEN LEKISISEGI ERGIVDSISG
1910 1920 1930 1940 1950
QRLLEAQACT GGIIHPTTGQ KLSLQDAVSQ GLIDQDMATR LKPAQKAFIG
1960 1970 1980 1990 2000
FEGVKGKKKM SAAEAVKEKW LPYEAGQRFL EFQYLTGGLV DPEVQGRIST
2010 2020 2030 2040 2050
EEAIRKGYID GRAAQRLQDT STYGKILTCP KTKLKISYKD AINRSMVEDV
2060 2070 2080 2090 2100
TGLRLLEAAS VSSKGLPSPY NMSSAPGSRS GSRSGSRSGS RSGSRSGSRR
2110 2120
GSFDATGNSS YSYCYSFSSS SIGH
Length:2,124
Mass (Da):241,270
Last modified:April 10, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i73C61E35BA393BFF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E1BKT9E1BKT9_BOVIN
Desmoplakin
DSP
2,889Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000083587; ENSBTAP00000074540; ENSBTAG00000015106

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSBTAT00000083587; ENSBTAP00000074540; ENSBTAG00000015106

Organism-specific databases

VGNCiVGNC:28225, DSP

Phylogenomic databases

GeneTreeiENSGT00940000154843

Gene expression databases

ExpressionAtlasiA0A3Q1MR22, baseline and differential

Family and domain databases

Gene3Di3.90.1290.10, 3 hits
InterProiView protein in InterPro
IPR028462, Desmoplakin
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
PANTHERiPTHR23169, PTHR23169, 2 hits
PTHR23169:SF26, PTHR23169:SF26, 2 hits
PfamiView protein in Pfam
PF00681, Plectin, 8 hits
PF17902, SH3_10, 1 hit
PF18373, Spectrin_like, 1 hit
SMARTiView protein in SMART
SM00250, PLEC, 18 hits
SM00150, SPEC, 3 hits
SUPFAMiSSF75399, SSF75399, 4 hits
PROSITEiView protein in PROSITE
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3Q1MR22_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3Q1MR22
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 10, 2019
Last sequence update: April 10, 2019
Last modified: June 2, 2021
This is version 13 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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