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Entry version 11 (10 Feb 2021)
Sequence version 1 (13 Feb 2019)
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Protein

Non-specific serine/threonine protein kinase

Gene
N/A
Organism
Schistosoma mansoni (Blood fluke)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinasePROSITE-ProRule annotationARBA annotation, Transferase
Biological processDNA damage, DNA repairARBA annotation
LigandATP-bindingARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchistosoma mansoni (Blood fluke)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6183 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaSpiraliaLophotrochozoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008854 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1704 – 2418FATInterPro annotationAdd BLAST715
Domaini2561 – 2904PI3K/PI4KInterPro annotationAdd BLAST344
Domaini2872 – 2904FATCInterPro annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2809 – 2840DisorderedSequence analysisAdd BLAST32

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family. ATM subfamily.ARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1070.11, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR003152, FATC_dom
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR003151, PIK-rel_kinase_FAT
IPR014009, PIK_FAT
IPR012993, UME

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02259, FAT, 1 hit
PF02260, FATC, 1 hit
PF00454, PI3_PI4_kinase, 1 hit
PF08064, UME, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01343, FATC, 1 hit
SM00146, PI3Kc, 1 hit
SM00802, UME, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51189, FAT, 1 hit
PS51190, FATC, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A3Q0KRJ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKNSESFDPQ DTVKFIYCIL DEIAGSVDHI GECQVTGLLP LLSRVESTFK
60 70 80 90 100
YRHYQLSQAL TSFLMDDFST WCIYRLIVIA CRPPFTYHLQ VVGDLIRSLM
110 120 130 140 150
LFLERHHLNI YLKKAVHLVS VLNDLLNTMG LFDQRGSDDF SWVLRAPTKQ
160 170 180 190 200
NAIVPPEDSK SDELRFHCLP IELSALREAY RLVSILSYTL GSLIASFHAY
210 220 230 240 250
LPSVVQHIFR ILCIAVELTD VHGKQKALDA IYQGTDALIN LVHEPIYGST
260 270 280 290 300
TLNYIYAASG LVLTFLSSWH DRTVNLPSDL LIVDECTNLE NTTVLCLRLL
310 320 330 340 350
SMIEQRIVKL NQPGYECFNH QKLLNRICFQ ILESDWIKSS NHRDLKYAII
360 370 380 390 400
DFNLHFLSIY LLSNGKNLLC LLPFISNVDE EVTKCFEEDE YFSNPLSIII
410 420 430 440 450
PIEMFGIQYK SIISKILFSC DIVSVKEFLE AHVVKNPVCD DISQETTKEW
460 470 480 490 500
IVFIRIWSGL SDLQSLMELK DIIQKLSAQS FHGVFDYLTK SIFFSSTMKP
510 520 530 540 550
INSKKFATTY FGLRLLANAV ITIQDFSLYD TSVLQSLITW LKNIKCQVKC
560 570 580 590 600
DERHWIYICG PTISLLCSLM FWFSTANVMS AEELSDILVD YIMSYITLDE
610 620 630 640 650
DHITIWLHYL LDKMSKSSSD GNFELAVKQC LFLKLFKQLK TNQSMTKPMI
660 670 680 690 700
ILLCRLSASI LCSVNNCPTD PSLYCTHSIH NRFDFSNSSN ENNADNLENL
710 720 730 740 750
SLFEYIEFLS FIFDQSKVVE NVDALINDFA VYLASHIRWS FMSTDQIRIY
760 770 780 790 800
FTLIMENLCG LTPSTVRKIF CDTSNNLSKT NLNSWITVHK SIMELLNNQS
810 820 830 840 850
NEKSTDISIA TTVEYHIMIY GALGCCLASC YTDFMFNQKL QMNNYEFFCG
860 870 880 890 900
RMSSETLGIN GSSCVTSTQV IDLVVSILSI LCRLGLVHQY SHGLFGTVYT
910 920 930 940 950
QIQELILLLH LPSAQVIRLS DHQLAQIIVE HMDQSLCQAM ESLSRLFRVD
960 970 980 990 1000
KKILFKELIA ALFITLVIRG NQESHLRIRQ LISEVPYLDS QQDYIGKIVQ
1010 1020 1030 1040 1050
LCILPETLVY IFTRTSKDDQ AVHLAFLEAH LNMSIERIAR LNDISRLMHQ
1060 1070 1080 1090 1100
FILRLYPYRV GACLGLRWIS SIILPQISRT LVSGRNFVLA DFLGHYVCGI
1110 1120 1130 1140 1150
LAFFDNMLLN DDVILEHRWS ALRSLVVFIK LLGSNHVTRM RAKFMANLKI
1160 1170 1180 1190 1200
CMRYNTSPFG KVVVKAWRSF IRMLEPESLE ELLPDLGATL VGLLSSDSDQ
1210 1220 1230 1240 1250
VVDLFHYLFL EKREQIGDRL SCLFFLPRLP ALLTCQQILD DLCPWRATCF
1260 1270 1280 1290 1300
INSVNSTEAE FHQPLTAWLS ALTHSSRSVR RLTLTSEVNL GANDQHGKIL
1310 1320 1330 1340 1350
QSRLWGLPSL LDRSISSAKG GEIRSMSSDT IHCVDSVCGI SFRGNTALLA
1360 1370 1380 1390 1400
DIVASLLEGL TRDTDEKMRL LYAQWLGNLG AVDPCKLYLS NGEVKTGQNE
1410 1420 1430 1440 1450
KESVIFVNDR RFPFHILCEL AKIYLRAASP RQLDSAALAV QELLKLFKVP
1460 1470 1480 1490 1500
DVGKSNNSSS LTAQDPADSS LSSFFWGSEL WNLFPEHLRD LFAPLLTSRY
1510 1520 1530 1540 1550
VVESFINWSA IRIPIITNEV DLNYESWIRL WSGSLSSHIK SPVVFNIFQF
1560 1570 1580 1590 1600
CEPVVKADAT FARLMLEHSA LQVLLDDSEN GISALKSEIL AVFTEVTESS
1610 1620 1630 1640 1650
HENGSHIEFD YLLKNINLQE DHPPSYRPWQ PWFPLSVQTI FSLLDYLKHW
1660 1670 1680 1690 1700
LRIQQEYQAT KSTVKSATAV QNVPKDVNVL QHAVAPSEGI ERVSSFLSNI
1710 1720 1730 1740 1750
PNLLQAKASL RCGSFARALL HWELAYGEDT VAQQSAFVTG TAICRSNTDH
1760 1770 1780 1790 1800
TLGFTKTVPD QVGINSISSS DIQSTLHFSN GLGKTGFTIL VGLLDTYASL
1810 1820 1830 1840 1850
HDSDGLAGVL SATQLSFTAF RQEFYKEKQH ESKLCNKNMK LLSDTAQRFS
1860 1870 1880 1890 1900
LLRALELENE GQLDMAAAAY EHSLATSESS HRSSQCQQPS KEIRDNQHLL
1910 1920 1930 1940 1950
MYSGLFRCEL PDPARLHGLV ERAGALVRKS KSHSNTFGNS SVWVDCLNAH
1960 1970 1980 1990 2000
RAEAAWRLGD WETLQETTNM NLLECSWSVG LGRLFLAMKD KRTSDWSKIL
2010 2020 2030 2040 2050
ARLRIDQVTE LGAAALEGPG GYIRAYDTIV RLSSLSDIEL ISSLGDVIMN
2060 2070 2080 2090 2100
EIRNPTNSRS SESNLSNIVE TSLKLLETRI RVSRPTFHTL EPVLAIQHAA
2110 2120 2130 2140 2150
LQLVTSALSS FNSDTYQISN REVLNSTISR LRTALGYNWL ERAKLARKSG
2160 2170 2180 2190 2200
QFMAAYTCVL RAEDFGIPDA LLERAKLLWK TDKREAAQTC LDKGIPDVFG
2210 2220 2230 2240 2250
CNIFNVRNKP SNENNEVSTE YRTISAQQAL LLRTRYCEET NRYDFETTGK
2260 2270 2280 2290 2300
LYEQVCSFNS GYEEAHFRLA RYVDRARTQA VGCKQQNALI KVALQQYGLA
2310 2320 2330 2340 2350
LSYGSQFIYQ SMPRLLTLWL DYGQDSVRNS HELNKSQKHT EENNLHSEQK
2360 2370 2380 2390 2400
VFNEVQELMR INCQRIPVYQ FYTALSQLLS RVCHEIPTVV TTLIALIVRI
2410 2420 2430 2440 2450
FETYPLQTMW FLIPLNDSTV RQRRDRCQQI FNMIKTKQPH LSKFIADSIA
2460 2470 2480 2490 2500
LCNHLKTVCG LFMTADRREL RNFSLRQTVR PITRLIESSE FSRILIPIHR
2510 2520 2530 2540 2550
QLVPNHLLPN ATPEQIAHHW PFAEQPDRLV CLTHIEDTVE ILGSQTRPKK
2560 2570 2580 2590 2600
MTWVGSDGRE YIIVAKPNDD LRKDSRLMEL NGMINKFLVI NENTRRRALQ
2610 2620 2630 2640 2650
IRTYAVIPLS EKGGLIEWVR NTQPFRSIIT RLYNEIGKPI NWANMSRVAP
2660 2670 2680 2690 2700
LLEDPLSVKR DKYLNKWLPM FPLVFYNWFL STFSNPSSWY SGRECYARTC
2710 2720 2730 2740 2750
AVMSMVGYVL GLGDRHTENI LFDSISGDLV HVDFSCVFNN GLTLPWPERV
2760 2770 2780 2790 2800
PFRLTRNMVH AMGPTGYEGT FRRCSEAVMR LLRHEIDPLL AVFRPIYFDA
2810 2820 2830 2840 2850
VVEQTGNVRS NAFPGGESSG RTRRGGSTSD GSASSDLDLT ERATRAATEK
2860 2870 2880 2890 2900
LARMEDRLKG KITEHDGFSQ ILPMSVEGQV DTLIKEATDV DRLCQMYKGW

MPFL
Length:2,904
Mass (Da):330,381
Last modified:February 13, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E74BE153D6DDE76
GO

Genome annotation databases

WormBase ParaSite

More...
WBParaSitei
Smp_162340.1; Smp_162340.1; Smp_162340

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

WBParaSiteiSmp_162340.1; Smp_162340.1; Smp_162340

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR003152, FATC_dom
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR003151, PIK-rel_kinase_FAT
IPR014009, PIK_FAT
IPR012993, UME
PfamiView protein in Pfam
PF02259, FAT, 1 hit
PF02260, FATC, 1 hit
PF00454, PI3_PI4_kinase, 1 hit
PF08064, UME, 1 hit
SMARTiView protein in SMART
SM01343, FATC, 1 hit
SM00146, PI3Kc, 1 hit
SM00802, UME, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51189, FAT, 1 hit
PS51190, FATC, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3Q0KRJ9_SCHMA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3Q0KRJ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 13, 2019
Last sequence update: February 13, 2019
Last modified: February 10, 2021
This is version 11 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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