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UniProtKB - A0A3Q0EIJ3 (A0A3Q0EIJ3_CARSF)

Entry version 10 (10 Feb 2021)
Sequence version 1 (13 Feb 2019)
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Protein
Submitted name:

kinectin isoform X3

Gene

KTN1

Organism
Carlito syrichta (Philippine tarsier) (Tarsius syrichta)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
kinectin isoform X3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KTN1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCarlito syrichta (Philippine tarsier) (Tarsius syrichta)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1868482 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Tarsiiformes › Tarsiidae › Carlito
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000189704 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 29HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 163Rib_recp_KP_regInterPro annotationAdd BLAST135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni49 – 80DisorderedSequence analysisAdd BLAST32
Regioni110 – 217DisorderedSequence analysisAdd BLAST108

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili341 – 368Sequence analysisAdd BLAST28
Coiled coili373 – 393Sequence analysisAdd BLAST21
Coiled coili405 – 432Sequence analysisAdd BLAST28
Coiled coili441 – 503Sequence analysisAdd BLAST63
Coiled coili564 – 591Sequence analysisAdd BLAST28
Coiled coili602 – 622Sequence analysisAdd BLAST21
Coiled coili654 – 720Sequence analysisAdd BLAST67
Coiled coili730 – 753Sequence analysisAdd BLAST24
Coiled coili758 – 785Sequence analysisAdd BLAST28
Coiled coili796 – 816Sequence analysisAdd BLAST21
Coiled coili839 – 866Sequence analysisAdd BLAST28
Coiled coili874 – 897Sequence analysisAdd BLAST24
Coiled coili905 – 932Sequence analysisAdd BLAST28
Coiled coili940 – 960Sequence analysisAdd BLAST21
Coiled coili971 – 1012Sequence analysisAdd BLAST42
Coiled coili1092 – 1140Sequence analysisAdd BLAST49
Coiled coili1152 – 1224Sequence analysisAdd BLAST73
Coiled coili1274 – 1294Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi63 – 80PolyampholyteSequence analysisAdd BLAST18
Compositional biasi110 – 139PolyampholyteSequence analysisAdd BLAST30
Compositional biasi162 – 186PolyampholyteSequence analysisAdd BLAST25
Compositional biasi194 – 217PolyampholyteSequence analysisAdd BLAST24

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR024854, Kinectin
IPR007794, Rib_rcpt_KP

The PANTHER Classification System

More...PANTHERi		PTHR18864, PTHR18864, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05104, Rib_recp_KP_reg, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A3Q0EIJ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEFYESTYFI VLIPSIVITV IFLFFWLFMK ETLYDEVLAK QKREQKLIPT 
        60         70         80         90        100
KTDKKKAEKK KNKKKEIQNG NLHESDSESV PRDFKLSDAL TVEDEQVVLA 
       110        120        130        140        150
PLNVIETSSS VRERKKREKR QKPVLEEQVI KESDVSKIPG KKAEPVPVTK 
       160        170        180        190        200
QPTPPSEVAA SKKKPGQKKS KNGSDDQDKK VETLMASSKK QETLPLHQET 
       210        220        230        240        250
KQEIGSGKKK VSSKKQKTEN VLVDEPLIHA TTYIPLMDNA DSNPVVDKRE 
       260        270        280        290        300
VTDLIKPDQV EGIQKSGTKK LKTETDKENA EVKFKDFLLS LKTMMFSEDE 
       310        320        330        340        350
ALCIVDLLKE KSGVIQDALK KSNKGELTAL IHQLQEKDKV LAAVKEDAAA 
       360        370        380        390        400
TKDRCKQLTQ EMMTEKERNN VVIARMKDRI GTLEKEHNVF QNKIHVSYQE 
       410        420        430        440        450
TQQMQMKFQQ VREQMEAEIA HLKQENGILR DAVSNTTNQL ENKQSAELSK 
       460        470        480        490        500
LRQDYARLVN ELTEKTGKLQ QEEVQKKSAE QAVTQLKAQL QEAERRWDEV 
       510        520        530        540        550
QSYIRKRTAE HEAAQQDLQG KFVAKENEVQ SLHSKLTDTL VSKQQLEQRL 
       560        570        580        590        600
MQLMESEQKR VNKEEALQMQ VQDILEQNEA LKTQIQQFHS QIAAQTSASV 
       610        620        630        640        650
LAEELHKVIA EKDKQIKQTE DSLANEHDHL TSKEEELKDI QNMNFLLKAE 
       660        670        680        690        700
VQKLQALANE QAAAALELEK MQKSIHVKDD KIRLLEEQLQ CEISNKMEEF 
       710        720        730        740        750
KILNDQNKAL KLEVQKLQAL VTEQPNKDVV EQMEKCIQEK DEKLKTVEEL 
       760        770        780        790        800
LETGLIQVAT KEEELNAIRT ENSSLTKEVQ DLKAKQNDQV SFASLVEELK 
       810        820        830        840        850
KVIHEKDGKI KSVEELLEAE LLKVANKEKT VQLSVTSQVQ ELQNLLKGKE 
       860        870        880        890        900
EQMNSMKAVL EEKEKDLANR GNWLQDLQEE NESLKSHVQE LAQHNLKEAC 
       910        920        930        940        950
STSQFEELEI MLKEKENEMK RIEAMLKERE SDLSSKTRLL QMVQDENRSF 
       960        970        980        990       1000
QSHIEQLKQQ NYQQASSFSP QEELLKVISE REKEISGLQN ELESLKDAVE 
      1010       1020       1030       1040       1050
YQRKKNNDLR EKNWEAMEAL ASTEKMLQDK VNKTSKERQQ HVEAVELESK 
      1060       1070       1080       1090       1100
DVLRKLFPKV SVPSSLSYSE WLYGFEKKAK EYMAGTSGSE EVKVLEHKLK 
      1110       1120       1130       1140       1150
EADEMHTLLQ LECEKYKSVL AETEGILQKL QRSVEQEENK WKVKVDESQK 
      1160       1170       1180       1190       1200
TIQQMQSSFI SSEQELEQLR RENKEIENLR KEREHLEMEL EKAEIERSTY 
      1210       1220       1230       1240       1250
VTEVRELKTQ LNATVTKLKT EQSERQKVAG DLHKAQQSLD LIQSKIVKAA 
      1260       1270       1280       1290       1300
GDTTVIENSD ISPETESSEK ETMAVSLNQT ITQLQQLLQA VNQQLTKEKE 
      1310 
PEPCLVPVWS SCGLP
Length:1,315
Mass (Da):151,400
Last modified:February 13, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8801AFFD7E8A9245
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q0EEA7A0A3Q0EEA7_CARSF
kinectin isoform X1
KTN1
1,366Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q0EG46A0A3Q0EG46_CARSF
kinectin isoform X2
KTN1
1,359Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...RefSeqi		XP_021573913.1, XM_021718238.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_021573913.1, XM_021718238.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Family and domain databases

InterProiView protein in InterPro
IPR024854, Kinectin
IPR007794, Rib_rcpt_KP
PANTHERiPTHR18864, PTHR18864, 1 hit
PfamiView protein in Pfam
PF05104, Rib_recp_KP_reg, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3Q0EIJ3_CARSF
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3Q0EIJ3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 13, 2019
Last sequence update: February 13, 2019
Last modified: February 10, 2021
This is version 10 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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