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Entry version 3 (05 Jun 2019)
Sequence version 1 (13 Feb 2019)
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Protein
Submitted name:

coiled-coil domain-containing protein 88B

Gene

Ccdc88b

Organism
Mesocricetus auratus (Golden hamster)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
coiled-coil domain-containing protein 88BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ccdc88bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMesocricetus auratus (Golden hamster)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10036 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeMesocricetus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000189706 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501800117426 – 1470Sequence analysisAdd BLAST1445

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni424 – 446DisorderedSequence analysisAdd BLAST23
Regioni493 – 601DisorderedSequence analysisAdd BLAST109
Regioni626 – 708DisorderedSequence analysisAdd BLAST83
Regioni1320 – 1470DisorderedSequence analysisAdd BLAST151

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili198 – 218Sequence analysisAdd BLAST21
Coiled coili251 – 323Sequence analysisAdd BLAST73
Coiled coili334 – 354Sequence analysisAdd BLAST21
Coiled coili358 – 385Sequence analysisAdd BLAST28
Coiled coili403 – 423Sequence analysisAdd BLAST21
Coiled coili459 – 479Sequence analysisAdd BLAST21
Coiled coili721 – 748Sequence analysisAdd BLAST28
Coiled coili763 – 902Sequence analysisAdd BLAST140
Coiled coili918 – 952Sequence analysisAdd BLAST35
Coiled coili981 – 1029Sequence analysisAdd BLAST49
Coiled coili1086 – 1134Sequence analysisAdd BLAST49
Coiled coili1138 – 1214Sequence analysisAdd BLAST77
Coiled coili1222 – 1256Sequence analysisAdd BLAST35
Coiled coili1261 – 1292Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi530 – 547PolarSequence analysisAdd BLAST18
Compositional biasi557 – 577PolarSequence analysisAdd BLAST21
Compositional biasi640 – 675PolyampholyteSequence analysisAdd BLAST36
Compositional biasi1393 – 1409PolarSequence analysisAdd BLAST17
Compositional biasi1439 – 1459PolyampholyteSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036872 CH_dom_sf
IPR008636 Hook-like_fam

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05622 HOOK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A3Q0CMX5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGAKGPRLK DFLSGSLATW ALGLAGLVGE AEESAGTEEE DKGPLCAEKR
60 70 80 90 100
FLQLSDGALL LRVLGIIAPS SRGRGLRMIR DQDGPAACRM WNLHHLWGRL
110 120 130 140 150
RDFYQEELQL LILSPPPDLQ TLGFDPLSEE AVGELEGILR LLLGASVQCE
160 170 180 190 200
HRELFIRHIR GLSLDVQSEL AIVIQEVTQP GAGVVMALAG PESGEIEAVE
210 220 230 240 250
LEIQIRNLMG TMSRLVRERD LGAQRLAEML LEREPARLPE APANAPAEGP
260 270 280 290 300
SHHLALQLTN AKAQLRRLRQ EVEEKAELLL DSQAEVQGLE AEIRRLRQEA
310 320 330 340 350
QALSGQAKRA ELYREEAEAL RERAGRLPRL QEELRRCRER LQAAEVFKGQ
360 370 380 390 400
LEEERLLSGA LEASKAMLEE QLEVARERST RLHETQRENL LLRTRLGEAH
410 420 430 440 450
AELDSLRHQW EQLVEENVEL ELELQRSLEP PPGSPGEAPL LGAAPSLQDE
460 470 480 490 500
VREAEAGRLR TVERENQELL GLLQMMQQQL GSQHPLLEEQ SKDSMLPVPN
510 520 530 540 550
LGPPTPLGPD HSLQSWACQR GGEGPESLDL ASSASDSDIT RSSECPQAPD
560 570 580 590 600
SHPEVMESSF QRASRDPQTS ALTFQESDPT VEEKHGSLEK SSQGVSLQGP
610 620 630 640 650
IVWAQTQGPE IRIEVQELLG EPRSREVLQE ELVPEAQVLK QESPERRPRS
660 670 680 690 700
SDFKLDQESL DQELELSKQQ TEAGGHELKP ETLVSSPAPR KPQQTSEGAP
710 720 730 740 750
DAWSREEPIL EETLASAVPE EQALRDEVAQ LKREVVGLEA KLQAQAQRLE
760 770 780 790 800
ARSAEAICLS EELAQARRAE AEAHQEAETW AQEQARLREA VDTASLELEA
810 820 830 840 850
ASREREALAE ALAAAGRERR QWEREGPRLR AQVEAAEQQV QTLESQVRRH
860 870 880 890 900
LEEAEREHLE KRALREELEK AVVRGQELGA RLEHLQQELG QAALERQEFL
910 920 930 940 950
REQESQHQRY QGLELRLEAE LQAAATSKEE ALMELKARAL KLEEELIQLR
960 970 980 990 1000
QYPVGLTTEA GAEPRTVETQ NGRLIEVERS NATLVAEKAA LQGQLQHLEG
1010 1020 1030 1040 1050
QLGSLQGRAQ ELLLQSQRAQ EHSSRLQAEK SMMEKQGQEL HRKLGMLEEE
1060 1070 1080 1090 1100
VRAARLAQEE TRGQQQALLR DHEALAQLQR RQESELEGLL VRHRDLKANM
1110 1120 1130 1140 1150
RALELAHREL QGRHEQLQAQ RASVEAQEVA LLAERERLMQ DGRRQRGLEE
1160 1170 1180 1190 1200
ELRRLQNEHD RAQKLLAEVS RERGELQGER GELRGRLARL ELERAQLEMQ
1210 1220 1230 1240 1250
SQQLRESNQQ LDLSACRLTT QCELLTQLRS AQEEENRQLL AEVQALSREN
1260 1270 1280 1290 1300
RELLERSLES RDHLHREQRE YLDQLNALRR EKQKLVEKIM DQYRVLEPGP
1310 1320 1330 1340 1350
LPRTKKGSWL ADKVKRLIRP RREGALHGGP RLGADGAGST ESLGGPLETE
1360 1370 1380 1390 1400
LPEGREADGT GSSSPAPMRR AQSSLCLGEE TLAGGQRRRL SSRLPGGRSS
1410 1420 1430 1440 1450
ESFSPGDTPR QRFRQRRPGP LGAPSAHSKG SGVEWDGSIK TLPEHETDAS
1460 1470
REALQDQKPE KHPLTSSLSQ
Length:1,470
Mass (Da):165,063
Last modified:February 13, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE66607BCB8239718
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_021082031.1, XM_021226372.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_021082031.1, XM_021226372.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR036872 CH_dom_sf
IPR008636 Hook-like_fam
PfamiView protein in Pfam
PF05622 HOOK, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3Q0CMX5_MESAU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3Q0CMX5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 13, 2019
Last sequence update: February 13, 2019
Last modified: June 5, 2019
This is version 3 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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