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Entry version 11 (07 Oct 2020)
Sequence version 1 (13 Feb 2019)
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Protein

Reverse transcriptase

Gene
N/A
Organism
Oryzias latipes (Japanese rice fish) (Japanese killifish)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonucleaseARBA annotation, Hydrolase, Nuclease, Nucleotidyltransferase, RNA-directed DNA polymeraseARBA annotation, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Reverse transcriptaseARBA annotation (EC:2.7.7.49ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryzias latipes (Japanese rice fish) (Japanese killifish)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000265180 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini698 – 877Reverse transcriptaseInterPro annotationAdd BLAST180
Domaini1242 – 1400Integrase catalyticInterPro annotationAdd BLAST159

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 21DisorderedSequence analysisAdd BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili114 – 134Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT01000000214524

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.70.10, 1 hit
3.30.420.10, 1 hit
3.30.70.270, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001969, Aspartic_peptidase_AS
IPR043502, DNA/RNA_pol_sf
IPR001584, Integrase_cat-core
IPR041588, Integrase_H2C2
IPR021109, Peptidase_aspartic_dom_sf
IPR005162, Retrotrans_gag_dom
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
IPR000477, RT_dom
IPR041373, RT_RNaseH

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17921, Integrase_H2C2, 1 hit
PF03732, Retrotrans_gag, 1 hit
PF17917, RT_RNaseH, 1 hit
PF00665, rve, 1 hit
PF00078, RVT_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50630, SSF50630, 1 hit
SSF53098, SSF53098, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00141, ASP_PROTEASE, 1 hit
PS50994, INTEGRASE, 1 hit
PS50878, RT_POL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A3P9MP57-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESRTSAGLS GLYNPDALKD HESVDPDFTV GQFVTIREKS PSEITSMLGS
60 70 80 90 100
LYLDDEEDEN ECIAPEDIRH RKAKLLTNVE VVHVNADDDG ANAVDEQQYR
110 120 130 140 150
RSKDQEEQNI KADLNCVTLE VVALKEQVHN LEVRLGDSIT SSFNRESNFR
160 170 180 190 200
EYIDVCFAKM ENNLISKVEK LEKDVVNCML RRDWKWKNQL KNIKAESTPI
210 220 230 240 250
AQRSIAISTE LQYSTLSDEP RLIVPSQPGA THFYSTPTVH SQPGVTPFYS
260 270 280 290 300
TPPVRLDFPS FGTSSESSDV VIFIEQCENY LDIRPLSNHE LMGALSAVLK
310 320 330 340 350
GPALSWWKAT KHQIQDWTSF KNAFMAAFLP ADYLTEVEEK MRTTVQKPDQ
360 370 380 390 400
CLRDFAYDYR ALCLKWKRDM SEEEVVRRIL NNINPKVAGC LRGTVSTVAQ
410 420 430 440 450
LVKIGAMVEK DCTGAKDYWQ RVHANSDRFP KKPPDRKANQ KGTVGVTVVP
460 470 480 490 500
QHTIREPNLL MIPVSIRGMQ VEAVVDTGST FTLMRESLWN QLTGPEEIFQ
510 520 530 540 550
LTERQRFVMA DGTVHQELGH KTLCLEWHQD QWTINVHVME DRHLAFSLVL
560 570 580 590 600
GLDFLSKSGA ILDMSRNSYG VKTDHGYKFH AFLHQTGDFR EWKKSTISSC
610 620 630 640 650
LSPVSLYYAL QPGEFPPCWS VVTATDMVQT CDTDNPDSSR LLHKLVEDWP
660 670 680 690 700
TITSGILGKT TVEKHTILLQ DEIPVRSRAY RVSPFKKNII EEHVAKMLKD
710 720 730 740 750
GIIEPSQSAW SSPVVLVDKP DGSYRFCVDY RRVNAKTLPD AYPMPLIHDI
760 770 780 790 800
LESMDGASWF STLDLQSGYW QVAMDEQSKP QTAFITSIGL FQFKCMPFGL
810 820 830 840 850
RNAAATFQRL MEKVLGELKG KLCFVYIDDI IVYSKTQEDH LKDLAEVFHR
860 870 880 890 900
LHRANLSLNM DKCHFFKKQL RFLGHVVSGE GVAADPAKTQ AIAEFPVPTD
910 920 930 940 950
IKSLQRFLGL AGWYHKFIAN FSDIAAPLNH LKKKGVEWHW STECQASMDA
960 970 980 990 1000
LKKALTSPPI LAQPDMSLPF QVHTDASEVG LGAILSQETK DGERVIAYAS
1010 1020 1030 1040 1050
RGLRGPERNY STSEKECLAV VWAVEKWRHY LEGKEFSVYT DHAALSWAFN
1060 1070 1080 1090 1100
CPKTTSRLTR WILRLQQFHF KVLYRKGCLN VAPDALSRGY TPLIIKPSPC
1110 1120 1130 1140 1150
FAVTLKSPSD LPTSLAEIAQ AQDHDPKLKE MKRTQSDINT SPQRISFAEH
1160 1170 1180 1190 1200
QGVLYRRIPL QNQGERFQLV VPQALVPVFL RYFHDNPLGG HLGRLKTLLK
1210 1220 1230 1240 1250
ILDVAWWPSV RKDVWEHTKK CETCQKYKPG NCKPSGLLQN ITVNKPGEML
1260 1270 1280 1290 1300
GIDLMGPFPR SKKSNVFLLV VVDYYSKWVE LFPLRDSKTP RIIKILIEEI
1310 1320 1330 1340 1350
FTRWGVPQYL VSDRGPQFTS SLLIDLCNTW GVVQKLTTSY HPQTNLTERV
1360 1370 1380 1390 1400
NRTLKTMIAS FVGQHHHAWD QWLPEFRFAI NTAQQETTGK TPAELALGRN
1410 1420 1430 1440 1450
LYGPLQRLIY KPPSPQQQAT YNLVERQQQL AEEVKRRVGV HQARNAKYYN
1460 1470 1480 1490 1500
TRRKDAHFLP GDLVWVRSHP LSKATEKFSA KLAPKWEGPA KIIKKLGPIN
1510 1520
YRVIWGDPQK KEDTVNVVNL KTYHGVFP
Length:1,528
Mass (Da):173,960
Last modified:February 13, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6D0C5FAB8A6CB39E
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSORLT00020029619; ENSORLP00020034677; ENSORLG00020021286

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSORLT00020029619; ENSORLP00020034677; ENSORLG00020021286

Phylogenomic databases

GeneTreeiENSGT01000000214524

Family and domain databases

Gene3Di2.40.70.10, 1 hit
3.30.420.10, 1 hit
3.30.70.270, 2 hits
InterProiView protein in InterPro
IPR001969, Aspartic_peptidase_AS
IPR043502, DNA/RNA_pol_sf
IPR001584, Integrase_cat-core
IPR041588, Integrase_H2C2
IPR021109, Peptidase_aspartic_dom_sf
IPR005162, Retrotrans_gag_dom
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
IPR000477, RT_dom
IPR041373, RT_RNaseH
PfamiView protein in Pfam
PF17921, Integrase_H2C2, 1 hit
PF03732, Retrotrans_gag, 1 hit
PF17917, RT_RNaseH, 1 hit
PF00665, rve, 1 hit
PF00078, RVT_1, 1 hit
SUPFAMiSSF50630, SSF50630, 1 hit
SSF53098, SSF53098, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS00141, ASP_PROTEASE, 1 hit
PS50994, INTEGRASE, 1 hit
PS50878, RT_POL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3P9MP57_ORYLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3P9MP57
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 13, 2019
Last sequence update: February 13, 2019
Last modified: October 7, 2020
This is version 11 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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