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Entry version 6 (31 Jul 2019)
Sequence version 1 (13 Feb 2019)
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Protein

Protein kinase domain-containing protein

Gene
N/A
Organism
Esox lucius (Northern pike)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein kinase domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEsox lucius (Northern pike)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8010 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiEsociformesEsocidaeEsox
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000265140 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: LG19

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini218 – 476Protein kinaseInterPro annotationAdd BLAST259

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 34DisorderedSequence analysisAdd BLAST34
Regioni155 – 208DisorderedSequence analysisAdd BLAST54
Regioni565 – 675DisorderedSequence analysisAdd BLAST111
Regioni715 – 847DisorderedSequence analysisAdd BLAST133
Regioni864 – 896DisorderedSequence analysisAdd BLAST33
Regioni1100 – 1416DisorderedSequence analysisAdd BLAST317
Regioni1431 – 1508DisorderedSequence analysisAdd BLAST78
Regioni1529 – 1556DisorderedSequence analysisAdd BLAST28
Regioni1618 – 1736DisorderedSequence analysisAdd BLAST119

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi18 – 33PolarSequence analysisAdd BLAST16
Compositional biasi165 – 208PolyampholyteSequence analysisAdd BLAST44
Compositional biasi565 – 585PolyampholyteSequence analysisAdd BLAST21
Compositional biasi586 – 606PolarSequence analysisAdd BLAST21
Compositional biasi618 – 674PolarSequence analysisAdd BLAST57
Compositional biasi715 – 760PolarSequence analysisAdd BLAST46
Compositional biasi804 – 847PolarSequence analysisAdd BLAST44
Compositional biasi877 – 895BasicSequence analysisAdd BLAST19
Compositional biasi1115 – 1181PolarSequence analysisAdd BLAST67
Compositional biasi1203 – 1273PolarSequence analysisAdd BLAST71
Compositional biasi1283 – 1297PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1299 – 1313PolarSequence analysisAdd BLAST15
Compositional biasi1331 – 1351PolarSequence analysisAdd BLAST21
Compositional biasi1364 – 1378PolarSequence analysisAdd BLAST15
Compositional biasi1431 – 1484PolarSequence analysisAdd BLAST54
Compositional biasi1490 – 1508PolarSequence analysisAdd BLAST19
Compositional biasi1645 – 1736PolarSequence analysisAdd BLAST92

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155474

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR024678 Kinase_OSR1/WNK_CCT
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12202 OSR1_C, 1 hit
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A3P9AN54-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEKPNDKMV KFLAPASKSG NGNGNNGSSS DSLVGERMEV AVRRRHHTME
60 70 80 90 100
RDRCNAEHRT FFRRSVISDS NATALDLPLP GKIPVETPLV PCVQEVLPAG
110 120 130 140 150
ATIFPRVVPR VTVTEESTES EGEVKVVSVV QKAAVVQDIC DGEIVVSQPA
160 170 180 190 200
NIVAAQPPSQ TTNRGSEVKE REVGEEGEED KEKARVEAEQ REAEKKVQDD
210 220 230 240 250
IEEAETKAVG TSPDGRFLKF DIEIGRGSFK TVYKGLDTET TVEVAWCELQ
260 270 280 290 300
DRKLSKSERQ RFKEEAGMLK GLQHPNIVRF YDSWEAPVKG RKCIVLVTEL
310 320 330 340 350
MTSGTLKTYL KRFKVMKIKV LRSWCRQILK GLHFLHTRAP PIIHRDLKCD
360 370 380 390 400
NIFITGPTGS VKIGDLGLAT LKRASFAKSV IGTPEFMAPE MYEEKYDESV
410 420 430 440 450
DVYAFGMCML EMATSEYPYS ECQNAAQIYR RVTSGVKPGS FDKVAIPEVK
460 470 480 490 500
EIIEGCIRQN KDERYSIKDL LNHAFFQEET GVRVELAEED DGEMEAIKLW
510 520 530 540 550
LRIEDIKKLK GKYKDNEAIE FSFDLSKDVP EDVAQEMVES GYVCEGDHKT
560 570 580 590 600
MAKAIKDRVS LISRKREQRQ QVREEQEKRR LEEEQGQQQL QQQQQLQPSQ
610 620 630 640 650
PLPGVQSGLE APQPAQPQAA PQLGQQAASY VPAQPTQLPG QANLPMAQYM
660 670 680 690 700
PPQTAQGGSY IPQPTGQLPL SVPLSSQAPV HPELEAPELD PQQTEKDRVQ
710 720 730 740 750
VSSILSETHP VQPVVSYSSL PNQQPQPQAT YPQAPPSVQT NQSQQSMVVS
760 770 780 790 800
GAQPAAVVSG PPSSQPAPGA PQQYGGYYHP SLPTKVPPTS QPVPPLHLQQ
810 820 830 840 850
PQLEGISAPH SQSSAPSPLL PAAQQTQAPV SVSQAGEPTA GQTAVGPQSV
860 870 880 890 900
EGCLSDAASG LSDGCEGVSG GRHEGRSMIK RHQRRSVRSR SHHEKTTKAK
910 920 930 940 950
LNVLNISNMG DRVAECQLET HNRKMVTFKF DLDGDNPDEI AAIMVVSEFI
960 970 980 990 1000
LESERDSFIE QVREVIEMAD DKGEGLKEGY TQPPFTQIVI DDPSQQSDMH
1010 1020 1030 1040 1050
TPLPGVLPSV AAQVVHSAGR RFIVSPVPES RLREQFFGPC SANTSFGDEL
1060 1070 1080 1090 1100
PPVSLGLSLS APSGRLQQAF TEMRQMHGER RATMSNIAES HPSIVPCPQA
1110 1120 1130 1140 1150
GMRPSSPPFL APQDPTAPTI SSSTLPPVSV IPSGSSSLPP CQVATGRVSP
1160 1170 1180 1190 1200
TPAPVTTDTT PHFQPGYQPA PVTTTPLAAS QDIPASLPPA SAPVPPVSGA
1210 1220 1230 1240 1250
TPCYSETVPS SEQQSAANPV PIQSSQLISS SGPGTQPSSS QSQPVPTSVP
1260 1270 1280 1290 1300
LAQALTPFPP STQPSQPVDS DGGESQSKVP GIDDIHALDK KLRSLFKDTS
1310 1320 1330 1340 1350
SAEAGNTGTT SPPTETVSPP PGAALVPPSN LSLTAGGQGT SVTSSVPGQD
1360 1370 1380 1390 1400
VTPGGLAQAP SEKPGQATRA QAGTPTSEQL PPFPGPNQPV GSQDGQLKRA
1410 1420 1430 1440 1450
PSPETVPVSS GAVPPATGVV KLGRFQVSVA SDAGNSSTPD PLNIASSSSL
1460 1470 1480 1490 1500
TPSSSSSSSS SSSSSLSSPE NTLHRSSSLS RGVRRGNSVD GLSTVPTQPT
1510 1520 1530 1540 1550
TIGRFRVSTS ASLSSASKVG RFSVTPATAN PTDLSASSHF HQNGPSSSTM
1560 1570 1580 1590 1600
SDPQNCNPAM NNNLFHSYIS SDNEDDSGPE DEAFQMEISR LREKHMKEIQ
1610 1620 1630 1640 1650
TLYSRQKEEI EALFTKLGKP PPSAVLSPAV AMAGGRRRPK SKTSKLSRSS
1660 1670 1680 1690 1700
GQPSPLHLGA PVSGQSPQAS PPKQTTLPTA GVSESGSQTS LQNLKSSPSL
1710 1720 1730 1740 1750
PSFSTSTMGI TGTSSDSGAN PSQSQLSGPN VAPALTQSRK GTFTDDLHLL
1760 1770 1780 1790 1800
VDNWARDAII LSQGKKGPKG PAQGPGHDIP LHIPPQANMG RKFSAPGHLC
1810 1820 1830 1840 1850
PTLPITTATA LTGAHLPITT NPSIPLCQRQ GSLAASSQGF GYGTAPYSAP
1860 1870 1880 1890 1900
QWPGSAGSCQ VGLLAPTQPL AQYQPQVPSS TSAPLQQAFH MGATQKPVSN

PGGPNLRPT
Length:1,909
Mass (Da):203,240
Last modified:February 13, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE735C517FB2FEB6E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3P8Z9A1A0A3P8Z9A1_ESOLU
Protein kinase domain-containing pr...
1,941Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3P8Z996A0A3P8Z996_ESOLU
Protein kinase domain-containing pr...
1,929Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_019895851.1, XM_020040292.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSELUT00000036614; ENSELUP00000042491; ENSELUG00000000998

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
105022160

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_019895851.1, XM_020040292.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSELUT00000036614; ENSELUP00000042491; ENSELUG00000000998
GeneIDi105022160

Phylogenomic databases

GeneTreeiENSGT00940000155474

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR024678 Kinase_OSR1/WNK_CCT
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF12202 OSR1_C, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3P9AN54_ESOLU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3P9AN54
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 13, 2019
Last sequence update: February 13, 2019
Last modified: July 31, 2019
This is version 6 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
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