Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - A0A3P8Y2B6 (A0A3P8Y2B6_ESOLU)

Entry version 12 (10 Feb 2021)
Sequence version 1 (13 Feb 2019)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Uncharacterized protein

Gene

EVC2

Organism
Esox lucius (Northern pike)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EVC2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEsox lucius (Northern pike)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8010 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Protacanthopterygii › Esociformes › Esocidae › Esox
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000265140 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: LG17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 25HelicalSequence analysisAdd BLAST20
Transmembranei319 – 343HelicalSequence analysisAdd BLAST25

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membraneARBA annotation, Cell projectionARBA annotation, Cytoplasm, CytoskeletonARBA annotation, Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni912 – 943DisorderedSequence analysisAdd BLAST32
Regioni1061 – 1099DisorderedSequence analysisAdd BLAST39
Regioni1366 – 1400DisorderedSequence analysisAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili483 – 503Sequence analysisAdd BLAST21
Coiled coili655 – 682Sequence analysisAdd BLAST28
Coiled coili1130 – 1150Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi928 – 943PolyampholyteSequence analysisAdd BLAST16

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154127

Identification of Orthologs from Complete Genome Data

More...OMAi		ENMETDT

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR022076, Limbin
IPR026501, Limbin/Ellis-van_Creveld

The PANTHER Classification System

More...PANTHERi		PTHR16795, PTHR16795, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12297, EVC2_like, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A3P8Y2B6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIQVHIFVEG LITVCCVFLC FQLQYRPLFR IQQRSIYLYG FHNFSHSQNT 
        60         70         80         90        100
CQSAFRGDSN NIHSALCNAL LSWGTPQNQY ESGKPRYWPG PIRHNPGVKS 
       110        120        130        140        150
AEPIVKMNGQ QGPCGPSAFC VERGPLHSGA PTPGPWGQPF YASVSHLVNM 
       160        170        180        190        200
VQRGARRRRS SLIRHITGHA LPQTESAAQP AGFGLKFNKC AQVGEGTEFP 
       210        220        230        240        250
HLTFFLLIHN IGPPGGTNLS QLAIRDSVSG IAPLQSGGTV VEKGFQTFTI 
       260        270        280        290        300
DSLPAGSRYT VTYTALIKGH KSVVLDLPAF LTFSNASLND VSMFGPVVAN 
       310        320        330        340        350
LTLRLNSTDK IYPNHGVHFA GFVCGFFLSL LLLSLGFLAI NLICARARKN 
       360        370        380        390        400
SLQQRIKRGD SDPEYAVCNM SETVKEEAAF EDKMVDIMVL EEPQNMYQAL 
       410        420        430        440        450
ENLEMSSLLQ ATSSLESSRV QMYKDVIAAL LASLRSQNHM SQQAEQRLLS 
       460        470        480        490        500
VLHGQLMGME GKLKEEHVAR MATLAAQCNL ETREQMEAEH RREAQEKAQA 
       510        520        530        540        550
EVLFRHADQQ ELLQVSVLLE KLHKLNQSQL QRSLLVKHEE ASARVQRQIV 
       560        570        580        590        600
EWRRVELHKI FSEELEEATR MGELEKNVAR SLLHDYFTCQ NQLEEVLDVV 
       610        620        630        640        650
LANQRCMLGE RHAQRRFLVH SLYSLKGLIS ETFSKTSSQM ENCFKEHGRG 
       660        670        680        690        700
SDVSEEQREQ QLDKVQKELV LVKQRLDEAL NRERRAMHCG LVKKRRELLS 
       710        720        730        740        750
DMLQGHKQRQ RELSALSRGG LEGERAEVDP AQHLLCWQSL LTTQCQELGE 
       760        770        780        790        800
LINNLDEEAA ADIRKVTMRL IHSSMAEVKV IQAASQALLA LGPPQQPDAG 
       810        820        830        840        850
ATAGAGTSAL SQAQERLHLE GKGAVRILQA SRDSLRQGMM REQRAQLEMR 
       860        870        880        890        900
ARARAFFRSL CSSQLTLSDE DLLRMMLEFQ KCLSRMDHCL VVPHALSRSK 
       910        920        930        940        950
LQTALTSWRK EVLEEQTEPL QQPENKTRPR GKSTEDRQRA GPSELLLFRK 
       960        970        980        990       1000
KMEGRIQLFE KEKEMENTIM EKVLEEMQGE REVELQSQVD GLAVQMAALH 
      1010       1020       1030       1040       1050
YQKAERRTRV LETSRALLTV QSLITEELRA SRSLASAPIA QSIQNHYLGL 
      1060       1070       1080       1090       1100
EEAEHQLQRE HAELESLETG PSKPPEHKLP KHSDASANED EGEEEDGRLF 
      1110       1120       1130       1140       1150
RIERDSRMAA ILHEALYKCD QVTSLQMERL QEANARSQAM EDLKEQLELK 
      1160       1170       1180       1190       1200
RLYSNCDQDL EFAARLVRQS QISTEVLLEA LRLLLPTLPE SELLSLIDAL 
      1210       1220       1230       1240       1250
CPKQPTLLGS TEQQNPSWPE GAGKSLLVRL RAEMIGRNVS AHSTILEQNQ 
      1260       1270       1280       1290       1300
FQEKRPSLLE RLFMNPRPEA PRDIMPVLVQ EKGREGATLL TPQQLASKPV 
      1310       1320       1330       1340       1350
VTGTSRTPAS EQLQDSVLIS VGGASVNSET VFDSQRTTAA STFGSASGAV 
      1360       1370       1380       1390       1400
MVDIPTTGER VFVFRSPPDP LSTQGTTDCK RKKRNFLNLK KGSVAPMDRP
Length:1,400
Mass (Da):157,118
Last modified:February 13, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3EBE91707694E92B
GO

Sequence databases

NCBI Reference Sequences

More...RefSeqi		XP_019911278.1, XM_020055719.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSELUT00000001538; ENSELUP00000010806; ENSELUG00000011257

Database of genes from NCBI RefSeq genomes

More...GeneIDi		105016757

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		els:105016757

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_019911278.1, XM_020055719.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENSELUT00000001538; ENSELUP00000010806; ENSELUG00000011257
GeneIDi105016757
KEGGiels:105016757

Phylogenomic databases

GeneTreeiENSGT00940000154127
OMAiENMETDT

Family and domain databases

InterProiView protein in InterPro
IPR022076, Limbin
IPR026501, Limbin/Ellis-van_Creveld
PANTHERiPTHR16795, PTHR16795, 1 hit
PfamiView protein in Pfam
PF12297, EVC2_like, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3P8Y2B6_ESOLU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3P8Y2B6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 13, 2019
Last sequence update: February 13, 2019
Last modified: February 10, 2021
This is version 12 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again