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Entry version 5 (31 Jul 2019)
Sequence version 1 (13 Feb 2019)
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Protein
Submitted name:

MAP-kinase activating death domain

Gene
N/A
Organism
Amphiprion percula (Orange clownfish) (Lutjanus percula)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
MAP-kinase activating death domainImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAmphiprion percula (Orange clownfish) (Lutjanus percula)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri161767 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaPomacentridaeAmphiprion
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000265080 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 576UDENNInterPro annotationAdd BLAST563

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni105 – 181DisorderedSequence analysisAdd BLAST77
Regioni618 – 646DisorderedSequence analysisAdd BLAST29
Regioni691 – 727DisorderedSequence analysisAdd BLAST37
Regioni770 – 811DisorderedSequence analysisAdd BLAST42
Regioni846 – 891DisorderedSequence analysisAdd BLAST46
Regioni1003 – 1036DisorderedSequence analysisAdd BLAST34
Regioni1072 – 1099DisorderedSequence analysisAdd BLAST28
Regioni1122 – 1158DisorderedSequence analysisAdd BLAST37

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili934 – 954Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi711 – 727PolarSequence analysisAdd BLAST17
Compositional biasi795 – 811PolarSequence analysisAdd BLAST17
Compositional biasi870 – 891PolarSequence analysisAdd BLAST22
Compositional biasi1016 – 1035PolarSequence analysisAdd BLAST20

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156718

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR039980 MADD
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom

The PANTHER Classification System

More...
PANTHERi
PTHR13008 PTHR13008, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02141 DENN, 1 hit
PF03456 uDENN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00800 uDENN, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50211 DENN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

A0A3P8RKT6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
KMEKKKTCPR LLDYLVVVGA RQPSSDSVAQ TPQLLRRYPL EDHHDFPLPP
60 70 80 90 100
DVVFFCQPEG CLSIRQRRVS LRDDSSFVFT LTDKDSGITR YGICVNFYRS
110 120 130 140 150
FQRGHHRSRG DKSRDAESAA PPVETATEAS EDGGPTSTLA PPNNAESAPP
160 170 180 190 200
PSSGEEGEKP AAEQNAGKSP QHRRSTAKMA ARNRNSTLTS LCILSHYPFF
210 220 230 240 250
STFRECLYIL KRLVDCCSQR LTQRAGLPRA TQRDTMWRVF TGATSVEEKG
260 270 280 290 300
SQLLADLREI ESWVYRLLRS PVPLAGQRRV DVEVLPHELK RALTFALPDN
310 320 330 340 350
SRFAMVDFPL HLPLELLGVD ACLQVLSCVL LEHKVILQSR DYNALSMSVM
360 370 380 390 400
AFVAMIYPLE YMFPVIPLLP TCMASAEQLL LAPTPYIIGV PASFFLYKSD
410 420 430 440 450
FKMPDDLWLV DLDSSKVIAP TNAEILPPLP EPEAGELKKH LKQALASMSL
460 470 480 490 500
NTQPILNLEK FQEGQEMPLL PPGRDKASPS STEFNPLIYG NDVDSVDVAT
510 520 530 540 550
RVAMVRFFNS PNVLQGFQMH TRTLRLFPRP VVAFQSTSFL ASRPRRSSFA
560 570 580 590 600
DKLSHTQAVE FYGEWALNPT NLAFQRIHNN VFDPSLIGDK PKWYAHQLQP
610 620 630 640 650
VLYRVYDGSS QLVEAMAGPL EDEGNESDPT DSGSDSEAYD DSSSSYSSLG
660 670 680 690 700
DLVSEMIQGD IQGDTPSLDP LTHAALGDAS EVEFQDFQDF REGHGAEGPP
710 720 730 740 750
SGDGPADPSD GQPLRSSSST TASSSPSTII QGVNHVCSPS SLAKATFTAV
760 770 780 790 800
FLHLFLLYVA AKSDAGLVDP ANKKQEAQRP LRPSSLRLPG ESDGEGDSHN
810 820 830 840 850
SSPNSTISNS SNDGFGGLMS FASNLYKNHG TSFSLSNLAL PNKAAREKST
860 870 880 890 900
PFPSLKGARA PRALVDQKSS VIKHSPTVKR ESPSPQGRVN NTSENQQFLK
910 920 930 940 950
EVVQSVLDGQ GVGWLNMKKV RRLLENEQLR VFVLSKLNRA VQSEEDARQE
960 970 980 990 1000
IIRDVEVSRK VYKGMLDILK CTVSSLEHSY TNAGLGGMAS VFSLLEIART
1010 1020 1030 1040 1050
HYQTKDPEKR KRSPTDSAGS PGSKESPSGR METSRPQGLL NIPHLQLPHH
1060 1070 1080 1090 1100
TTGKGARHFD TRSLNEENFI ASIGSEGAKQ QRPQVTDAEE KKSQISADSG
1110 1120 1130 1140 1150
LSVASGSQVC CWLSAISNSS GETLGADSDL SSTGGDGLGG RTAPHLAQSR
1160 1170 1180 1190 1200
GTLSDSEIET NPATSAVFGK THTLKSGAKD QVPAVAKGPP AQPMEDISMR
1210 1220 1230 1240 1250
IYLCEGLLGR DKSSVWDQLE DAAMETFSLS KERSTLWDQV QFWEDAFLDA
1260 1270 1280 1290 1300
VMLEREGMGM DQGPQEMIER YLSLGEHDRK RLEDDEDRLL ATLLHNMIAY
1310 1320 1330 1340 1350
MLMLKVNKND IRKKVRRLMG KSHIGLTYSQ EINEILDKLA NMNGRELSIR
1360 1370 1380 1390 1400
PSGSRHIKKQ TFVVHAGTDT TGDIFFMEVC DDCIVLRSNI GTVYERWWYE
1410 1420 1430 1440 1450
KLINMTYCPK TKVLCLWRRN GQETQLNKFY TKKCRELYYC VKDSMERAAA
1460 1470 1480 1490 1500
RQQSIKPGPE LGGEFPVQDM KTGEGGLLQV TLEGINLKFM HSQVRGRKIK
1510
IKKDKIKSKL NKDTI
Length:1,515
Mass (Da):167,655
Last modified:February 13, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC24C02ED002BC62F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3P8RI17A0A3P8RI17_AMPPE
MAP-kinase activating death domain
1,655Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3P8RIW0A0A3P8RIW0_AMPPE
MAP-kinase activating death domain
1,659Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3P8RJ92A0A3P8RJ92_AMPPE
MAP-kinase activating death domain
1,657Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3P8RKT1A0A3P8RKT1_AMPPE
MAP-kinase activating death domain
1,676Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3P8RLC5A0A3P8RLC5_AMPPE
MAP-kinase activating death domain
1,591Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSAPET00000000142; ENSAPEP00000000140; ENSAPEG00000000100

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSAPET00000000142; ENSAPEP00000000140; ENSAPEG00000000100

Phylogenomic databases

GeneTreeiENSGT00940000156718

Family and domain databases

InterProiView protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR039980 MADD
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom
PANTHERiPTHR13008 PTHR13008, 1 hit
PfamiView protein in Pfam
PF02141 DENN, 1 hit
PF03456 uDENN, 1 hit
SMARTiView protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00800 uDENN, 1 hit
PROSITEiView protein in PROSITE
PS50211 DENN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3P8RKT6_AMPPE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3P8RKT6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 13, 2019
Last sequence update: February 13, 2019
Last modified: July 31, 2019
This is version 5 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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