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UniProtKB - A0A3F2YNW8 (A0A3F2YNW8_HUMAN)
Protein
Inositol 1,4,5-trisphosphate receptor
Gene
ITPR1
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
UniRule annotationGO - Molecular functioni
- inositol 1,4,5 trisphosphate binding Source: UniProtKB-UniRule
- inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Source: UniProtKB-UniRule
GO - Biological processi
- regulation of cardiac conduction Source: UniProt
Keywordsi
Molecular function | Calcium channelUniRule annotationARBA annotation, Ion channel, Ligand-gated ion channelUniRule annotationARBA annotation, ReceptorUniRule annotationARBA annotation |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium |
Names & Taxonomyi
Protein namesi | Recommended name: Inositol 1,4,5-trisphosphate receptorUniRule annotation |
Gene namesi | Name:ITPR1 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6180, ITPR1 |
VEuPathDBi | HostDB:ENSG00000150995 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-UniRule
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 2275 – 2297 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 2309 – 2327 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 2396 – 2421 | HelicalUniRule annotationAdd BLAST | 26 | |
Transmembranei | 2441 – 2463 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 2571 – 2594 | HelicalUniRule annotationAdd BLAST | 24 |
Keywords - Cellular componenti
Endoplasmic reticulumUniRule annotationARBA annotation, MembraneInteractioni
Subunit structurei
Homotetramer.
UniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 112 – 166 | MIRInterPro annotationAdd BLAST | 55 | |
Domaini | 231 – 287 | MIRInterPro annotationAdd BLAST | 57 | |
Domaini | 379 – 435 | MIRInterPro annotationAdd BLAST | 57 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1006 – 1027 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 1137 – 1169 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 1701 – 1731 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 1752 – 1789 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 1882 – 1907 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 1931 – 1952 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 2721 – 2750 | DisorderedSequence analysisAdd BLAST | 30 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1594 – 1614 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1007 – 1024 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1146 – 1164 | Basic and acidic residuesSequence analysisAdd BLAST | 19 |
Domaini
The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.UniRule annotation
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155071 |
Family and domain databases
InterProi | View protein in InterPro IPR014821, Ins145_P3_rcpt IPR000493, InsP3_rcpt IPR005821, Ion_trans_dom IPR036300, MIR_dom_sf IPR016093, MIR_motif IPR013662, RIH_assoc-dom IPR000699, RIH_dom IPR035910, RyR/IP3R_RIH_dom_sf |
Pfami | View protein in Pfam PF08709, Ins145_P3_rec, 1 hit PF00520, Ion_trans, 1 hit PF02815, MIR, 1 hit PF08454, RIH_assoc, 1 hit PF01365, RYDR_ITPR, 2 hits |
PRINTSi | PR00779, INSP3RECEPTR |
SMARTi | View protein in SMART SM00472, MIR, 4 hits |
SUPFAMi | SSF100909, SSF100909, 2 hits SSF82109, SSF82109, 2 hits |
PROSITEi | View protein in PROSITE PS50919, MIR, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 16 potential isoforms that are computationally mapped.Show allAlign All
A0A3F2YNW8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PETGDLNNPP
60 70 80 90 100
KKFRDCLFKL CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK
110 120 130 140 150
KQNETENRKL LGTVIQYGNV IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT
160 170 180 190 200
LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD KVVLNPVNAG QPLHASSHQL
210 220 230 240 250
VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV RLFHAEQEKF
260 270 280 290 300
LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN
310 320 330 340 350
SLFRFKHLAT GHYLAAEVDP DFEEECLEFQ PSVDPDQDAS RSRLRNAQEK
360 370 380 390 400
MVYSLVSVPE GNDISSIFEL DPTTLRGGDS LVPRNSYVRL RHLCTNTWVH
410 420 430 440 450
STNIPIDKEE EKPVMLKIGT SPVKEDKEAF AIVPVSPAEV RDLDFANDAS
460 470 480 490 500
KVLGSIAGKL EKGTITQNER RSVTKLLEDL VYFVTGGTNS GQDVLEVVFS
510 520 530 540 550
KPNRERQKLM REQNILKQIF KLLQAPFTDC GDGPMLRLEE LGDQRHAPFR
560 570 580 590 600
HICRLCYRVL RHSQQDYRKN QEYIAKQFGF MQKQIGYDVL AEDTITALLH
610 620 630 640 650
NNRKLLEKHI TAAEIDTFVS LVRKNREPRF LDYLSDLCVS MNKSIPVTQE
660 670 680 690 700
LICKAVLNPT NADILIETKL VLSRFEFEGV SSTGENALEA GEDEEEVWLF
710 720 730 740 750
WRDSNKEIRS KSVRELAQDA KEGQKEDRDV LSYYRYQLNL FARMCLDRQY
760 770 780 790 800
LAINEISGQL DVDLILRCMS DENLPYDLRA SFCRLMLHMH VDRDPQEQVT
810 820 830 840 850
PVKYARLWSE IPSEIAIDDY DSSGASKDEI KERFAQTMEF VEEYLRDVVC
860 870 880 890 900
QRFPFSDKEK NKLTFEVVNL ARNLIYFGFY NFSDLLRLTK ILLAILDCVH
910 920 930 940 950
VTTIFPISKM AKGEENKGSN VMRSIHGVGE LMTQVVLRGG GFLPMTPMAA
960 970 980 990 1000
APEGNVKQAE PEKEDIMVMD TKLKIIEILQ FILNVRLDYR ISCLLCIFKR
1010 1020 1030 1040 1050
EFDESNSQTS ETSSGNSSQE GPSNVPGALD FEHIEEQAEG IFGGSEENTP
1060 1070 1080 1090 1100
LDLDDHGGRT FLRVLLHLTM HDYPPLVSGA LQLLFRHFSQ RQEVLQAFKQ
1110 1120 1130 1140 1150
VQLLVTSQDV DNYKQIKQDL DQLRSIVEKS ELWVYKGQGP DETMDGASGE
1160 1170 1180 1190 1200
NEHKKTEEGN NKPQKHESTS SYNYRVVKEI LIRLSKLCVQ ESASVRKSRK
1210 1220 1230 1240 1250
QQQRLLRNMG AHAVVLELLQ IPYEKAEDTK MQEIMRLAHE FLQNFCAGNQ
1260 1270 1280 1290 1300
QNQALLHKHI NLFLNPGILE AVTMQHIFMN NFQLCSEINE RVVQHFVHCI
1310 1320 1330 1340 1350
ETHGRNVQYI KFLQTIVKAE GKFIKKCQDM VMAELVNSGE DVLVFYNDRA
1360 1370 1380 1390 1400
SFQTLIQMMR SERDRMDENS PLMYHIHLVE LLAVCTEGKN VYTEIKCNSL
1410 1420 1430 1440 1450
LPLDDIVRVV THEDCIPEVK IAYINFLNHC YVDTEVEMKE IYTSNHMWKL
1460 1470 1480 1490 1500
FENFLVDICR ACNNTSDRKH ADSILEKYVT EIVMSIVTTF FSSPFSDQST
1510 1520 1530 1540 1550
TLQTRQPVFV QLLQGVFRVY HCNWLMPSQK ASVESCIRVL SDVAKSRAIA
1560 1570 1580 1590 1600
IPVDLDSQVN NLFLKSHSIV QKTAMNWRLS ARNAARRDSV LAASRDYRNI
1610 1620 1630 1640 1650
IERLQDIVSA LEDRLRPLVQ AELSVLVDVL HRPELLFPEN TDARRKCESG
1660 1670 1680 1690 1700
GFICKLIKHT KQLLEENEEK LCIKVLQTLR EMMTKDRGYG EKLISIDELD
1710 1720 1730 1740 1750
NAELPPAPDS ENATEQELEP SPPLRQLEDH KRGEALRQVL VNRYYGNVRP
1760 1770 1780 1790 1800
SGRRESLTSF GNGPLSAGGP GKPGGGGGGS GSSSMSRGEM SLAEVQCHLD
1810 1820 1830 1840 1850
KEGASNLVID LIMNASSDRV FHESILLAIA LLEGGNTTIQ HSFFCRLTED
1860 1870 1880 1890 1900
KKSEKFFKVF YDRMKVAQQE IKATVTVNTS DLGNKKKDDE VDRDAPSRKK
1910 1920 1930 1940 1950
AKEPTTQITE EVRDQLLEAS AATRKAFTTF RREADPDDHY QPGEGTQATA
1960 1970 1980 1990 2000
DKAKDDLEMS AVITIMQPIL RFLQLLCENH NRDLQNFLRC QNNKTNYNLV
2010 2020 2030 2040 2050
CETLQFLDCI CGSTTGGLGL LGLYINEKNV ALINQTLESL TEYCQGPCHE
2060 2070 2080 2090 2100
NQNCIATHES NGIDIITALI LNDINPLGKK RMDLVLELKN NASKLLLAIM
2110 2120 2130 2140 2150
ESRHDSENAE RILYNMRPKE LVEVIKKAYM QGEVEFEDGE NGEDGAASPR
2160 2170 2180 2190 2200
NVGHNIYILA HQLARHNKEL QSMLKPGGQV DGDEALEFYA KHTAQIEIVR
2210 2220 2230 2240 2250
LDRTMEQIVF PVPSICEFLT KESKLRIYYT TERDEQGSKI NDFFLRSEDL
2260 2270 2280 2290 2300
FNEMNWQKKL RAQPVLYWCA RNMSFWSSIS FNLAVLMNLL VAFFYPFKGV
2310 2320 2330 2340 2350
RGGTLEPHWS GLLWTAMLIS LAIVIALPKP HGIRALIAST ILRLIFSVGL
2360 2370 2380 2390 2400
QPTLFLLGAF NVCNKIIFLM SFVGNCGTFT RGYRAMVLDV EFLYHLLYLV
2410 2420 2430 2440 2450
ICAMGLFVHE FFYSLLLFDL VYREETLLNV IKSVTRNGRS IILTAVLALI
2460 2470 2480 2490 2500
LVYLFSIVGY LFFKDDFILE VDRLPNETAV PETGESLASE FLFSDVCRVE
2510 2520 2530 2540 2550
SGENCSSPAP REELVPAEET EQDKEHTCET LLMCIVTVLS HGLRSGGGVG
2560 2570 2580 2590 2600
DVLRKPSKEE PLFAARVIYD LLFFFMVIII VLNLIFGVII DTFADLRSEK
2610 2620 2630 2640 2650
QKKEEILKTT CFICGLERDK FDNKTVTFEE HIKEEHNMWH YLCFIVLVKV
2660 2670 2680 2690 2700
KDSTEYTGPE SYVAEMIKER NLDWFPRMRA MSLVSSDSEG EQNELRNLQE
2710 2720 2730 2740 2750
KLESTMKLVT NLSGQLSELK DQMTEQRKQK QRIGLLGHPP HMNVNPQQPA
Computationally mapped potential isoform sequencesi
There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ14643 | ITPR1_HUMAN | Inositol 1,4,5-trisphosphate recept... | ITPR1 INSP3R1 | 2,758 | Annotation score: | ||
A0A3B3ITU8 | A0A3B3ITU8_HUMAN | Inositol 1,4,5-trisphosphate recept... | ITPR1 | 2,744 | Annotation score: | ||
A0A3B3IU04 | A0A3B3IU04_HUMAN | Inositol 1,4,5-trisphosphate recept... | ITPR1 | 2,749 | Annotation score: | ||
A0A3B3ITQ1 | A0A3B3ITQ1_HUMAN | Inositol 1,4,5-trisphosphate recept... | ITPR1 | 2,012 | Annotation score: | ||
B7ZMI3 | B7ZMI3_HUMAN | Inositol 1,4,5-trisphosphate recept... | ITPR1 | 721 | Annotation score: | ||
A0A3B3IRT5 | A0A3B3IRT5_HUMAN | Inositol 1,4,5-trisphosphate recept... | ITPR1 | 296 | Annotation score: | ||
A0A3B3ITM6 | A0A3B3ITM6_HUMAN | Inositol 1,4,5-trisphosphate recept... | ITPR1 | 714 | Annotation score: | ||
A0A8C8KBY2 | A0A8C8KBY2_HUMAN | Inositol 1,4,5-trisphosphate recept... | ITPR1 | 1,668 | Annotation score: | ||
A0A3B3IU05 | A0A3B3IU05_HUMAN | Inositol 1,4,5-trisphosphate recept... | ITPR1 | 1,818 | Annotation score: | ||
A0A3B3IU13 | A0A3B3IU13_HUMAN | Inositol 1,4,5-trisphosphate recept... | ITPR1 | 1,739 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC024168 Genomic DNA No translation available. AC069248 Genomic DNA No translation available. AC090944 Genomic DNA No translation available. KF457537 Genomic DNA No translation available. KF457539 Genomic DNA No translation available. KF457546 Genomic DNA No translation available. KF495812 Genomic DNA No translation available. |
RefSeqi | XP_011531986.1, XM_011533684.1 |
Genome annotation databases
Ensembli | ENST00000354582.12; ENSP00000346595.8; ENSG00000150995.21 |
GeneIDi | 3708 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC024168 Genomic DNA No translation available. AC069248 Genomic DNA No translation available. AC090944 Genomic DNA No translation available. KF457537 Genomic DNA No translation available. KF457539 Genomic DNA No translation available. KF457546 Genomic DNA No translation available. KF495812 Genomic DNA No translation available. |
RefSeqi | XP_011531986.1, XM_011533684.1 |
3D structure databases
SMRi | A0A3F2YNW8 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | A0A3F2YNW8 |
Protocols and materials databases
Antibodypediai | 5503, 413 antibodies from 41 providers |
DNASUi | 3708 |
Genome annotation databases
Ensembli | ENST00000354582.12; ENSP00000346595.8; ENSG00000150995.21 |
GeneIDi | 3708 |
Organism-specific databases
CTDi | 3708 |
HGNCi | HGNC:6180, ITPR1 |
OpenTargetsi | ENSG00000150995 |
VEuPathDBi | HostDB:ENSG00000150995 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155071 |
Miscellaneous databases
ChiTaRSi | ITPR1, human |
Gene expression databases
ExpressionAtlasi | A0A3F2YNW8, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR014821, Ins145_P3_rcpt IPR000493, InsP3_rcpt IPR005821, Ion_trans_dom IPR036300, MIR_dom_sf IPR016093, MIR_motif IPR013662, RIH_assoc-dom IPR000699, RIH_dom IPR035910, RyR/IP3R_RIH_dom_sf |
Pfami | View protein in Pfam PF08709, Ins145_P3_rec, 1 hit PF00520, Ion_trans, 1 hit PF02815, MIR, 1 hit PF08454, RIH_assoc, 1 hit PF01365, RYDR_ITPR, 2 hits |
PRINTSi | PR00779, INSP3RECEPTR |
SMARTi | View protein in SMART SM00472, MIR, 4 hits |
SUPFAMi | SSF100909, SSF100909, 2 hits SSF82109, SSF82109, 2 hits |
PROSITEi | View protein in PROSITE PS50919, MIR, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A3F2YNW8_HUMAN | |
Accessioni | A0A3F2YNW8Primary (citable) accession number: A0A3F2YNW8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 16, 2019 |
Last sequence update: | January 16, 2019 | |
Last modified: | May 25, 2022 | |
This is version 20 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |