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UniProtKB - A0A3F2YNW8 (A0A3F2YNW8_HUMAN)

Entry version 20 (25 May 2022)
Sequence version 1 (16 Jan 2019)
Previous versions | rss
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Protein

Inositol 1,4,5-trisphosphate receptor

Gene

ITPR1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.

UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelUniRule annotationARBA annotation, Ion channel, Ligand-gated ion channelUniRule annotationARBA annotation, ReceptorUniRule annotationARBA annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inositol 1,4,5-trisphosphate receptorUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ITPR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6180, ITPR1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000150995

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2275 – 2297HelicalUniRule annotationAdd BLAST23
Transmembranei2309 – 2327HelicalUniRule annotationAdd BLAST19
Transmembranei2396 – 2421HelicalUniRule annotationAdd BLAST26
Transmembranei2441 – 2463HelicalUniRule annotationAdd BLAST23
Transmembranei2571 – 2594HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotationARBA annotation, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000150995

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...PeptideAtlasi		A0A3F2YNW8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A0A3F2YNW8, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

UniRule annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A0A3F2YNW8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini112 – 166MIRInterPro annotationAdd BLAST55
Domaini231 – 287MIRInterPro annotationAdd BLAST57
Domaini379 – 435MIRInterPro annotationAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1006 – 1027DisorderedSequence analysisAdd BLAST22
Regioni1137 – 1169DisorderedSequence analysisAdd BLAST33
Regioni1701 – 1731DisorderedSequence analysisAdd BLAST31
Regioni1752 – 1789DisorderedSequence analysisAdd BLAST38
Regioni1882 – 1907DisorderedSequence analysisAdd BLAST26
Regioni1931 – 1952DisorderedSequence analysisAdd BLAST22
Regioni2721 – 2750DisorderedSequence analysisAdd BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1594 – 1614Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1007 – 1024Polar residuesSequence analysisAdd BLAST18
Compositional biasi1146 – 1164Basic and acidic residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.UniRule annotation

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the InsP3 receptor family.UniRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155071

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR014821, Ins145_P3_rcpt
IPR000493, InsP3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR035910, RyR/IP3R_RIH_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF01365, RYDR_ITPR, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00779, INSP3RECEPTR

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00472, MIR, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF100909, SSF100909, 2 hits
SSF82109, SSF82109, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50919, MIR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 16 potential isoforms that are computationally mapped.Show allAlign All

A0A3F2YNW8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PETGDLNNPP 
        60         70         80         90        100
KKFRDCLFKL CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK 
       110        120        130        140        150
KQNETENRKL LGTVIQYGNV IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT 
       160        170        180        190        200
LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD KVVLNPVNAG QPLHASSHQL 
       210        220        230        240        250
VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV RLFHAEQEKF 
       260        270        280        290        300
LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 
       310        320        330        340        350
SLFRFKHLAT GHYLAAEVDP DFEEECLEFQ PSVDPDQDAS RSRLRNAQEK 
       360        370        380        390        400
MVYSLVSVPE GNDISSIFEL DPTTLRGGDS LVPRNSYVRL RHLCTNTWVH 
       410        420        430        440        450
STNIPIDKEE EKPVMLKIGT SPVKEDKEAF AIVPVSPAEV RDLDFANDAS 
       460        470        480        490        500
KVLGSIAGKL EKGTITQNER RSVTKLLEDL VYFVTGGTNS GQDVLEVVFS 
       510        520        530        540        550
KPNRERQKLM REQNILKQIF KLLQAPFTDC GDGPMLRLEE LGDQRHAPFR 
       560        570        580        590        600
HICRLCYRVL RHSQQDYRKN QEYIAKQFGF MQKQIGYDVL AEDTITALLH 
       610        620        630        640        650
NNRKLLEKHI TAAEIDTFVS LVRKNREPRF LDYLSDLCVS MNKSIPVTQE 
       660        670        680        690        700
LICKAVLNPT NADILIETKL VLSRFEFEGV SSTGENALEA GEDEEEVWLF 
       710        720        730        740        750
WRDSNKEIRS KSVRELAQDA KEGQKEDRDV LSYYRYQLNL FARMCLDRQY 
       760        770        780        790        800
LAINEISGQL DVDLILRCMS DENLPYDLRA SFCRLMLHMH VDRDPQEQVT 
       810        820        830        840        850
PVKYARLWSE IPSEIAIDDY DSSGASKDEI KERFAQTMEF VEEYLRDVVC 
       860        870        880        890        900
QRFPFSDKEK NKLTFEVVNL ARNLIYFGFY NFSDLLRLTK ILLAILDCVH 
       910        920        930        940        950
VTTIFPISKM AKGEENKGSN VMRSIHGVGE LMTQVVLRGG GFLPMTPMAA 
       960        970        980        990       1000
APEGNVKQAE PEKEDIMVMD TKLKIIEILQ FILNVRLDYR ISCLLCIFKR 
      1010       1020       1030       1040       1050
EFDESNSQTS ETSSGNSSQE GPSNVPGALD FEHIEEQAEG IFGGSEENTP 
      1060       1070       1080       1090       1100
LDLDDHGGRT FLRVLLHLTM HDYPPLVSGA LQLLFRHFSQ RQEVLQAFKQ 
      1110       1120       1130       1140       1150
VQLLVTSQDV DNYKQIKQDL DQLRSIVEKS ELWVYKGQGP DETMDGASGE 
      1160       1170       1180       1190       1200
NEHKKTEEGN NKPQKHESTS SYNYRVVKEI LIRLSKLCVQ ESASVRKSRK 
      1210       1220       1230       1240       1250
QQQRLLRNMG AHAVVLELLQ IPYEKAEDTK MQEIMRLAHE FLQNFCAGNQ 
      1260       1270       1280       1290       1300
QNQALLHKHI NLFLNPGILE AVTMQHIFMN NFQLCSEINE RVVQHFVHCI 
      1310       1320       1330       1340       1350
ETHGRNVQYI KFLQTIVKAE GKFIKKCQDM VMAELVNSGE DVLVFYNDRA 
      1360       1370       1380       1390       1400
SFQTLIQMMR SERDRMDENS PLMYHIHLVE LLAVCTEGKN VYTEIKCNSL 
      1410       1420       1430       1440       1450
LPLDDIVRVV THEDCIPEVK IAYINFLNHC YVDTEVEMKE IYTSNHMWKL 
      1460       1470       1480       1490       1500
FENFLVDICR ACNNTSDRKH ADSILEKYVT EIVMSIVTTF FSSPFSDQST 
      1510       1520       1530       1540       1550
TLQTRQPVFV QLLQGVFRVY HCNWLMPSQK ASVESCIRVL SDVAKSRAIA 
      1560       1570       1580       1590       1600
IPVDLDSQVN NLFLKSHSIV QKTAMNWRLS ARNAARRDSV LAASRDYRNI 
      1610       1620       1630       1640       1650
IERLQDIVSA LEDRLRPLVQ AELSVLVDVL HRPELLFPEN TDARRKCESG 
      1660       1670       1680       1690       1700
GFICKLIKHT KQLLEENEEK LCIKVLQTLR EMMTKDRGYG EKLISIDELD 
      1710       1720       1730       1740       1750
NAELPPAPDS ENATEQELEP SPPLRQLEDH KRGEALRQVL VNRYYGNVRP 
      1760       1770       1780       1790       1800
SGRRESLTSF GNGPLSAGGP GKPGGGGGGS GSSSMSRGEM SLAEVQCHLD 
      1810       1820       1830       1840       1850
KEGASNLVID LIMNASSDRV FHESILLAIA LLEGGNTTIQ HSFFCRLTED 
      1860       1870       1880       1890       1900
KKSEKFFKVF YDRMKVAQQE IKATVTVNTS DLGNKKKDDE VDRDAPSRKK 
      1910       1920       1930       1940       1950
AKEPTTQITE EVRDQLLEAS AATRKAFTTF RREADPDDHY QPGEGTQATA 
      1960       1970       1980       1990       2000
DKAKDDLEMS AVITIMQPIL RFLQLLCENH NRDLQNFLRC QNNKTNYNLV 
      2010       2020       2030       2040       2050
CETLQFLDCI CGSTTGGLGL LGLYINEKNV ALINQTLESL TEYCQGPCHE 
      2060       2070       2080       2090       2100
NQNCIATHES NGIDIITALI LNDINPLGKK RMDLVLELKN NASKLLLAIM 
      2110       2120       2130       2140       2150
ESRHDSENAE RILYNMRPKE LVEVIKKAYM QGEVEFEDGE NGEDGAASPR 
      2160       2170       2180       2190       2200
NVGHNIYILA HQLARHNKEL QSMLKPGGQV DGDEALEFYA KHTAQIEIVR 
      2210       2220       2230       2240       2250
LDRTMEQIVF PVPSICEFLT KESKLRIYYT TERDEQGSKI NDFFLRSEDL 
      2260       2270       2280       2290       2300
FNEMNWQKKL RAQPVLYWCA RNMSFWSSIS FNLAVLMNLL VAFFYPFKGV 
      2310       2320       2330       2340       2350
RGGTLEPHWS GLLWTAMLIS LAIVIALPKP HGIRALIAST ILRLIFSVGL 
      2360       2370       2380       2390       2400
QPTLFLLGAF NVCNKIIFLM SFVGNCGTFT RGYRAMVLDV EFLYHLLYLV 
      2410       2420       2430       2440       2450
ICAMGLFVHE FFYSLLLFDL VYREETLLNV IKSVTRNGRS IILTAVLALI 
      2460       2470       2480       2490       2500
LVYLFSIVGY LFFKDDFILE VDRLPNETAV PETGESLASE FLFSDVCRVE 
      2510       2520       2530       2540       2550
SGENCSSPAP REELVPAEET EQDKEHTCET LLMCIVTVLS HGLRSGGGVG 
      2560       2570       2580       2590       2600
DVLRKPSKEE PLFAARVIYD LLFFFMVIII VLNLIFGVII DTFADLRSEK 
      2610       2620       2630       2640       2650
QKKEEILKTT CFICGLERDK FDNKTVTFEE HIKEEHNMWH YLCFIVLVKV 
      2660       2670       2680       2690       2700
KDSTEYTGPE SYVAEMIKER NLDWFPRMRA MSLVSSDSEG EQNELRNLQE 
      2710       2720       2730       2740       2750
KLESTMKLVT NLSGQLSELK DQMTEQRKQK QRIGLLGHPP HMNVNPQQPA
Length:2,750
Mass (Da):313,029
Last modified:January 16, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA3E67D0371F6846B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q14643ITPR1_HUMAN
Inositol 1,4,5-trisphosphate recept...
ITPR1 INSP3R1
2,758Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITU8A0A3B3ITU8_HUMAN
Inositol 1,4,5-trisphosphate recept...
ITPR1
2,744Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IU04A0A3B3IU04_HUMAN
Inositol 1,4,5-trisphosphate recept...
ITPR1
2,749Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITQ1A0A3B3ITQ1_HUMAN
Inositol 1,4,5-trisphosphate recept...
ITPR1
2,012Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7ZMI3B7ZMI3_HUMAN
Inositol 1,4,5-trisphosphate recept...
ITPR1
721Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IRT5A0A3B3IRT5_HUMAN
Inositol 1,4,5-trisphosphate recept...
ITPR1
296Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITM6A0A3B3ITM6_HUMAN
Inositol 1,4,5-trisphosphate recept...
ITPR1
714Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A8C8KBY2A0A8C8KBY2_HUMAN
Inositol 1,4,5-trisphosphate recept...
ITPR1
1,668Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IU05A0A3B3IU05_HUMAN
Inositol 1,4,5-trisphosphate recept...
ITPR1
1,818Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IU13A0A3B3IU13_HUMAN
Inositol 1,4,5-trisphosphate recept...
ITPR1
1,739Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC024168 Genomic DNA No translation available.
AC069248 Genomic DNA No translation available.
AC090944 Genomic DNA No translation available.
KF457537 Genomic DNA No translation available.
KF457539 Genomic DNA No translation available.
KF457546 Genomic DNA No translation available.
KF495812 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_011531986.1, XM_011533684.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000354582.12; ENSP00000346595.8; ENSG00000150995.21

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3708

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024168 Genomic DNA No translation available.
AC069248 Genomic DNA No translation available.
AC090944 Genomic DNA No translation available.
KF457537 Genomic DNA No translation available.
KF457539 Genomic DNA No translation available.
KF457546 Genomic DNA No translation available.
KF495812 Genomic DNA No translation available.
RefSeqiXP_011531986.1, XM_011533684.1

3D structure databases

SMRiA0A3F2YNW8
ModBaseiSearch...

Proteomic databases

PeptideAtlasiA0A3F2YNW8

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		5503, 413 antibodies from 41 providers

The DNASU plasmid repository

More...DNASUi		3708

Genome annotation databases

EnsembliENST00000354582.12; ENSP00000346595.8; ENSG00000150995.21
GeneIDi3708

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3708
HGNCiHGNC:6180, ITPR1
OpenTargetsiENSG00000150995
VEuPathDBiHostDB:ENSG00000150995

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000155071

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ITPR1, human

Gene expression databases

ExpressionAtlasiA0A3F2YNW8, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR014821, Ins145_P3_rcpt
IPR000493, InsP3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR035910, RyR/IP3R_RIH_dom_sf
PfamiView protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF01365, RYDR_ITPR, 2 hits
PRINTSiPR00779, INSP3RECEPTR
SMARTiView protein in SMART
SM00472, MIR, 4 hits
SUPFAMiSSF100909, SSF100909, 2 hits
SSF82109, SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50919, MIR, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3F2YNW8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3F2YNW8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 16, 2019
Last sequence update: January 16, 2019
Last modified: May 25, 2022
This is version 20 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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