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UniProtKB - A0A3B3IUB6 (A0A3B3IUB6_HUMAN)
Protein
Submitted name:
Forkhead box protein P1
Gene
FOXP1
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 460 – 533 | Fork-headPROSITE-ProRule annotationAdd BLAST | 74 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: InterPro
- metal ion binding Source: UniProtKB-KW
- sequence-specific DNA binding Source: InterPro
GO - Biological processi
- animal organ development Source: UniProt
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotation, RepressorARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Forkhead box protein P1Imported |
Gene namesi | Name:FOXP1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3823, FOXP1 |
VEuPathDBi | HostDB:ENSG00000114861 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 460 – 533 | Fork-headInterPro annotationAdd BLAST | 74 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 43 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 235 – 254 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 259 – 294 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 386 – 418 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 606 – 672 | DisorderedSequence analysisAdd BLAST | 67 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 344 – 364 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 24 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 259 – 282 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 386 – 401 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 606 – 620 | Polar residuesSequence analysisAdd BLAST | 15 |
Keywords - Domaini
Coiled coilSequence analysis, Zinc-fingerARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000159892 |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR032354, FOXP-CC IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit PF16159, FOXP-CC, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 26 potential isoforms that are computationally mapped.Show allAlign All
A0A3B3IUB6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMQESGTETK SNGSAIQNGS GGSNHLLECG GLREGRSNGE TPAVDIGAAD
60 70 80 90 100
LAHAQQQQQQ VARQLLLQQQ QQQQVSGLKS PKRNDKQPAL QVPVSVAMMT
110 120 130 140 150
PQVITPQQMQ QILQQQVLSP QQLQVLLQQQ QALMLQQQLQ EFYKKQQEQL
160 170 180 190 200
QLQLLQQQHA GKQPKEQQQV ATQQLAFQQQ LLQMQQLQQQ HLLSLQRQGL
210 220 230 240 250
LTIQPGQPAL PLQPLAQGMI PTELQQLWKE VTSAHTAEET TGNNHSSLDL
260 270 280 290 300
TTTCVSSSAP SKTSLIMNPH ASTNGQLSVH TPKRESLSHE EHPHSHPLYG
310 320 330 340 350
HGVCKWPGCE AVCEDFQSFL KHLNSEHALD DRSTAQCRVQ MQVVQQLELQ
360 370 380 390 400
LAKDKERLQA MMTHLHVKST EPKAAPQPLN LVSSVTLSKS ASEASPQSLP
410 420 430 440 450
HTPTTPTAPL TPVTQGPSVI TTTSMHTVGP IRRRYSDKYN VPISSDIAQN
460 470 480 490 500
QEFYKNAEVR PPFTYASLIR QAILESPEKQ LTLNEIYNWF TRMFAYFRRN
510 520 530 540 550
AATWKNAVRH NLSLHKCFVR VENVKGAVWT VDEVEFQKRR PQKISGNPSL
560 570 580 590 600
IKNMQSSHAY CTPLNAALQA SMAENSIPLY TTASMGNPTL GNLASAIREE
610 620 630 640 650
LNGAMEHTNS NESDSSPGRS PMQAVHPVHV KEEPLDPEEA EGPLSLVTTA
660 670
NHSPDFDHDR DYEDEPVNED ME
Computationally mapped potential isoform sequencesi
There are 26 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9H334 | FOXP1_HUMAN | Forkhead box protein P1 | FOXP1 HSPC215 | 677 | Annotation score: | ||
H0Y882 | H0Y882_HUMAN | Forkhead box protein P1 | FOXP1 | 490 | Annotation score: | ||
A0A0B4J2F3 | A0A0B4J2F3_HUMAN | Forkhead box protein P1 | FOXP1 | 576 | Annotation score: | ||
A0A3B3IS87 | A0A3B3IS87_HUMAN | Forkhead box protein P1 | FOXP1 | 468 | Annotation score: | ||
A0A3B3IST0 | A0A3B3IST0_HUMAN | Forkhead box protein P1 | FOXP1 | 676 | Annotation score: | ||
A0A3B3IST6 | A0A3B3IST6_HUMAN | Forkhead box protein P1 | FOXP1 | 628 | Annotation score: | ||
A0A3B3IT66 | A0A3B3IT66_HUMAN | Forkhead box protein P1 | FOXP1 | 577 | Annotation score: | ||
G5E965 | G5E965_HUMAN | Forkhead box P1, isoform CRA_f | FOXP1 hCG_1778483 | 566 | Annotation score: | ||
A0A3B3IRS5 | A0A3B3IRS5_HUMAN | Forkhead box P1, isoform CRA_g | FOXP1 hCG_1778483 | 675 | Annotation score: | ||
A0A3B3IRW5 | A0A3B3IRW5_HUMAN | Forkhead box protein P1 | FOXP1 | 576 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC097632 Genomic DNA No translation available. AC097634 Genomic DNA No translation available. AC103586 Genomic DNA No translation available. AC104442 Genomic DNA No translation available. AC104645 Genomic DNA No translation available. AC138058 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000649431; ENSP00000498174; ENSG00000114861 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC097632 Genomic DNA No translation available. AC097634 Genomic DNA No translation available. AC103586 Genomic DNA No translation available. AC104442 Genomic DNA No translation available. AC104645 Genomic DNA No translation available. AC138058 Genomic DNA No translation available. |
3D structure databases
SMRi | A0A3B3IUB6 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | A0A3B3IUB6 |
Protocols and materials databases
Antibodypediai | 902, 826 antibodies from 49 providers |
Genome annotation databases
Ensembli | ENST00000649431; ENSP00000498174; ENSG00000114861 |
Organism-specific databases
HGNCi | HGNC:3823, FOXP1 |
OpenTargetsi | ENSG00000114861 |
VEuPathDBi | HostDB:ENSG00000114861 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000159892 |
Miscellaneous databases
ChiTaRSi | FOXP1, human |
Gene expression databases
ExpressionAtlasi | A0A3B3IUB6, baseline and differential |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR032354, FOXP-CC IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit PF16159, FOXP-CC, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A3B3IUB6_HUMAN | |
Accessioni | A0A3B3IUB6Primary (citable) accession number: A0A3B3IUB6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 5, 2018 |
Last sequence update: | December 5, 2018 | |
Last modified: | January 19, 2022 | |
This is version 16 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |