UniProtKB - A0A3B3IU51 (A0A3B3IU51_HUMAN)
Protein
Submitted name:
Tight junction protein ZO-2
Gene
TJP2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Tight junction protein ZO-2Imported |
Gene namesi | Name:TJP2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11828, TJP2 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
Other locations
- tight junction ARBA annotation
- Membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- bicellular tight junction Source: UniProtKB-SubCell
Keywords - Cellular componenti
MembraneARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 37 – 124 | PDZInterPro annotationAdd BLAST | 88 | |
Domaini | 311 – 389 | PDZInterPro annotationAdd BLAST | 79 | |
Domaini | 513 – 594 | PDZInterPro annotationAdd BLAST | 82 | |
Domaini | 608 – 673 | SH3InterPro annotationAdd BLAST | 66 | |
Domaini | 694 – 880 | Guanylate kinase-likeInterPro annotationAdd BLAST | 187 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 156 – 310 | DisorderedSequence analysisAdd BLAST | 155 | |
Regioni | 412 – 510 | DisorderedSequence analysisAdd BLAST | 99 | |
Regioni | 924 – 961 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 977 – 1047 | DisorderedSequence analysisAdd BLAST | 71 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 166 – 300 | PolyampholyteSequence analysisAdd BLAST | 135 | |
Compositional biasi | 412 – 449 | PolyampholyteSequence analysisAdd BLAST | 38 | |
Compositional biasi | 931 – 945 | AcidicSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1014 – 1029 | PolyampholyteSequence analysisAdd BLAST | 16 |
Keywords - Domaini
SH3 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000158634 |
Family and domain databases
CDDi | cd12027, SH3_ZO-2, 1 hit |
Gene3Di | 2.30.42.10, 3 hits |
InterProi | View protein in InterPro IPR008145, GK/Ca_channel_bsu IPR008144, Guanylate_kin-like_dom IPR027417, P-loop_NTPase IPR001478, PDZ IPR036034, PDZ_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR005417, ZO IPR005419, ZO-2 IPR035598, ZO-2_SH3 |
Pfami | View protein in Pfam PF00625, Guanylate_kin, 1 hit PF00595, PDZ, 3 hits PF07653, SH3_2, 1 hit |
PRINTSi | PR01597, ZONOCCLUDNS PR01599, ZONOCCLUDNS2 |
SMARTi | View protein in SMART SM00072, GuKc, 1 hit SM00228, PDZ, 3 hits |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF50156, SSF50156, 3 hits SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50052, GUANYLATE_KINASE_2, 1 hit PS50106, PDZ, 3 hits PS50002, SH3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All
A0A3B3IU51-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKTAQALHRM WIQAVKKLRR WKGRAPGMEE LIWEQYTVTL QKDSKRGFGI
60 70 80 90 100
AVSGGRDNPH FENGETSIVI SDVLPGGPAD GLLQENDRVV MVNGTPMEDV
110 120 130 140 150
LHSFAVQQLR KSGKVAAIVV KRPRKVQVAA LQASPPLDQD DRAFEVMDEF
160 170 180 190 200
DGRSFRSGYS ERSRLNSHGG RSRSWEDSPE RGRPHERARS RERDLSRDRS
210 220 230 240 250
RGRSLERGLD QDHARTRDRS RGRSLERGLD HDFGPSRDRD RDRSRGRSID
260 270 280 290 300
QDYERAYHRA YDPDYERAYS PEYRRGARHD ARSRGPRSRS REHPHSRSPS
310 320 330 340 350
PEPRGRPGPI GVLLMKSRAN EEYGLRLGSQ IFVKEMTRTG LATKDGNLHE
360 370 380 390 400
GDIILKINGT VTENMSLTDA RKLIEKSRGK LQLVVLRDSQ QTLINIPSLN
410 420 430 440 450
DSDSEIEDIS EIESNRSFSP EERRHQYSDY DYHSSSEKLK ERPSSREDTP
460 470 480 490 500
SRLSRMGATP TPFKSTGDIA GTVVPETNKE PRYQEDPPAP QPKAAPRTFL
510 520 530 540 550
RPSPEDEAIY GPNTKMVRFK KGDSVGLRLA GGNDVGIFVA GIQEGTSAEQ
560 570 580 590 600
EGLQEGDQIL KVNTQDFRGL VREDAVLYLL EIPKGEMVTI LAQSRADVYR
610 620 630 640 650
DILACGRGDS FFIRSHFECE KETPQSLAFT RGEVFRVVDT LYDGKLGNWL
660 670 680 690 700
AVRIGNELEK GLIPNKSRAE QMASVQNAQR DNAGDRADFW RMRGQRSGVK
710 720 730 740 750
KNLRKSREDL TAVVSVSTKF PAYERVLLRE AGFKRPVVLF GPIADIAMEK
760 770 780 790 800
LANELPDWFQ TAKTEPKDAG SEKSTGVVRL NTVRQIIEQD KHALLDVTPK
810 820 830 840 850
AVDLLNYTQW FPIVIFFNPD SRQGVKTMRQ RLNPTSNKSS RKLFDQANKL
860 870 880 890 900
KKTCAHLFTA TINLNSANDS WFGSLKDTIQ HQQGEAVWVS EGKMEGMDDD
910 920 930 940 950
PEDRMSYLTA MGADYLSCDS RLISDFEDTD GEGGAYTDNE LDEPAEEPLV
960 970 980 990 1000
SSITRSSEPV QHEEIEIAQK HPDIYAVPIK THKPDPGTPQ HTSSRPPEPQ
1010 1020 1030 1040
KAPSRPYQDT RGSYGSDAEE EEYRQQLSEH SKRGYYGQSA RYRDTEL
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9UDY2 | ZO2_HUMAN | Tight junction protein ZO-2 | TJP2 X104, ZO2 | 1,190 | Annotation score: | ||
A0A1B0GTW1 | A0A1B0GTW1_HUMAN | Tight junction protein ZO-2 | TJP2 | 1,249 | Annotation score: | ||
A0A3B3IRI3 | A0A3B3IRI3_HUMAN | Tight junction protein ZO-2 | TJP2 | 1,128 | Annotation score: | ||
A0A3B3IRV6 | A0A3B3IRV6_HUMAN | Tight junction protein ZO-2 | TJP2 | 851 | Annotation score: | ||
A0A3B3ISF1 | A0A3B3ISF1_HUMAN | Tight junction protein ZO-2 | TJP2 | 989 | Annotation score: | ||
A0A3B3ISZ5 | A0A3B3ISZ5_HUMAN | Tight junction protein ZO-2 | TJP2 | 1,099 | Annotation score: | ||
A0A3B3ITE1 | A0A3B3ITE1_HUMAN | Tight junction protein ZO-2 | TJP2 | 1,191 | Annotation score: | ||
A0A3B3IT83 | A0A3B3IT83_HUMAN | Tight junction protein ZO-2 | TJP2 | 621 | Annotation score: | ||
B1AN86 | B1AN86_HUMAN | Tight junction protein ZO-2 | TJP2 | 161 | Annotation score: | ||
A0A3B3IS03 | A0A3B3IS03_HUMAN | Tight junction protein ZO-2 | TJP2 | 652 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL162730 Genomic DNA No translation available. AL358113 Genomic DNA No translation available. AL590238 Genomic DNA No translation available. |
RefSeqi | XP_016870817.1, XM_017015328.1 |
Genome annotation databases
Ensembli | ENST00000649134; ENSP00000498068; ENSG00000119139 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL162730 Genomic DNA No translation available. AL358113 Genomic DNA No translation available. AL590238 Genomic DNA No translation available. |
RefSeqi | XP_016870817.1, XM_017015328.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A0A3B3IU51 |
Protocols and materials databases
Antibodypediai | 784, 387 antibodies |
Genome annotation databases
Ensembli | ENST00000649134; ENSP00000498068; ENSG00000119139 |
Organism-specific databases
HGNCi | HGNC:11828, TJP2 |
OpenTargetsi | ENSG00000119139 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158634 |
Miscellaneous databases
ChiTaRSi | TJP2, human |
Gene expression databases
ExpressionAtlasi | A0A3B3IU51, baseline and differential |
Family and domain databases
CDDi | cd12027, SH3_ZO-2, 1 hit |
Gene3Di | 2.30.42.10, 3 hits |
InterProi | View protein in InterPro IPR008145, GK/Ca_channel_bsu IPR008144, Guanylate_kin-like_dom IPR027417, P-loop_NTPase IPR001478, PDZ IPR036034, PDZ_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR005417, ZO IPR005419, ZO-2 IPR035598, ZO-2_SH3 |
Pfami | View protein in Pfam PF00625, Guanylate_kin, 1 hit PF00595, PDZ, 3 hits PF07653, SH3_2, 1 hit |
PRINTSi | PR01597, ZONOCCLUDNS PR01599, ZONOCCLUDNS2 |
SMARTi | View protein in SMART SM00072, GuKc, 1 hit SM00228, PDZ, 3 hits |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF50156, SSF50156, 3 hits SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50052, GUANYLATE_KINASE_2, 1 hit PS50106, PDZ, 3 hits PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A3B3IU51_HUMAN | |
Accessioni | A0A3B3IU51Primary (citable) accession number: A0A3B3IU51 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 5, 2018 |
Last sequence update: | December 5, 2018 | |
Last modified: | October 7, 2020 | |
This is version 13 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |