The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - A0A3B3ITM6 (A0A3B3ITM6_HUMAN)
Protein
Inositol 1,4,5-trisphosphate receptor
Gene
ITPR1
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
UniRule annotationGO - Molecular functioni
- inositol 1,4,5 trisphosphate binding Source: UniProtKB-UniRule
- inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Source: UniProtKB-UniRule
Keywordsi
Molecular function | Calcium channelUniRule annotationARBA annotation, Ion channel, Ligand-gated ion channelUniRule annotation, ReceptorUniRule annotation |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium |
Names & Taxonomyi
Protein namesi | Recommended name: Inositol 1,4,5-trisphosphate receptorUniRule annotation |
Gene namesi | Name:ITPR1 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6180, ITPR1 |
VEuPathDBi | HostDB:ENSG00000150995 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-UniRule
Keywords - Cellular componenti
Endoplasmic reticulumUniRule annotation, MembraneUniRule annotationInteractioni
Subunit structurei
Homotetramer.
UniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 73 | MIRInterPro annotationAdd BLAST | 55 | |
Domaini | 138 – 194 | MIRInterPro annotationAdd BLAST | 57 | |
Domaini | 201 – 265 | MIRInterPro annotationAdd BLAST | 65 | |
Domaini | 271 – 327 | MIRInterPro annotationAdd BLAST | 57 |
Domaini
The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.UniRule annotation
Sequence similaritiesi
Belongs to the InsP3 receptor family.UniRule annotation
Keywords - Domaini
RepeatARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155071 |
Family and domain databases
InterProi | View protein in InterPro IPR014821, Ins145_P3_rcpt IPR000493, InsP3_rcpt IPR036300, MIR_dom_sf IPR016093, MIR_motif IPR000699, RIH_dom IPR035910, RyR/IP3R_RIH_dom_sf |
Pfami | View protein in Pfam PF08709, Ins145_P3_rec, 1 hit PF02815, MIR, 1 hit PF01365, RYDR_ITPR, 1 hit |
PRINTSi | PR00779, INSP3RECEPTR |
SMARTi | View protein in SMART SM00472, MIR, 4 hits |
SUPFAMi | SSF100909, SSF100909, 1 hit SSF82109, SSF82109, 2 hits |
PROSITEi | View protein in PROSITE PS50919, MIR, 4 hits |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 16 potential isoforms that are computationally mapped.Show allAlign All
A0A3B3ITM6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
HAADLEKKQN ETENRKLLGT VIQYGNVIQL LHLKSNKYLT VNKRLPALLE
60 70 80 90 100
KNAMRVTLDE AGNEGSWFYI QPFYKLRSIG DSVVIGDKVV LNPVNAGQPL
110 120 130 140 150
HASSHQLVDN PGCNEVNSVN CNTSWKIVLF MKWSDNKDDI LKGGDVVRLF
160 170 180 190 200
HAEQEKFLTC DEHRKKQHVF LRTTGRQSAT SATSSKALWE VEVVQHDPCR
210 220 230 240 250
GGAGYWNSLF RFKHLATGHY LAAEVDPDQD ASRSRLRNAQ EKMVYSLVSV
260 270 280 290 300
PEGNDISSIF ELDPTTLRGG DSLVPRNSYV RLRHLCTNTW VHSTNIPIDK
310 320 330 340 350
EEEKPVMLKI GTSPVKEDKE AFAIVPVSPA EVRDLDFAND ASKVLGSIAG
360 370 380 390 400
KLEKGTITQN ERRSVTKLLE DLVYFVTGGT NSGQDVLEVV FSKPNRERQK
410 420 430 440 450
LMREQNILKQ IFKLLQAPFT DCGDGPMLRL EELGDQRHAP FRHICRLCYR
460 470 480 490 500
VLRHSQQDYR KNQEYIAKQF GFMQKQIGYD VLAEDTITAL LHNNRKLLEK
510 520 530 540 550
HITAAEIDTF VSLVRKNREP RFLDYLSDLC VSMNKSIPVT QELICKAVLN
560 570 580 590 600
PTNADILIET KLVLSRFEFE GVSSTGENAL EAGEDEEEVW LFWRDSNKEI
610 620 630 640 650
RSKSVRELAQ DAKEGQKEDR DVLSYYSCHD SLYVYPSARF PVCTCLTSAT
660 670 680 690 700
HLHGPQCLLG SSCKTCQSCH LKGREGEERK EVNQLILLKE KEREDKARLL
710
LFFNKINKTA DKMP
Computationally mapped potential isoform sequencesi
There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ14643 | ITPR1_HUMAN | Inositol 1,4,5-trisphosphate recept... | ITPR1 INSP3R1 | 2,758 | Annotation score: | ||
A0A3B3ITU8 | A0A3B3ITU8_HUMAN | Inositol 1,4,5-trisphosphate recept... | ITPR1 | 2,744 | Annotation score: | ||
A0A3F2YNW8 | A0A3F2YNW8_HUMAN | Inositol 1,4,5-trisphosphate recept... | ITPR1 | 2,750 | Annotation score: | ||
A0A3B3IU04 | A0A3B3IU04_HUMAN | Inositol 1,4,5-trisphosphate recept... | ITPR1 | 2,749 | Annotation score: | ||
A0A3B3ITQ1 | A0A3B3ITQ1_HUMAN | Inositol 1,4,5-trisphosphate recept... | ITPR1 | 2,012 | Annotation score: | ||
B7ZMI3 | B7ZMI3_HUMAN | Inositol 1,4,5-trisphosphate recept... | ITPR1 | 721 | Annotation score: | ||
A0A3B3IRT5 | A0A3B3IRT5_HUMAN | Inositol 1,4,5-trisphosphate recept... | ITPR1 | 296 | Annotation score: | ||
A0A8C8KBY2 | A0A8C8KBY2_HUMAN | Inositol 1,4,5-trisphosphate recept... | ITPR1 | 1,668 | Annotation score: | ||
A0A3B3IU05 | A0A3B3IU05_HUMAN | Inositol 1,4,5-trisphosphate recept... | ITPR1 | 1,818 | Annotation score: | ||
A0A3B3IU13 | A0A3B3IU13_HUMAN | Inositol 1,4,5-trisphosphate recept... | ITPR1 | 1,739 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC024168 Genomic DNA No translation available. AC069248 Genomic DNA No translation available. AC090944 Genomic DNA No translation available. KF457537 Genomic DNA No translation available. KF457539 Genomic DNA No translation available. KF457546 Genomic DNA No translation available. KF495812 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000649051.1; ENSP00000497851.1; ENSG00000150995.21 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC024168 Genomic DNA No translation available. AC069248 Genomic DNA No translation available. AC090944 Genomic DNA No translation available. KF457537 Genomic DNA No translation available. KF457539 Genomic DNA No translation available. KF457546 Genomic DNA No translation available. KF495812 Genomic DNA No translation available. |
3D structure databases
SMRi | A0A3B3ITM6 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | A0A3B3ITM6 |
Genome annotation databases
Ensembli | ENST00000649051.1; ENSP00000497851.1; ENSG00000150995.21 |
Organism-specific databases
HGNCi | HGNC:6180, ITPR1 |
OpenTargetsi | ENSG00000150995 |
VEuPathDBi | HostDB:ENSG00000150995 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155071 |
Miscellaneous databases
ChiTaRSi | ITPR1, human |
Gene expression databases
ExpressionAtlasi | A0A3B3ITM6, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR014821, Ins145_P3_rcpt IPR000493, InsP3_rcpt IPR036300, MIR_dom_sf IPR016093, MIR_motif IPR000699, RIH_dom IPR035910, RyR/IP3R_RIH_dom_sf |
Pfami | View protein in Pfam PF08709, Ins145_P3_rec, 1 hit PF02815, MIR, 1 hit PF01365, RYDR_ITPR, 1 hit |
PRINTSi | PR00779, INSP3RECEPTR |
SMARTi | View protein in SMART SM00472, MIR, 4 hits |
SUPFAMi | SSF100909, SSF100909, 1 hit SSF82109, SSF82109, 2 hits |
PROSITEi | View protein in PROSITE PS50919, MIR, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A3B3ITM6_HUMAN | |
Accessioni | A0A3B3ITM6Primary (citable) accession number: A0A3B3ITM6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 5, 2018 |
Last sequence update: | December 5, 2018 | |
Last modified: | May 25, 2022 | |
This is version 16 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |