UniProtKB - A0A3B3IT83 (A0A3B3IT83_HUMAN)
Protein
Submitted name:
Tight junction protein ZO-2
Gene
TJP2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Tight junction protein ZO-2Imported |
Gene namesi | Name:TJP2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11828, TJP2 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
Other locations
- tight junction ARBA annotation
- Membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- bicellular tight junction Source: UniProtKB-SubCell
Keywords - Cellular componenti
MembraneARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 65 – 143 | PDZInterPro annotationAdd BLAST | 79 | |
Domaini | 267 – 348 | PDZInterPro annotationAdd BLAST | 82 | |
Domaini | 362 – 427 | SH3InterPro annotationAdd BLAST | 66 | |
Domaini | 448 – 621 | Guanylate kinase-likeInterPro annotationAdd BLAST | 174 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 66 | DisorderedSequence analysisAdd BLAST | 66 | |
Regioni | 164 – 264 | DisorderedSequence analysisAdd BLAST | 101 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 54 | PolyampholyteSequence analysisAdd BLAST | 54 | |
Compositional biasi | 164 – 203 | PolyampholyteSequence analysisAdd BLAST | 40 |
Keywords - Domaini
SH3 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000158634 |
Family and domain databases
CDDi | cd12027, SH3_ZO-2, 1 hit |
Gene3Di | 2.30.42.10, 2 hits |
InterProi | View protein in InterPro IPR008145, GK/Ca_channel_bsu IPR008144, Guanylate_kin-like_dom IPR027417, P-loop_NTPase IPR001478, PDZ IPR036034, PDZ_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR005417, ZO IPR035598, ZO-2_SH3 |
Pfami | View protein in Pfam PF00625, Guanylate_kin, 1 hit PF00595, PDZ, 2 hits PF07653, SH3_2, 1 hit |
PRINTSi | PR01597, ZONOCCLUDNS |
SMARTi | View protein in SMART SM00072, GuKc, 1 hit SM00228, PDZ, 2 hits |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF50156, SSF50156, 2 hits SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50052, GUANYLATE_KINASE_2, 1 hit PS50106, PDZ, 2 hits PS50002, SH3, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All
A0A3B3IT83-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XSIDQDYERA YHRAYDPDYE RAYSPEYRRG ARHDARSRGP RSRSREHPHS
60 70 80 90 100
RSPSPEPRGR PGPIGVLLMK SRANEEYGLR LGSQIFVKEM TRTGLATKDG
110 120 130 140 150
NLHEGDIILK INGTVTENMS LTDARKLIEK SRGKLQLVVL RDSQQTLINI
160 170 180 190 200
PSLNDSDSEI EDISEIESNR SFSPEERRHQ YSDYDYHSSS EKLKERPSSR
210 220 230 240 250
EDTPSRLSRM GATPTPFKST GDIAGTVVPE TNKEPRYQED PPAPQPKAAP
260 270 280 290 300
RTFLRPSPED EAIYGPNTKM VRFKKGDSVG LRLAGGNDVG IFVAGIQEGT
310 320 330 340 350
SAEQEGLQEG DQILKVNTQD FRGLVREDAV LYLLEIPKGE MVTILAQSRA
360 370 380 390 400
DVYRDILACG RGDSFFIRSH FECEKETPQS LAFTRGEVFR VVDTLYDGKL
410 420 430 440 450
GNWLAVRIGN ELEKGLIPNK SRAEQMASVQ NAQRDNAGDR ADFWRMRGQR
460 470 480 490 500
SGVKKNLRKS REDLTAVVSV STKFPAYERV LLREAGFKRP VVLFGPIADI
510 520 530 540 550
AMEKLANELP DWFQTAKTEP KDAGSEKSTG VVRLNTVRQI IEQDKHALLD
560 570 580 590 600
VTPKAVDLLN YTQWFPIVIF FNPDSRQGVK TMRQRLNPTS NKSSRKLFDQ
610 620
ANKLKKTCAH LFTDRNCPEA S
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9UDY2 | ZO2_HUMAN | Tight junction protein ZO-2 | TJP2 X104, ZO2 | 1,190 | Annotation score: | ||
A0A1B0GTW1 | A0A1B0GTW1_HUMAN | Tight junction protein ZO-2 | TJP2 | 1,249 | Annotation score: | ||
A0A3B3ITE1 | A0A3B3ITE1_HUMAN | Tight junction protein ZO-2 | TJP2 | 1,191 | Annotation score: | ||
A0A3B3IU51 | A0A3B3IU51_HUMAN | Tight junction protein ZO-2 | TJP2 | 1,047 | Annotation score: | ||
A0A3B3IRI3 | A0A3B3IRI3_HUMAN | Tight junction protein ZO-2 | TJP2 | 1,128 | Annotation score: | ||
A0A3B3IRV6 | A0A3B3IRV6_HUMAN | Tight junction protein ZO-2 | TJP2 | 851 | Annotation score: | ||
A0A3B3ISF1 | A0A3B3ISF1_HUMAN | Tight junction protein ZO-2 | TJP2 | 989 | Annotation score: | ||
A0A3B3ISZ5 | A0A3B3ISZ5_HUMAN | Tight junction protein ZO-2 | TJP2 | 1,099 | Annotation score: | ||
B1AN86 | B1AN86_HUMAN | Tight junction protein ZO-2 | TJP2 | 161 | Annotation score: | ||
A0A3B3IS03 | A0A3B3IS03_HUMAN | Tight junction protein ZO-2 | TJP2 | 652 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL162730 Genomic DNA No translation available. AL358113 Genomic DNA No translation available. AL590238 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000650460; ENSP00000497787; ENSG00000119139 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL162730 Genomic DNA No translation available. AL358113 Genomic DNA No translation available. AL590238 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | A0A3B3IT83 |
Genome annotation databases
Ensembli | ENST00000650460; ENSP00000497787; ENSG00000119139 |
Organism-specific databases
HGNCi | HGNC:11828, TJP2 |
OpenTargetsi | ENSG00000119139 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158634 |
Miscellaneous databases
ChiTaRSi | TJP2, human |
Gene expression databases
ExpressionAtlasi | A0A3B3IT83, baseline and differential |
Family and domain databases
CDDi | cd12027, SH3_ZO-2, 1 hit |
Gene3Di | 2.30.42.10, 2 hits |
InterProi | View protein in InterPro IPR008145, GK/Ca_channel_bsu IPR008144, Guanylate_kin-like_dom IPR027417, P-loop_NTPase IPR001478, PDZ IPR036034, PDZ_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR005417, ZO IPR035598, ZO-2_SH3 |
Pfami | View protein in Pfam PF00625, Guanylate_kin, 1 hit PF00595, PDZ, 2 hits PF07653, SH3_2, 1 hit |
PRINTSi | PR01597, ZONOCCLUDNS |
SMARTi | View protein in SMART SM00072, GuKc, 1 hit SM00228, PDZ, 2 hits |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF50156, SSF50156, 2 hits SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50052, GUANYLATE_KINASE_2, 1 hit PS50106, PDZ, 2 hits PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A3B3IT83_HUMAN | |
Accessioni | A0A3B3IT83Primary (citable) accession number: A0A3B3IT83 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 5, 2018 |
Last sequence update: | December 5, 2018 | |
Last modified: | October 7, 2020 | |
This is version 11 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |