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Entry version 10 (07 Apr 2021)
Sequence version 1 (05 Dec 2018)
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Protein
Submitted name:

Kelch domain-containing protein 7B

Gene

KLHDC7B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Kelch domain-containing protein 7BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KLHDC7BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25145, KLHDC7B

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000130487

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A0A3B3ISF6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A3B3ISF6, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni78 – 114DisorderedSequence analysisAdd BLAST37
Regioni131 – 253DisorderedSequence analysisAdd BLAST123
Regioni272 – 628DisorderedSequence analysisAdd BLAST357
Regioni647 – 815DisorderedSequence analysisAdd BLAST169

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi228 – 250PolyampholyteSequence analysisAdd BLAST23
Compositional biasi419 – 435Pro-richSequence analysisAdd BLAST17
Compositional biasi483 – 506PolarSequence analysisAdd BLAST24
Compositional biasi507 – 610Pro-richSequence analysisAdd BLAST104
Compositional biasi667 – 691PolarSequence analysisAdd BLAST25
Compositional biasi741 – 755Pro-richSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Kelch repeatARBA annotation, RepeatARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163480

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.80, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015915, Kelch-typ_b-propeller
IPR006652, Kelch_1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01344, Kelch_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00612, Kelch, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117281, SSF117281, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A3B3ISF6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIQGTLEPDG PLWGWDWDSD NDWDSAVLAL LALAVVAATA LALHWFGSGH
60 70 80 90 100
DQEAAEPVST ALGAQPHQAG GAELALQPKS KVSDGSEGQS PGQGKPEPPG
110 120 130 140 150
RGQQSPVPAA APGGGLAAMA RLPLKTAVEE ARREALGQQR GSATPAAPRA
160 170 180 190 200
EGKEPPRPGT ALLGRSEAGG MSAPLLIHFT PRSPGSEAEA ETGGVRASSR
210 220 230 240 250
QAAGPAGQQD TGPWQAGAGP SGSMGRGRGR RRRMDAGSGD RARRPRKLDP
260 270 280 290 300
LRLGAAGSVW DAVDGAAALD AHARGLPTGP PLAQEPALPA LPAPRALQPG
310 320 330 340 350
SQTEGSGAKG GWSREASGVP APGGGWPWVS REVPGTRSFG PAPDSTRPWL
360 370 380 390 400
ESPPQGRPLS SQGPGATGAY DAGEAGADSS RDNSPAADLG PTRPPEQAKP
410 420 430 440 450
AAAGHSRAPS RSREPRPRSA SPPAAPGPGF PPEALTLPSP SDFLPLEVTQ
460 470 480 490 500
DPSVGENLRA APAPSSASAQ VLTSAPASVL APALASSPSS APTSATTSTS
510 520 530 540 550
SPTSAPAPAP TSAPTSTPAP APSPAAAATP APAPVPVPTL TPPSPALTPV
560 570 580 590 600
PTPALSPAPT PALTPAASPA LTPVPTPALS PAPTPAPTPA ASPAPAPTSA
610 620 630 640 650
PTPTPAASPA PADGSKPQES VALPRRYQEG QVSASWGNLI AMVLRSHPFP
660 670 680 690 700
RQDRPQGSVP RAVPGSPVGP STSTHSEDRH GPSSSVGTVI GTGTGGLVEA
710 720 730 740 750
GGQPQPRSSE TNGSPSPDPP PGLRGEGTRE KSLDPLPQAA MPRGPAQPPA
760 770 780 790 800
QRPPGPAASS SARRSQPVPQ LRKRSRCEIA PSSEQEVRPA ASGDPQGEAP
810 820 830 840 850
GEGGSPAGRS GALTEKQEEA RKLMVFLQRP GGWGVVEGPR KPSSRALEPA
860 870 880 890 900
TAAALRRRLD LGSCLDVLAF AQQHGEPGLA QETYALMSDN LLRVLGDPCL
910 920 930 940 950
YRRLSAADRE RILSLRTGRG RAVLGVLVLP SLYQGGRSGL PRGPRGEEPP
960 970 980 990 1000
AAAPVSLPLP AHLHVFNPRE NTWRPLTQVP EEAPLRGCGL CTMHNYLFLA
1010 1020 1030 1040 1050
GGIRGSGAKA VCSNEVFCYN PLTNIWSQVR PMQQARAQLK LVALDGLLYA
1060 1070 1080 1090 1100
IGGECLYSME CYDPRTDAWT PRAPLPAGTF PVAHEAVACR GDIYVTGGHL
1110 1120 1130 1140 1150
FYRLLRYSPV KDAWDECPYS ASHRRSSDIV ALGGFLYRFD LLRGVGAAVM
1160 1170 1180 1190 1200
RYNTVTGSWS RAASLPLPAP APLHCTTLGN TIYCLNPQVT ATFTVSGGTA
1210 1220 1230
QFQAKELQPF PLGSTGVLSP FILTLPPEDR LQTSL
Length:1,235
Mass (Da):126,661
Last modified:December 5, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA5E880E6BC5AE5D4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96G42KLD7B_HUMAN
Kelch domain-containing protein 7B
KLHDC7B
594Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U62317 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000648057; ENSP00000497256; ENSG00000130487

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62317 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiA0A3B3ISF6

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
237, 79 antibodies

Genome annotation databases

EnsembliENST00000648057; ENSP00000497256; ENSG00000130487

Organism-specific databases

HGNCiHGNC:25145, KLHDC7B
OpenTargetsiENSG00000130487

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000163480

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KLHDC7B, human

Gene expression databases

ExpressionAtlasiA0A3B3ISF6, baseline and differential

Family and domain databases

Gene3Di2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR015915, Kelch-typ_b-propeller
IPR006652, Kelch_1
PfamiView protein in Pfam
PF01344, Kelch_1, 2 hits
SMARTiView protein in SMART
SM00612, Kelch, 3 hits
SUPFAMiSSF117281, SSF117281, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3B3ISF6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3B3ISF6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 5, 2018
Last sequence update: December 5, 2018
Last modified: April 7, 2021
This is version 10 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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