UniProtKB - A0A3B3IS87 (A0A3B3IS87_HUMAN)
Protein
Submitted name:
Forkhead box protein P1
Gene
FOXP1
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 278 – 351 | Fork-headPROSITE-ProRule annotationAdd BLAST | 74 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: InterPro
- sequence-specific DNA binding Source: InterPro
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotationSAAS annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Forkhead box protein P1Imported |
Gene namesi | Name:FOXP1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3823 FOXP1 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 278 – 351 | Fork-headInterPro annotationAdd BLAST | 74 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 78 – 111 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 203 – 235 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 424 – 468 | DisorderedSequence analysisAdd BLAST | 45 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 161 – 181 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 78 – 99 | PolarSequence analysisAdd BLAST | 22 | |
Compositional biasi | 203 – 218 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 424 – 438 | PolarSequence analysisAdd BLAST | 15 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000159892 |
Family and domain databases
CDDi | cd00059 FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766 Fork_head_dom IPR032354 FOXP-CC IPR030456 TF_fork_head_CS_2 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250 Forkhead, 1 hit PF16159 FOXP-CC, 1 hit |
PRINTSi | PR00053 FORKHEAD |
SMARTi | View protein in SMART SM00339 FH, 1 hit |
SUPFAMi | SSF46785 SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00658 FORK_HEAD_2, 1 hit PS50039 FORK_HEAD_3, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 27 potential isoforms that are computationally mapped.Show allAlign All
A0A3B3IS87-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQQLQQQHLL SLQRQGLLTI QPGQPALPLQ PLAQGMIPTE LQQLWKEVTS
60 70 80 90 100
AHTAEETTGN NHSSLDLTTT CVSSSAPSKT SLIMNPHAST NGQLSVHTPK
110 120 130 140 150
RESLSHEEHP HSHPLYGHGV CKWPGCEAVC EDFQSFLKHL NSEHALDDRS
160 170 180 190 200
TAQCRVQMQV VQQLELQLAK DKERLQAMMT HLHVKSTEPK AAPQPLNLVS
210 220 230 240 250
SVTLSKSASE ASPQSLPHTP TTPTAPLTPV TQGPSVITTT SMHTVGPIRR
260 270 280 290 300
RYSDKYNVPI SSADIAQNQE FYKNAEVRPP FTYASLIRQA ILESPEKQLT
310 320 330 340 350
LNEIYNWFTR MFAYFRRNAA TWKNAVRHNL SLHKCFVRVE NVKGAVWTVD
360 370 380 390 400
EVEFQKRRPQ KISGNPSLIK NMQSSHAYCT PLNAALQASM AENSIPLYTT
410 420 430 440 450
ASMGNPTLGN LASAIREELN GAMEHTNSNE SDSSPGRSPM QAVHPVHVKE
460
EPLDPEEAEG PLSLVTTA
Computationally mapped potential isoform sequencesi
There are 27 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9H334 | FOXP1_HUMAN | Forkhead box protein P1 | FOXP1 HSPC215 | 677 | Annotation score: | ||
A0A0B4J2F3 | A0A0B4J2F3_HUMAN | Forkhead box protein P1 | FOXP1 | 576 | Annotation score: | ||
C9J0F0 | C9J0F0_HUMAN | Forkhead box protein P1 | FOXP1 | 612 | Annotation score: | ||
G5E965 | G5E965_HUMAN | Forkhead box P1, isoform CRA_f | FOXP1 hCG_1778483 | 566 | Annotation score: | ||
A0A3B3IS20 | A0A3B3IS20_HUMAN | Forkhead box protein P1 | FOXP1 | 678 | Annotation score: | ||
A0A3B3IT66 | A0A3B3IT66_HUMAN | Forkhead box protein P1 | FOXP1 | 577 | Annotation score: | ||
A0A3B3IRS5 | A0A3B3IRS5_HUMAN | Forkhead box P1, isoform CRA_g | FOXP1 hCG_1778483 | 675 | Annotation score: | ||
A0A3B3IST0 | A0A3B3IST0_HUMAN | Forkhead box protein P1 | FOXP1 | 676 | Annotation score: | ||
A0A3B3IRW5 | A0A3B3IRW5_HUMAN | Forkhead box protein P1 | FOXP1 | 576 | Annotation score: | ||
A0A3B3IST6 | A0A3B3IST6_HUMAN | Forkhead box protein P1 | FOXP1 | 628 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 468 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC097632 Genomic DNA No translation available. AC097634 Genomic DNA No translation available. AC103586 Genomic DNA No translation available. AC104442 Genomic DNA No translation available. AC104645 Genomic DNA No translation available. AC138058 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000649513; ENSP00000497237; ENSG00000114861 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC097632 Genomic DNA No translation available. AC097634 Genomic DNA No translation available. AC103586 Genomic DNA No translation available. AC104442 Genomic DNA No translation available. AC104645 Genomic DNA No translation available. AC138058 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENST00000649513; ENSP00000497237; ENSG00000114861 |
Organism-specific databases
HGNCi | HGNC:3823 FOXP1 |
OpenTargetsi | ENSG00000114861 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000159892 |
Miscellaneous databases
ChiTaRSi | FOXP1 human |
Gene expression databases
ExpressionAtlasi | A0A3B3IS87 baseline and differential |
Family and domain databases
CDDi | cd00059 FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766 Fork_head_dom IPR032354 FOXP-CC IPR030456 TF_fork_head_CS_2 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250 Forkhead, 1 hit PF16159 FOXP-CC, 1 hit |
PRINTSi | PR00053 FORKHEAD |
SMARTi | View protein in SMART SM00339 FH, 1 hit |
SUPFAMi | SSF46785 SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00658 FORK_HEAD_2, 1 hit PS50039 FORK_HEAD_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A3B3IS87_HUMAN | |
Accessioni | A0A3B3IS87Primary (citable) accession number: A0A3B3IS87 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 5, 2018 |
Last sequence update: | December 5, 2018 | |
Last modified: | October 16, 2019 | |
This is version 6 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |