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Entry version 16 (29 Sep 2021)
Sequence version 1 (05 Dec 2018)
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Protein

Mediator of RNA polymerase II transcription subunit 13

Gene

MED13L

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivatorUniRule annotation, RepressorUniRule annotationARBA annotation
Biological processTranscription, Transcription regulationUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 13UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MED13LImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:22962, MED13L

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000123066

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusUniRule annotationARBA annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000123066

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A0A3B3IS46

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A3B3IS46, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

UniRule annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini811 – 1155MID_MedPIWIInterPro annotationAdd BLAST345
Domaini1191 – 1594Med13_CInterPro annotationAdd BLAST404

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni92 – 111DisorderedSequence analysisAdd BLAST20
Regioni137 – 168DisorderedSequence analysisAdd BLAST32
Regioni391 – 495DisorderedSequence analysisAdd BLAST105
Regioni921 – 1067DisorderedSequence analysisAdd BLAST147
Regioni1405 – 1425DisorderedSequence analysisAdd BLAST21
Regioni1438 – 1483DisorderedSequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi152 – 168Polar residuesSequence analysisAdd BLAST17
Compositional biasi405 – 433Polar residuesSequence analysisAdd BLAST29
Compositional biasi455 – 491Polar residuesSequence analysisAdd BLAST37
Compositional biasi953 – 1020Polar residuesSequence analysisAdd BLAST68
Compositional biasi1028 – 1045Polar residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Mediator complex subunit 13 family.UniRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013680

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009401, Med13_C
IPR041285, MID_MedPIWI

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06333, Med13_C, 1 hit
PF18296, MID_MedPIWI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

A0A3B3IS46-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XLPLMAEVSE TALYCGIRPS NPESSEKWWH SYRLPPSDDA EFRPPELQGE
60 70 80 90 100
RCDAKMEVNS ESTALQRLLA QPNKRFKIWQ DKQPQLQPLH FLDPLPLSQQ
110 120 130 140 150
PGDSLGEVND PYTFEDGDIK YIFTANKKCK QGTEKDSLKK NKSEDGFGTK
160 170 180 190 200
DVTTPGHSTP VPDGKNAMSI FSSATKTDVR QDNAAGRAGS SSLTQVTDLA
210 220 230 240 250
PSLHDLDNIF DNSDDDELGA VSPALRSSKM PAVGTEDRPL GKDGRAAVPY
260 270 280 290 300
PPIADLQRMF PTPPSLEQHP AFSPVMNYKD GISSETVTAL GMMESPMVSM
310 320 330 340 350
VSTQLTEFKM EVEDGLGSPK PEEIKDFSYV HKVPSFQPFV GSSMFAPLKM
360 370 380 390 400
LPSHCLLPLK IPDACLFRPS WAIPPKIEQL PMPPAATFIR DGYNNVPSVG
410 420 430 440 450
SLADPDYLNT PQMNTPVTLN SAAPASNSGA GVLPSPATPR FSVPTPRTPR
460 470 480 490 500
TPRTPRGGGT ASGQGSVKYD STDQGSPAST PSTTRPLNSV EPATMQPIPE
510 520 530 540 550
AHSLYVTLIL SDSVMNIFKD RNFDSCCICA CNMNIKGADV GLYIPDSSNE
560 570 580 590 600
DQYRCTCGFS AIMNRKLGYN SGLFLEDELD IFGKNSDIGQ AAERRLMMCQ
610 620 630 640 650
STFLPQVEGT KKPQEPPISL LLLLQNQHTQ PFASLNFLDY ISSNNRQTLP
660 670 680 690 700
CVSWSYDRVQ ADNNDYWTEC FNALEQGRQY VDNPTGGKVD EALVRSATVH
710 720 730 740 750
SWPHSNVLDI SMLSSQDVVR MLLSLQPFLQ DAIQKKRTGR TWENIQHVQG
760 770 780 790 800
PLTWQQFHKM AGRGTYGSEE SPEPLPIPTL LVGYDKDFLT ISPFSLPFWE
810 820 830 840 850
RLLLDPYGGH RDVAYIVVCP ENEALLEGAK TFFRDLSAVY EMCRLGQHKP
860 870 880 890 900
ICKVLRDGIM RVGKTVAQKL TDELVSEWFN QPWSGEENDN HSRLKLYAQV
910 920 930 940 950
CRHHLAPYLA TLQLDSSLLI PPKYQTPPAA AQGQATPGNA GPLAPNGSAA
960 970 980 990 1000
PPAGSAFNPT SNSSSTNPAA SSSASGSSVP PVSSSASAPG ISQISTTSSS
1010 1020 1030 1040 1050
GFSGSVGGQN PSTGGISADR TQGNIGCGGD TDPGQSSSQP SQDGQESVTE
1060 1070 1080 1090 1100
RERIGIPTEP DSADSHAHPP AVVIYMVDPF TYAAEEDSTS GNFWLLSLMR
1110 1120 1130 1140 1150
CYTEMLDNLP EHMRNSFILQ IVPCQYMLQT MKDEQVFYIQ YLKSMAFSVY
1160 1170 1180 1190 1200
CQCRRPLPTQ IHIKSLTGFG PAASIEMTLK NPERPSPIQL YSPPFILAPI
1210 1220 1230 1240 1250
KDKQTELGET FGEASQKYNV LFVGYCLSHD QRWLLASCTD LHGELLETCV
1260 1270 1280 1290 1300
VNIALPNRSR RSKVSARKIG LQKLWEWCIG IVQMTSLPWR VVIGRLGRLG
1310 1320 1330 1340 1350
HGELKDWSIL LGECSLQTIS KKLKDVCRMC GISAADSPSI LSACLVAMEP
1360 1370 1380 1390 1400
QGSFVVMPDA VTMGSVFGRS TALNMQSSQL NTPQDASCTH ILVFPTSSTI
1410 1420 1430 1440 1450
QVAPANYPNE DGFSPNNDDM FVDLPFPDDM DNDIGILMTG NLHSSPNSSP
1460 1470 1480 1490 1500
VPSPGSPSGI GVGSHFQHSR SQGERLLSRE APEELKQQPL ALGYFVSTAK
1510 1520 1530 1540 1550
AENLPQWFWS SCPQAQNQCP LFLKASLHHH ISVAQTDELL PARNSQRVPH
1560 1570 1580 1590 1600
PLDSKTTSDV LRFVLEQYNA LSWLTCNPAT QDRTSCLPVH FVVLTQLYNA

IMNIL
Length:1,605
Mass (Da):175,708
Last modified:December 5, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6654A66536CE39A2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q71F56MD13L_HUMAN
Mediator of RNA polymerase II trans...
MED13L KIAA1025, PROSIT240, THRAP2, TRAP240L
2,210Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IRX3A0A3B3IRX3_HUMAN
Mediator of RNA polymerase II trans...
MED13L
2,222Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHC1H0YHC1_HUMAN
Mediator of RNA polymerase II trans...
MED13L
1,545Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IRS4A0A3B3IRS4_HUMAN
Mediator of RNA polymerase II trans...
MED13L
495Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VRB8F8VRB8_HUMAN
Mediator of RNA polymerase II trans...
MED13L
1,081Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IS48A0A3B3IS48_HUMAN
Mediator of RNA polymerase II trans...
MED13L
437Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IS36A0A3B3IS36_HUMAN
Mediator of RNA polymerase II trans...
MED13L
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC009321 Genomic DNA No translation available.
AC012157 Genomic DNA No translation available.
AC026334 Genomic DNA No translation available.
AC060226 Genomic DNA No translation available.
AC130895 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000649607; ENSP00000497064; ENSG00000123066

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009321 Genomic DNA No translation available.
AC012157 Genomic DNA No translation available.
AC026334 Genomic DNA No translation available.
AC060226 Genomic DNA No translation available.
AC130895 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Proteomic databases

PeptideAtlasiA0A3B3IS46

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
31301, 89 antibodies

Genome annotation databases

EnsembliENST00000649607; ENSP00000497064; ENSG00000123066

Organism-specific databases

HGNCiHGNC:22962, MED13L
OpenTargetsiENSG00000123066
VEuPathDBiHostDB:ENSG00000123066

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00390000013680

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MED13L, human

Gene expression databases

ExpressionAtlasiA0A3B3IS46, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR009401, Med13_C
IPR041285, MID_MedPIWI
PfamiView protein in Pfam
PF06333, Med13_C, 1 hit
PF18296, MID_MedPIWI, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3B3IS46_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3B3IS46
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 5, 2018
Last sequence update: December 5, 2018
Last modified: September 29, 2021
This is version 16 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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