UniProtKB - A0A3B3IS03 (A0A3B3IS03_HUMAN)
Protein
Submitted name:
Tight junction protein ZO-2
Gene
TJP2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Tight junction protein ZO-2Imported |
Gene namesi | Name:TJP2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11828, TJP2 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 79 – 160 | PDZInterPro annotationAdd BLAST | 82 | |
Domaini | 174 – 239 | SH3InterPro annotationAdd BLAST | 66 | |
Domaini | 260 – 446 | Guanylate kinase-likeInterPro annotationAdd BLAST | 187 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 76 | DisorderedSequence analysisAdd BLAST | 76 | |
Regioni | 479 – 541 | DisorderedSequence analysisAdd BLAST | 63 | |
Regioni | 558 – 652 | DisorderedSequence analysisAdd BLAST | 95 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 15 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 619 – 634 | PolyampholyteSequence analysisAdd BLAST | 16 |
Keywords - Domaini
SH3 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000158634 |
Family and domain databases
CDDi | cd12027, SH3_ZO-2, 1 hit |
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR008145, GK/Ca_channel_bsu IPR008144, Guanylate_kin-like_dom IPR027417, P-loop_NTPase IPR001478, PDZ IPR036034, PDZ_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR005419, ZO-2 IPR035598, ZO-2_SH3 |
Pfami | View protein in Pfam PF00625, Guanylate_kin, 1 hit PF00595, PDZ, 1 hit PF07653, SH3_2, 1 hit |
PRINTSi | PR01599, ZONOCCLUDNS2 |
SMARTi | View protein in SMART SM00072, GuKc, 1 hit SM00228, PDZ, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF50156, SSF50156, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50052, GUANYLATE_KINASE_2, 1 hit PS50106, PDZ, 1 hit PS50002, SH3, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All
A0A3B3IS03-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XSEKLKERPS SREDTPSRLS RMGATPTPFK STGDIAGTVV PETNKEPRYQ
60 70 80 90 100
EDPPAPQPKA APRTFLRPSP EDEAIYGPNT KMVRFKKGDS VGLRLAGGND
110 120 130 140 150
VGIFVAGIQE GTSAEQEGLQ EGDQILKVNT QDFRGLVRED AVLYLLEIPK
160 170 180 190 200
GEMVTILAQS RADVYRDILA CGRGDSFFIR SHFECEKETP QSLAFTRGEV
210 220 230 240 250
FRVVDTLYDG KLGNWLAVRI GNELEKGLIP NKSRAEQMAS VQNAQRDNAG
260 270 280 290 300
DRADFWRMRG QRSGVKKNLR KSREDLTAVV SVSTKFPAYE RVLLREAGFK
310 320 330 340 350
RPVVLFGPIA DIAMEKLANE LPDWFQTAKT EPKDAGSEKS TGVVRLNTVR
360 370 380 390 400
QIIEQDKHAL LDVTPKAVDL LNYTQWFPIV IFFNPDSRQG VKTMRQRLNP
410 420 430 440 450
TSNKSSRKLF DQANKLKKTC AHLFTATINL NSANDSWFGS LKDTIQHQQG
460 470 480 490 500
EAVWVSEGKA KTQNKEESYD FSKSYEYKSN PSAVAGNETP GASTKGYPPP
510 520 530 540 550
VAAKPTFGRS ILKPSTPIPP QEGEEVGESS EEQDNAPKSV LGKVKIFEKM
560 570 580 590 600
DHKARLQRMQ ELQEAQNARI EIAQKHPDIY AVPIKTHKPD PGTPQHTSSR
610 620 630 640 650
PPEPQKAPSR PYQDTRGSYG SDAEEEEYRQ QLSEHSKRGY YGQSARYRDT
EL
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9UDY2 | ZO2_HUMAN | Tight junction protein ZO-2 | TJP2 X104, ZO2 | 1,190 | Annotation score: | ||
A0A1B0GTW1 | A0A1B0GTW1_HUMAN | Tight junction protein ZO-2 | TJP2 | 1,249 | Annotation score: | ||
A0A3B3ITE1 | A0A3B3ITE1_HUMAN | Tight junction protein ZO-2 | TJP2 | 1,191 | Annotation score: | ||
A0A3B3IU51 | A0A3B3IU51_HUMAN | Tight junction protein ZO-2 | TJP2 | 1,047 | Annotation score: | ||
A0A3B3IRI3 | A0A3B3IRI3_HUMAN | Tight junction protein ZO-2 | TJP2 | 1,128 | Annotation score: | ||
A0A3B3IRV6 | A0A3B3IRV6_HUMAN | Tight junction protein ZO-2 | TJP2 | 851 | Annotation score: | ||
A0A3B3ISF1 | A0A3B3ISF1_HUMAN | Tight junction protein ZO-2 | TJP2 | 989 | Annotation score: | ||
A0A3B3ISZ5 | A0A3B3ISZ5_HUMAN | Tight junction protein ZO-2 | TJP2 | 1,099 | Annotation score: | ||
A0A3B3IT83 | A0A3B3IT83_HUMAN | Tight junction protein ZO-2 | TJP2 | 621 | Annotation score: | ||
B1AN86 | B1AN86_HUMAN | Tight junction protein ZO-2 | TJP2 | 161 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL162730 Genomic DNA No translation available. AL358113 Genomic DNA No translation available. AL590238 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000648042; ENSP00000497059; ENSG00000119139 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL162730 Genomic DNA No translation available. AL358113 Genomic DNA No translation available. AL590238 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | A0A3B3IS03 |
Protocols and materials databases
Antibodypediai | 784, 395 antibodies |
Genome annotation databases
Ensembli | ENST00000648042; ENSP00000497059; ENSG00000119139 |
Organism-specific databases
HGNCi | HGNC:11828, TJP2 |
OpenTargetsi | ENSG00000119139 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158634 |
Miscellaneous databases
ChiTaRSi | TJP2, human |
Gene expression databases
ExpressionAtlasi | A0A3B3IS03, baseline and differential |
Family and domain databases
CDDi | cd12027, SH3_ZO-2, 1 hit |
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR008145, GK/Ca_channel_bsu IPR008144, Guanylate_kin-like_dom IPR027417, P-loop_NTPase IPR001478, PDZ IPR036034, PDZ_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR005419, ZO-2 IPR035598, ZO-2_SH3 |
Pfami | View protein in Pfam PF00625, Guanylate_kin, 1 hit PF00595, PDZ, 1 hit PF07653, SH3_2, 1 hit |
PRINTSi | PR01599, ZONOCCLUDNS2 |
SMARTi | View protein in SMART SM00072, GuKc, 1 hit SM00228, PDZ, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF50156, SSF50156, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50052, GUANYLATE_KINASE_2, 1 hit PS50106, PDZ, 1 hit PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A3B3IS03_HUMAN | |
Accessioni | A0A3B3IS03Primary (citable) accession number: A0A3B3IS03 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 5, 2018 |
Last sequence update: | December 5, 2018 | |
Last modified: | April 7, 2021 | |
This is version 12 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |