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Entry version 8 (31 Jul 2019)
Sequence version 1 (05 Dec 2018)
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Protein

HP domain-containing protein

Gene
N/A
Organism
Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HP domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAstyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7994 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCharaciformesCharacoideiCharacidaeAstyanax
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000018467 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2089 – 2152HPInterPro annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni154 – 175DisorderedSequence analysisAdd BLAST22
Regioni203 – 222DisorderedSequence analysisAdd BLAST20
Regioni232 – 340DisorderedSequence analysisAdd BLAST109
Regioni390 – 436DisorderedSequence analysisAdd BLAST47
Regioni478 – 553DisorderedSequence analysisAdd BLAST76
Regioni587 – 620DisorderedSequence analysisAdd BLAST34
Regioni795 – 817DisorderedSequence analysisAdd BLAST23
Regioni838 – 879DisorderedSequence analysisAdd BLAST42
Regioni914 – 1038DisorderedSequence analysisAdd BLAST125
Regioni1165 – 1189DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi243 – 261PolarSequence analysisAdd BLAST19
Compositional biasi262 – 286PolyampholyteSequence analysisAdd BLAST25
Compositional biasi392 – 407PolarSequence analysisAdd BLAST16
Compositional biasi478 – 497PolyampholyteSequence analysisAdd BLAST20
Compositional biasi505 – 531PolyampholyteSequence analysisAdd BLAST27
Compositional biasi538 – 552PolyampholyteSequence analysisAdd BLAST15
Compositional biasi797 – 814PolyampholyteSequence analysisAdd BLAST18
Compositional biasi854 – 879PolarSequence analysisAdd BLAST26
Compositional biasi929 – 957PolyampholyteSequence analysisAdd BLAST29
Compositional biasi958 – 983PolarSequence analysisAdd BLAST26
Compositional biasi990 – 1018PolarSequence analysisAdd BLAST29
Compositional biasi1023 – 1038PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1170 – 1185PolarSequence analysisAdd BLAST16

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154653

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.950.10, 1 hit
3.40.20.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR007123 Gelsolin-like_dom
IPR015628 SV/p205
IPR007122 Villin/Gelsolin
IPR003128 Villin_headpiece
IPR036886 Villin_headpiece_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11977 PTHR11977, 1 hit
PTHR11977:SF86 PTHR11977:SF86, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00626 Gelsolin, 1 hit
PF02209 VHP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00262 GEL, 4 hits
SM00153 VHP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47050 SSF47050, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51089 HP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A3B1KJC7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYQNRWITNY LSHVKFCQGI TSETATKVSK PKLQRRALSF QKQFSFEDKD
60 70 80 90 100
EANQTNKAVD ANPLVTLPKV SELRKRFETI STSQSDCWNM NRKERIARRL
110 120 130 140 150
EGIDSDIQLS LPTTGLVTNR LLEEDTPRYT RAADSCDPCT VPVQHFGKDD
160 170 180 190 200
ATVSRAHADP SYNPVSVDKS EQESKAERIA RYKAERRRQL SERYRILLDE
210 220 230 240 250
ESDPACSSHY SRVRREPEGS DRQHKLLEEG AEEVEHNAHT SRSRAGRTPA
260 270 280 290 300
QTGTDPDYTR ELSGSLSEHE RRMNLENQRR AQDRGAVRGG GEAAPDHSAY
310 320 330 340 350
MDTSGSAKAP AREHGYTGVT VVPSSPKAGQ TPKPASSPGD MFIEQQAHQI
360 370 380 390 400
LHRQGIRVRE RLARDEPPHR SPELSSRSEA LLYHRHTQPL TGYHERSSYQ
410 420 430 440 450
EQPNPRLLYQ PSHPPHSRSD RQPEPHHPGC HAYLSMGSEP VPQVWQEAEV
460 470 480 490 500
GLEEAGSQRQ GRQEVRVEGL LRSRKAVLPS EVHRRERSTE DPTRGRFEGM
510 520 530 540 550
DFPLQHQGHS EDPRGRRGGW SRREEATEHV SRLQATEAIH SRARHAQERT
560 570 580 590 600
DDWYQQRVPS TGYPQAQVPV PVQTHAHAYA PPPALAHAHA PTAGGRWAPD
610 620 630 640 650
PPKQVSHYLP ETGSAQKPSA PIQEPFYSRE LVPQETIANG DHSPPVDALK
660 670 680 690 700
VSVAQLRHSY LENVTSPRKP EQSCPASEPQ IVEADEEKLD DRAKMSVAAK
710 720 730 740 750
RSLFRELEKT VDGAAVKPHS QNAAIARRLR RNQDRYRTQP VTSEEVVIAA
760 770 780 790 800
TVPGAVSQTV SVHSSVARVP SPTVVHSSVT RHSSVVREQA KNARLLQESS
810 820 830 840 850
EAEKSVHTVP ADTHEEPDLS TLSLAEKMAI FNRLTQQSSL SPITRRDSRS
860 870 880 890 900
RRSNARYQTQ PITPGEIGGG SHLSSASSIK SSTVSTAHAG DIHLTTPVST
910 920 930 940 950
VAYDERVLPP WQQPTTVVQN QKGPSELPVG QREEGKRKLP SPDSVKQPAR
960 970 980 990 1000
EWEEHQGYTK TAVTSDFQET DGQQRSNMAV SGLPEQPVSV RAVPQSSSSN
1010 1020 1030 1040 1050
WSAALTPHTH THAHSAQPPE PSRTFPEERE RKRERDRDLY AEEADELADI
1060 1070 1080 1090 1100
MSSRQMSIKE RLALLRKSGE EDWRNRINKK QDVVQVAISE RHAQLWEVEQ
1110 1120 1130 1140 1150
TFKKKRIGNE VVESHHMERM EMSIHERKQL ITAREDAWKS KGYGAANDST
1160 1170 1180 1190 1200
QFTVAGRMVK KGLAAPTALT NPPLTPTSSK NKNTISKPQE EIEVRQDMKV
1210 1220 1230 1240 1250
ESDRKLDKLE SFLGRLNKQV EGFPETTLTV TEKTVKEVMT LDDECFDKFY
1260 1270 1280 1290 1300
RHTEELANVT GKVEISDDFD AIFGTQMPKL TSEMVQHKRA VRPARNVQSS
1310 1320 1330 1340 1350
RNPLKLLASR EDIRHEYTEQ RLNIGMLESK RIKQEKMSKN SGFSAVALAG
1360 1370 1380 1390 1400
LASKENFSSV SLRSVNITEQ SSHSSAMPYK STMLMQVKGR RHVQTRLVEP
1410 1420 1430 1440 1450
RSSSLNSGDC FLLVTPHHCF IWVGEFANVI EKAKAAELAT FIQTKHDLGC
1460 1470 1480 1490 1500
RASYVQTIEE GCNTHSHAAK EFWKILGGQA SYQAAGTPEE DEFYETAIVE
1510 1520 1530 1540 1550
TNCVYRLQED KLVPDDDYWG RVPRCSMLNP TEVLVLDFGS EVYVWHGKEV
1560 1570 1580 1590 1600
TLAQRKVAFQ LAKHLWNGTF DYTTCDINPL DPGECNSLIP RKGQGRPDWA
1610 1620 1630 1640 1650
VFGRLTQHNE TTLFKEKFLD WTDSKKAAKK NGNTQEVEEK DGQSGECRPY
1660 1670 1680 1690 1700
DASLMLPLSQ APVRTILDGV DVGRGYGMVD GEDGRGFEIS TLSVDVWHIL
1710 1720 1730 1740 1750
EFDYSRLPKQ SIGQFHEGDT YVVKWKYMVS TAVGKRFHSE RVVGPGKEKC
1760 1770 1780 1790 1800
SYFFWQGRNS TVSEKGTSAL MTVELDEERG AQVQVLQGKE PPCFLQCFNG
1810 1820 1830 1840 1850
GMIVHAGKRE EEEDNAQNDW RLYCVRGEKP IEGHLLEVLC HCSSLRSRTS
1860 1870 1880 1890 1900
MILLNIPKAS MYLWHGCKAQ MHTRDVGRTA ANKIKEQCPL EAGLHNSSKV
1910 1920 1930 1940 1950
TIQECDEGTE PVGFWEALGK RDRKAYDCMI HDLGKFNFTP RLYQLSSASG
1960 1970 1980 1990 2000
EFTAVEFNCP FREPKLVNSM PFHQEDLYTA AQPALFLVDN HHEVYLWQGW
2010 2020 2030 2040 2050
WPQDSENTGS ARIRWDSDRK CAMETVLHYC REKNEKKPPK AYLIHAGLEP
2060 2070 2080 2090 2100
LTFTNMFPCW EHREDIAEIT EKEAEVCNQI ILVEDVLARL CKATYPLADL
2110 2120 2130 2140 2150
QARPLPEGVD PLRLEIYLSD EDFEKALEMT RSDYEALPGW KQVNVKKAKG

LF
Length:2,152
Mass (Da):242,955
Last modified:December 5, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00A7C0553291C630
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
W5KZR3W5KZR3_ASTMX
HP domain-containing protein
2,145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B1IKJ3A0A3B1IKJ3_ASTMX
HP domain-containing protein
2,120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B1IQS7A0A3B1IQS7_ASTMX
HP domain-containing protein
1,828Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSAMXT00000049110; ENSAMXP00000053941; ENSAMXG00000012684

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSAMXT00000049110; ENSAMXP00000053941; ENSAMXG00000012684

Phylogenomic databases

GeneTreeiENSGT00940000154653

Family and domain databases

Gene3Di1.10.950.10, 1 hit
3.40.20.10, 5 hits
InterProiView protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR007123 Gelsolin-like_dom
IPR015628 SV/p205
IPR007122 Villin/Gelsolin
IPR003128 Villin_headpiece
IPR036886 Villin_headpiece_dom_sf
PANTHERiPTHR11977 PTHR11977, 1 hit
PTHR11977:SF86 PTHR11977:SF86, 1 hit
PfamiView protein in Pfam
PF00626 Gelsolin, 1 hit
PF02209 VHP, 1 hit
SMARTiView protein in SMART
SM00262 GEL, 4 hits
SM00153 VHP, 1 hit
SUPFAMiSSF47050 SSF47050, 1 hit
PROSITEiView protein in PROSITE
PS51089 HP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3B1KJC7_ASTMX
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3B1KJC7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 5, 2018
Last sequence update: December 5, 2018
Last modified: July 31, 2019
This is version 8 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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