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Entry version 6 (31 Jul 2019)
Sequence version 1 (05 Dec 2018)
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Protein
Submitted name:

Blast:Down syndrome cell adhesion molecule-like protein Dscam2

Gene

DGUA_6G000541

Organism
Drosophila guanche (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Blast:Down syndrome cell adhesion molecule-like protein Dscam2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:DGUA_6G000541Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila guanche (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7266 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000268350 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1626 – 1647HelicalSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 32Sequence analysisAdd BLAST32
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501734990933 – 2026Sequence analysisAdd BLAST1994

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 138Ig-likeInterPro annotationAdd BLAST96
Domaini142 – 237Ig-likeInterPro annotationAdd BLAST96
Domaini254 – 346Ig-likeInterPro annotationAdd BLAST93
Domaini350 – 429Ig-likeInterPro annotationAdd BLAST80
Domaini436 – 530Ig-likeInterPro annotationAdd BLAST95
Domaini535 – 621Ig-likeInterPro annotationAdd BLAST87
Domaini626 – 717Ig-likeInterPro annotationAdd BLAST92
Domaini722 – 814Ig-likeInterPro annotationAdd BLAST93
Domaini819 – 911Ig-likeInterPro annotationAdd BLAST93
Domaini920 – 1014Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini1019 – 1123Fibronectin type-IIIInterPro annotationAdd BLAST105
Domaini1124 – 1220Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini1224 – 1317Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini1319 – 1401Ig-likeInterPro annotationAdd BLAST83
Domaini1409 – 1502Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini1506 – 1601Fibronectin type-IIIInterPro annotationAdd BLAST96

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1705 – 1725DisorderedSequence analysisAdd BLAST21
Regioni1795 – 1855DisorderedSequence analysisAdd BLAST61
Regioni1871 – 2026DisorderedSequence analysisAdd BLAST156

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1818 – 1845PolarSequence analysisAdd BLAST28
Compositional biasi1957 – 1974PolyampholyteSequence analysisAdd BLAST18
Compositional biasi1984 – 2001PolyampholyteSequence analysisAdd BLAST18
Compositional biasi2004 – 2018PolarSequence analysisAdd BLAST15

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 6 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 16 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021012 Dscam_C
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12355 Dscam_C, 1 hit
PF00041 fn3, 5 hits
PF07679 I-set, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 6 hits
SM00409 IG, 10 hits
SM00408 IGc2, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 9 hits
SSF49265 SSF49265, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 6 hits
PS50835 IG_LIKE, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A3B0JKG9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYTMDMANE RHKWLMLYAA VALLAFASQT LAANPPDADQ KGPVFLKEPT
60 70 80 90 100
NRIDFSNSTG AEIECKASGN PMPEIIWIRS DGTAVGDVPG LRQISSDGKL
110 120 130 140 150
VFPPFRAEDY RQEVHAQVYA CLARNQFGSI ISRDVHVRAV VPQSYTVNVM
160 170 180 190 200
DESILRGNSA IMKCHIPSFV ADFIVVDSWV EDEQRDIYAQ EDITASDGKY
210 220 230 240 250
LVLPSGELHI REVGPEDGYK SYQCRTKHRL TGETRLSATK GRLVITEPVG
260 270 280 290 300
AKAPTFSGES KSFTFVKEIA TSFALLCQAQ AYPVPIIRWY KFIEGTTRKQ
310 320 330 340 350
AVVLNDRVKQ VSGTLIIKDA VVEDSGKYLC VVNNSVGGES VETVLTVTAP
360 370 380 390 400
LSAKIDPPTQ TVDFGRPAVF TCQYTGNPIK TVSWMKDGKA MGHSEPVLRI
410 420 430 440 450
ESVKKEDKGM YQCFVRNDQE SAEASAELKL GGRFDPPVIR QAFQEETMEP
460 470 480 490 500
GPSVFLKCVA GGNPTPEISW ELDGKKIANN DRYQVGQYVT VNGDVVSYLN
510 520 530 540 550
ITSVHANDGG LYKCIAKSKV GEAEHSAKLN VYGLPYIRQM EKKAIVAGET
560 570 580 590 600
LIVTCPVAGY PIDSIVWERD NRALPINRKQ KVFPNGTLII ENVERNSDQA
610 620 630 640 650
TYTCVAKNQE GYSARGSLEV QVMVLPRIIP FAFEEGPAQV GQYLTLHCSV
660 670 680 690 700
PGGDLPLQID WTLDGQAMPE DLGISTARVG RRGSVLTIEA VEASHAGNFT
710 720 730 740 750
CHARNSAGHQ QYTAPLNVYV PPRWILEPTD KAFAQGSDAK VECKADGFPK
760 770 780 790 800
PQVTWKKAVG DTPGEYKDLK KSDNIRVEEG TLHVDNIQKT NEGYYLCEAI
810 820 830 840 850
NGIGSGLSAV IMISVQAPPE FTEKLRNQTA RRGEPAVLQC EAKGEKPIGI
860 870 880 890 900
LWNMNNMRLD PKNDNRYTIR EEILSTGVMS SLSIKRTERS DSALFTCVAT
910 920 930 940 950
NAFGSDDASI NMIVQEVPEM PYALKVLDKS GRSVQLSWAQ PYDGNSPLNR
960 970 980 990 1000
YIIEFKRSRA SWSEIDRVMV PGHTTEAQVQ KLSPATTYNI RIVAENVIGT
1010 1020 1030 1040 1050
SQSSEAVTII TAEEAPSGKP QNIKVEPVNQ TTMRVTWKPP PRTEWNGEIL
1060 1070 1080 1090 1100
GYYVGYKLSN TNSSYVFETI NFITEEGKEH NLELQNLRVY TQYSVVIQAF
1110 1120 1130 1140 1150
NKIGAGPLSE EEKQFTAEGT PSQPPSDTSC TTLTSQTIRV SWVSPPLESA
1160 1170 1180 1190 1200
NGVIKTYKVV YAPSDEWYDE TKRHYKKTAS SDTVLHGLKK YTNYTMQVLA
1210 1220 1230 1240 1250
TTAGGDGVRS APIHCQTEPD VPEAPTDVKA LVMGNAAILV SWRQPAQPNG
1260 1270 1280 1290 1300
IITQYTVYSK AEGAETETKT QKVPHYQMSF EASELEKNKP YEFWVTASTT
1310 1320 1330 1340 1350
IGEGQQSKSI VAMPSDQVPA KIASFDDTFT ATFKEDAKMP CLAVGAPQPE
1360 1370 1380 1390 1400
ITWKIKGVDF SANDRMRLLP DGSLLIKSVN RQDAGDYSCH AENSIAKDSI
1410 1420 1430 1440 1450
THKLIVLAPP QSPHVTLSAT TTDALTVKLK PHEGDTAPLH GYTLHYKPEF
1460 1470 1480 1490 1500
GEWETAEVSV DSQKQNIENL LCGSRYQVYA TGFNNIGAGE ASDILNTRTK
1510 1520 1530 1540 1550
GQKPKLPEKP RFIEVSSNSV SLHFKAWKDG GCPMSHFVVE SKKRDQIEWN
1560 1570 1580 1590 1600
QISNNVKPDN NYVVLDLEPA TWYNLRITAH NSAGFTVAEY DFATLTVTGG
1610 1620 1630 1640 1650
TIAPSRDLPE LSAEDTIRII LSNLNLVVPV VAALLVIIIA IIVICILRSK
1660 1670 1680 1690 1700
GNHHKDDVVY NQTMGPGATL DKRRPDLRDE LGYIAPPNRK LPPVPGSNYN
1710 1720 1730 1740 1750
TCDRIKRGRG GGLRSNHSTW DPRRPNLYEE LKAPPVPLHG NQYGHAHGNG
1760 1770 1780 1790 1800
PAECHYRHPG MEDEICPYAT FHLLGFREEM DPTKAMNFQT FPHQNGHTGP
1810 1820 1830 1840 1850
VPGHAGTMLP PGHPGHVHSR SGSQSMPRAN RYQRKNSQGG QSSIYTPAPE
1860 1870 1880 1890 1900
YDDPANCAEE DQYRRYTRVN SQGGSLYSGP GPEYDDPANC APEEDQYGSQ
1910 1920 1930 1940 1950
YGGPYGQPYD HYGSRGSMGR RSVGSARNPG NGSPEPPPPP PRNHDMSNSS
1960 1970 1980 1990 2000
FNDSKESNEI SEAECDRDHG PRGNYGAVKR SPQPKDQRTT EEMRKLIERN
2010 2020
EAGPKQLQLQ QQANGAGFTA YDTMAV
Length:2,026
Mass (Da):223,338
Last modified:December 5, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA380D7DFD59C2BC9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
OUUW01000001 Genomic DNA Translation: SPP73121.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
OUUW01000001 Genomic DNA Translation: SPP73121.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd00063 FN3, 6 hits
Gene3Di2.60.40.10, 16 hits
InterProiView protein in InterPro
IPR021012 Dscam_C
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF12355 Dscam_C, 1 hit
PF00041 fn3, 5 hits
PF07679 I-set, 5 hits
SMARTiView protein in SMART
SM00060 FN3, 6 hits
SM00409 IG, 10 hits
SM00408 IGc2, 9 hits
SUPFAMiSSF48726 SSF48726, 9 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 6 hits
PS50835 IG_LIKE, 10 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3B0JKG9_DROGU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3B0JKG9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 5, 2018
Last sequence update: December 5, 2018
Last modified: July 31, 2019
This is version 6 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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