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Entry version 6 (03 Jul 2019)
Sequence version 1 (05 Dec 2018)
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Protein

Malformin synthetase mlfA

Gene

BO97DRAFT_465346

Organism
Aspergillus homomorphus (strain CBS 101889)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of malformins, cyclic pentapeptides with a disulfide bond between 2 consecutive cysteins, that show potential anti-tumor as well as antimalarial and antitrypanosomal properties (PubMed:30560908). The nonribosomal peptide synthetase mlfA is responsible of the formation of the cyclic pentapeptide (Probable). The malformin biosynthesis clusters in malformin-producing fungi also contain enzymes involved in the formation of the disulfide bond between the two consecutive cysteins within malformins, in addition to additionnal tailoring enzymes such as methyltransferases or oxidoreductases. They are also composed of up to 4 major facilitator superfamily transporters, and transcription factors probably involved in the regulation of the expression of those clusters (Probable).1 Publication1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Secondary metabolite biosynthesis

This protein is involved in Secondary metabolite biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in Secondary metabolite biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Malformin synthetase mlfA1 Publication (EC:6.3.2.-1 Publication)
Alternative name(s):
Malformin biosynthesis cluster protein A1 Publication
Nonribosomal peptide synthetase mlfA1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:BO97DRAFT_465346
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAspergillus homomorphus (strain CBS 101889)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1450537 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000248961 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

Malformins show anti-tumor properties against human colorectal and prostate cancer cells by the inhibition of proliferation and induction of apoptosis through the activation of the p38 signaling pathway (PubMed:26540166, PubMed:26645406, PubMed:28713983). Malformin C has also been shown to exhibit potent antimalarial and antitrypanosomal properties (PubMed:19876076).4 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004464311 – 5098Malformin synthetase mlfAAdd BLAST5098

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei790O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei1890O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3066O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei4613O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini756 – 829Carrier 1PROSITE-ProRule annotationAdd BLAST74
Domaini1853 – 1930Carrier 2PROSITE-ProRule annotationAdd BLAST78
Domaini3029 – 3105Carrier 3PROSITE-ProRule annotationAdd BLAST77
Domaini4576 – 4652Carrier 4PROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni225 – 616Adenylation 1Sequence analysisAdd BLAST392
Regioni867 – 1298Condensation 1Sequence analysisAdd BLAST432
Regioni1326 – 1715Adenylation 2Sequence analysisAdd BLAST390
Regioni2063 – 2478Condensation 2Sequence analysisAdd BLAST416
Regioni2501 – 2893Adenylation 3Sequence analysisAdd BLAST393
Regioni3122 – 3587Condensation 3Sequence analysisAdd BLAST466
Regioni3608 – 4027Condensation 4Sequence analysisAdd BLAST420
Regioni4052 – 4442Adenylation 4Sequence analysisAdd BLAST391
Regioni4689 – 5016Condensation 5Sequence analysisAdd BLAST328

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module. Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product. Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, epimerase (E) domains (responsible for L- to D- amino acid conversion) are present within the NRP synthetase. MlfA has the following architecture: A-T-C-A-T-C-A-T-C-C-A-T-C, with the functions of the five condensation domains during malformin biosynthesis being DL-joining (epimerizing subtype), LL-joining, epimerization, DL-joining and cyclizing domain, respectively.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRP synthase family.Curated

Keywords - Domaini

Repeat

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 4 hits
3.30.559.10, 5 hits
3.40.50.12780, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071 AA_adenyl_domain
IPR036736 ACP-like_sf
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501 AMP-binding, 4 hits
PF00668 Condensation, 5 hits
PF00550 PP-binding, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823 PKS_PP, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336 SSF47336, 4 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733 AA-adenyl-dom, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455 AMP_BINDING, 3 hits
PS50075 CARRIER, 4 hits
PS00012 PHOSPHOPANTETHEINE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A395I3F8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRFSCIFPT LTDGYVPNPD NTRAAGQRTY AIDLSRRNAP SSETESHILA
60 70 80 90 100
AWGLVLYSYV GTDEVAFYVV PKSGPDTTAL AELKVEGDMS RQALTHAAEQ
110 120 130 140 150
LFPTGSVGAG QVSGDTANTI IDFANDIESL FVTQTEESFL SLHVHGDEQG
160 170 180 190 200
HVSLSLTYHL SLLTDLQAAN VGTAMAQALA EVGKDDCDRL IKDLNLMSPT
210 220 230 240 250
HLEHIWKFNA NVPGTWEECF HDVIERHAAN RPHSLAVDAW DTKLTYADLV
260 270 280 290 300
REASLLAAYL QQRGVRPGSV VPISFERSGA ALVAMLAVSK AGGAFVSVPP
310 320 330 340 350
NLPAGRLDAI LEVIEAPFVV TWSKYESFWA ERLPTLPIDN YPKPSADAAV
360 370 380 390 400
EALGKPEDLF YVIFTSGSTG RPKGCMLSHS NWLNGALRNA PSWKYGPESR
410 420 430 440 450
VLQMLSHTFD MSLLEICTSL GSGACVCVPR TEEIETSVSD AINRWQVNHV
460 470 480 490 500
IMTPSLARAL RPDDVPGLKT MCLGGEAFPK EIVTMWSERI NLWQFYGPSE
510 520 530 540 550
CSINSSSRAI TRPDADPLNI GPPNSAACWV VDTQDYNKLV PVGAIGELLV
560 570 580 590 600
SGPIVGMGYL KNPVKTAEAF LDQVGFVAKD DPQFGGFRFY RTGDLVRWNS
610 620 630 640 650
DGTITFCGRA DTQVKLNGQR LELAEVEYQL GLEAGVQYAI AMAPQTGRCK
660 670 680 690 700
NNLIAILTVK GTSTSNQGNA AEISLLDRRD PIVQQTVKKL RSQLQHALPR
710 720 730 740 750
YMVPTIWAFV GRMPMSPSGK IDRVQLRNWV QDMSQEAFDA ITGRSFEAED
760 770 780 790 800
HVLGLSRLEQ EIQLAWAEAL GLSAAEVGVQ QPFVALGGDS IKALDAVARC
810 820 830 840 850
RARQIKISMV HILSCEGVRE AASLAKVQET PAQQVAEMAV DYSDLWTRLS
860 870 880 890 900
TDYELGKLGI SQLEEVEDVF PCTTMQEGMF LGQIRRPGAY HMRFFHRVQL
910 920 930 940 950
KGGCLPPVER IQQAWAALVE RHPSLRTVFV DDLSPEAIYH SVVLRSVPME
960 970 980 990 1000
LTMREVPRDL NPEAALAMFT EELVPFRPNA PLHRMLLLTC RGRVPYFMLE
1010 1020 1030 1040 1050
ISHVIMDGYA LSVFRREFIQ ACSSTAPLPR GPDYRMFANY HRTRQTDESA
1060 1070 1080 1090 1100
KYWTDYLADC TGCHIPTHAE AAPTDVPPKW PRTLQRRDFG FDNSAAFLQR
1110 1120 1130 1140 1150
CKERQVTLAC AIRAAWALVL RAYTQSQDVC FGYVSSGRNV PVPEVETIFG
1160 1170 1180 1190 1200
LCLSMQVCRA KLSEASTMAR LARKIQEDYV ASLPFQHYPL AEAQRGLKQT
1210 1220 1230 1240 1250
RGQGLFNTAI SMEWVPPTAE DENALLDLEE IREQDDPTEY DIAISVDVHE
1260 1270 1280 1290 1300
GHIKLGFLYW PNLTDFEIAH LAEALQGALN CFAFQPDEAL DSLTLLQASD
1310 1320 1330 1340 1350
FCSTLGDRST MLPLEAVRGN VMSMIDGWVT RQPESAAIDG WDGSLSYKKL
1360 1370 1380 1390 1400
HEQSSWVAHN LLHQGVQPGD RVLVCADRSS RTVATILGLV RAGCVLVLST
1410 1420 1430 1440 1450
PTDPEKRLQW LAQKCNAALV VADPAYEKRF ATAGPRVLST TSVCVPAAWD
1460 1470 1480 1490 1500
YEFPALDEQD LVSILFTSGS TGTPKGTLMD HGALATSVLL GHGRTLRFSR
1510 1520 1530 1540 1550
HTRMLHFASL TFDAALAEIF TTLAHGGCIC VPCEEDRLSD VPGCISRFAV
1560 1570 1580 1590 1600
NTAMLTPSVG RLLDPGALPT LKALVMIGEP MSRLDVERFA PVLDLYNGAG
1610 1620 1630 1640 1650
PTETSIMVTI AGPMKPTDDP VNLGYPVTGV RLWVTEAENP NRLAPLGAVG
1660 1670 1680 1690 1700
ELIVEGRLVT RGYLDDPSRT QEAFLTSLPW LPSQHALYRT GDLVRYADDG
1710 1720 1730 1740 1750
SLRYMGRKDT QVKLRGQRIE LQEVEYHLRK ILPQAQVVVE MVVPEGKMRA
1760 1770 1780 1790 1800
QASLVAFVSG LTAADVESSS ACNFEESMPM SQIVFPRSAL QTLEEALPRH
1810 1820 1830 1840 1850
MIPSVYYALD TIPLSINGKV DRRRLREMGA ALLASSAAHK GAVDEMSEPV
1860 1870 1880 1890 1900
KWTAASELER TLSELWAATL ELEAEAIHCD DSFFELGGDS VSAMKLVAMA
1910 1920 1930 1940 1950
RDQFKLSLSV PQMFRYPTIR QLAAEFGEPA GQSASSASST TEEGFTFSTP
1960 1970 1980 1990 2000
DDSSTNDGVD DDFLQLATAQ LAQLAREKGK KVDIASLLKQ LQGSSSSSKT
2010 2020 2030 2040 2050
PSGSSSSSSS SSRKKKSARV VSPVKVPAPV PVPFSLLDGG ADVVEKVCVY
2060 2070 2080 2090 2100
AVDQCKIPHE DIEDIYPATA LQEGMMALMA RTPGVYTTTL TCELPEQVDF
2110 2120 2130 2140 2150
ARLHAAWDKT AEAHPILRTR IILTDNNTAM QVVQRAKELP WDTYYLQDGD
2160 2170 2180 2190 2200
ILPDLTSNMT LGSPLLRLAE IHRQDQPRML MVAIHHALYD GWSMPLLKQA
2210 2220 2230 2240 2250
VEDVYHGRPL QSQPFTPFIN YLNAGKPAAQ AFWTAHLDSF AGGVFPTLPS
2260 2270 2280 2290 2300
IDHHVQLTER RTRSLTVPAA LPGSQYTLAT KIQTAWAVTV SRYAEAEDIV
2310 2320 2330 2340 2350
FGTVSTGRSA PVPAIDRMVG PTITTVPVRI SLSDQAERVI SLLQRVQEDG
2360 2370 2380 2390 2400
WNRMDHEHLG LQHIRRLGES CAATCSLQTL LVIQPREQPR AKSGSTLLAG
2410 2420 2430 2440 2450
LQDVAELEGV DTYPLMLVCE PDGASLHLTA MFDPAVLDEV MLGRMLAHWE
2460 2470 2480 2490 2500
LILTQLWSEP DMAVMELDAL SHSDRQTLVR WNAGERVADG CAHDAVHEWS
2510 2520 2530 2540 2550
VRTPHAPAVC AWDGEWTYEE LEKCSSLIVR QILAHGVSSG DFVALYHEKS
2560 2570 2580 2590 2600
RWAAAGILAV FKAGGILVTL DPAHPKDRIK DIVYQARPRL ILTSQSLLGE
2610 2620 2630 2640 2650
ARELEVPVLS VSFAASQQTP EECSPLPIVS STQAAYAPFT SGSTGRPKGI
2660 2670 2680 2690 2700
VLDHRGLAAS TASVAHACLL RPASRVLHFA SFAFDASMME HLIAWHAGGC
2710 2720 2730 2740 2750
LCIPDETARQ TDLASCIRDF EITWAFLTPS CLRLITPDDV QSLEALGLGG
2760 2770 2780 2790 2800
ESMTSEDISI WGPRLRQIVQ LYGPAECCIV AALTEVTKPS ENRLIGRPNA
2810 2820 2830 2840 2850
CRCWVVDPQN PDRLAPLGAV GELVIEGITV GWGYIDDPER TTQAFIRPPT
2860 2870 2880 2890 2900
WLQTLYPNSQ QPGRLYRTGD LVRYAGADGK LTFIGRRDGQ LKLHGQRIEL
2910 2920 2930 2940 2950
ADVEAHLRPL MPGTQKIVVE MVHSADNQHP LLAAFVEEPL ASQNPSEQEV
2960 2970 2980 2990 3000
GLLHPSQTQC ALDVKAIDSV LSRMVPQYMI PSMYLHISRL PLSASGKLNR
3010 3020 3030 3040 3050
RHLREIVAEF PRQRLNEYAA GSGLTVPDRP VTAQEREMQA IWARVLSLDP
3060 3070 3080 3090 3100
DTIGINEDFF RIGGDSISGM QVATKCNAAG MHITGADLFR HRTIEQLMRH
3110 3120 3130 3140 3150
LSATRKSGCA SISLPAEPVG EWVALAPIQQ LFFEIAPQGP NHFNQSLLLR
3160 3170 3180 3190 3200
TGRRVSVEEL AGGLDILVER HSMLRARFCR DDSGQWSQQV RSLGSYPASA
3210 3220 3230 3240 3250
FYRLATHNQV APQSLPTLLT ASQLALSIQE GPLLAVDLVD LADGAQLVYL
3260 3270 3280 3290 3300
VAHHLIIDLV SWRILHGELE EYLQTGSLAS ATGSVSFLTW SRAQAEYSAN
3310 3320 3330 3340 3350
HLTPTRALPD FQEANDGFDA PKYWGISSES NTFGQTSSSR FTLDRTVTDQ
3360 3370 3380 3390 3400
LFGSANNVLD TRPVEILQAA LWYSFTRSLT DRPGPSIYVE GHGREPWTES
3410 3420 3430 3440 3450
IDLSRTVGWF TTMSPLVSAP WDSLSRTRMR DFLDALSYIK DQRRRIPANG
3460 3470 3480 3490 3500
WAYFTSRYLN DEGKVAYGRM KSVVEIMFNY MGQYQEMNRE DAILQLAGDD
3510 3520 3530 3540 3550
IQSGTGAADI AGNVPRFSLI DVSAFTANGC LTFEFIFPES MQQDARLKQW
3560 3570 3580 3590 3600
FKECERTLIV AASTLSTESP RKTLTDFPLM PALTYDQLNQ CLDQTLPSMG
3610 3620 3630 3640 3650
LCARDVVNIY PCSSVQQGML LAQLRDQQAY QQRLRFQVNS RGPTDRLTLE
3660 3670 3680 3690 3700
RVKDAWTEVI NRHDILRTLL LPVSDYNHLD QVVMAPGSLQ HLVRMNAMDA
3710 3720 3730 3740 3750
NPTQGLPHSI NITSDSTGTV ICEWNVSHAL VDAMSIAVIQ REVNQALQGS
3760 3770 3780 3790 3800
LGQHQNLPRY ADYVQWLSLQ DNTETQAYWQ NYLEGVEPCL FPKLTSLPDK
3810 3820 3830 3840 3850
VNPEGTISAI RATWTRDARM HDLCQKHGIT LTNLFHMIWA LVLGAYVGTD
3860 3870 3880 3890 3900
EVCFGYTTLG RDVPVDGVEK MVGPLVNVVA TIVQLQEDDS ILNALLTHQT
3910 3920 3930 3940 3950
HLTNSLQHQH YALADLYASS GLVGSRLFNT IVSLQDMSHF DAPDEQPTWL
3960 3970 3980 3990 4000
EMLPANDVSE YDVALNIGVD QSSIQLVCSY RTLSLSAVQA DALLRTASHV
4010 4020 4030 4040 4050
LSEMLRDPTQ RFSELEVISP ECKEQLMKWN AAMPAPTEEY IHEKIQGQCR
4060 4070 4080 4090 4100
LHASREAVCA WDGIFTYAEV DDLSSRLAAR LIRMGVTSEH IIPIYAPKSR
4110 4120 4130 4140 4150
WTVIAILGVL KSGAAFTLLE TSHPMARLQV ICHEIKADMI IAPASHAGPA
4160 4170 4180 4190 4200
ANLAPIIVGL DRITSMSPQT SDLLPTVGMP PAAEALAYLI FTSGSTGNPK
4210 4220 4230 4240 4250
GVMVTHQNLC SNASIMTTSV NMMSDSRVLQ FASHAFDGCL WEILGPLFAG
4260 4270 4280 4290 4300
ACLIIPSESE SQEDLAGCIE RMVVTWAFLT PSVARILKPE TLPSLRVLTL
4310 4320 4330 4340 4350
GGEPIAASDL DMWRGHVQVV CAYGPTETTI LASTTSPSTF PTDGRDIGVP
4360 4370 4380 4390 4400
TGSSLWIVDK RNYLKLAPLG ATGELLIEGP NVSQGYLGDP EKTNEAFPVA
4410 4420 4430 4440 4450
PRWLSQLRQS PTRIYRTGDL VRFDTSTGTI RFVGRKDNQI KFHGQRIELG
4460 4470 4480 4490 4500
EIEHHAQQAF SNSSTVIVDL ITPAQPQRPY IVAFVHQPDT KTATADPIDA
4510 4520 4530 4540 4550
ILLPPSESFR AEALGAQNHM HKRLPHYMVP TVFLPLQWLP LSGTGKADRK
4560 4570 4580 4590 4600
RLRQCALALP SPDLDAYRAT ALMKRMPSTA AERKMQELVA TVLGRGVSEI
4610 4620 4630 4640 4650
GMDDSFFYLG GDSVQAMRLV AEGRHQGLAL SLRAIFDAPR LGDLAYRTTN
4660 4670 4680 4690 4700
LVKVNQPIQA TSPVTLRDEC NHIETIVATH PIKKTDVVDV LPTTSFQRHW
4710 4720 4730 4740 4750
LDIQLMSYIV VDIPGPIDPE RLLTAMQRVV EAHPILRASF VPYEDTTMQV
4760 4770 4780 4790 4800
ILRTRVAMTA ADLSTTTVED ICRQDEDAPM ILGTPYMRVI LASQGDVGHK
4810 4820 4830 4840 4850
LIMRLSHAQY DAVSLSLLMN DLRHAYANET RPFPSSHSPP FTDYITYQQT
4860 4870 4880 4890 4900
LRADPTATTF WHSLLQDVPI TCLNLQPAET STSNGTPITR TRDINISPFP
4910 4920 4930 4940 4950
SLPNGITIAT AVKAAWSLVL AQKTDSLAVI FGQVVHGRGI ALPGVEGIVG
4960 4970 4980 4990 5000
PCANITPVVA RLGRQTAGLE LMQTLQDQHR SAMPYETVDL DDALAYSKDS
5010 5020 5030 5040 5050
QARRKGLQTI VQHQNNVVVD DMELSLGEVK CGVDVRAVDH VPREVWIYSS
5060 5070 5080 5090
VDEKRPRILE VKIMSSTLVL NEEVAEELMD LLIEKIVGLF RDPEGVCV
Length:5,098
Mass (Da):561,352
Last modified:December 5, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i34A126C8E29C047F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
KZ824274 Genomic DNA Translation: RAL14731.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KZ824274 Genomic DNA Translation: RAL14731.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di1.10.1200.10, 4 hits
3.30.559.10, 5 hits
3.40.50.12780, 4 hits
InterProiView protein in InterPro
IPR010071 AA_adenyl_domain
IPR036736 ACP-like_sf
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501 AMP-binding, 4 hits
PF00668 Condensation, 5 hits
PF00550 PP-binding, 4 hits
SMARTiView protein in SMART
SM00823 PKS_PP, 3 hits
SUPFAMiSSF47336 SSF47336, 4 hits
TIGRFAMsiTIGR01733 AA-adenyl-dom, 4 hits
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 3 hits
PS50075 CARRIER, 4 hits
PS00012 PHOSPHOPANTETHEINE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMLFA_ASPHC
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A395I3F8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 10, 2019
Last sequence update: December 5, 2018
Last modified: July 3, 2019
This is version 6 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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