UniProtKB - A0A384N6C2 (A0A384N6C2_HUMAN)
Protein
Inosine-5'-monophosphate dehydrogenase
Gene
IMPDH
Organism
Homo sapiens (Human)
Status
Functioni
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.UniRule annotation
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
Catalytic activityi
- EC:1.1.1.205UniRule annotation
Cofactori
K+UniRule annotation
Activity regulationi
Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.UniRule annotation
: XMP biosynthesis via de novo pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes XMP from IMP.UniRule annotationProteins known to be involved in this subpathway in this organism are:
- Inosine-5'-monophosphate dehydrogenase (IMPDH), Inosine-5'-monophosphate dehydrogenase (IMPDH1), Inosine-5'-monophosphate dehydrogenase (IMPDH), Inosine-5'-monophosphate dehydrogenase (IMPDH1), Inosine-5'-monophosphate dehydrogenase (IMPDH), Inosine-5'-monophosphate dehydrogenase (IMPDH), Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1), Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2), Inosine-5'-monophosphate dehydrogenase (DKFZp781N0678), Inosine-5'-monophosphate dehydrogenase (IMPDH1)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes XMP from IMP, the pathway XMP biosynthesis via de novo pathway and in Purine metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 326 | Potassium; via carbonyl oxygenUniRule annotation | 1 | |
Metal bindingi | 328 | Potassium; via carbonyl oxygenUniRule annotation | 1 | |
Binding sitei | 329 | IMPUniRule annotation | 1 | |
Active sitei | 331 | Thioimidate intermediateUniRule annotation | 1 | |
Metal bindingi | 331 | Potassium; via carbonyl oxygenUniRule annotation | 1 | |
Active sitei | 429 | Proton acceptorUniRule annotation | 1 | |
Binding sitei | 441 | IMPUniRule annotation | 1 | |
Metal bindingi | 496 | Potassium; via carbonyl oxygen; shared with tetrameric partnerUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 274 – 276 | NADUniRule annotation | 3 | |
Nucleotide bindingi | 324 – 326 | NADUniRule annotation | 3 |
GO - Molecular functioni
- identical protein binding Source: Ensembl
- IMP dehydrogenase activity Source: UniProtKB-UniRule
- metal ion binding Source: UniProtKB-UniRule
- nucleotide binding Source: UniProtKB-UniRule
GO - Biological processi
- cellular response to interleukin-4 Source: Ensembl
- GMP biosynthetic process Source: UniProtKB-UniRule
- lymphocyte proliferation Source: Ensembl
- retina development in camera-type eye Source: Ensembl
Keywordsi
Molecular function | OxidoreductaseUniRule annotationARBA annotation |
Biological process | GMP biosynthesisUniRule annotation, Purine biosynthesis |
Ligand | Metal-bindingUniRule annotationARBA annotation, NADUniRule annotation, PotassiumUniRule annotationARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00601;UER00295 |
Names & Taxonomyi
Protein namesi | Recommended name: Inosine-5'-monophosphate dehydrogenaseUniRule annotation (EC:1.1.1.205UniRule annotation)Short name: IMP dehydrogenaseUniRule annotation Short name: IMPDUniRule annotation Short name: IMPDHUniRule annotation |
Gene namesi | Name:IMPDHUniRule annotation |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmUniRule annotation, NucleusUniRule annotationInteractioni
Subunit structurei
Homotetramer.
UniRule annotationGO - Molecular functioni
- identical protein binding Source: Ensembl
Chemistry databases
BindingDBi | A0A384N6C2 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 114 – 173 | CBSInterPro annotationAdd BLAST | 60 | |
Domaini | 179 – 237 | CBSInterPro annotationAdd BLAST | 59 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 364 – 366 | IMP bindingUniRule annotation | 3 | |
Regioni | 387 – 388 | IMP bindingUniRule annotation | 2 | |
Regioni | 411 – 415 | IMP bindingUniRule annotation | 5 |
Sequence similaritiesi
Keywords - Domaini
CBS domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
OMAi | HDYHMTL |
Family and domain databases
CDDi | cd00381, IMPDH, 1 hit |
Gene3Di | 3.20.20.70, 2 hits |
HAMAPi | MF_01964, IMPDH, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR000644, CBS_dom IPR005990, IMP_DH IPR015875, IMP_DH/GMP_Rdtase_CS IPR001093, IMP_DH_GMPRt |
Pfami | View protein in Pfam PF00571, CBS, 2 hits PF00478, IMPDH, 1 hit |
PIRSFi | PIRSF000130, IMPDH, 1 hit |
SMARTi | View protein in SMART SM00116, CBS, 2 hits |
TIGRFAMsi | TIGR01302, IMP_dehydrog, 1 hit |
PROSITEi | View protein in PROSITE PS51371, CBS, 2 hits PS00487, IMP_DH_GMP_RED, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A384N6C2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADYLISGGT SYVPDDGLTA QQLFNCGDGL TYNDFLILPG YIDFTADQVD
60 70 80 90 100
LTSALTKKIT LKTPLVSSPM DTVTEAGMAI AMALTGGIGF IHHNCTPEFQ
110 120 130 140 150
ANEVRKVKKY EQGFITDPVV LSPKDRVRDV FEAKARHGFC GIPITDTGRM
160 170 180 190 200
GSRLVGIISS RDIDFLKEEE HDCFLEEIMT KREDLVVAPA GITLKEANEI
210 220 230 240 250
LQRSKKGKLP IVNEDDELVA IIARTDLKKN RDYPLASKDA KKQLLCGAAI
260 270 280 290 300
GTHEDDKYRL DLLAQAGVDV VVLDSSQGNS IFQINMIKYI KDKYPNLQVI
310 320 330 340 350
GGNVVTAAQA KNLIDAGVDA LRVGMGSGSI CITQEVLACG RPQATAVYKV
360 370 380 390 400
SEYARRFGVP VIADGGIQNV GHIAKALALG ASTVMMGSLL AATTEAPGEY
410 420 430 440 450
FFSDGIRLKK YRGMGSLDAM DKHLSSQNRY FSEADKIKVA QGVSGAVQDK
460 470 480 490 500
GSIHKFVPYL IAGIQHSCQD IGAKSLTQVR AMMYSGELKF EKRTSSAQVE
510
GGVHSLHSYE KRLF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GQ900937 mRNA Translation: ADO22454.1 |
RefSeqi | NP_000875.2, NM_000884.2 |
Genome annotation databases
GeneIDi | 3615 |
KEGGi | hsa:3615 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GQ900937 mRNA Translation: ADO22454.1 |
RefSeqi | NP_000875.2, NM_000884.2 |
3D structure databases
SMRi | A0A384N6C2 |
ModBasei | Search... |
Chemistry databases
BindingDBi | A0A384N6C2 |
Protocols and materials databases
Antibodypediai | 30367, 361 antibodies |
Genome annotation databases
GeneIDi | 3615 |
KEGGi | hsa:3615 |
Organism-specific databases
CTDi | 3615 |
Phylogenomic databases
OMAi | HDYHMTL |
Enzyme and pathway databases
UniPathwayi | UPA00601;UER00295 |
Gene expression databases
ExpressionAtlasi | A0A384N6C2, baseline and differential |
Family and domain databases
CDDi | cd00381, IMPDH, 1 hit |
Gene3Di | 3.20.20.70, 2 hits |
HAMAPi | MF_01964, IMPDH, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR000644, CBS_dom IPR005990, IMP_DH IPR015875, IMP_DH/GMP_Rdtase_CS IPR001093, IMP_DH_GMPRt |
Pfami | View protein in Pfam PF00571, CBS, 2 hits PF00478, IMPDH, 1 hit |
PIRSFi | PIRSF000130, IMPDH, 1 hit |
SMARTi | View protein in SMART SM00116, CBS, 2 hits |
TIGRFAMsi | TIGR01302, IMP_dehydrog, 1 hit |
PROSITEi | View protein in PROSITE PS51371, CBS, 2 hits PS00487, IMP_DH_GMP_RED, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A384N6C2_HUMAN | |
Accessioni | A0A384N6C2Primary (citable) accession number: A0A384N6C2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 5, 2018 |
Last sequence update: | December 5, 2018 | |
Last modified: | December 2, 2020 | |
This is version 12 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |