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Entry version 7 (16 Oct 2019)
Sequence version 1 (07 Nov 2018)
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Protein
Submitted name:

Coatomer alpha subunit, putative

Gene

PKH_114250

Organism
Plasmodium knowlesi (strain H)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Coatomer alpha subunit, putativeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PKH_114250Imported, PKNA1_C2_1143500Imported, PKNA1_H1_1143500Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium knowlesi (strain H)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5851 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Plasmodium)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000031513 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 368WD_REPEATS_REGIONInterPro annotationAdd BLAST364
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati5 – 39WDPROSITE-ProRule annotationAdd BLAST35
Repeati47 – 80WDPROSITE-ProRule annotationAdd BLAST34
Repeati89 – 121WDPROSITE-ProRule annotationAdd BLAST33
Repeati131 – 165WDPROSITE-ProRule annotationAdd BLAST35
Repeati241 – 272WDPROSITE-ProRule annotationAdd BLAST32
Repeati285 – 327WDPROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni929 – 961DisorderedSequence analysisAdd BLAST33
Regioni984 – 1008DisorderedSequence analysisAdd BLAST25

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

WD repeatPROSITE-ProRule annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000195913

KEGG Orthology (KO)

More...
KOi
K05236

Identification of Orthologs from Complete Genome Data

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OMAi
GNQVFCL

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010714 Coatomer_asu_C
IPR006692 Coatomer_WD-assoc_reg
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04053 Coatomer_WDAD, 1 hit
PF06957 COPI_C, 1 hit
PF00400 WD40, 5 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00320 GPROTEINBRPT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A384LMM1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLVKCETKSQ RVKSISFHPK INLILAGLHN GIIQLWDYRI GILIDKFEEH
60 70 80 90 100
EGPVRGIDFH TVQPLFVSGA DDYLIKVWNI HLKKCVFNLV GHLDYIRKVQ
110 120 130 140 150
FHLTYPWILS ASDDQTIRIW NWQSRVCIAI LTGHNHYVMC AEFHPTQDLI
160 170 180 190 200
ISSSLDKTLR VWDIKLLREK NVILTNENVM NDLPYGLSKG IYNQDVVGTV
210 220 230 240 250
GDNQMGMHSF VTNNQQLQHL QQQQNNNNMF GASDAICKFV LEGHEKGVNC
260 270 280 290 300
CAFHHSLPII ASGSDDKLVK LWRYNDNKCW ELDTLRGHFN NVSSLVFHQS
310 320 330 340 350
NDDLLLSNSE DRTIRIWDIS KRACIHTFRR ENDRFWILSF KPNSNLIASG
360 370 380 390 400
HDSGMVIFKF EKEKCPFDKY GTLLLYVKEK RIYAYDVRNN KHTCLCPVRK
410 420 430 440 450
NGNAMVSGYY KLLYNQFCTT HVMLLFVYKE EDHYSFDLII CDTVGESSGA
460 470 480 490 500
GRAVSASPPA SPSTPSALHF FKSWARGASG NNANVSPQRN IQAVRNPEEF
510 520 530 540 550
NPDSVKYLIK NKHCSSVAFY TRNKYLLVEK RSGNYLLSIQ NIPEDNTSKR
560 570 580 590 600
VEVPFKVEAV YPLNNNKVII LSESKIYLYD ISLKKILNEM NHTDSIISVE
610 620 630 640 650
ILKDHNIAFV FKYNVVLTTI DLVHLCTVHE YIRVKSGVWD EENKNVFIYN
660 670 680 690 700
TLSHLKYILI NGEKGLIKCL EEPVYLFKIY NNRLFYITRK QDVISEPLND
710 720 730 740 750
TEYLFKLSLA NNDEHSAYHY LDIQHKGNTF ANGPHNEGKK KLYFSYNLIG
760 770 780 790 800
YIKKKGFANL AVQMVNNNHT LFNLSIQLGH LNNALKAAKK INKKHIWNLL
810 820 830 840 850
SVHALLLGSY DIAEYALLRM KAYDKLSFLY LFSGNIEKLK KMQTISIIRA
860 870 880 890 900
DLISMFLNSL YLGDIQQRIN IFVQQNQVNL AWACSQLYDI PINLSEKNLD
910 920 930 940 950
FDINECSYCP EKSFYLCPPI PIVRIDPNAA QKKNTSTEES TEQMRVGKEA
960 970 980 990 1000
QNGPSLKDAP PKWGIPSAWN GSYNWPVINL EKTFQPRDDP SASAPQWSKK
1010 1020 1030 1040 1050
KGPVKSGKEQ ATSHFGYFPF WLLPRLATSQ IGHFPDWPLP ILATSQLYDF
1060 1070 1080 1090 1100
FIPSLPYRAD QRSNASEADD VWKDEVNDED IINIDLDLED HKDILSKSAA
1110 1120 1130 1140 1150
TPTGSTKIER VDNLYEIMAK KYGRIMDHIR TGNIKSALDL ISKKYGIVDM
1160 1170 1180 1190 1200
KPLKTIIKNV YISTYAYLTP MPNFAPMKIP INSNEDATNT NVYINEHFLF
1210 1220 1230 1240 1250
NQIKKAHKLV TLGKFCSALD LFRSSLYHMI FITPGDKDRE MNEYLHMCTS
1260 1270 1280 1290 1300
YILAMRLEEE RNTTATEDPR RSLELMAYFT CCPMQNSHLY LVLRRGMGLA
1310 1320 1330 1340 1350
WKAQNYVTAG SFAKRLINGN YESIKGSEEE IVKAKKILLM CEQKSTEQYN
1360 1370 1380 1390 1400
IDYDPNDYHN MRVCSVSLTR IKPNEETVSC PFCQSVSKRE YTSKMCPNCL
1410
IAHLGKKALG FDFLNKNA
Length:1,418
Mass (Da):162,981
Last modified:November 7, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1AA1D63B4E0E16D1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AM910993 Genomic DNA Translation: CAQ41012.1
CWHQ02000018 Genomic DNA Translation: SBO26167.1
CWHR02000010 Genomic DNA Translation: SBO26949.1

NCBI Reference Sequences

More...
RefSeqi
XP_002261607.1, XM_002261571.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7321646

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pkn:PKH_114250

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM910993 Genomic DNA Translation: CAQ41012.1
CWHQ02000018 Genomic DNA Translation: SBO26167.1
CWHR02000010 Genomic DNA Translation: SBO26949.1
RefSeqiXP_002261607.1, XM_002261571.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi7321646
KEGGipkn:PKH_114250

Phylogenomic databases

HOGENOMiHOG000195913
KOiK05236
OMAiGNQVFCL

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR010714 Coatomer_asu_C
IPR006692 Coatomer_WD-assoc_reg
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF04053 Coatomer_WDAD, 1 hit
PF06957 COPI_C, 1 hit
PF00400 WD40, 5 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A384LMM1_PLAKH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A384LMM1
Secondary accession number(s): A0A1A7VVN8, B3L7Y9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 7, 2018
Last sequence update: November 7, 2018
Last modified: October 16, 2019
This is version 7 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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