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Entry version 4 (13 Feb 2019)
Sequence version 1 (07 Nov 2018)
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Protein
Submitted name:

LOW QUALITY PROTEIN: protocadherin-16

Gene

DCHS1

Organism
Ursus maritimus (Polar bear) (Thalarctos maritimus)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalciumSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
LOW QUALITY PROTEIN: protocadherin-16Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DCHS1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiUrsus maritimus (Polar bear) (Thalarctos maritimus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri29073 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaUrsidaeUrsus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000261680 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2719 – 2745HelicalSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini89 – 154CAInterPro annotationAdd BLAST66
Domaini178 – 266CAInterPro annotationAdd BLAST89
Domaini290 – 373CAInterPro annotationAdd BLAST84
Domaini401 – 483CAInterPro annotationAdd BLAST83
Domaini508 – 589CAInterPro annotationAdd BLAST82
Domaini613 – 696CAInterPro annotationAdd BLAST84
Domaini720 – 801CAInterPro annotationAdd BLAST82
Domaini825 – 905CAInterPro annotationAdd BLAST81
Domaini929 – 1003CAInterPro annotationAdd BLAST75
Domaini1035 – 1116CAInterPro annotationAdd BLAST82
Domaini1140 – 1222CAInterPro annotationAdd BLAST83
Domaini1252 – 1332CAInterPro annotationAdd BLAST81
Domaini1350 – 1431CAInterPro annotationAdd BLAST82
Domaini1455 – 1533CAInterPro annotationAdd BLAST79
Domaini1556 – 1637CAInterPro annotationAdd BLAST82
Domaini1661 – 1742CAInterPro annotationAdd BLAST82
Domaini1770 – 1850CAInterPro annotationAdd BLAST81
Domaini1874 – 1953CAInterPro annotationAdd BLAST80
Domaini1977 – 2059CAInterPro annotationAdd BLAST83
Domaini2082 – 2158CAInterPro annotationAdd BLAST77
Domaini2182 – 2264CAInterPro annotationAdd BLAST83
Domaini2288 – 2384CAInterPro annotationAdd BLAST97
Domaini2408 – 2488CAInterPro annotationAdd BLAST81
Domaini2512 – 2595CAInterPro annotationAdd BLAST84
Domaini2619 – 2710CAInterPro annotationAdd BLAST92

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K16507

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028 Cadherin, 22 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 25 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 25 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A384DR27-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQSLRSGWAW SLAQSWSPSR NWTAPVMQKE AGTAPSCTGM QSSRPLPLVP
60 70 80 90 100
LLLLLLLLGA GVSGAWGQAG SLDLQIDEEQ PAGTLIGDIS AGLPPGTAAP
110 120 130 140 150
PMYFISAQEG SGVGTDLAID EHSGVVRTAR VLDRERRDRY RFTXRVADIN
160 170 180 190 200
DHAPAFPQAR AALQIPEHTA LGTRYPLEPA RDADAGRLGT QGYALSGDGA
210 220 230 240 250
GQTFQLETRP GPDGAPVPEL VVTGELDREN RSQYMLQLEA YDGGSPPRRA
260 270 280 290 300
QALLDVTLLD INDHAPAFNQ SRYHAVVSES LAPGSPVLQV YASDADAGAN
310 320 330 340 350
GAVTYEINRR QSEGDGPFSI DAHTGLLRLE RPLDFEQRRV HELVVQARDG
360 370 380 390 400
GAHPELGSAF VTVNVRDAND NQPSMTVIFL SADGSPRVSE AAPPGQLVAR
410 420 430 440 450
ISVSDPDDGD FAHVNVSLEG GEGHFALSTQ DSVIYLVCVA RQLDREERDA
460 470 480 490 500
YNLRVTATDS GSPPLRAEAT FVLHVTDVND NAPTFDRQLY RPEPLPEVAL
510 520 530 540 550
PGSFVVRVMA RDPDQGSNGQ VTYSLAPGAH TRWFSIDPTS GIITTTAALD
560 570 580 590 600
YELEPQPQLI VVATDGGLPP LASSATVSVA LQDVNDNEPQ FQRTFYNASL
610 620 630 640 650
PEGTQPGTCF LQVTATDADS GPFGLLSYSL GAGLGTSGSP PFRIDAHSGD
660 670 680 690 700
VCTTRTLDRD QGPSSFDFTV TAVDGGGLKS MVYVKVFVSD ENDNPPQFYP
710 720 730 740 750
REYAASLSAQ STPGTAILRV RAHDPDQGPH GRLSYHILAG NNPPLFALDE
760 770 780 790 800
HSGLLTVAWP LARRANSVVQ LEIGAQDGGG LQAEPSARVN VSIVPGTPVP
810 820 830 840 850
PVFEQLQYVF SVPEDVAPGT SVGIVQAHNP PGRLGSVTLA LSGGDPRGLF
860 870 880 890 900
SLDGASGLLQ TLRPLDRELL GPVLELEVRA GSGVPPAFAV ARVRVLLDDV
910 920 930 940 950
NDNSPAFPAP EDTVLLPPNT APGTPIYTLR ALDPDAGINS RVTFTLLAGG
960 970 980 990 1000
GGAFTVDPTT GHVRLMGPLG PPGGPAHELE LEARDGGSPP RTSHFRLRVV
1010 1020 1030 1040 1050
VQDLGTRGLA PHFDSPTYRV DLPSGTSPGT QVLQVQAQAP DGGPITYHLA
1060 1070 1080 1090 1100
ADGPSNPFGL EPQSGWLWVR AALDREAQEL YTLKVMAVSG SKAELGQQTG
1110 1120 1130 1140 1150
TATVRVSILN QNDHSPRLSE EPTFLAVAEN QPPGTSVGRV FATDRDSGPN
1160 1170 1180 1190 1200
GRLTYSLRPL SEDSKAFRIH PQTGEMTTLQ TLDRERQSSY QLLVQVQDGG
1210 1220 1230 1240 1250
SPPRSTTGTV HIAVLDLNDN SPSFLQASGA AGGGLPIQVP DRVPPGTLVT
1260 1270 1280 1290 1300
TLQAKDPDEG ENGTILYTLT GPGSELFSLH PHSGELLTAA PLIRAERPHY
1310 1320 1330 1340 1350
VLTLSAHDQG SPPRSSSLQL LVQVLPSVRS AEPPPDPSEP DPAAPVPVVL
1360 1370 1380 1390 1400
TVTAAEGLQP GSLLGSVASP EPAGYFRLHS STGALSVVRS LDREQRAEHI
1410 1420 1430 1440 1450
LTVVASDHGS PPRSATQLLT VSVADVNDEA PAFQQQEYSV LLRENSPPGT
1460 1470 1480 1490 1500
SLLTLRATDP DLGANGQVTY GGISGESFSL DPDTGVLTTL RALDREEQEE
1510 1520 1530 1540 1550
INLTVYARDR GSPPLLTHVT VRVAVEDEND HAPTFGSAHL SLEVPEGQDP
1560 1570 1580 1590 1600
QTLTVLRASD PDVGANGQLQ YRILDGDPSG AFVLDLASGE FGTTRPLDRE
1610 1620 1630 1640 1650
VEPAFQLRIE ARDGGQPALS ATLLVTVTVL DANDHAPAFP VPAYSVEVPE
1660 1670 1680 1690 1700
DAPAGTLLLQ LQAHDPDAGA NGRVTYYLGT GAAGAFLLEP SSGELRTATA
1710 1720 1730 1740 1750
LDREQCPSYA FSVSAVDGAA AGPLSTTVPV TITVRDVNDH APTFPTSPLR
1760 1770 1780 1790 1800
LRLPRPGPSL STPTLALATL RAEDRDAGAN ASILYRLAGT PPPGTTVDSY
1810 1820 1830 1840 1850
TGEIRVTRSP VALGPRDRVL FVVATDLGRP ARSATGVVIV GLQGESERGP
1860 1870 1880 1890 1900
RFPRTSSEAM LRENAPPGTP VVSPKAVHAG GSSGPITYSI LSGNEKGTFA
1910 1920 1930 1940 1950
IQPSTGAITV RSAEGLDFEA SPRLRLVLQA ESGGAFAFSV LTLTLQDAND
1960 1970 1980 1990 2000
NAPRFLQPHY VAFLPESRPL EGPLLQVEAD DLDQGPSGQI SYSLAASQPA
2010 2020 2030 2040 2050
RGLFHVDPAT GTITTTAILD REIWAETRLV LMATDRGSPA LVGSATLTVM
2060 2070 2080 2090 2100
VIDTNDNRPT IPQPWELQVS EDALLGSEIA QVTGNDVDSG PVLWYVLSPS
2110 2120 2130 2140 2150
GPQDPFSIGR YGGRLSLTGP LDFEQRDRYH LQLLAHDGPH EGRANLTVFV
2160 2170 2180 2190 2200
EDVNDNTPAF SQSLYQVTLL EHTPPGSAIL SVSATDRDSG ANGHISYHLA
2210 2220 2230 2240 2250
SPAEGFSVDP NNGTLFTTVG TVAFGQEGPG VVDVVLEARD HGMPGRAARA
2260 2270 2280 2290 2300
TVHVQLQDQN DHTPSFTLPH YRVAVTEDLP PGSTLLTLEA TDADGSRTHA
2310 2320 2330 2340 2350
TVDYSIVSGN RGRVFQLEPR LAETEEGSGL GPRALGCLVL LEPLDFESLT
2360 2370 2380 2390 2400
QYNLTVAAAD RGQPPRSSAV PVTVTVLDVN DNPPVFSRAS YRMAVPEDTP
2410 2420 2430 2440 2450
VGAELLHVEA SDADPGPHGL VRFTLSSGDP SGLFELDESS GALRLARPLD
2460 2470 2480 2490 2500
CETQARHQLV VQAADPAGAH FALAPVTIEV QDVNDHGPIF PLSLLSTSLA
2510 2520 2530 2540 2550
ENQPPGTLVT TLHAIDGDAG AFGRLRYSLL EAGPGSEGRE AFALNSSTGE
2560 2570 2580 2590 2600
LRARVAFDYE HTGSFQLLVG AADAGNLSAS VTVSVLVTGE DEYDPVFLAP
2610 2620 2630 2640 2650
AFHFQVPEGA RRGYSLGHVQ ATDEDGGADG LVLYSLAASS PYFGINQTTG
2660 2670 2680 2690 2700
ALYLRVDSRA PGSGTGNSGS GGRTRREAPR ELRLEVVARG PLPGSRSATV
2710 2720 2730 2740 2750
PVTVDITHTA LGLAPDLNLL LVGAVAASLG VVVVLALAAL VLGLVRARSR
2760 2770 2780 2790 2800
KAEAAPGPMS QAAPLASGSL QKLGREPPSP PPSEHLYHQT LPSYGGPGAG
2810 2820 2830 2840 2850
GPYPRGGSLD PSHSSGRGSA EAAEDDEIRM INEFPRVASV ASSLAARGPD
2860 2870 2880 2890 2900
SGIQQDADGL SDTSCEPPAP DTWYKGRKAG LLLPGAGATL YREEGPPATA
2910 2920 2930 2940 2950
TAFPGGXGLR PPGDLGSPAD GKPCVAGALT AIVAGEEELR GSYNWDYLLS
2960 2970 2980 2990 3000
WCPQFQPLAS VFTEIARLKD EARPCPPAPR IDPPPLITAV AHPGAKSVPP
3010 3020 3030 3040 3050
KPASTAATRA IFPPASHRSP ISHEGSLSSA AMSPSFSPSL SPLAARSPVV
3060 3070 3080
SPFGVAQGPS ASALSAESGL EPPDDTELHI
Length:3,080
Mass (Da):323,353
Last modified:November 7, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFBA8951A15A74397
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_008709219.1, XM_008710997.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
103681434

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
umr:103681434

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_008709219.1, XM_008710997.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi103681434
KEGGiumr:103681434

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8642

Phylogenomic databases

KOiK16507

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
PfamiView protein in Pfam
PF00028 Cadherin, 22 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 25 hits
SUPFAMiSSF49313 SSF49313, 25 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 11 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A384DR27_URSMA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A384DR27
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 7, 2018
Last sequence update: November 7, 2018
Last modified: February 13, 2019
This is version 4 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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