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Entry version 4 (13 Feb 2019)
Sequence version 1 (07 Nov 2018)
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Protein
Submitted name:

CDK5 regulatory subunit-associated protein 2 isoform X4

Gene

CDK5RAP2

Organism
Ursus maritimus (Polar bear) (Thalarctos maritimus)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CDK5 regulatory subunit-associated protein 2 isoform X4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDK5RAP2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiUrsus maritimus (Polar bear) (Thalarctos maritimus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri29073 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaUrsidaeUrsus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000261680 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini44 – 114Cnn_1NInterPro annotationAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili44 – 64Sequence analysisAdd BLAST21
Coiled coili87 – 114Sequence analysisAdd BLAST28
Coiled coili126 – 146Sequence analysisAdd BLAST21
Coiled coili200 – 227Sequence analysisAdd BLAST28
Coiled coili262 – 296Sequence analysisAdd BLAST35
Coiled coili304 – 338Sequence analysisAdd BLAST35
Coiled coili364 – 451Sequence analysisAdd BLAST88
Coiled coili573 – 603Sequence analysisAdd BLAST31
Coiled coili950 – 977Sequence analysisAdd BLAST28
Coiled coili1189 – 1223Sequence analysisAdd BLAST35
Coiled coili1285 – 1308Sequence analysisAdd BLAST24
Coiled coili1393 – 1417Sequence analysisAdd BLAST25
Coiled coili1468 – 1512Sequence analysisAdd BLAST45

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012943 Cnn_1N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07989 Cnn_1N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A384CQF1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPSGLVPNL PDEVDGISPI AGLGNGVLPD VSEETVSPTR ARNMKDFENQ
60 70 80 90 100
ITELKKENFN LKLRIYFLEE RMQQEFDGPT EHVYKTNIEL KVEVESLKRE
110 120 130 140 150
LQEREQLLIK ASKAVESLAE GGGSEVQRVK EDARKKVQQV EDLLTKRIFH
160 170 180 190 200
LEEDVKAAQA ELEKAFAGTE TEKALRLNLE NKLSEMKKRH EGDSDMAVVL
210 220 230 240 250
EQKDRLIEEL KLSLKSKEAL IQCLKEQKSQ TAGPDESVSS GELRGLSAAP
260 270 280 290 300
RGEQERGAEA VQTERRKERQ RFEERIQALQ EDLREKEREI ATEKKNSLKR
310 320 330 340 350
DKAIQGLTMA LKSKEKEVEA LTSEIEELSA AFAKVTEAPP EAQTQKFQGS
360 370 380 390 400
EDYEAALLEK AALLAQLNSE NLTKNAENHR LRRNIKKVTQ ELSTLQQERE
410 420 430 440 450
RLEKDLEEAR RERGRGDHTI RDLRNEVEKL RDEVNEREKA VENRYKSLLS
460 470 480 490 500
ESNKKLHSQE QLIRSLTGSI DPKDLLLQKF SEKGPEAVQH SRPSQTGGEL
510 520 530 540 550
GVRTEGLPAK CSLQRSPGGN CIFSEEKQQL DYEELIQVLK KEQDIYTHLV
560 570 580 590 600
KSLQDPDSTN SLQAELNSIF ALRKQLEQDV LSYRNLRKTL EEQISEIRRR
610 620 630 640 650
EEEPFSFYSD QTSYLSICLE EPNRFQVEHF SQEELKKKVS DLIQLVKELY
660 670 680 690 700
TDNQHLKKTI FDLSCVGFQG GDRLESIEQS ELLASKEDED TTRTEEEDEN
710 720 730 740 750
NFLSDQHLEQ SDKIMEDYSK GGCKNGYLRH TDSSILDYDG THKPGCPGDQ
760 770 780 790 800
SPEEGELLTL LAPFFNEKAT LLLESRPDLL KVLRELLLER MCLTEQGVSA
810 820 830 840 850
EHLDGETEKS LKQMAVQLGG ELRHFTQVNS LSKSHDERQS PQTAQLGRMG
860 870 880 890 900
QVSKLELKDA SVQTVAAEGD TLRFQNEGKR EAWEEKPPDA VFHTEGLPDN
910 920 930 940 950
VCTAPRSQAT ALSFPNGTDK DVKKSRLPVL LKPSRSLGNV YRLPAGQEVV
960 970 980 990 1000
AQLQGQILEL QGELKEFKIR NKQLHQKLIL AEAMMEGRPA ADKTLQKAQP
1010 1020 1030 1040 1050
LVGAAYQDSP GEQKGITTMP CVWRDKEGDS DQHTSYETDS EICQPDGLAI
1060 1070 1080 1090 1100
LPTCKGNPSE DFPGPASVAA YLSSKNQLPT KVSVMGTHQS ENIDTSSDTE
1110 1120 1130 1140 1150
NLKQKICDLE AELEGYRNFL FQLQKHSQCS EAILTVLCGT EGGQDVSSKP
1160 1170 1180 1190 1200
KGSTDDEEMT FSSLHQVHYV KHMKVLHQLA PEATQGGLLE GLRQQLVEQE
1210 1220 1230 1240 1250
YELQKEQNLN MELFSEIHNL QNKFRDLSPS RYDSLVQSQA RELSLQRQQI
1260 1270 1280 1290 1300
KDSHGICVLY RQHMNATMKA FEQLLQASDV DHYVAEGFQE QLNQCAELLE
1310 1320 1330 1340 1350
KLEKLFLNGK SVEVDTSPQN EVMERLEEDS VTYQHILPES PEPSASHALS
1360 1370 1380 1390 1400
DCEMSEKSSV LSRDQKQDSE TGKTSVLANH FSQDLVMEHI QEIRSLRRHL
1410 1420 1430 1440 1450
EESIKTNEKL RGQLERQGSE LDPGSTNAFA YGSELHNSLT SEICFLRKQN
1460 1470 1480 1490 1500
QALNTMLAKG SRDKQKENEK LRESLSRKAA NLELLQREYA CVKEENERLQ
1510 1520 1530 1540
REVCEQERHN QQLLQEACSS RSELSRGWNR GVRRRLEGAG PFQ
Length:1,543
Mass (Da):175,102
Last modified:November 7, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1DB904088C7BF32A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A384CRE0A0A384CRE0_URSMA
CDK5 regulatory subunit-associated ...
CDK5RAP2
1,888Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A384CQF3A0A384CQF3_URSMA
CDK5 regulatory subunit-associated ...
CDK5RAP2
1,847Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A384CRF6A0A384CRF6_URSMA
CDK5 regulatory subunit-associated ...
CDK5RAP2
1,849Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A384CQH6A0A384CQH6_URSMA
CDK5 regulatory subunit-associated ...
CDK5RAP2
1,516Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_008697057.1, XM_008698835.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
103670376

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_008697057.1, XM_008698835.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi103670376

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55755

Family and domain databases

InterProiView protein in InterPro
IPR012943 Cnn_1N
PfamiView protein in Pfam
PF07989 Cnn_1N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A384CQF1_URSMA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A384CQF1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 7, 2018
Last sequence update: November 7, 2018
Last modified: February 13, 2019
This is version 4 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health

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