UniProtKB - A0A384BC65 (A0A384BC65_BALAS)
Protein
Mothers against decapentaplegic homolog
Gene
SMAD4
Organism
Balaenoptera acutorostrata scammoni (North Pacific minke whale) (Balaenoptera davidsoni)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- regulation of transcription, DNA-templated Source: InterPro
- transforming growth factor beta receptor signaling pathway Source: InterPro
Keywordsi
Molecular function | DNA-bindingUniRule annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Ligand | Metal-bindingARBA annotation, ZincARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Mothers against decapentaplegic homologUniRule annotationShort name: MAD homologUniRule annotation Short name: Mothers against DPP homologUniRule annotation Alternative name(s): SMAD family memberUniRule annotation |
Gene namesi | Name:SMAD4Imported |
Organismi | Balaenoptera acutorostrata scammoni (North Pacific minke whale) (Balaenoptera davidsoni)Imported |
Taxonomic identifieri | 310752 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Whippomorpha › Cetacea › Mysticeti › Balaenopteridae › Balaenoptera › |
Proteomesi |
|
Subcellular locationi
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-SubCell
- transcription regulator complex Source: InterPro
Keywords - Cellular componenti
CytoplasmUniRule annotation, NucleusUniRule annotationARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 142 | MH1InterPro annotationAdd BLAST | 125 | |
Domaini | 324 – 553 | MH2InterPro annotationAdd BLAST | 230 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 167 – 301 | DisorderedSequence analysisAdd BLAST | 135 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 37 – 64 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 171 – 230 | PolarSequence analysisAdd BLAST | 60 | |
Compositional biasi | 238 – 284 | PolarSequence analysisAdd BLAST | 47 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisFamily and domain databases
Gene3Di | 2.60.200.10, 1 hit 3.90.520.10, 1 hit |
InterProi | View protein in InterPro IPR013790, Dwarfin IPR003619, MAD_homology1_Dwarfin-type IPR013019, MAD_homology_MH1 IPR017855, SMAD-like_dom_sf IPR001132, SMAD_dom_Dwarfin-type IPR008984, SMAD_FHA_dom_sf IPR036578, SMAD_MH1_sf |
PANTHERi | PTHR13703, PTHR13703, 1 hit |
Pfami | View protein in Pfam PF03165, MH1, 1 hit PF03166, MH2, 1 hit |
SMARTi | View protein in SMART SM00523, DWA, 1 hit SM00524, DWB, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF56366, SSF56366, 1 hit |
PROSITEi | View protein in PROSITE PS51075, MH1, 1 hit PS51076, MH2, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A384BC65-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDAMSITNTP TSNDACLSIV HSLMCHRQGG ESETFAKRAI ESLVKKLKEK
60 70 80 90 100
KDELDSLITA ITTNGAHPSK CVTIQRTLDG RLQVAGRKGF PHVIYARLWR
110 120 130 140 150
WPDLHKNELK HVKYCQYAFD LKCDSVCVNP YHYERVVSPG IDLSGLTLQS
160 170 180 190 200
NAPPSMLVKD EYVHDFEGQP SLSTEGHSIQ TIQHPPSNRA STETYSAPAL
210 220 230 240 250
LAPSESNATS TTNFPNIPVA STSQPASILA GSHSEGLLQI ASGPQPGQQQ
260 270 280 290 300
NGFTGQPATY HHNSTTTWTG SRTAPYTPNL PHHQNGHLQH HPPLPPHPGH
310 320 330 340 350
YWPPVHNELA FQPPISNHPA PENXCSIAYF EMDVQVGETF KVPSSCPVVT
360 370 380 390 400
VDGYVDPSGG DRFCLGQLSN VHRTEAIERA RLHIGKGVQL ECKGEGDVWV
410 420 430 440 450
RCLSDHAVFV QSYYLDREAG RAPGDAVHKI YPSAYIKVFD LRQCHRQMQQ
460 470 480 490 500
QAATAQAAAA AQAAAVAGNI PGPGSVGGIA PAISLSAAAG IGVDDLRRLC
510 520 530 540 550
ILRMSFVKGW GPDYPRQSIK ETPCWIEIHL HRALQLLDEV LHTMPIADPQ
PLD
Sequence databases
RefSeqi | XP_007197312.1, XM_007197250.1 |
Genome annotation databases
GeneIDi | 103014916 |
KEGGi | bacu:103014916 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_007197312.1, XM_007197250.1 |
3D structure databases
ModBasei | Search... |
Genome annotation databases
GeneIDi | 103014916 |
KEGGi | bacu:103014916 |
Organism-specific databases
CTDi | 4089 |
Family and domain databases
Gene3Di | 2.60.200.10, 1 hit 3.90.520.10, 1 hit |
InterProi | View protein in InterPro IPR013790, Dwarfin IPR003619, MAD_homology1_Dwarfin-type IPR013019, MAD_homology_MH1 IPR017855, SMAD-like_dom_sf IPR001132, SMAD_dom_Dwarfin-type IPR008984, SMAD_FHA_dom_sf IPR036578, SMAD_MH1_sf |
PANTHERi | PTHR13703, PTHR13703, 1 hit |
Pfami | View protein in Pfam PF03165, MH1, 1 hit PF03166, MH2, 1 hit |
SMARTi | View protein in SMART SM00523, DWA, 1 hit SM00524, DWB, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF56366, SSF56366, 1 hit |
PROSITEi | View protein in PROSITE PS51075, MH1, 1 hit PS51076, MH2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A384BC65_BALAS | |
Accessioni | A0A384BC65Primary (citable) accession number: A0A384BC65 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 7, 2018 |
Last sequence update: | November 7, 2018 | |
Last modified: | February 10, 2021 | |
This is version 12 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |