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Entry version 12 (10 Feb 2021)
Sequence version 1 (07 Nov 2018)
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Protein
Submitted name:

neurogenic locus notch homolog protein 4 isoform X1

Gene

NOTCH4

Organism
Balaenoptera acutorostrata scammoni (North Pacific minke whale) (Balaenoptera davidsoni)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi452Calcium 1; via carbonyl oxygenUniRule annotation1
Metal bindingi455Calcium 1; via amide nitrogenUniRule annotation1
Metal bindingi472Calcium 2UniRule annotation1
Metal bindingi475Calcium 2UniRule annotation1
Metal bindingi489Calcium 2UniRule annotation1
Metal bindingi511Calcium 3; via carbonyl oxygenUniRule annotation1
Metal bindingi513Calcium 3UniRule annotation1
Metal bindingi527Calcium 3UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivatorARBA annotation, Developmental proteinARBA annotation, ReceptorARBA annotation
Biological processDifferentiationARBA annotation, Notch signaling pathwayARBA annotation, Transcription, Transcription regulationARBA annotation
LigandCalciumUniRule annotation, Metal-bindingUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
neurogenic locus notch homolog protein 4 isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NOTCH4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBalaenoptera acutorostrata scammoni (North Pacific minke whale) (Balaenoptera davidsoni)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri310752 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaWhippomorphaCetaceaMysticetiBalaenopteridaeBalaenoptera
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000261681 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane, NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501687181622 – 1992Sequence analysisAdd BLAST1971

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi51 ↔ 60PROSITE-ProRule annotation
Disulfide bondi103 ↔ 112PROSITE-ProRule annotation
Disulfide bondi120 ↔ 130PROSITE-ProRule annotation
Disulfide bondi142 ↔ 151PROSITE-ProRule annotation
Disulfide bondi179 ↔ 188PROSITE-ProRule annotation
Disulfide bondi219 ↔ 228PROSITE-ProRule annotation
Disulfide bondi261 ↔ 270PROSITE-ProRule annotation
Disulfide bondi299 ↔ 308PROSITE-ProRule annotation
Disulfide bondi340 ↔ 349PROSITE-ProRule annotation
Disulfide bondi378 ↔ 387PROSITE-ProRule annotation
Disulfide bondi398 ↔ 415PROSITE-ProRule annotation
Disulfide bondi417 ↔ 426PROSITE-ProRule annotation
Disulfide bondi433 ↔ 449UniRule annotation
Disulfide bondi443 ↔ 458UniRule annotation
Disulfide bondi460 ↔ 469UniRule annotation
Disulfide bondi476 ↔ 487UniRule annotation
Disulfide bondi481 ↔ 496UniRule annotation
Disulfide bondi498 ↔ 507UniRule annotation
Disulfide bondi514 ↔ 525UniRule annotation
Disulfide bondi519 ↔ 534UniRule annotation
Disulfide bondi536 ↔ 545UniRule annotation
Disulfide bondi574 ↔ 583PROSITE-ProRule annotation
Disulfide bondi612 ↔ 621PROSITE-ProRule annotation
Disulfide bondi714 ↔ 723PROSITE-ProRule annotation
Disulfide bondi752 ↔ 761PROSITE-ProRule annotation
Disulfide bondi790 ↔ 799PROSITE-ProRule annotation
Disulfide bondi829 ↔ 838PROSITE-ProRule annotation
Disulfide bondi867 ↔ 876PROSITE-ProRule annotation
Disulfide bondi894 ↔ 904PROSITE-ProRule annotation
Disulfide bondi915 ↔ 924PROSITE-ProRule annotation
Disulfide bondi953 ↔ 962PROSITE-ProRule annotation
Disulfide bondi991 ↔ 1000PROSITE-ProRule annotation
Disulfide bondi1012 ↔ 1029PROSITE-ProRule annotation
Disulfide bondi1031 ↔ 1040PROSITE-ProRule annotation
Disulfide bondi1072 ↔ 1081PROSITE-ProRule annotation
Disulfide bondi1113 ↔ 1122PROSITE-ProRule annotation
Disulfide bondi1158 ↔ 1167PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationARBA annotation, GlycoproteinARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 61EGF-likeInterPro annotationAdd BLAST40
Domaini62 – 113EGF-likeInterPro annotationAdd BLAST52
Domaini116 – 152EGF-likeInterPro annotationAdd BLAST37
Domaini153 – 189EGF-likeInterPro annotationAdd BLAST37
Domaini191 – 229EGF-likeInterPro annotationAdd BLAST39
Domaini231 – 271EGF-likeInterPro annotationAdd BLAST41
Domaini273 – 309EGF-likeInterPro annotationAdd BLAST37
Domaini311 – 350EGF-likeInterPro annotationAdd BLAST40
Domaini352 – 388EGF-likeInterPro annotationAdd BLAST37
Domaini389 – 427EGF-likeInterPro annotationAdd BLAST39
Domaini429 – 470EGF-likeInterPro annotationAdd BLAST42
Domaini472 – 508EGF-likeInterPro annotationAdd BLAST37
Domaini510 – 546EGF-likeInterPro annotationAdd BLAST37
Domaini548 – 584EGF-likeInterPro annotationAdd BLAST37
Domaini586 – 622EGF-likeInterPro annotationAdd BLAST37
Domaini623 – 656EGF-likeInterPro annotationAdd BLAST34
Domaini688 – 724EGF-likeInterPro annotationAdd BLAST37
Domaini726 – 762EGF-likeInterPro annotationAdd BLAST37
Domaini764 – 800EGF-likeInterPro annotationAdd BLAST37
Domaini803 – 839EGF-likeInterPro annotationAdd BLAST37
Domaini841 – 877EGF-likeInterPro annotationAdd BLAST37
Domaini890 – 925EGF-likeInterPro annotationAdd BLAST36
Domaini927 – 963EGF-likeInterPro annotationAdd BLAST37
Domaini965 – 1001EGF-likeInterPro annotationAdd BLAST37
Domaini1003 – 1041EGF-likeInterPro annotationAdd BLAST39
Domaini1043 – 1082EGF-likeInterPro annotationAdd BLAST40
Domaini1084 – 1123EGF-likeInterPro annotationAdd BLAST40
Domaini1127 – 1168EGF-likeInterPro annotationAdd BLAST42
Domaini1167 – 1210LNRInterPro annotationAdd BLAST44
Domaini1211 – 1247LNRInterPro annotationAdd BLAST37
Domaini1248 – 1292LNRInterPro annotationAdd BLAST45
Domaini1630 – 1816ANK_REP_REGIONInterPro annotationAdd BLAST187
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1630 – 1662ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1663 – 1685ANKPROSITE-ProRule annotationAdd BLAST23
Repeati1697 – 1729ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1730 – 1762ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1763 – 1795ANKPROSITE-ProRule annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1343 – 1372DisorderedSequence analysisAdd BLAST30
Regioni1480 – 1505DisorderedSequence analysisAdd BLAST26
Regioni1821 – 1857DisorderedSequence analysisAdd BLAST37
Regioni1961 – 1992DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1358 – 1372PolarSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NOTCH family.ARBA annotation

Keywords - Domaini

ANK repeatPROSITE-ProRule annotationARBA annotation, EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR008297, Notch
IPR035993, Notch-like_dom_sf
IPR022355, Notch_4
IPR000800, Notch_dom
IPR010660, Notch_NOD_dom
IPR011656, Notch_NODP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 1 hit
PF00008, EGF, 13 hits
PF07645, EGF_CA, 4 hits
PF12661, hEGF, 3 hits
PF06816, NOD, 1 hit
PF07684, NODP, 1 hit
PF00066, Notch, 3 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002279, Notch, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01452, LNOTCHREPEAT
PR01987, NOTCH4

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 5 hits
SM00181, EGF, 29 hits
SM00179, EGF_CA, 23 hits
SM00004, NL, 3 hits
SM01338, NOD, 1 hit
SM01339, NODP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit
SSF57184, SSF57184, 5 hits
SSF90193, SSF90193, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 5 hits
PS00010, ASX_HYDROXYL, 9 hits
PS00022, EGF_1, 27 hits
PS01186, EGF_2, 21 hits
PS50026, EGF_3, 28 hits
PS01187, EGF_CA, 3 hits
PS50258, LNR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A384B325-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQPPSLLLPL LLLLCRSVVQ TRGLQCGSFP EPCANGGTCL SLSQGQGTCQ
60 70 80 90 100
CAPGFLGETC QFPDPCQDAQ LCQNGGSCQA LLPTLPSSPS LPSPLAPSFF
110 120 130 140 150
CTCPSGFTGD RCQAQLKDPC ASFCSKMGRC HIQASGRPQC SCMPGWTGEH
160 170 180 190 200
CQLRDFCSAN PCVNGGVCLA TYPQIQCRCP PGFEGHACER DVNECFLDPG
210 220 230 240 250
PCPKGTSCHN TLGSFQCLCP AGWGGPRCEL RPGPCPPRGC PSGGTCQVVP
260 270 280 290 300
GRDSTFHLCL CPPGFTGPSC EVNPDDCVGH QCQNGGTCQD GLGTYTCLCP
310 320 330 340 350
EAWTGWDCSE DVDECEVQGL PRCRNGGTCQ NSAGGFHCVC VSGWGGTGCE
360 370 380 390 400
ENLDDCVAAT CAPGSTCIDR VGSFSCLCPP GRTGLLCHME DMCLSQPCHQ
410 420 430 440 450
EAQCNTNPLR GSTFCVCQPG YTGPTCHQDL DECQMAQQGP SPCEHGGSCL
460 470 480 490 500
NTPGSFECLC PPGYTGSRCE ADHNECLSQP CHPGSTCLDL LATFQCLCPP
510 520 530 540 550
GLEGQLCEVE TDECASAPCL NEADCQDLLN GFRCVCRPGF TGSRCEEDIN
560 570 580 590 600
ECRSSPCANG GQCQDQPGSF HCKCLPGFEG PRCQAEVDEC LSGPCPTGAS
610 620 630 640 650
CLDLPGAFLC LCPSGFTGHL CEIPLCAPNL CQPKQRCQDP EEEAHCLCPS
660 670 680 690 700
GSPGCAPAED NCTCHHGHCQ RSSCVCDVGW TGPECDTELG GCVSTPCAHG
710 720 730 740 750
GTCHPQPFGY NCTCATGYTG PTCSEELTAC HSGPCLNGGS CSPSPEGYSC
760 770 780 790 800
TCPPSHTGLR CQTSIDHCAS APCLHGGTCV NRPSASSCLC TTGFQGPRCE
810 820 830 840 850
GRIRPSCADS PCRNRATCQD GPQGPRCLCP PGYTGGSCQT LMDSCAQKPC
860 870 880 890 900
PHNSHCLQTG PSFQCLCLQG WTGPLCNLPL SSCQKAALSQ GTEVSSLCQN
910 920 930 940 950
GGICIDSGPS HFCHCPPGFQ GSICQERVNP CESRPCQHGA TCVAQPNGYL
960 970 980 990 1000
CQCTPGYSGQ NCSKEPDACQ SQPCHNHGTC TPKPGGFHCA CPPGFVGLRC
1010 1020 1030 1040 1050
EGDVDECLDQ PCHPTGTAAC HSLANAFYCQ CLPGHTGQRC EVELDPCQSQ
1060 1070 1080 1090 1100
PCSHGGSCEA TAGPPPGFTC HCPQGFEGPT CSHRAPSCGL HHCHHGGLCL
1110 1120 1130 1140 1150
PSPKPGFPPR CACLNGYGGP DCLTPPAPPG CGPPSPCLHN GSCSETPGLG
1160 1170 1180 1190 1200
GPGFRCSCPP SSPGPRCQRP GAKGCEGRSG DGACDAGCSG PGGNWDGGDC
1210 1220 1230 1240 1250
SLGVPDPWKG CPSHSRCWLL FRDGQCHPQC DSEECLFDGY DCETPPACTP
1260 1270 1280 1290 1300
AYDQYCRDHF HNGHCEKGCN TAECGWDGGD CRPEDGDSEW GPSLALLVVL
1310 1320 1330 1340 1350
SPSTLDQQLL ALARVLSLTL RVGLWVRKDS DGRNMVYPYP GAQAEEELGG
1360 1370 1380 1390 1400
TPDPSHHERA APQTQPTGKE TDSLSTGFVV VMDVDLSRCG PDHPASRCPW
1410 1420 1430 1440 1450
DPGLLLRFLA AMAAVGALEP LLPGPLLAAH PRAGTEPPAN QLPWPVLCSP
1460 1470 1480 1490 1500
VAGVLLLALG ALLVLQLIRR KRREHGALWL PPGFTRRSQT QPVPRRRRPP
1510 1520 1530 1540 1550
LGEDSIGLKA LKPEAEVDED GVVMCSGPKE GEEADQVEEM ASPSKCQLWP
1560 1570 1580 1590 1600
LSSDCQELPQ AAMLTPPQDS EMDVPDVDTR GPDGVTPLMS AVCCGGVESR
1610 1620 1630 1640 1650
TYQETWLGSP EPWEPLLGGG ACPQVHTVGT GETPLHLAAR FSRPTAARRL
1660 1670 1680 1690 1700
LEAGADPNQP DRAGRTPLHT AVAADAREVC QLLLRSRQTA VDARTEDGTT
1710 1720 1730 1740 1750
ALMLAARLAV EDLVEELIAA QADVGARDKW GKTALHWAAA VNNARAARSL
1760 1770 1780 1790 1800
LQAGADKDAL DGREQTPLFL AAREGAMEVA QLLLGLGAAR GLRDQAGLAP
1810 1820 1830 1840 1850
GDIARQRNHW DLLTLLEGVG PPEARHKATP GRGAGALQRA RTASGSVPPR
1860 1870 1880 1890 1900
GGGAQPRCRT LSAGAYPQAR TLSVDLAAHG GGAYSHCRSL SKGAGEGPPL
1910 1920 1930 1940 1950
RGRRFSAGMR GPPSNPAIVR GRSGVAAGSG GVASAVDWPC DWVALGACGP
1960 1970 1980 1990
ASNTPIPPPC LTPSPERGSP QVAWGPPAHQ VIPLSAGGEG QK
Length:1,992
Mass (Da):208,026
Last modified:November 7, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i80BEA8C1B1F2A160
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A384B2V6A0A384B2V6_BALAS
neurogenic locus notch homolog prot...
NOTCH4
1,741Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A384B2L5A0A384B2L5_BALAS
neurogenic locus notch homolog prot...
NOTCH4
1,870Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A384B2T3A0A384B2T3_BALAS
neurogenic locus notch homolog prot...
NOTCH4
1,876Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A384B3S4A0A384B3S4_BALAS
neurogenic locus notch homolog prot...
NOTCH4
1,951Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_007193953.1, XM_007193891.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
103008998

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bacu:103008998

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_007193953.1, XM_007193891.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
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Genome annotation databases

GeneIDi103008998
KEGGibacu:103008998

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4855

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR008297, Notch
IPR035993, Notch-like_dom_sf
IPR022355, Notch_4
IPR000800, Notch_dom
IPR010660, Notch_NOD_dom
IPR011656, Notch_NODP_dom
PfamiView protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 1 hit
PF00008, EGF, 13 hits
PF07645, EGF_CA, 4 hits
PF12661, hEGF, 3 hits
PF06816, NOD, 1 hit
PF07684, NODP, 1 hit
PF00066, Notch, 3 hits
PIRSFiPIRSF002279, Notch, 3 hits
PRINTSiPR01452, LNOTCHREPEAT
PR01987, NOTCH4
SMARTiView protein in SMART
SM00248, ANK, 5 hits
SM00181, EGF, 29 hits
SM00179, EGF_CA, 23 hits
SM00004, NL, 3 hits
SM01338, NOD, 1 hit
SM01339, NODP, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
SSF57184, SSF57184, 5 hits
SSF90193, SSF90193, 2 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 5 hits
PS00010, ASX_HYDROXYL, 9 hits
PS00022, EGF_1, 27 hits
PS01186, EGF_2, 21 hits
PS50026, EGF_3, 28 hits
PS01187, EGF_CA, 3 hits
PS50258, LNR, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A384B325_BALAS
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A384B325
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 7, 2018
Last sequence update: November 7, 2018
Last modified: February 10, 2021
This is version 12 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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