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UniProtKB - A0A383ZMK1 (A0A383ZMK1_BALAS)

Entry version 10 (10 Feb 2021)
Sequence version 1 (07 Nov 2018)
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Protein

Delta-like protein

Gene

JAG2

Organism
Balaenoptera acutorostrata scammoni (North Pacific minke whale) (Balaenoptera davidsoni)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative Notch ligand involved in the mediation of Notch signaling.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental proteinUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Delta-like proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:JAG2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBalaenoptera acutorostrata scammoni (North Pacific minke whale) (Balaenoptera davidsoni)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri310752 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Whippomorpha › Cetacea › Mysticeti › Balaenopteridae › Balaenoptera ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000261681 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi28 ↔ 37PROSITE-ProRule annotation
Disulfide bondi41 ↔ 53PROSITE-ProRule annotation
Disulfide bondi61 ↔ 70PROSITE-ProRule annotation
Disulfide bondi94 ↔ 103PROSITE-ProRule annotation
Disulfide bondi165 ↔ 174PROSITE-ProRule annotation
Disulfide bondi203 ↔ 212PROSITE-ProRule annotation
Disulfide bondi241 ↔ 250PROSITE-ProRule annotation
Disulfide bondi279 ↔ 288PROSITE-ProRule annotation
Disulfide bondi295 ↔ 305PROSITE-ProRule annotation
Disulfide bondi316 ↔ 325PROSITE-ProRule annotation
Disulfide bondi332 ↔ 342PROSITE-ProRule annotation
Disulfide bondi353 ↔ 362PROSITE-ProRule annotation
Disulfide bondi391 ↔ 400PROSITE-ProRule annotation
Disulfide bondi458 ↔ 467PROSITE-ProRule annotation
Disulfide bondi534 ↔ 543PROSITE-ProRule annotation
Disulfide bondi573 ↔ 582PROSITE-ProRule annotation
Disulfide bondi611 ↔ 620PROSITE-ProRule annotation
Disulfide bondi649 ↔ 658PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 70DSLInterPro annotationAdd BLAST45
Domaini71 – 104EGF-likeInterPro annotationAdd BLAST34
Domaini137 – 175EGF-likeInterPro annotationAdd BLAST39
Domaini177 – 213EGF-likeInterPro annotationAdd BLAST37
Domaini215 – 251EGF-likeInterPro annotationAdd BLAST37
Domaini253 – 289EGF-likeInterPro annotationAdd BLAST37
Domaini291 – 326EGF-likeInterPro annotationAdd BLAST36
Domaini328 – 363EGF-likeInterPro annotationAdd BLAST36
Domaini365 – 401EGF-likeInterPro annotationAdd BLAST37
Domaini432 – 468EGF-likeInterPro annotationAdd BLAST37
Domaini470 – 506EGF-likeInterPro annotationAdd BLAST37
Domaini508 – 544EGF-likeInterPro annotationAdd BLAST37
Domaini547 – 583EGF-likeInterPro annotationAdd BLAST37
Domaini585 – 621EGF-likeInterPro annotationAdd BLAST37
Domaini623 – 659EGF-likeInterPro annotationAdd BLAST37
Domaini666 – 740VWFCInterPro annotationAdd BLAST75

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatUniRule annotationARBA annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001774, DSL
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR026219, Jagged/Serrate
IPR001007, VWF_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01414, DSL, 1 hit
PF00008, EGF, 10 hits
PF07645, EGF_CA, 1 hit
PF12661, hEGF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR02059, JAGGEDFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00051, DSL, 1 hit
SM00181, EGF, 16 hits
SM00179, EGF_CA, 13 hits
SM00215, VWC_out, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57184, SSF57184, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00010, ASX_HYDROXYL, 10 hits
PS51051, DSL, 1 hit
PS00022, EGF_1, 13 hits
PS01186, EGF_2, 9 hits
PS50026, EGF_3, 14 hits
PS01187, EGF_CA, 3 hits
PS50184, VWFC_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A383ZMK1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MINPEDRWKS LHFSGHVAHL ELKIRVRCDE NYYSATCNKF CRPRNDFFGH 
        60         70         80         90        100
YTCDQYGNKA CMDGWMGKEC KEAVCKQGCN LLHGGCSVPG ECRCSYGWQG 
       110        120        130        140        150
RFCDECVPYP GCVHGSCVEP WQCSCETNWG GLLCNKDLNY CGSHHPCTNG 
       160        170        180        190        200
GTCINAEPDQ YRCACPDGYS GKNCERAEHA CASNPCANGG SCHEVPSGFE 
       210        220        230        240        250
CHCPSGWSGP TCALDIDECT SNPCAAGGTC VDQVDGFECI CPEQWGGATC 
       260        270        280        290        300
QLDANECEGK PCLNAFSCKN LIGGYYCDCI PGWKGANCHI NVNDCGGQCQ 
       310        320        330        340        350
HGGTCKDLVN GYQCVCPRGF GGRHCERQLD ECASSPCHVG LCEDLVDGFR 
       360        370        380        390        400
CHCPQGFSGP LCEVHTDFCQ PSPCRDGARC YNLEGDYYCA CPEDMGGKNC 
       410        420        430        440        450
SEPRAPCPGG ACRGGCSCVC DSGFTGTYCH ENIDDCLGQP CRNGGTCIDE 
       460        470        480        490        500
VDAFRCFCPS GWEGELCDTN PNDCLPDPCH SRGRCYDLVN DFYCACDDGW 
       510        520        530        540        550
KGKTSHSREF QCDAYTCSNG GTCYDSGDTF RCACPPGWKG STCTVAKNSS 
       560        570        580        590        600
CLPNPCVNGG TCVGSGDSFS CICRDGWEGR TCTHNTNDCN PLPCYNGGVC 
       610        620        630        640        650
VDGVNWFRCE CAPGFAGPDC RINIDECQSS PCAYGATCVD EINGYRCSCP 
       660        670        680        690        700
PGRSGPRCQE VIVFGRSCWS QGVPFPHGSS WVEDCNSCRC LDGRRDCSKV 
       710        720        730        740        750
WCGRKPCLLA GRPDTLSTQC PPGQQCQEKA PGQCLQPPCM AWGECGAEEP 
       760        770        780        790        800
WLPSTPCRPR SGHLDNSCAR LTLHFNRDQV PQGTTVGAVC SGIRALPATR 
       810        820        830        840        850
AVARDRLLVL LCDRPSSEAS AVEVAMSFSP ARDLPDSSLI QSAAHAIVAA 
       860        870        880        890 
ITRRGNSSLL LAVTEVKVET VVMGSSSTEV PFLTALFSPG RRQY
Length:894
Mass (Da):96,273
Last modified:November 7, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i47E8FB1940D11F4A
GO

Sequence databases

NCBI Reference Sequences

More...RefSeqi		XP_007176333.1, XM_007176271.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		102997766

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		bacu:102997766

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_007176333.1, XM_007176271.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

GeneIDi102997766
KEGGibacu:102997766

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3714

Family and domain databases

InterProiView protein in InterPro
IPR001774, DSL
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR026219, Jagged/Serrate
IPR001007, VWF_dom
PfamiView protein in Pfam
PF01414, DSL, 1 hit
PF00008, EGF, 10 hits
PF07645, EGF_CA, 1 hit
PF12661, hEGF, 1 hit
PRINTSiPR02059, JAGGEDFAMILY
SMARTiView protein in SMART
SM00051, DSL, 1 hit
SM00181, EGF, 16 hits
SM00179, EGF_CA, 13 hits
SM00215, VWC_out, 1 hit
SUPFAMiSSF57184, SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 10 hits
PS51051, DSL, 1 hit
PS00022, EGF_1, 13 hits
PS01186, EGF_2, 9 hits
PS50026, EGF_3, 14 hits
PS01187, EGF_CA, 3 hits
PS50184, VWFC_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A383ZMK1_BALAS
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A383ZMK1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 7, 2018
Last sequence update: November 7, 2018
Last modified: February 10, 2021
This is version 10 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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