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Entry version 12 (10 Feb 2021)
Sequence version 1 (07 Nov 2018)
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Protein
Submitted name:

neurogenic locus notch homolog protein 3

Gene

NOTCH3

Organism
Balaenoptera acutorostrata scammoni (North Pacific minke whale) (Balaenoptera davidsoni)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi410Calcium 1; via carbonyl oxygenUniRule annotation1
Metal bindingi413Calcium 1; via amide nitrogenUniRule annotation1
Metal bindingi430Calcium 2UniRule annotation1
Metal bindingi431Calcium 2; via carbonyl oxygenUniRule annotation1
Metal bindingi433Calcium 2UniRule annotation1
Metal bindingi447Calcium 2UniRule annotation1
Metal bindingi471Calcium 3UniRule annotation1
Metal bindingi485Calcium 3UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivatorARBA annotation, Developmental proteinARBA annotation, ReceptorARBA annotation
Biological processDifferentiationARBA annotation, Notch signaling pathwayARBA annotation, Transcription, Transcription regulationARBA annotation
LigandCalciumUniRule annotation, Metal-bindingUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
neurogenic locus notch homolog protein 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NOTCH3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBalaenoptera acutorostrata scammoni (North Pacific minke whale) (Balaenoptera davidsoni)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri310752 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaWhippomorphaCetaceaMysticetiBalaenopteridaeBalaenoptera
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000261681 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane, NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 38Sequence analysisAdd BLAST38
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501704594739 – 2257Sequence analysisAdd BLAST2219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi66 ↔ 75PROSITE-ProRule annotation
Disulfide bondi107 ↔ 116PROSITE-ProRule annotation
Disulfide bondi145 ↔ 154PROSITE-ProRule annotation
Disulfide bondi184 ↔ 193PROSITE-ProRule annotation
Disulfide bondi223 ↔ 232PROSITE-ProRule annotation
Disulfide bondi261 ↔ 270PROSITE-ProRule annotation
Disulfide bondi301 ↔ 310PROSITE-ProRule annotation
Disulfide bondi339 ↔ 348PROSITE-ProRule annotation
Disulfide bondi359 ↔ 376PROSITE-ProRule annotation
Disulfide bondi378 ↔ 387PROSITE-ProRule annotation
Disulfide bondi394 ↔ 407UniRule annotation
Disulfide bondi401 ↔ 416UniRule annotation
Disulfide bondi418 ↔ 427UniRule annotation
Disulfide bondi434 ↔ 445UniRule annotation
Disulfide bondi439 ↔ 454UniRule annotation
Disulfide bondi456 ↔ 465UniRule annotation
Disulfide bondi472 ↔ 483UniRule annotation
Disulfide bondi477 ↔ 492UniRule annotation
Disulfide bondi494 ↔ 503UniRule annotation
Disulfide bondi532 ↔ 541PROSITE-ProRule annotation
Disulfide bondi548 ↔ 558PROSITE-ProRule annotation
Disulfide bondi569 ↔ 578PROSITE-ProRule annotation
Disulfide bondi607 ↔ 616PROSITE-ProRule annotation
Disulfide bondi623 ↔ 633PROSITE-ProRule annotation
Disulfide bondi644 ↔ 653PROSITE-ProRule annotation
Disulfide bondi682 ↔ 691PROSITE-ProRule annotation
Disulfide bondi698 ↔ 708PROSITE-ProRule annotation
Disulfide bondi719 ↔ 728PROSITE-ProRule annotation
Disulfide bondi759 ↔ 768PROSITE-ProRule annotation
Disulfide bondi797 ↔ 806PROSITE-ProRule annotation
Disulfide bondi836 ↔ 845PROSITE-ProRule annotation
Disulfide bondi874 ↔ 883PROSITE-ProRule annotation
Disulfide bondi890 ↔ 900PROSITE-ProRule annotation
Disulfide bondi911 ↔ 920PROSITE-ProRule annotation
Disulfide bondi949 ↔ 958PROSITE-ProRule annotation
Disulfide bondi987 ↔ 996PROSITE-ProRule annotation
Disulfide bondi1025 ↔ 1034PROSITE-ProRule annotation
Disulfide bondi1052 ↔ 1062PROSITE-ProRule annotation
Disulfide bondi1073 ↔ 1082PROSITE-ProRule annotation
Disulfide bondi1111 ↔ 1120PROSITE-ProRule annotation
Disulfide bondi1149 ↔ 1158PROSITE-ProRule annotation
Disulfide bondi1194 ↔ 1203PROSITE-ProRule annotation
Disulfide bondi1235 ↔ 1244PROSITE-ProRule annotation
Disulfide bondi1278 ↔ 1287PROSITE-ProRule annotation
Disulfide bondi1316 ↔ 1325PROSITE-ProRule annotation
Disulfide bondi1345 ↔ 1362PROSITE-ProRule annotation
Disulfide bondi1364 ↔ 1373PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationARBA annotation, GlycoproteinARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 76EGF-likeInterPro annotationAdd BLAST39
Domaini77 – 117EGF-likeInterPro annotationAdd BLAST41
Domaini118 – 155EGF-likeInterPro annotationAdd BLAST38
Domaini157 – 194EGF-likeInterPro annotationAdd BLAST38
Domaini196 – 233EGF-likeInterPro annotationAdd BLAST38
Domaini235 – 271EGF-likeInterPro annotationAdd BLAST37
Domaini273 – 311EGF-likeInterPro annotationAdd BLAST39
Domaini313 – 349EGF-likeInterPro annotationAdd BLAST37
Domaini350 – 388EGF-likeInterPro annotationAdd BLAST39
Domaini390 – 428EGF-likeInterPro annotationAdd BLAST39
Domaini430 – 466EGF-likeInterPro annotationAdd BLAST37
Domaini468 – 504EGF-likeInterPro annotationAdd BLAST37
Domaini506 – 542EGF-likeInterPro annotationAdd BLAST37
Domaini544 – 579EGF-likeInterPro annotationAdd BLAST36
Domaini581 – 617EGF-likeInterPro annotationAdd BLAST37
Domaini619 – 654EGF-likeInterPro annotationAdd BLAST36
Domaini656 – 692EGF-likeInterPro annotationAdd BLAST37
Domaini694 – 729EGF-likeInterPro annotationAdd BLAST36
Domaini733 – 769EGF-likeInterPro annotationAdd BLAST37
Domaini770 – 807EGF-likeInterPro annotationAdd BLAST38
Domaini809 – 846EGF-likeInterPro annotationAdd BLAST38
Domaini848 – 884EGF-likeInterPro annotationAdd BLAST37
Domaini886 – 921EGF-likeInterPro annotationAdd BLAST36
Domaini923 – 959EGF-likeInterPro annotationAdd BLAST37
Domaini961 – 997EGF-likeInterPro annotationAdd BLAST37
Domaini999 – 1035EGF-likeInterPro annotationAdd BLAST37
Domaini1048 – 1083EGF-likeInterPro annotationAdd BLAST36
Domaini1085 – 1121EGF-likeInterPro annotationAdd BLAST37
Domaini1123 – 1159EGF-likeInterPro annotationAdd BLAST37
Domaini1161 – 1204EGF-likeInterPro annotationAdd BLAST44
Domaini1206 – 1245EGF-likeInterPro annotationAdd BLAST40
Domaini1247 – 1288EGF-likeInterPro annotationAdd BLAST42
Domaini1290 – 1326EGF-likeInterPro annotationAdd BLAST37
Domaini1336 – 1374EGF-likeInterPro annotationAdd BLAST39
Domaini1388 – 1428LNRInterPro annotationAdd BLAST41
Domaini1429 – 1459LNRInterPro annotationAdd BLAST31
Domaini1468 – 1506LNRInterPro annotationAdd BLAST39
Domaini1780 – 2025ANK_REP_REGIONInterPro annotationAdd BLAST246
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1839 – 1871ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1906 – 1938ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1939 – 1971ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1972 – 2004ANKPROSITE-ProRule annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 20DisorderedSequence analysisAdd BLAST20
Regioni2025 – 2044DisorderedSequence analysisAdd BLAST20
Regioni2054 – 2126DisorderedSequence analysisAdd BLAST73
Regioni2142 – 2257DisorderedSequence analysisAdd BLAST116

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2195 – 2225PolarSequence analysisAdd BLAST31
Compositional biasi2233 – 2249PolarSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NOTCH family.ARBA annotation

Keywords - Domaini

ANK repeatPROSITE-ProRule annotationARBA annotation, EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR024600, DUF3454_notch
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR008297, Notch
IPR035993, Notch-like_dom_sf
IPR022331, Notch_3
IPR000800, Notch_dom
IPR010660, Notch_NOD_dom
IPR011656, Notch_NODP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 2 hits
PF11936, DUF3454, 1 hit
PF00008, EGF, 21 hits
PF07645, EGF_CA, 5 hits
PF12661, hEGF, 3 hits
PF06816, NOD, 1 hit
PF07684, NODP, 1 hit
PF00066, Notch, 3 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002279, Notch, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01452, LNOTCHREPEAT
PR01986, NOTCH3

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 6 hits
SM01334, DUF3454, 1 hit
SM00181, EGF, 34 hits
SM00179, EGF_CA, 32 hits
SM00004, NL, 3 hits
SM01338, NOD, 1 hit
SM01339, NODP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit
SSF57184, SSF57184, 6 hits
SSF90193, SSF90193, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits
PS00010, ASX_HYDROXYL, 18 hits
PS00022, EGF_1, 32 hits
PS01186, EGF_2, 26 hits
PS50026, EGF_3, 34 hits
PS01187, EGF_CA, 8 hits
PS50258, LNR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A383ZEF4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPGPRGRRR RRLMSPPPPL PSVRTLPLLL LLAGPGAAAP PCLDGSPCAN
60 70 80 90 100
GGRCTQLPSR EAACLCPPGW VGERCQLEDP CHSGPCAGHG VCQSSVVAGT
110 120 130 140 150
ARFSCRCPRG FRGPDCSLPD PCLSSPCAHG ARCSVGSDGR YACSCPPGYQ
160 170 180 190 200
GRSCRSDVDE CRVGGPCRHG GTCLNTPGSF RCQCPAGYTG PLCESPSVAC
210 220 230 240 250
APSPCRNGGT CRQSGDLTYD CACLPGFEGQ NCEVNVDDCP GHRCLNGGTC
260 270 280 290 300
VDGVNTYNCQ CPPEWTGQFC TEDVDECQLQ PNACHNGGTC FNTLGGHSCV
310 320 330 340 350
CVNGWTGESC SQNIDDCATA VCFHGATCHD RVASFYCACP MGKTGLLCHL
360 370 380 390 400
DDACVSNPCH EDAICDTNPV NGRAICTCPP GFTGGACDQD VDECSIGANP
410 420 430 440 450
CEHLGRCVNT QGSFLCQCGR GYTGPRCETD VNECLSGPCR NQATCLDRIG
460 470 480 490 500
QFTCICMAGF TGTYCEVDMD ECQSSPCVNG GVCKDRVNGF SCTCPSGFSG
510 520 530 540 550
AMCQLDVDEC ASTPCRNGAK CVDQPDGYEC RCAEGFEGTV CEHNVDDCSP
560 570 580 590 600
DPCHHGRCVD GIASFSCACA PGYTGTRCES QVDECRSQPC RHGGKCLDLV
610 620 630 640 650
DKYLCRCPPG TTGVNCEVNI DDCASNPCTF GICRDSINRY DCVCQPGFTG
660 670 680 690 700
PLCNVEINEC ASSPCGEGGS CVDGENGFQC LCPPGSLPPL CLPPSHPCAQ
710 720 730 740 750
EPCSHGVCHD APGGFRCVCE LGWSGPQCSQ SLARDACESH PCWAGGTCTS
760 770 780 790 800
DGTGFRCTCP PGVQGRQCEL LSPCTPNPCE HGGYCESAPG QLAVCSCPPG
810 820 830 840 850
WQGSRCQQDV DECAGPSPCG PHGTCTNLAG SFSCTCHEGY SGPSCDQDID
860 870 880 890 900
DCDPNPCLNG GSCQDGVGSF SCSCLPGFAG SRCARDVDEC LSSPCGPGTC
910 920 930 940 950
TDHVASFTCT CPPGYGGFLC EQDLADCSPS SCFNGGTCVD GVNSFSCLCR
960 970 980 990 1000
LGYTGAHCQH EADPCLSRPC LHGGVCTASH PGFRCACPEG FTGAQCQTLV
1010 1020 1030 1040 1050
DWCSRTPCQN GGHCARTGAS FYCLCAPGWS GRLCDIQSLP CREAAAQIGV
1060 1070 1080 1090 1100
PMEQLCQAGG QCVDKDSSHY CVCPEGHTGS HCEREVDPCL AQPCQHGGTC
1110 1120 1130 1140 1150
RGYMGGYVCE CPAGYTSDNC EEDMDECASQ PCQHGGVCID LVARYLCSCP
1160 1170 1180 1190 1200
PGTLGVLCEI NEDDCGPGPP LDPGPRCLHN GTCVDLVGGF RCTCPPGYTG
1210 1220 1230 1240 1250
LRCEADINEC RPGACHAAHT RDCLQDPGGG FHCLCHAGFT GPHCQTVLSA
1260 1270 1280 1290 1300
CESQPCQHGG QCHPSPGSGG ALTFSCHCVP PFWGPRCERV ARSCWELQCP
1310 1320 1330 1340 1350
VGVPCQQTVR GPRCACPPGL SGPACRGSRG SPLGAANASC VTSPCLHGGS
1360 1370 1380 1390 1400
CRPETLAPFF RCACAPGWAG PRCEIPAAVP EAPEEPSCPR AACEAKSGDK
1410 1420 1430 1440 1450
RCDRECNSPG CGWDGGDCSL SVSDPWRQCA ALQCWLLFNN SRCDPACSSP
1460 1470 1480 1490 1500
ACLYDNFDCR AGGRERTCNP VYEKYCADHF ADGRCDQGCN TEECGWDGLD
1510 1520 1530 1540 1550
CAGEVPALLA RGVLVLTVLL PPEELLRSSA DFLQRLSGIL RTSLRFRLDE
1560 1570 1580 1590 1600
NGQAMVFPYH RPGPGSESRN RRELAPEVIG SVVMLEIDNR LCLQSPENDH
1610 1620 1630 1640 1650
CFPDAQSAAD YLGALSAVER LDFPYPLRAA RGEPLELPEP SVPLLPLLAA
1660 1670 1680 1690 1700
SAVFLLVILV LGVMVARRKR EHSTLWFPEG FALHKDAAAG HKGRREPVGQ
1710 1720 1730 1740 1750
DALGMKNMAK GESLMGEVAT DWMDTECPEA KRLKVEEPGV GAEDAVDCRQ
1760 1770 1780 1790 1800
WTQHHLVAAD IRVAPAMALT PPQGDADADG MDVNVRGPDG FTPLMLASFC
1810 1820 1830 1840 1850
GGALEAIPAE EDEAEDTSAS IISDLICQGA QLGARTDRTG ETALHLAARY
1860 1870 1880 1890 1900
ARADAAKRLL DAGADTNAQD HSGRTPLHTA VTADAQGVFQ ILIRNRSTDL
1910 1920 1930 1940 1950
DARMADGSTA LILAARLAVE GMVEELIASH ADVNAVDELG KSALHWAAAV
1960 1970 1980 1990 2000
NNVEATLALL KNGANKDMQD SKEETPLFLA AREGSFEAAK LLLDHFANRE
2010 2020 2030 2040 2050
ITDHLDRLPR DVAQERLHQD IVRLLDQPSG PRSPPGPHGL GPLLCPPGAF
2060 2070 2080 2090 2100
LPGLKVAQSG GKKSRRPPGK AGLGPQGARG RGKKLTLACP GPLAESSVTL
2110 2120 2130 2140 2150
SPVDSLDSPR PFGGPPASPG GFPLEGPYAA ATATAVSLAQ LGGERPPPYL
2160 2170 2180 2190 2200
AAPGHGDEFP AAGAHSSPPK ARFLRVPSEH PYLTPSPESP EHWASPSPPS
2210 2220 2230 2240 2250
LSDWSDSTPS PATATGATAA GTLSAQPLPL SVPGPLAQSQ TQLGSQPEVT

PKRQVLA
Length:2,257
Mass (Da):236,412
Last modified:November 7, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA6C4B7CA9D62E26
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_007173570.1, XM_007173508.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
103013129

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bacu:103013129

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_007173570.1, XM_007173508.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi103013129
KEGGibacu:103013129

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4854

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR024600, DUF3454_notch
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR008297, Notch
IPR035993, Notch-like_dom_sf
IPR022331, Notch_3
IPR000800, Notch_dom
IPR010660, Notch_NOD_dom
IPR011656, Notch_NODP_dom
PfamiView protein in Pfam
PF12796, Ank_2, 2 hits
PF11936, DUF3454, 1 hit
PF00008, EGF, 21 hits
PF07645, EGF_CA, 5 hits
PF12661, hEGF, 3 hits
PF06816, NOD, 1 hit
PF07684, NODP, 1 hit
PF00066, Notch, 3 hits
PIRSFiPIRSF002279, Notch, 4 hits
PRINTSiPR01452, LNOTCHREPEAT
PR01986, NOTCH3
SMARTiView protein in SMART
SM00248, ANK, 6 hits
SM01334, DUF3454, 1 hit
SM00181, EGF, 34 hits
SM00179, EGF_CA, 32 hits
SM00004, NL, 3 hits
SM01338, NOD, 1 hit
SM01339, NODP, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
SSF57184, SSF57184, 6 hits
SSF90193, SSF90193, 3 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits
PS00010, ASX_HYDROXYL, 18 hits
PS00022, EGF_1, 32 hits
PS01186, EGF_2, 26 hits
PS50026, EGF_3, 34 hits
PS01187, EGF_CA, 8 hits
PS50258, LNR, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A383ZEF4_BALAS
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A383ZEF4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 7, 2018
Last sequence update: November 7, 2018
Last modified: February 10, 2021
This is version 12 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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