UniProtKB - A0A345ALS2 (A0A345ALS2_HUMAN)
Protein
ATP synthase protein 8
Gene
ATP8
Organism
Homo sapiens (Human)
Status
Functioni
Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.SAAS annotation
GO - Molecular functioni
- proton transmembrane transporter activity Source: InterPro
GO - Biological processi
- ATP synthesis coupled proton transport Source: InterPro
Keywordsi
Biological process | ATP synthesisSAAS annotation, Hydrogen ion transport, Ion transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: ATP synthase protein 8UniRule annotationSAAS annotation |
Gene namesi | Name:ATP8Imported |
Encoded oni | MitochondrionImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Mitochondrion
- Mitochondrion membrane UniRule annotationSAAS annotation; Single-pass membrane protein UniRule annotationSAAS annotation
Mitochondrion
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 6 – 24 | HelicalSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
CF(0)UniRule annotationSAAS annotation, Membrane, MitochondrionUniRule annotationSAAS annotationImportedInteractioni
Subunit structurei
F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel.
SAAS annotationFamily & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisSAAS annotationFamily and domain databases
InterProi | View protein in InterPro IPR039017 ATP8_mammal IPR001421 ATP8_metazoa |
PANTHERi | PTHR13722 PTHR13722, 1 hit |
Pfami | View protein in Pfam PF00895 ATP-synt_8, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A345ALS2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPQLNTTVWP TMITPMLLTL FLITQLKMLN TNYHLXXXXX XXXXXXYNKP
60
WEPKWTKICS LHSLPPQS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | MG182530 Genomic DNA Translation: AXF37372.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | MG182530 Genomic DNA Translation: AXF37372.1 |
3D structure databases
ModBasei | Search... |
Miscellaneous databases
ChiTaRSi | ATP8 human |
Family and domain databases
InterProi | View protein in InterPro IPR039017 ATP8_mammal IPR001421 ATP8_metazoa |
PANTHERi | PTHR13722 PTHR13722, 1 hit |
Pfami | View protein in Pfam PF00895 ATP-synt_8, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A345ALS2_HUMAN | |
Accessioni | A0A345ALS2Primary (citable) accession number: A0A345ALS2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 7, 2018 |
Last sequence update: | November 7, 2018 | |
Last modified: | October 16, 2019 | |
This is version 6 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |