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Entry version 6 (31 Jul 2019)
Sequence version 1 (10 Oct 2018)
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Protein
Submitted name:

Down syndrome cell adhesion molecule-like protein 1

Gene

DSCAML1

Organism
Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Down syndrome cell adhesion molecule-like protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DSCAML1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1706337 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaOdontocetiPhocoenidaeNeophocaena
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000252040 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini176 – 278Ig-likeInterPro annotationAdd BLAST103
Domaini287 – 371Ig-likeInterPro annotationAdd BLAST85
Domaini375 – 457Ig-likeInterPro annotationAdd BLAST83
Domaini469 – 562Ig-likeInterPro annotationAdd BLAST94
Domaini567 – 647Ig-likeInterPro annotationAdd BLAST81
Domaini657 – 746Ig-likeInterPro annotationAdd BLAST90
Domaini751 – 845Ig-likeInterPro annotationAdd BLAST95
Domaini849 – 946Ig-likeInterPro annotationAdd BLAST98
Domaini948 – 1045Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini1050 – 1149Fibronectin type-IIIInterPro annotationAdd BLAST100
Domaini1154 – 1250Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini1254 – 1349Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini1339 – 1438Ig-likeInterPro annotationAdd BLAST100
Domaini1444 – 1538Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini1539 – 1639Fibronectin type-IIIInterPro annotationAdd BLAST101

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 53DisorderedSequence analysisAdd BLAST53
Regioni513 – 532DisorderedSequence analysisAdd BLAST20
Regioni1841 – 1862DisorderedSequence analysisAdd BLAST22
Regioni1901 – 1945DisorderedSequence analysisAdd BLAST45
Regioni2017 – 2121DisorderedSequence analysisAdd BLAST105

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1675 – 1695Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi514 – 532PolarSequence analysisAdd BLAST19
Compositional biasi1901 – 1927PolarSequence analysisAdd BLAST27
Compositional biasi2047 – 2079Pro-richSequence analysisAdd BLAST33
Compositional biasi2093 – 2121PolarSequence analysisAdd BLAST29

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 6 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 16 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033029 DSCAML1
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set

The PANTHER Classification System

More...
PANTHERi
PTHR13817:SF54 PTHR13817:SF54, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 5 hits
PF07679 I-set, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 6 hits
SM00409 IG, 10 hits
SM00408 IGc2, 9 hits
SM00406 IGv, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 10 hits
SSF49265 SSF49265, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 6 hits
PS50835 IG_LIKE, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A341C0S1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGAREPRRE EPPPPPPSAG LRSRESGARS AGGWERAERG RGAAARPATG
60 70 80 90 100
PPPRRIGPLY GMWLVTFLLF YETRHQARPE DVGTSLYFVN DSLQQVIFSS
110 120 130 140 150
SVGVVVPCPA AGSPSAALRW YLATGDDIYD VPHIRHVHAN GTLQLYPFSP
160 170 180 190 200
SAFNSFIHDN DYFCTAENAA GKIRSPNIRV KAVFREPYTV RVEDQRSMRG
210 220 230 240 250
SVAVFKCLIP SSVQEYVSVV SWEKDTVAII PENRFFITYH GGLYISDVQK
260 270 280 290 300
EDALSTYRCI TKHKYSGETR QSNGARLSVT DPAESIPTIL DGFHSQEVWA
310 320 330 340 350
GLNMELPCTA SGYPIPAIRW LKDGRPLPAD SRWTKHITGL TISDLRTEDS
360 370 380 390 400
GTYICEVTNT FGSAEATGTL TVIDPLHVTL TPKKLKTGIG STVILSCTLT
410 420 430 440 450
GSPEFTIRWY RNTELLLPNE AISIRGLSNE TLLITSAQKS HSGAYQCFAT
460 470 480 490 500
RKAQTAQDFA IIVLEDGTPR IVSSFSEKVV NPGEQFSLMC AAKGAPPPTV
510 520 530 540 550
TWALDDEPIM RDGSHRTSQY TMSDGTTISH MNVTGPQIRD GGVYRCTARN
560 570 580 590 600
SVGSAEYQAR INVRGPPSIR AMRNITAVAG RDTLINCRVI GYPYYSIKWY
610 620 630 640 650
KDALLLPDNH RQVVFENGTL KLTDVQKGMD EGEYLCSVLV QPQLSISQSV
660 670 680 690 700
HVAVKVPPLI QPFEFPPASI GQLLYIPCVV SSGDMPIRIT WRKDGQVIIS
710 720 730 740 750
GSGVTIESKE FMSSLQISSV SLKHNGNYTC IASNTAATVS RERQLIVRVP
760 770 780 790 800
PRFVVQPNNQ DGIYGKAGVL NCSVDGYPPP KVMWKHARGS GNPQQYHPVP
810 820 830 840 850
LTGRIQILPN SSLLIRHVLE EDIGYYLCQA SNGVGTDISK SMFLTVKIPA
860 870 880 890 900
MITSHPNTTI AIKGHAKELN CTARGERPII IRWEKGDTVI DPDRVMRYAI
910 920 930 940 950
ATKDNGDEVV STLKLKPADR GDSVFFSCHA INSYGEDRGL IQLTVQEPPD
960 970 980 990 1000
PPELEIREVK ARSMNLRWTQ RFDGNSIITG FDIEYKNKSD SWDFKQSTRN
1010 1020 1030 1040 1050
ISPTINQANI VDLHPASVYS IRMYSFNKIG RSEPSKELTI STEEAAPDGP
1060 1070 1080 1090 1100
PMDVTLQPVT SQSIQVTWKA PKKELQNGVI RGYQIGYREN SPGSNGQYSI
1110 1120 1130 1140 1150
VEMKATGDSE VYTLDNLKKF AQYGVVVQAF NRAGTGPSSS EINATTLEDV
1160 1170 1180 1190 1200
PSQPPENVRA LSITSDVAVI SWSEPPRSTL NGVLKGYRVI FWSLYVDGEW
1210 1220 1230 1240 1250
GEMQNITTTR ERVELRGMEK FTNYSVQVLA YTQAGDGVRS SVLYIQTKED
1260 1270 1280 1290 1300
VPGPPAGIKA VPSSASSVVV SWLPPTKPNG VIRKYTIFCF SPGSGQPAPS
1310 1320 1330 1340 1350
EYETSPEQLF YRIAHLNRGQ QYLLWVAAVT SAGRGNGSEK VTIEPAGKAP
1360 1370 1380 1390 1400
AKIISFGGTV TTPWMRDVRL PCNSVGDPAP AVKWTKDSED SAIPVSMDGH
1410 1420 1430 1440 1450
WLIHTNGTLL LRAVKAEDSG YYTCTATNTG GFDTIIVNLL VQVPPDQPRL
1460 1470 1480 1490 1500
TVSKTSASSI TLTWIPGDNG GSSIRGFVLQ YSVDNSEEWK DVFVSSSERS
1510 1520 1530 1540 1550
FRLDSLKCGT WYKVKLAAKN SVGSGRISEI IEAKTHGREP SFSKDQHLFT
1560 1570 1580 1590 1600
HINSTHARLN LQGWSNGGCP ITAIVLEYRP KGTWAWQGLR ANRSGEVFLT
1610 1620 1630 1640 1650
ELREATWYEL RMRACNSAGC GNETAQFATL DYDGSTIPPI KSAQGEGDDV
1660 1670 1680 1690 1700
KKLFTIGCPV ILATLGVALL FIVRKKRKEK RLKRLRDAKS LAEMLISKNN
1710 1720 1730 1740 1750
RSFDTPVKGP PQGPRLHIDI PRVQLLIEDK EGIKQLGDDK ATIPVTDAEF
1760 1770 1780 1790 1800
SQAVNPQSFC TGVSLHHPAL IQSTGPLIDM SDIRPGTNPV SRKNVKSAHS
1810 1820 1830 1840 1850
TRNRYSSQWT LTKCQASTPA RTLTSDWRTV GSQHGVTVTE SDSYSASLSQ
1860 1870 1880 1890 1900
DTDKGRNSMV STESASSTYE ELARAYEHAK LEEQLQHAKF EITECFISDS
1910 1920 1930 1940 1950
SSDQMTTGTN ENADSMTSMS TPSEPGICRF TASPPKPQDA DRGKNVAVPI
1960 1970 1980 1990 2000
PHRANKSDYC NLPLYAKSEA FFRKADGREP CPVVPPREAS IRNLARTYQP
2010 2020 2030 2040 2050
QARHLTLXXX XXXXXXXXXX XXXXXXXXPG AAATATLPQR TLAMPAPPAG
2060 2070 2080 2090 2100
TAPPAPGPTP AEPPAAPSAA PPAPSTEPPR AGGPHTKMGG SRDSLLEMST
2110 2120
SGVGRSQKQG AGAYSKSYTL V
Length:2,121
Mass (Da):232,064
Last modified:October 10, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C35352AAEE78678
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_024607507.1, XM_024751739.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_024607507.1, XM_024751739.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd00063 FN3, 6 hits
Gene3Di2.60.40.10, 16 hits
InterProiView protein in InterPro
IPR033029 DSCAML1
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PANTHERiPTHR13817:SF54 PTHR13817:SF54, 1 hit
PfamiView protein in Pfam
PF00041 fn3, 5 hits
PF07679 I-set, 6 hits
SMARTiView protein in SMART
SM00060 FN3, 6 hits
SM00409 IG, 10 hits
SM00408 IGc2, 9 hits
SM00406 IGv, 2 hits
SUPFAMiSSF48726 SSF48726, 10 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 6 hits
PS50835 IG_LIKE, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A341C0S1_9CETA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A341C0S1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 10, 2018
Last sequence update: October 10, 2018
Last modified: July 31, 2019
This is version 6 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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