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Entry version 5 (31 Jul 2019)
Sequence version 1 (10 Oct 2018)
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Protein
Submitted name:

formin-1 isoform X2

Gene

FMN1

Organism
Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
formin-1 isoform X2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FMN1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1706337 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaOdontocetiPhocoenidaeNeophocaena
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000252040 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini755 – 1171FH2InterPro annotationAdd BLAST417

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 25DisorderedSequence analysisAdd BLAST25
Regioni67 – 114DisorderedSequence analysisAdd BLAST48
Regioni144 – 270DisorderedSequence analysisAdd BLAST127
Regioni322 – 491DisorderedSequence analysisAdd BLAST170
Regioni596 – 761DisorderedSequence analysisAdd BLAST166
Regioni1182 – 1202DisorderedSequence analysisAdd BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili503 – 523Sequence analysisAdd BLAST21
Coiled coili1046 – 1073Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi164 – 191PolarSequence analysisAdd BLAST28
Compositional biasi247 – 264PolarSequence analysisAdd BLAST18
Compositional biasi373 – 391PolarSequence analysisAdd BLAST19
Compositional biasi424 – 471PolyampholyteSequence analysisAdd BLAST48
Compositional biasi607 – 646PolarSequence analysisAdd BLAST40
Compositional biasi647 – 744Pro-richSequence analysisAdd BLAST98
Compositional biasi1182 – 1196PolyampholyteSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.2220, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015425 FH2_Formin
IPR042201 FH2_Formin_sf
IPR001265 Formin_Cappuccino_subfam

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02181 FH2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00828 FORMIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00498 FH2, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51444 FH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A341ACB6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDVGNAPNG SDGSEPGQPE AGLDVAQSIL TKFSMKSLFG FTSKLESVQP
60 70 80 90 100
EEEDAVLKAF RSLVVDPTPQ LEEPSSGLDP PEAEAQVPPD LGNDGKTPRV
110 120 130 140 150
ETETGLEGSR GEAGAGISLP GQELLPLAAL SVCRDNVILV RGTLVNTTSD
160 170 180 190 200
SDSDDGGQEP EEGSNINDPK SPSGVLSEPA EQSQETPGDG RENTATGERG
210 220 230 240 250
DAEPSGEGPQ RTLQEINSKL EPEDGGLQTE HSPGQRQAGE EGSKVLPVVT
260 270 280 290 300
DQNSSVGVTE NTSSKKEVPG EKSFQLPAFF SGLRVLKKGA PAEVGETITE
310 320 330 340 350
IKPKDGDLAL LKLTQPVQRS LAQAGPQAVK MGEKTNDPKA APTLLEQLSQ
360 370 380 390 400
LLNIDVPKAE SKAEDPEQPR GEEMSGSTPQ ESQSSPGEAQ TQGGEVKPKP
410 420 430 440 450
PETALEAFRA LFIRPPKKGT TADTSELEAL KRKMRHEKES LRAVFERSRS
460 470 480 490 500
RPADGPSDSK SPDHSPTEQD DRTPGRLQAV WPPPKTKDTE EKVGLKYTEA
510 520 530 540 550
EYQAAILHLK REHKEEIENL QAQFELQAFH IRGEHAMITA RLEETIENLK
560 570 580 590 600
DEIEHRWRGG CEEMRDVCVS TDDDCPPKTF RNVCIQTDRE TFLKPCEGED
610 620 630 640 650
RTTRSNQIIP KKLNISSLSQ LSPPNDSRDT SVPLQSAESI SSSQQKATPP
660 670 680 690 700
APPPPPAPPL LAAIPPPPPL PPALGPLPLA PPPPPVNTGP PPPPPPPLPP
710 720 730 740 750
SAGPPPPPPP PPLPHSTAPP NSGGPPSAPP PPGPVPPPPP ALFFGVNPSA
760 770 780 790 800
SQCPRKPAVE PSCPMKPLYW TRIQISDKSQ NSTPTLWDSL EEPDIRDTSE
810 820 830 840 850
FEYLFSKDTP QQKKKPLSES YEKKNKIKKI IKLLDGKRSQ TVGILISSLH
860 870 880 890 900
LEMKDIQQAI FNVDDSVVDL ETLAALYENR AQEDELVKIR KYYETSKEEE
910 920 930 940 950
LKLLDKPEQF LHELAQIPNF AERAQCIIFR SVFSEGITAV HRKVEIITRA
960 970 980 990 1000
SKGLLQMKSV KDILALILAF GNYMNGGNRT RGQADGYSLE ILPKLKDVKS
1010 1020 1030 1040 1050
RDNGINLVDY VVKYYLRYYD QEAGTEKSVF PLPEPQDFFL ASQVKFEDLI
1060 1070 1080 1090 1100
KDLRKLKRQL EASEKQMAVV CKESPKEYLQ PFKDRLKEFF QKAKKEHTVE
1110 1120 1130 1140 1150
ESHLENAQKS FETTVGYFGM KPKSGEKEIT PNYVFMVWYE FCSDFKTIWK
1160 1170 1180 1190 1200
RESKNISKER LKMAQESVSK LTAEKKVETK KINPTASLKE RLRQKEASVS

TN
Length:1,202
Mass (Da):132,185
Last modified:October 10, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD6C7B63922BD4738
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_024588275.1, XM_024732507.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_024588275.1, XM_024732507.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di1.20.58.2220, 1 hit
InterProiView protein in InterPro
IPR015425 FH2_Formin
IPR042201 FH2_Formin_sf
IPR001265 Formin_Cappuccino_subfam
PfamiView protein in Pfam
PF02181 FH2, 1 hit
PRINTSiPR00828 FORMIN
SMARTiView protein in SMART
SM00498 FH2, 1 hit
PROSITEiView protein in PROSITE
PS51444 FH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A341ACB6_9CETA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A341ACB6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 10, 2018
Last sequence update: October 10, 2018
Last modified: July 31, 2019
This is version 5 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health

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