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Entry version 8 (31 Jul 2019)
Sequence version 1 (10 Oct 2018)
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Protein
Submitted name:

cullin-associated NEDD8-dissociated protein 2

Gene

CAND2

Organism
Lipotes vexillifer (Yangtze river dolphin)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
cullin-associated NEDD8-dissociated protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAND2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLipotes vexillifer (Yangtze river dolphin)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri118797 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaOdontocetiLipotidaeLipotes
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000265300 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1158 – 1318TIP120InterPro annotationAdd BLAST161

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 65DisorderedSequence analysisAdd BLAST65
Regioni429 – 458DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi23 – 37Pro-richSequence analysisAdd BLAST15
Compositional biasi431 – 457AcidicSequence analysisAdd BLAST27

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR039852 CAND1/CAND2
IPR013932 TATA-bd_TIP120

The PANTHER Classification System

More...
PANTHERi
PTHR12696 PTHR12696, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08623 TIP120, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A340XJR1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRLQGWRRA ETTELLAGPS RQPPPANRLP PPAAAAKAEP PSLLLAAGST
60 70 80 90 100
PAPETPPPRL CARRKPGLSS PRIACPVLSG TPAQLRLPPC KLQPLAAEWC
110 120 130 140 150
SMLLRQPQLS VTFQLRLHCN FKCRGQGIRP HGSAQLFMAT SDLMSELQKD
160 170 180 190 200
SIQLDEDSER KVVKMLLRLL EDKNGEVQNL AVKCLGPLVG KVKEYQVETI
210 220 230 240 250
VDALCANMRS DKEQLRDIAG IGLKTVLSEL PPAATGSGLA TSVCRKITGQ
260 270 280 290 300
LTSAIAQQED AAVQLEALDI LSDMLSRLGA PLGAFHASLL HCLLPQLSSP
310 320 330 340 350
RLAVRKRAVG ALGHLAAACS TDLFVELADH LLDRLPGPRA PASPAAIRTL
360 370 380 390 400
IQCLGSVGRQ AGHRLGTHLD RLVPLVEEFC KLDDDELRES CLQAFEAFLR
410 420 430 440 450
KCPKEMGPHV PSVTSLCLQY IKHDPNYNCD SDEEEEKMET EDSEFSEQQS
460 470 480 490 500
EDEYSDDDDM SWKVRRAAAK CLVALISSRP DLLTNFHCTL APVLIRRFRE
510 520 530 540 550
REENVKADVF GAYIVLLRQT RSLKGWLEAV EEPTQSGSNL QMLRGQVPLV
560 570 580 590 600
MKALQRQLKD RSVRARQGCF SLLTELAGIL PGSLAEHMPV LVAGIIFSLA
610 620 630 640 650
DRSSSSTIRM DALAFLQGLL GTEPAEAFHP QLPTLLPPVM ACVADPFYKI
660 670 680 690 700
AAEALLVLQE LVRALWPLDR PRVLDPEPYI GEMSAATLAR LRATDLDQEV
710 720 730 740 750
KERAISCVGH LVGHLGDRLG DNLEPSLLLL LDRLRNEITR LSAVKALTLV
760 770 780 790 800
AVSPLRIDLQ PILAEALPIL ASFLRKNQRA LRLAALAALA ALAQSQGLGL
810 820 830 840 850
PPSTVRAVLA ELPSLVSEND MHVAQLAVDF LATVTRAQPA SLAEVSGPVL
860 870 880 890 900
AELLRLLHSP LLPAGVLAAA EGFLQALVGT RPPCVDYAEL VGLLTAPVYE
910 920 930 940 950
QVADGGPGLH KQVFHSLARC VAALAVACPQ EVVDTVNRLV SDARSPSSSP
960 970 980 990 1000
GVKVLAFLSL AEVGQVAGPG PQRELKAVLL EALGSPSEDV RAAASYALGR
1010 1020 1030 1040 1050
VGAGNLPDFL PFLLGQMEAE PRRRYLLLHS LREALGAAQP DSLKPYAEDV
1060 1070 1080 1090 1100
WALLFQRCEG AEEGTRGVVA ECLGKLVLVN PPFLLPRFRK QLAAGQPHTR
1110 1120 1130 1140 1150
CTVITAVKFL ISDQPHPIDP ILKTFVGEFM ESLQDPDLNV RRATLAFFNS
1160 1170 1180 1190 1200
AVHNKPSLVR DLLDDILPLL YQETKIRRDL IREVEMGPFK HTVDDGLDVR
1210 1220 1230 1240 1250
KAAFECMYSL LESCLGQLDI CEFLNHVEDG LKDHYDIRML TFIMLARLAT
1260 1270 1280 1290 1300
LCPVPVLQRV DRLIEPLRAT CTAKVKAGSV KQEFEKQDEL KRSAMRAVAT
1310 1320 1330 1340
LLTIPEVGKS PIMADFSSQI RSNPELAALF ESIQKDSASA PSTDSMELS
Length:1,349
Mass (Da):146,864
Last modified:October 10, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i67C21BC352659484
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_007461641.1, XM_007461579.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
103070302

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
lve:103070302

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_007461641.1, XM_007461579.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi103070302
KEGGilve:103070302

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23066

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR039852 CAND1/CAND2
IPR013932 TATA-bd_TIP120
PANTHERiPTHR12696 PTHR12696, 1 hit
PfamiView protein in Pfam
PF08623 TIP120, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A340XJR1_LIPVE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A340XJR1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 10, 2018
Last sequence update: October 10, 2018
Last modified: July 31, 2019
This is version 8 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
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