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Entry version 9 (31 Jul 2019)
Sequence version 1 (10 Oct 2018)
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Protein
Submitted name:

DEP domain-containing protein 5 isoform X2

Gene

DEPDC5

Organism
Lipotes vexillifer (Yangtze river dolphin)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DEP domain-containing protein 5 isoform X2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DEPDC5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLipotes vexillifer (Yangtze river dolphin)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri118797 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaOdontocetiLipotidaeLipotes
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000265300 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1188 – 1263DEPInterPro annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni427 – 451DisorderedSequence analysisAdd BLAST25
Regioni496 – 526DisorderedSequence analysisAdd BLAST31
Regioni697 – 723DisorderedSequence analysisAdd BLAST27
Regioni819 – 842DisorderedSequence analysisAdd BLAST24
Regioni1017 – 1038DisorderedSequence analysisAdd BLAST22
Regioni1057 – 1085DisorderedSequence analysisAdd BLAST29
Regioni1120 – 1167DisorderedSequence analysisAdd BLAST48

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi427 – 443PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1063 – 1081PolarSequence analysisAdd BLAST19

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000591 DEP_dom
IPR027244 IML1
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13179 PTHR13179, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00610 DEP, 1 hit
PF12257 IML1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00049 DEP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50186 DEP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

A0A340WUR5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTTKVYKLV IHKKGFGGSD DELVVNPKVF PYIKLGDIVE IAHPNDEYSP
60 70 80 90 100
LLLQVKSLKE DLQKETISVD QTVTQVFRLR PYQDVYVNVV DPKDVTLDLV
110 120 130 140 150
ELTFKDQYIG RGDMWRLKKS LVSTCAYITQ KVEFAGIRAQ AGELWVKNEK
160 170 180 190 200
VMCGYISEDT RVVFRSTSAM VYIFIQMSCE MWDFDIYGDL YFEKAVNGFL
210 220 230 240 250
ADLFTKWKEK NCSHEVTVVL FSRTFYDAKS LDEFPEINRA SIRQDHKGRF
260 270 280 290 300
YEDFYKVVVQ NERREEWTSL LVTIKKLFIQ YPVLVRLEQA EGFPQGDNST
310 320 330 340 350
SAQGNYLEAI NLSFNVFDKH YINRNFDRTG QMSVVITPGV GVFEVDRLLM
360 370 380 390 400
ILTKQRMIDN GIGVDLVCMG EQPLHAVPLF KLHNRSGPRD SRLGDDYNIP
410 420 430 440 450
HWINHSFYTS KSQLFCNSFT PRIKLAGKKP ASEKAKNGRD TSLGTPKESE
460 470 480 490 500
NTLPIQVDYD AYDAQVFRLP GPSRAQRLAT CRFSVRARAX XXXKSASSCD
510 520 530 540 550
VSSSPSLPPQ PLPTEEVRSQ ASDDSSLGRS ANILMIPHPH LHQYEVSSSL
560 570 580 590 600
GYTSTRDVLE NMMEPPQRDS SAPGRFHVGS AESMLHFRPG GYMPQRALIN
610 620 630 640 650
PFAPSRMPMK LTSNRRRWMH TFPVGPSGEA IQIHHQTRQN MAELQGSGQR
660 670 680 690 700
DPTHSSAELL ELAYHEATGR HSTSHQPGDG TSFLNFTGTE ELSVNLLSSS
710 720 730 740 750
GAGMNPRTQN KDSLEDSVST SPDPILTLSA PPVVPGFCCT VGVDWKSLTT
760 770 780 790 800
PACLPLTTDY FPDRQGLQND YTEGCYDLLP EADIDRRDEE GVQMTAQQVF
810 820 830 840 850
EEFVCQRLMQ GYQIIVQPRA QQPSPAGPPP LSSSPLYGRG LVSRNRPEEE
860 870 880 890 900
DQYWLSMGRT FHKVTLKDKM ITVTRYLPKY PYESAQIHYT YSLCPSHSDS
910 920 930 940 950
EFVSCWVEFS HERLEEYKWN YLDQYICSAG SEDFSLIESL KFWRTRFLLL
960 970 980 990 1000
PACVTATKRI TEGEAHCDIY GDRPRADEEE WQLLDGFIRF VEGLNRIRRR
1010 1020 1030 1040 1050
HRSDRMMRKG ATMKGLQMAG PIPTHSLEST GPPVGKKGTS ALSALLEMEA
1060 1070 1080 1090 1100
TQKCLGEQQA AVHGGKSSAT PAESSGVAMT PTYVDSPRKD GAFFMEFVRS
1110 1120 1130 1140 1150
PRTASSTFYP QVSVDQTATP MLDSTSLGVS TGQSVDRGNS QTFGNSQSSG
1160 1170 1180 1190 1200
EQGFPSANSS DSSSQQLAAS SLTSSSTLVE ILEAMKHPST GVQLLPEQKG
1210 1220 1230 1240 1250
LSPCCFISAE VVHWLVNNVD GVQTQAMAID IMQKMLEEQL ITHASGEVWR
1260 1270 1280 1290 1300
TFIYGFYFYK IVMDREPERV AVQQPTAWHT TAVDDFASFQ RKWFEVAFVA
1310 1320 1330 1340 1350
EELLHSEIPA FLLPWLPSRP ASYASRHSSF SRSFGGRSQA AALLAATVPE
1360 1370 1380 1390 1400
QRTVTLDVDV NNRTDRLEWC SCYYHGNFSL NAAFEIKLHW MAVTAAVLFE
1410 1420 1430 1440 1450
MVQGWHRKAT SCGFLLVPVL EGPFALPSYL YGDPLRAQLF IPLNISCLLK
1460 1470 1480 1490 1500
EGSEHLFDSF EPETYWDRMH LFQEAIAHRF GFVQDKYSAS AFNFPAETKP
1510 1520 1530 1540 1550
QYIHVTGTVF LQLPYSKRKF SGQPRRRRNS TSSASQSLFC EERVGYSWAY
1560 1570 1580 1590 1600
NTMLTKTWRS SATGDERFAD RLLKDFTDFC VNRDNRLVTF WTSCLEKMHA

SAP
Length:1,603
Mass (Da):180,933
Last modified:October 10, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i400C61DCC7465649
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A340X004A0A340X004_LIPVE
DEP domain-containing protein 5 iso...
DEPDC5
1,629Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A340WUS1A0A340WUS1_LIPVE
DEP domain-containing protein 5 iso...
DEPDC5
1,572Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A340WW17A0A340WW17_LIPVE
DEP domain-containing protein 5 iso...
DEPDC5
1,503Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A340X009A0A340X009_LIPVE
DEP domain-containing protein 5 iso...
DEPDC5
1,503Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A340X1P6A0A340X1P6_LIPVE
DEP domain-containing protein 5 iso...
DEPDC5
1,594Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A340X266A0A340X266_LIPVE
DEP domain-containing protein 5 iso...
DEPDC5
1,533Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_007453218.1, XM_007453156.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
103082580

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_007453218.1, XM_007453156.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Genome annotation databases

GeneIDi103082580

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9681

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR027244 IML1
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR13179 PTHR13179, 1 hit
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF12257 IML1, 1 hit
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A340WUR5_LIPVE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A340WUR5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 10, 2018
Last sequence update: October 10, 2018
Last modified: July 31, 2019
This is version 9 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
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