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Entry version 8 (31 Jul 2019)
Sequence version 1 (10 Oct 2018)
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Protein
Submitted name:

nuclear factor of activated T-cells 5 isoform X2

Gene

NFAT5

Organism
Lipotes vexillifer (Yangtze river dolphin)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
nuclear factor of activated T-cells 5 isoform X2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NFAT5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLipotes vexillifer (Yangtze river dolphin)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri118797 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaOdontocetiLipotidaeLipotes
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000265300 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini282 – 461RHDInterPro annotationAdd BLAST180

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni56 – 107DisorderedSequence analysisAdd BLAST52
Regioni131 – 161DisorderedSequence analysisAdd BLAST31
Regioni193 – 238DisorderedSequence analysisAdd BLAST46
Regioni259 – 283DisorderedSequence analysisAdd BLAST25
Regioni657 – 688DisorderedSequence analysisAdd BLAST32
Regioni976 – 1014DisorderedSequence analysisAdd BLAST39
Regioni1109 – 1131DisorderedSequence analysisAdd BLAST23
Regioni1216 – 1323DisorderedSequence analysisAdd BLAST108
Regioni1340 – 1385DisorderedSequence analysisAdd BLAST46
Regioni1493 – 1522DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi60 – 74PolarSequence analysisAdd BLAST15
Compositional biasi86 – 107PolarSequence analysisAdd BLAST22
Compositional biasi131 – 156PolarSequence analysisAdd BLAST26
Compositional biasi193 – 213PolarSequence analysisAdd BLAST21
Compositional biasi259 – 279PolarSequence analysisAdd BLAST21

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
2.60.40.340, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR008366 NFAT
IPR015646 NFAT5
IPR008967 p53-like_TF_DNA-bd
IPR032397 RHD_dimer
IPR011539 RHD_DNA_bind_dom
IPR037059 RHD_DNA_bind_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12533 PTHR12533, 1 hit
PTHR12533:SF10 PTHR12533:SF10, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16179 RHD_dimer, 1 hit
PF00554 RHD_DNA_bind, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01789 NUCFACTORATC

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00429 IPT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50254 REL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A340WQR2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSDFISLLS ADLDLESPKS LYSRDSLKLH PSQNFHRAGL LEESVYDLLP
60 70 80 90 100
KELQLPPSRE PSVASMSQTS GGEAGSPPPA VVAADASSAP SSSSMGGACS
110 120 130 140 150
SFTTSSSPTI YSTSVTDSKA MQMESCSSAL GVSNRGVSEK QLTSNTVQQH
160 170 180 190 200
PSTPKRHTVL YISPPPEDLL DNSRMSCQDE GCGLESEQSC SMWMEDSPSN
210 220 230 240 250
FSNMSTSSYN DNTEVPRKSR KRNPKQRPGV KRRDCEESNM DIFDADSAKA
260 270 280 290 300
PHYVLSQLTT DNKGNSKAGN GTLENQKGTG VKKSPMLCGQ YPVKSEGKEL
310 320 330 340 350
KIVVQPETQH RARYLTEGSR GSVKDRTQQG FPTVKLEGHN EPVVLQVFVG
360 370 380 390 400
NDSGRVKPHG FYQACRVTGR NTTPCKEVDI EGTTVIEVGL DPTNNMTLAV
410 420 430 440 450
DCVGILKLRN ADVEARIGIA GSKKKSTRAR LVFRVNITRK DGSTLTLQTP
460 470 480 490 500
SSPILCTQPA GVPEILKKSL HSCSVKGEEE VFLIGKNFLK GTKVIFQENV
510 520 530 540 550
SDENSWKSEA EIDMELFHQN HLIVKVPPYH DQHITLPVSV GIYVVTNAGR
560 570 580 590 600
SHDVQPFTYT PDPAAAALNV NVKKEISSPA RPCSFEEAMK AMKTAGCNLD
610 620 630 640 650
KVNILPNALI TPLISSSVIK SEDVTPMEVT AEKRSSPIFK TTKTVGSTQQ
660 670 680 690 700
TLENISNIAG NGSFSSSSSS SHLPSENEKQ QQIQPKAYNP ETLTTIQTQD
710 720 730 740 750
ISQPGTFPAV SASSQLPNSD ALLQQATQFQ TRETQSREVL QSDGTVVNLS
760 770 780 790 800
HLTEASQQQQ QSPLQEQAQT LQQQISSNIF PSPNSVSQQL QNTIQQLQAG
810 820 830 840 850
SFTGSTTSGS NGNVDLVQQV LEAQQQLSSV LFSAPDGNEN VQEQLSADIF
860 870 880 890 900
QQVSQIQNSV SPGMFSSTEP AVHTRPDNLI AGRAESVHPQ NENTLSNQQQ
910 920 930 940 950
QQQQQQVMES SAAMVIEMQQ SICQAAAQIQ SELFPSTASA NGNLQQSPVY
960 970 980 990 1000
QQTSHMMSAL SANEDMQMQC ELFSSPPAVS GNETATTTTQ QVATPGTTMF
1010 1020 1030 1040 1050
QTSSSADGEE TGTQAKQIQN SVFQTMVQMQ HSGDSQPQVS LFSSTKSMIS
1060 1070 1080 1090 1100
VQNNGTQQQG NGLFQQGNEM MSLQSGNFLQ QSSHSQAQLF HPQNPIADAQ
1110 1120 1130 1140 1150
NLSQETQGSI FHSPSPIVHS QTSTTSSEQM QPPMFHSQNT MAVLQGSSVP
1160 1170 1180 1190 1200
QDQQSANIFL SQSPMNNLQT NTVAQEEQIS FFAAQNSISP LQSTSNTEQQ
1210 1220 1230 1240 1250
AAFQQQAPIS HIQTPMLSQE QAQPSQQGLF QPQVSLGSLP PNPMPQNQQG
1260 1270 1280 1290 1300
AIFQSQHSMV AIQSNSASQE QQQQQQQQQQ QQQQQQSILF SNQNTMAPLA
1310 1320 1330 1340 1350
SQKQPPPNMI FNPSQNPMAN QEQQNQSIFH QQNNMAPMNQ EQQPMQFQNQ
1360 1370 1380 1390 1400
PTVSSLQNPG PAQSESSQTS LFHSSPQIQL VQGSPTSQEQ QVTLFLSPAS
1410 1420 1430 1440 1450
MSALQNSINQ QDMQQSPLYS PQNNMPGIQG ATSSPQPQAT LFHNTTGGTM
1460 1470 1480 1490 1500
NQLQNSPGSS QQTSGMFLFG IQNNCSQLLT SGPATLPDQL MAISQPGQPQ
1510 1520 1530 1540 1550
NEGQPPVTTL LSQQMPENSP LASSINTNQN IEKIDLLVSL QNQGNNLTGS

F
Length:1,551
Mass (Da):168,099
Last modified:October 10, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3D12DFE43D735124
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A340WMP7A0A340WMP7_LIPVE
nuclear factor of activated T-cells...
NFAT5
1,552Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A340WK81A0A340WK81_LIPVE
nuclear factor of activated T-cells...
NFAT5
1,534Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A340WSE1A0A340WSE1_LIPVE
nuclear factor of activated T-cells...
NFAT5
1,533Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A340WSP9A0A340WSP9_LIPVE
nuclear factor of activated T-cells...
NFAT5
1,458Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_007449982.1, XM_007449920.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
103069147

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_007449982.1, XM_007449920.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi103069147

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10725

Family and domain databases

Gene3Di2.60.40.10, 1 hit
2.60.40.340, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR008366 NFAT
IPR015646 NFAT5
IPR008967 p53-like_TF_DNA-bd
IPR032397 RHD_dimer
IPR011539 RHD_DNA_bind_dom
IPR037059 RHD_DNA_bind_dom_sf
PANTHERiPTHR12533 PTHR12533, 1 hit
PTHR12533:SF10 PTHR12533:SF10, 1 hit
PfamiView protein in Pfam
PF16179 RHD_dimer, 1 hit
PF00554 RHD_DNA_bind, 1 hit
PRINTSiPR01789 NUCFACTORATC
SMARTiView protein in SMART
SM00429 IPT, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50254 REL_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A340WQR2_LIPVE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A340WQR2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 10, 2018
Last sequence update: October 10, 2018
Last modified: July 31, 2019
This is version 8 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
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