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Entry version 11 (11 Dec 2019)
Sequence version 1 (10 Oct 2018)
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Protein
Submitted name:

MDS1 and EVI1 complex locus protein EVI1 isoform X1

Gene

MECOM

Organism
Lipotes vexillifer (Yangtze river dolphin)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
MDS1 and EVI1 complex locus protein EVI1 isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MECOMImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLipotes vexillifer (Yangtze river dolphin)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri118797 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaWhippomorphaCetaceaOdontocetiLipotidaeLipotes
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000265300 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 147SETInterPro annotationAdd BLAST113
Domaini166 – 194C2H2-typeInterPro annotationAdd BLAST29
Domaini220 – 247C2H2-typeInterPro annotationAdd BLAST28
Domaini248 – 275C2H2-typeInterPro annotationAdd BLAST28
Domaini276 – 305C2H2-typeInterPro annotationAdd BLAST30
Domaini306 – 333C2H2-typeInterPro annotationAdd BLAST28
Domaini334 – 361C2H2-typeInterPro annotationAdd BLAST28
Domaini363 – 390C2H2-typeInterPro annotationAdd BLAST28
Domaini879 – 906C2H2-typeInterPro annotationAdd BLAST28
Domaini907 – 935C2H2-typeInterPro annotationAdd BLAST29
Domaini936 – 963C2H2-typeInterPro annotationAdd BLAST28

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni468 – 488DisorderedSequence analysisAdd BLAST21
Regioni504 – 578DisorderedSequence analysisAdd BLAST75
Regioni676 – 779DisorderedSequence analysisAdd BLAST104
Regioni957 – 977DisorderedSequence analysisAdd BLAST21
Regioni998 – 1080DisorderedSequence analysisAdd BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi469 – 488PolarSequence analysisAdd BLAST20
Compositional biasi505 – 537PolyampholyteSequence analysisAdd BLAST33
Compositional biasi538 – 558PolarSequence analysisAdd BLAST21
Compositional biasi560 – 578PolyampholyteSequence analysisAdd BLAST19
Compositional biasi719 – 743PolarSequence analysisAdd BLAST25
Compositional biasi744 – 764PolyampholyteSequence analysisAdd BLAST21
Compositional biasi961 – 976PolarSequence analysisAdd BLAST16
Compositional biasi998 – 1012PolarSequence analysisAdd BLAST15
Compositional biasi1033 – 1052AcidicSequence analysisAdd BLAST20
Compositional biasi1066 – 1080PolyampholyteSequence analysisAdd BLAST15

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K04462

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001214 SET_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00317 SET, 1 hit
SM00355 ZnF_C2H2, 10 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50280 SET, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A340WHH6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPDADGVAST LSLNIQEPCS PATSSEAFTP KEGPAEFELR ESNMPGAGLG
60 70 80 90 100
IWTKRKIEAG EKFGPYVGEQ RSNLKDPSYG WEILDEFCNV KFCIDASQPD
110 120 130 140 150
VGSWLKYIRF AGCYDQHNLV ACQINDQIFY RVVADIAPGE ELLLFMKSED
160 170 180 190 200
YPHDTMAPDI HEERQYRCED CDQLFESKAE LADHQKFPCS TPHSAFSMVE
210 220 230 240 250
EDFQQKLESE NDLREIHAIQ ECKECDQVFP DLQSLEKHML SHTEEREYKC
260 270 280 290 300
DQCPKAFNWK SNLIRHQMSH DSGKHYECEN CAKQVFTDPS NLQRHIRSQH
310 320 330 340 350
VGARAHACPE CGKTFATSSG LKQHKHIHSS VKPFICEVCH KSYTQFSNLC
360 370 380 390 400
RHKRMHADCR TQIKCKDCGQ MFSTTSSLNK HRRFCEGKNH FAAGGFFGQG
410 420 430 440 450
ISLPGTPAMD KTSMVNMSHA NPGLADYFGA NRHPAGLTFP TAPGFSFSFP
460 470 480 490 500
GLFPSGLYHR PPLIPASSPV KGLSSTEQTN KSQSPLMTHP QILPATQDIL
510 520 530 540 550
KALSKHPPVG DDKPVEFQPE RSSEERPLEK ISDQSESSDL DDVSTPSGSD
560 570 580 590 600
LETTSGSDLE SDIESDKEKF KENGKMFKDK VSPLPNLASI HNKKEYSNHS
610 620 630 640 650
IFSPSLEEQT AVSGAVNDSI KAIASIAEKY FGSAGLVGLQ DKKVGALPYP
660 670 680 690 700
SMFPLPFFPA FSQSMYPFPD RDLRSLPLKM EPQSPSEVKK LQKGSSESPF
710 720 730 740 750
DLTTKRKDEK PLTSVPAKPP VTPATSQDQP LDLSMGSRSR ASGTKLTEPR
760 770 780 790 800
KNHVFGEKKG GNGEPRPASD GSLQHARPTP FFMDPIYRVE KRKLTDPLEA
810 820 830 840 850
LKEKYLRPSP GFLFHPQFQL PDQRTWMSAI ENMAEKLESF SALKPEASEL
860 870 880 890 900
LQSVPSMFNF RAPPNALPEN LLRKGKERYT CRYCGKIFPR SANLTRHLRT
910 920 930 940 950
HTGEQPYRCK YCDRSFSISS NLQRHVRNIH NKEKPFKCHL CDRCFGQQTN
960 970 980 990 1000
LDRHLKKHEN GNMSGTATSS PHSELESTGA ILDDKEDAYF TEIRNFIGNS
1010 1020 1030 1040 1050
NHSSQSPRNT EERMNGSHFK DEKALVTSQN SDLLDDEEVE DEVLLDEEDE
1060 1070 1080 1090 1100
DNDITGKTGK EPGTSALHEG NHEDDYEDTS ALEMSCKTSP MRYKEEEYKT
1110 1120 1130 1140 1150
GLSALDHIRH FTDSLKMRKM EDNQYTEAEV SSFSASHVPE ELKQPLHRKS
1160 1170 1180 1190
KSQAYAMMLS LSDKESLHSS SHNSSNVWHS MARAAAESSA IQSISHV
Length:1,197
Mass (Da):134,431
Last modified:October 10, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i701C3474AB17EC27
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A340WD38A0A340WD38_LIPVE
MDS1 and EVI1 complex locus protein...
MECOM
1,196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A340WG12A0A340WG12_LIPVE
MDS1 and EVI1 complex locus protein...
MECOM
1,187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_007446490.1, XM_007446428.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
103078502

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
lve:103078502

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_007446490.1, XM_007446428.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi103078502
KEGGilve:103078502

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2122

Phylogenomic databases

KOiK04462

Family and domain databases

InterProiView protein in InterPro
IPR001214 SET_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00317 SET, 1 hit
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50280 SET, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A340WHH6_LIPVE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A340WHH6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 10, 2018
Last sequence update: October 10, 2018
Last modified: December 11, 2019
This is version 11 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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