UniProtKB - A0A336TY74 (A0A336TY74_HUMAN)
Protein
Submitted name:
CASP8 and FADD-like apoptosis regulator, isoform CRA_a
Gene
CFLAR
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- cysteine-type endopeptidase activity Source: InterPro
GO - Biological processi
- regulation of apoptotic process Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: CASP8 and FADD-like apoptosis regulator, isoform CRA_aImportedSubmitted name: Usurpin-beta splice variantImported |
Gene namesi | Name:CFLARImported ORF Names:hCG_16553Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 73 | DEDInterPro annotationAdd BLAST | 73 | |
Domaini | 92 – 170 | DEDInterPro annotationAdd BLAST | 79 | |
Domaini | 263 – 358 | CASPASE_P20InterPro annotationAdd BLAST | 96 |
Sequence similaritiesi
Belongs to the peptidase C14A family.ARBA annotation
Keywords - Domaini
RepeatARBA annotationFamily and domain databases
CDDi | cd00032, CASc, 1 hit |
InterProi | View protein in InterPro IPR029030, Caspase-like_dom_sf IPR011029, DEATH-like_dom_sf IPR001875, DED_dom IPR002398, Pept_C14 IPR001309, Pept_C14_p20 IPR015917, Pept_C14A |
PANTHERi | PTHR10454, PTHR10454, 1 hit |
Pfami | View protein in Pfam PF01335, DED, 2 hits |
SMARTi | View protein in SMART SM00115, CASc, 1 hit SM00031, DED, 2 hits |
SUPFAMi | SSF47986, SSF47986, 2 hits SSF52129, SSF52129, 1 hit |
PROSITEi | View protein in PROSITE PS50208, CASPASE_P20, 1 hit PS50168, DED, 2 hits |
i Sequence
Sequence statusi: Complete.
A0A336TY74-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL
60 70 80 90 100
SVGDLAELLY RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI
110 120 130 140 150
GEDLDKSDVS SLIFLMKDYM GRGKISKEKS FLDLVVELEK LNLVAPDQLD
160 170 180 190 200
LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT SYRNVLQAAI QKSLKDPSNN
210 220 230 240 250
FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP EERYKMKSKP
260 270 280 290 300
LGICLIIDCI GNETELLRDT FTSLGYEVQK FLHLSMHGIS QILGQFACMP
310 320 330 340 350
EHRDYDSFVC VLVSRGGSQS VYGVDQTHSG LPLHHIRRMF MGDSCPYLAG
360 370 380 390 400
KPKMFFIQNY VVSEGQLEDS SLLEVDGPAM KNVEFKAQKR GLCTVHREAD
410 420 430 440 450
FFWSLCTADM SLLEQSHSSP SLYLQCLSQK LRQERGTIPG SGITESKDMH
460
FSSLGCILLD VL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KR422625 mRNA Translation: AMY98472.1 CH471063 Genomic DNA Translation: EAW70235.1 |
RefSeqi | NP_001294971.1, NM_001308042.1 XP_016860681.1, XM_017005192.1 XP_016860682.1, XM_017005193.1 XP_016860683.1, XM_017005194.1 |
Genome annotation databases
GeneIDi | 8837 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KR422625 mRNA Translation: AMY98472.1 CH471063 Genomic DNA Translation: EAW70235.1 |
RefSeqi | NP_001294971.1, NM_001308042.1 XP_016860681.1, XM_017005192.1 XP_016860682.1, XM_017005193.1 XP_016860683.1, XM_017005194.1 |
3D structure databases
SMRi | A0A336TY74 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 19934, 924 antibodies |
Genome annotation databases
GeneIDi | 8837 |
Organism-specific databases
CTDi | 8837 |
Miscellaneous databases
ChiTaRSi | CFLAR, human |
Family and domain databases
CDDi | cd00032, CASc, 1 hit |
InterProi | View protein in InterPro IPR029030, Caspase-like_dom_sf IPR011029, DEATH-like_dom_sf IPR001875, DED_dom IPR002398, Pept_C14 IPR001309, Pept_C14_p20 IPR015917, Pept_C14A |
PANTHERi | PTHR10454, PTHR10454, 1 hit |
Pfami | View protein in Pfam PF01335, DED, 2 hits |
SMARTi | View protein in SMART SM00115, CASc, 1 hit SM00031, DED, 2 hits |
SUPFAMi | SSF47986, SSF47986, 2 hits SSF52129, SSF52129, 1 hit |
PROSITEi | View protein in PROSITE PS50208, CASPASE_P20, 1 hit PS50168, DED, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A336TY74_HUMAN | |
Accessioni | A0A336TY74Primary (citable) accession number: A0A336TY74 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 10, 2018 |
Last sequence update: | October 10, 2018 | |
Last modified: | October 7, 2020 | |
This is version 13 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |