Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 7 (11 Dec 2019)
Sequence version 1 (10 Oct 2018)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Malformin synthetase mlfA

Gene

mlfA

Organism
Aspergillus sclerotiicarbonarius (strain CBS 121057 / IBT 28362)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of malformins, cyclic pentapeptides with a disulfide bond between 2 consecutive cysteins, that show potential anti-tumor as well as antimalarial and antitrypanosomal properties (PubMed:30560908). The nonribosomal peptide synthetase mlfA is responsible of the formation of the cyclic pentapeptide (Probable). The malformin biosynthesis clusters in malformin-producing fungi also contain enzymes involved in the formation of the disulfide bond between the two consecutive cysteins within malformins, in addition to additionnal tailoring enzymes such as methyltransferases or oxidoreductases. They are also composed of up to 4 major facilitator superfamily transporters, and transcription factors probably involved in the regulation of the expression of those clusters (Probable).1 Publication1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Secondary metabolite biosynthesis

This protein is involved in Secondary metabolite biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in Secondary metabolite biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Malformin synthetase mlfA1 Publication (EC:6.3.2.-1 Publication)
Alternative name(s):
Malformin biosynthesis cluster protein A1 Publication
Nonribosomal peptide synthetase mlfA1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mlfA1 Publication
ORF Names:BO78DRAFT_455717
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAspergillus sclerotiicarbonarius (strain CBS 121057 / IBT 28362)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1448318 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000248423 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

Malformins show anti-tumor properties against human colorectal and prostate cancer cells by the inhibition of proliferation and induction of apoptosis through the activation of the p38 signaling pathway (PubMed:26540166, PubMed:26645406, PubMed:28713983). Malformin C has also been shown to exhibit potent antimalarial and antitrypanosomal properties (PubMed:19876076).4 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004464381 – 5099Malformin synthetase mlfAAdd BLAST5099

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei790O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei1894O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3069O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei4618O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini756 – 829Carrier 1PROSITE-ProRule annotationAdd BLAST74
Domaini1857 – 1934Carrier 2PROSITE-ProRule annotationAdd BLAST78
Domaini3032 – 3108Carrier 3PROSITE-ProRule annotationAdd BLAST77
Domaini4581 – 4657Carrier 4PROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni224 – 615Adenylation 1Sequence analysisAdd BLAST392
Regioni867 – 1297Condensation 1Sequence analysisAdd BLAST431
Regioni1325 – 1717Adenylation 2Sequence analysisAdd BLAST393
Regioni2067 – 2482Condensation 2Sequence analysisAdd BLAST416
Regioni2505 – 2897Adenylation 3Sequence analysisAdd BLAST393
Regioni3125 – 3589Condensation 3Sequence analysisAdd BLAST465
Regioni3610 – 4033Condensation 4Sequence analysisAdd BLAST424
Regioni4058 – 4446Adenylation 4Sequence analysisAdd BLAST389
Regioni4696 – 5017Condensation 5Sequence analysisAdd BLAST322

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module. Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product. Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, epimerase (E) domains (responsible for L- to D- amino acid conversion) are present within the NRP synthetase. MlfA has the following architecture: A-T-C-A-T-C-A-T-C-C-A-T-C, with the functions of the five condensation domains during malformin biosynthesis being DL-joining (epimerizing subtype), LL-joining, epimerization, DL-joining and cyclizing domain, respectively.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRP synthase family.Curated

Keywords - Domaini

Repeat

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 4 hits
3.30.559.10, 5 hits
3.40.50.12780, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071 AA_adenyl_domain
IPR036736 ACP-like_sf
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501 AMP-binding, 4 hits
PF00668 Condensation, 5 hits
PF00550 PP-binding, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823 PKS_PP, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336 SSF47336, 4 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733 AA-adenyl-dom, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455 AMP_BINDING, 3 hits
PS50075 CARRIER, 4 hits
PS00012 PHOSPHOPANTETHEINE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A319DV72-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRFSCIFPS LTDGYIPDPA HCRAAGRRVY EIDLGGWGPL PDRPDAHLVA
60 70 80 90 100
AWALILSSYV GTDEVAFYVV PARGPDATAL CELKVNGSLP RRSLTDDAWQ
110 120 130 140 150
LLHPLPLGPG QVSSETANTI ITFAEDIDPL FITQAEEAFL TLHVRNTSPG
160 170 180 190 200
NVALHLGYHL SLFTDAQAAN VGTAMAQVLT SLAGDPDELV RDVDHMSRTH
210 220 230 240 250
LDQIWHFNAN VPSTWQECFH DVVQRHAADR PHSLAIDAWD GRLTYAELVG
260 270 280 290 300
KATPLARHMQ ERGVRPGVVV PISFERSAGA LIAMLAVSKA GGAFVSVPTS
310 320 330 340 350
LPPGRLDAIL EVIEAPFVLT RSTHQSFWAG RLPALIIDNY PKPASTAVVE
360 370 380 390 400
TLAKADDLFY VIFTSGSTGR PKGCMLSHSN WLNGALRNAP NWKYGPNSRV
410 420 430 440 450
LQMLNHTFDM SLLEICTSLG SGACVCIPPA DEVEAGLAGA INRWQVNHVI
460 470 480 490 500
MTPSLARALR PGDVPGLRTM CLGGEAFPRE IVTMWSECIH LFQFYGPSEC
510 520 530 540 550
SINSSTRAIT GVDADPLNIG PPNSAACWVS DIQDHNKLVP IGAIGELLVS
560 570 580 590 600
GPIVGMGYLR NPVKTAEAFI DHVGFIPMDD PKFAGFRLYK TGDLVRWNSD
610 620 630 640 650
GTLTFCGRAD TQVKLNGQRL ELAEVEYQLG LEADVQLAIA LVPQVGRCKN
660 670 680 690 700
NLIAILTVRG AATSSRGVTA GEIPLLNRQD PIVQQAVKRL RAQLQQALPR
710 720 730 740 750
YMVPTIWAFV GHMPMSASGK IDRVRVRGWV EEMSQETFDA ITGRSFEADD
760 770 780 790 800
HLLGLTHLEN EIQLAWAEAL GLSAAEVGLH QPFVALGGDS IKALDAVGRC
810 820 830 840 850
RARQVDITMV STLSCEGVRE AASLAKVRDS PTQRVVEMAV DYSDLWDCLS
860 870 880 890 900
SDYDLAKLGI GNADEVEDVF PCTSMQEGMF LGQIRRPGAY HMRFFHRVQL
910 920 930 940 950
KGGGLPTVER IQTAWSSLVA RHPSLRTIFV DDLSPEAIYH SVVLRNVPVD
960 970 980 990 1000
TTTREVPRDL SPEDALSMFT QELVPFRPNA PLHRLRLFTC RGRVSYFMLE
1010 1020 1030 1040 1050
ISHVIMDGYA LSVFRREFIQ ACSTPASVPR GPDYRMFANY HRTRQTADSA
1060 1070 1080 1090 1100
AYWTAYLKDA APCHIPTYDQ AMAADGLDYP RTLLRRDFSY QTSGTFLQRC
1110 1120 1130 1140 1150
KERQVTLACA IRATWALVLR AYTQSQDVCF GYVSSGRNVP VPDVETIFGL
1160 1170 1180 1190 1200
CLSMQVCRAR VGESRTLVDL ARRIQEDYVE SLPYQHYPLA EVQRGLKQTR
1210 1220 1230 1240 1250
RQALFNTAIS MEWVPPAGDD EDALIDLEEI REQDDPTEYD IAISVDVHAG
1260 1270 1280 1290 1300
CIKLGFLYWP TLTEFEITHL AQAMQGAMDC FALQPDGPVD SLTLLKPGDL
1310 1320 1330 1340 1350
SSALVGWPDL LPLEAVRGNV MSMIDRWVNR QPDTLAIDGW DESLTYHQLQ
1360 1370 1380 1390 1400
QQSSWVARNL LHRGVHQGDR ILVCMDRSSR TVVTILGIVR SGAVLVLSNP
1410 1420 1430 1440 1450
ADPAKRLQWL TQKCNAAMIV ADPQYRDRFE APGNPSVTVV DAPSVCTPAA
1460 1470 1480 1490 1500
WDYLFPVLDG QDPVSILFTS GSTGTPKGIV MHHGSLATSV LLGHGRTLRF
1510 1520 1530 1540 1550
SRQTRMLHFA SLTFDAALAE IFTTLAHGGC MCIPSEDDRL SDVPGCIARF
1560 1570 1580 1590 1600
KVNTAMLTPS VGRILDPAAL PTLRTLVLVG EPMSRLDVER FAPALDLYNG
1610 1620 1630 1640 1650
AGPTETSIMV TIAGPMQPTD DPLNLGHAVA GVRLWVTETE APNRLAPLGA
1660 1670 1680 1690 1700
VGELVVEGSL VTQGYLDDPV RTQEAFLSKL AWLPSHNPLY RTGDLVRYVA
1710 1720 1730 1740 1750
DGSFRYMGRK DTQVKLRGQR IELQEVEYHL RCSWPHAQVV VEMVIPDGRT
1760 1770 1780 1790 1800
RSQAALVAFV SGLTPEDAHF LFNGALISAE APGIAQAVLS EKTTQALSEA
1810 1820 1830 1840 1850
LPRHMVPSIY LALETIPLSV NGKADRRRLR DLGASWLASS AFHPGPECLQ
1860 1870 1880 1890 1900
TPTAEWARAP ELERTLVELW ATTLSIEPGA IRGDDSFFEL GGDSVSAMKL
1910 1920 1930 1940 1950
VATARDKYKL SLSVPQVFRY PTIRQIATQC EGIAVQLASS ASSTTEEGFT
1960 1970 1980 1990 2000
FSTPDESSTN EGLDGEFWQL ASAQLADLAR EKGKTLDVAA ILKRMQQESS
2010 2020 2030 2040 2050
SSPAPSVSSS SSSSSAPKPL LAQPEPPTNL RDSVPEPFSL IGGGPSAVEQ
2060 2070 2080 2090 2100
ICQQAMEQCQ IPRESIEDIY PATPLQEGMM ALMAKTPGVY TTTLRCELSN
2110 2120 2130 2140 2150
QVDCARLQSA WDQASEAHPI LRTRIVLTND HRAMQVVQHG NRLPWDVYSL
2160 2170 2180 2190 2200
RDSDNLPDLT SQMTLGSPLL RLAEIRQAGG QGRLLLVTIH HALYDGWSFP
2210 2220 2230 2240 2250
LVKQAVEDAY SGQALKSQAF TPFIAYLNEG RLAAEQFWAD HLESFAGGAF
2260 2270 2280 2290 2300
PCLPTVDHRI RPTARLTRKL SLPVSAGHQY TLATKIQAAW AVTVSRYDDE
2310 2320 2330 2340 2350
TDVVFGTVST GRAAPVPGID RVAGPTITTI PVRVSLQDRA QRVGPFLQKV
2360 2370 2380 2390 2400
QEDGWRSLDH EHLGLQHIRR LGDSAAAACR LQTLLVLQPR QQPPAEPSSA
2410 2420 2430 2440 2450
ILAGLQDMAE LEGLDTYPLM LVCEPDGADV HLIAIFDPVV LHEAILARMV
2460 2470 2480 2490 2500
THWEHVLTQL WTEPDIAVVD LEALSPGDKK VLMRWNGASQ LPDGCVHESV
2510 2520 2530 2540 2550
HQWRLSTPHA PAVCAWDGDW TYEELDNLSS ALAHHLTLHG VSHGTSVALY
2560 2570 2580 2590 2600
HEKSRWAAVG LLAVFKAGGI LVTLDPAHPV DRLREILGQV QARVILSSQE
2610 2620 2630 2640 2650
HEATAKALGT LVLTVEEVAT QPEPELFRPV GPITSSQCAF TPFTSGSTGR
2660 2670 2680 2690 2700
PKGIPLEHRG MVATIASMAE RCLLTTTSRV LQFASFAFDA SVMEHLLAWY
2710 2720 2730 2740 2750
AGGCLCVPSE FDRQANLGEV IRDLRVNWAF LTPSCLRLIT PDDVPCLEGM
2760 2770 2780 2790 2800
GLGGEPVLPE HITTWAPRLR QLVQMYGPAE CSFVTVLTEV TQASENRLIG
2810 2820 2830 2840 2850
SPSACRCWVI DPMDPDRLMP LGAIGELVIE GLAVGRGYIN EPQRTAEAFI
2860 2870 2880 2890 2900
APPPWLQTLY PDDGQPRRLY RTGDLVRYAG DDGRLTFVGR KDGQLKLHGQ
2910 2920 2930 2940 2950
RIELGDVETH LRPLIPATQG IAVEMIVCAD DQNPLLAAFI EVSQDATALQ
2960 2970 2980 2990 3000
RNTHLVHPGR VQSAVDIKAI ESTLARTVPH YMVPSIYLHI SKLPLNPSGK
3010 3020 3030 3040 3050
LNRRQLREMV GALPRQSLNE YAIKCHSSTT NRPATAQERG LQTIWATVLA
3060 3070 3080 3090 3100
LDRDAIGVHD DFFRMGGDSI AGMQVATKCN AAGMRISSAD LFRHRTIARL
3110 3120 3130 3140 3150
VLHLQNTSQE SSAMITLPEE KFDEWVHLAP IQQLFFENAP DGPNHFNQSL
3160 3170 3180 3190 3200
LLRTGRQVDA QELAAGLDIL VQRHSMLRAR FRRTDSGRWT QQVMSLGPSP
3210 3220 3230 3240 3250
SSFYRLFTHG KASPETLPGI FTASQSAIDI QKGPLLSVDL VDLTDGSQLV
3260 3270 3280 3290 3300
YFVAHHLVID LVSWRILHAE LEDYLRTGSL AAMAESTPFL TWCRAQAEYS
3310 3320 3330 3340 3350
AKELSPAQSL PGYQSAANHF DPEGYWGISM ESNTFTQVAS YRFTLDGDTT
3360 3370 3380 3390 3400
ETLFGVANDA LGTQPVEIML AALWYSFTQT LTGRPEPSIY VEGHGREPWT
3410 3420 3430 3440 3450
DTIDLSGTVG WFTTMSPLVS SPWSNLSQAS MRDFADALRY IKDQRRRVPA
3460 3470 3480 3490 3500
NGWAYFASRY LNDEGRVVYG RTNPAVEILF NYMGQYQQLT REDAILQLVG
3510 3520 3530 3540 3550
DDIQAGTGAA DIAGDVRRFA LIDVSAFTAH GCLSFDFSFP ESIQHRDRLQ
3560 3570 3580 3590 3600
HWFEQCRQTL IVAASILSLQ TPQKTLTDFP LLPSLTYDQL SQCLDHTLPA
3610 3620 3630 3640 3650
VGLFPSDIVD IYPCSPVQRG MLLAQLRNPQ FYQQRFRFRV LPDTRTEAIG
3660 3670 3680 3690 3700
LVGLQQVRDA WIEVINRHDI LRTIFLPVSD QGYVDQVLLK PGSLHHLVRI
3710 3720 3730 3740 3750
GAGEPDTAID PGTPHWVNIS HDPTGTVVCD WNVSHALVDA VSVAIIQREV
3760 3770 3780 3790 3800
SQALQGHLST PPPQQYGNYI QWLSAQNMQE TQDYWKKYLQ AVEPCLFPRL
3810 3820 3830 3840 3850
AAHSDRLTSP VGIQATRATV DREVRIDQLC HQHGITLTNV FHLVWALVLR
3860 3870 3880 3890 3900
TYVGTNNVCF GYATQGRDVP VAGVEEMVGP VVNVLATTLR LQDSESVLDA
3910 3920 3930 3940 3950
LQTHQTHLAD NLAHQNHALV DIYATHGVAG SQLFNTIVSL QDLSHHETAD
3960 3970 3980 3990 4000
TQSLRLEVMP AHDSSEYDIA LNVGVNKTSI ELVCSYQTWS LSAEHADALL
4010 4020 4030 4040 4050
RTAARVLDEI LQTPLKTIGE VDVVSLTCKQ QAMRWNATLP ATVHEYVHEQ
4060 4070 4080 4090 4100
IQAQCRLYAN REAVCAWDGH FTFAEIDDLS SRLAGNLISL GAQPGRIVPI
4110 4120 4130 4140 4150
YSPKSRWVVI AILGVLKAGA AFTLLDASHP VARLQEICQG VNADLIISLA
4160 4170 4180 4190 4200
SHASVAAQLA AAIVILDNAP SMSSDEIIMC TRRQSLSTES LAYVIFTSGS
4210 4220 4230 4240 4250
TGKPKGVMVS HSNLCTSAMA QTVALNLTTE SRVLQFASYA FDACILEVIG
4260 4270 4280 4290 4300
ALFAGACVCI PSETDSKDDL VGSIERMRVT WALLTPSVAR ILNQETLPTL
4310 4320 4330 4340 4350
ETLVLGGEPI TLSDLEPWRS RLQLVCAYGP SECTIVSTTT ALSTFPNRSK
4360 4370 4380 4390 4400
NIGQRGACAT WVVDPQDYQK LVPFGATGEL LIEGPIVGQG YLGDAVRTAE
4410 4420 4430 4440 4450
CFPPPPRWLS QLRQAPTRVY RTGDLVRYES DGTIRFVGRK DSQIKFHGQR
4460 4470 4480 4490 4500
IELGDIEHHA QDAFRDAQTV IIDLITPGEL HKAYLAAFVL QKDTDAHLDK
4510 4520 4530 4540 4550
VDDDCILLSP SDRFRSRSLA AQEQMHEELP HYMVPAIFLP LSRVPLAKTG
4560 4570 4580 4590 4600
KTDRQYLRQC ALALQGHDLE AYRAASSTKR PPSTGMQQGI QALVATVLGK
4610 4620 4630 4640 4650
DTTEVGMDDS FFHLGGDSVQ AMRLVSVGRQ QGLAVSVLSI FDHPRLADLA
4660 4670 4680 4690 4700
EHISSRVKDR NSVRLPSSSL LPSISEAGQL DRLVEGHPFE KDDVVDILPT
4710 4720 4730 4740 4750
TGFQRYWLDM QLSSYVIIDI PGQVDWAQLT KALQRVIENC PILRTAFVPY
4760 4770 4780 4790 4800
RGSTVQVILK TIVSLIEVDL TGDLTSAVEE WCRQDAKTPV SPGTSYMHTV
4810 4820 4830 4840 4850
RASQGATQHK LIMRLSHAQY DAVALSLVLN HLSCTYADQL PLPDAPAFSD
4860 4870 4880 4890 4900
YLTYQRTRNK ERASSDFWGQ LLKGASITNL GPQGSRDDKE ATIARSRHIS
4910 4920 4930 4940 4950
VGPLPRGITM ATVVKAAWSL ILARRTGMCD VLFGQVVHGR NTSFPGIERV
4960 4970 4980 4990 5000
VGPCTNITPV RASIAPQWTG LDLLQALQDQ HRESMAWETV DLDDVLSYCA
5010 5020 5030 5040 5050
NWTPGSALQT VVQHQNVVLE DLGLRLGDVP STVSVRAFDH APREVWLYSS
5060 5070 5080 5090
TDDSHPDRLS LRIFSSSWTL DDTIAEELLG LVAEEIVELL RNPEQVLCV
Length:5,099
Mass (Da):560,492
Last modified:October 10, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i82A26FBC16BCB3A8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KZ826410 Genomic DNA Translation: PYI01631.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KZ826410 Genomic DNA Translation: PYI01631.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di1.10.1200.10, 4 hits
3.30.559.10, 5 hits
3.40.50.12780, 4 hits
InterProiView protein in InterPro
IPR010071 AA_adenyl_domain
IPR036736 ACP-like_sf
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501 AMP-binding, 4 hits
PF00668 Condensation, 5 hits
PF00550 PP-binding, 4 hits
SMARTiView protein in SMART
SM00823 PKS_PP, 3 hits
SUPFAMiSSF47336 SSF47336, 4 hits
TIGRFAMsiTIGR01733 AA-adenyl-dom, 4 hits
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 3 hits
PS50075 CARRIER, 4 hits
PS00012 PHOSPHOPANTETHEINE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMLFA_ASPSB
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A319DV72
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 10, 2019
Last sequence update: October 10, 2018
Last modified: December 11, 2019
This is version 7 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again