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Entry version 6 (03 Jul 2019)
Sequence version 1 (10 Oct 2018)
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Protein

Malformin synthetase mlfA

Gene

mlfA

Organism
Aspergillus eucalypticola (strain CBS 122712 / IBT 29274)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of malformins, cyclic pentapeptides with a disulfide bond between 2 consecutive cysteins, that show potential anti-tumor as well as antimalarial and antitrypanosomal properties (PubMed:30560908). The nonribosomal peptide synthetase mlfA is responsible of the formation of the cyclic pentapeptide (Probable). The malformin biosynthesis clusters in malformin-producing fungi also contain enzymes involved in the formation of the disulfide bond between the two consecutive cysteins within malformins, in addition to additionnal tailoring enzymes such as methyltransferases or oxidoreductases. They are also composed of up to 4 major facilitator superfamily transporters, and transcription factors probably involved in the regulation of the expression of those clusters (Probable).1 Publication1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Secondary metabolite biosynthesis

This protein is involved in Secondary metabolite biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in Secondary metabolite biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Malformin synthetase mlfA1 Publication (EC:6.3.2.-1 Publication)
Alternative name(s):
Malformin biosynthesis cluster protein A1 Publication
Nonribosomal peptide synthetase mlfA1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mlfA1 Publication
ORF Names:BO83DRAFT_417906
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAspergillus eucalypticola (strain CBS 122712 / IBT 29274)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1448314 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000246171 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

Malformins show anti-tumor properties against human colorectal and prostate cancer cells by the inhibition of proliferation and induction of apoptosis through the activation of the p38 signaling pathway (PubMed:26540166, PubMed:26645406, PubMed:28713983). Malformin C has also been shown to exhibit potent antimalarial and antitrypanosomal properties (PubMed:19876076).4 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004464301 – 5044Malformin synthetase mlfAAdd BLAST5044

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei747O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei1847O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3021O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei4559O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini710 – 786Carrier 1PROSITE-ProRule annotationAdd BLAST77
Domaini1810 – 1887Carrier 2PROSITE-ProRule annotationAdd BLAST78
Domaini2984 – 3060Carrier 3PROSITE-ProRule annotationAdd BLAST77
Domaini4522 – 4598Carrier 4PROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni181 – 572Adenylation 1Sequence analysisAdd BLAST392
Regioni824 – 1255Condensation 1Sequence analysisAdd BLAST432
Regioni1283 – 1672Adenylation 2Sequence analysisAdd BLAST390
Regioni2018 – 2433Condensation 2Sequence analysisAdd BLAST416
Regioni2456 – 2848Adenylation 3Sequence analysisAdd BLAST393
Regioni3077 – 3533Condensation 3Sequence analysisAdd BLAST457
Regioni3554 – 3973Condensation 4Sequence analysisAdd BLAST420
Regioni3998 – 4388Adenylation 4Sequence analysisAdd BLAST391
Regioni4635 – 4962Condensation 5Sequence analysisAdd BLAST328

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module. Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product. Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, epimerase (E) domains (responsible for L- to D- amino acid conversion) are present within the NRP synthetase. MlfA has the following architecture: A-T-C-A-T-C-A-T-C-C-A-T-C, with the functions of the five condensation domains during malformin biosynthesis being DL-joining (epimerizing subtype), LL-joining, epimerization, DL-joining and cyclizing domain, respectively.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRP synthase family.Curated

Keywords - Domaini

Repeat

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 4 hits
3.30.559.10, 5 hits
3.40.50.12780, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071 AA_adenyl_domain
IPR036736 ACP-like_sf
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501 AMP-binding, 4 hits
PF00668 Condensation, 5 hits
PF00550 PP-binding, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823 PKS_PP, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336 SSF47336, 4 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733 AA-adenyl-dom, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455 AMP_BINDING, 4 hits
PS50075 CARRIER, 4 hits
PS00012 PHOSPHOPANTETHEINE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A317VEE1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRFSCIFPT LTDGYLGTDQ VAFYVVPTTG PDTTALAELK VEGDMSRQSL
60 70 80 90 100
NYAANHLLHP GLVGAGQVSG ETANTIVTFA DDIESLFVTQ TEESFLSLHV
110 120 130 140 150
YRDEQGHISL SLTYYLSLLT DAQATNVGTA LVQALAEVGT CDNDRLIKDL
160 170 180 190 200
NLMSPAHLEH IWRFNADVPG IWEECFHDVI ERHAANRPHS LAVDAWDTKL
210 220 230 240 250
TYTDLVREAR LLAAYLQQRG VGPGSVVPIS FERSGAALVA MLAVSKAGGA
260 270 280 290 300
FVSVPPNLPA GRLDAILEVI EAPFVVTWTK YESFWAERLP TLPIDNYPKP
310 320 330 340 350
AADATVEALG KPEDLFYVIF TSGSTGRPKG CMLSHTNWLN GALRSAPNWK
360 370 380 390 400
YGPESRVLQM LSHTFDMSLL EICTSLGSGS CVCVPRAEEI ETSISDAINR
410 420 430 440 450
WQVNHVIMTP SLARALRPDD VPGLKTMCLG GEAFPKEIVT MWSERINLWQ
460 470 480 490 500
FYGPSECSIN SSSRPITRPD ADPLNIGPPN SAACWVVDVH DYNKLVPVGA
510 520 530 540 550
IGELLVSGPI VGMGYLKNPV KTAEAFLDEV GFVAKDDPQF GGLRFYRTGD
560 570 580 590 600
LVRWNSDGTI TFCGRADTQV KLNGQRLELA EVEYQLGLEA GVQYAIAMAP
610 620 630 640 650
QAGLCKNNLI AILTVKGTST GNQDTAADEI PLLDRRDPVV QETVKKLRSQ
660 670 680 690 700
LQHALPRYMV PTIWAFVGRM PMSASGKIDR VQLRDWVQKM SQETFDAITG
710 720 730 740 750
RSLEAEDHVL GLSRLERDIQ LAWAEALGLS AAEVGLQQPF VALGGDSIKA
760 770 780 790 800
LDAVARCRAR QIKISMVHIL SCEGVREAAS LAEVQITPPQ QVAEMAVDYS
810 820 830 840 850
NLWTRLSYDY DLDKLGVTQV EEVEDVFPCT TMQEGMFLGQ IRRPGAYHMR
860 870 880 890 900
FFHRVQLKGG CLPTVERIQQ AWASLVERHP SLRTVFVDDL SPEAIYHSIV
910 920 930 940 950
LRSVPMELRM REVPRDLSAE AALAMFTEEL VPFPANAPLH RMLLLTCRGR
960 970 980 990 1000
VLYFMLEISH VIMDGYALSV FRREFIRACS SSTPLPRGPD YRMFVNYNRT
1010 1020 1030 1040 1050
RQTDDSARYW TNYLADCVPC HIPTHAVSAP SDDPPEWPRT LQRRDFGFDN
1060 1070 1080 1090 1100
SAAFLQRCKE RQVTLACAIR AAWALVLRAY TQSEDVCFGY VSSGRNVPVP
1110 1120 1130 1140 1150
EVETIFGLCL SMQVCRARLS EASTIASLAR KIQEDYVASL PFQHYPLAEA
1160 1170 1180 1190 1200
QRGLKQAHGQ GLFNTAISME WVPPSVEDED ALLDLEEIRE QDDPTEYDIA
1210 1220 1230 1240 1250
ISVDVHEGHI KLGFLYWPNL TDFDIAHLAE ALRGAMNRFA FQPDEALNTL
1260 1270 1280 1290 1300
SLLQASDVCS ALAGGPTLLP LEAVRGNVVS MIDRWVTRQP EGAAIDGWDG
1310 1320 1330 1340 1350
SLSYKGLHEQ SSWVARNLLH QGVQLGDRVL VCADRSSRTV ATVLGIVRAG
1360 1370 1380 1390 1400
CVLVLSNPTD PEKRLQWLAN KCNAALIVAD PTYEERFATA GARVLSTTSV
1410 1420 1430 1440 1450
CAPAAWDYEF PSLDEHDLVS ILFTSGSTGT PKGILMEHGA LATSVLLGHG
1460 1470 1480 1490 1500
RTLRFSRHTR MLHFASLTFD AALAEMFTTL AHGGCICVPY EEDRLSDVPG
1510 1520 1530 1540 1550
CISRFAVNTA MLTPSVGRLL DPGALPTLKT LIMVGEPMSR LDVERFAPVL
1560 1570 1580 1590 1600
DLYNGAGPTE TSIMVTIAGP MKPTDEPVNL GYAVAGVRLW VTEAENPNRL
1610 1620 1630 1640 1650
APLGAVGELI VEGRLVTRGY LDDPARTQKA FLPSLPWLPS QHALYRTGDL
1660 1670 1680 1690 1700
VRYADDGSLR YMGRKDTQVK LRGQRIELQE VEYHLRKSLQ QAQIVVEMVV
1710 1720 1730 1740 1750
PAGKMRAQAS LVAFVSGLTA ADVESSSACN LEGTIPISQI VLPKSAFQAL
1760 1770 1780 1790 1800
EEVLPRHMIP SVYYALDTIP LSVNGKVDRR RLREMGTLLL ASSAAHKNII
1810 1820 1830 1840 1850
EGMSKSVKWT PASELERTLL ELWAATPGLE ADTIHGDDSF LELGGDSVSA
1860 1870 1880 1890 1900
MKLVATARDK YKLSLSVPQM FRYPTICQLA AEVGGPAGQS ASSASSTTEE
1910 1920 1930 1940 1950
GFTFSTPDDS STNDGVDDDF LQLAAAQLAQ LAQDKGKKVD IAALLKQLQG
1960 1970 1980 1990 2000
GSSSNKTLSV SFSSSSSSSS KRKKKAALAE AAAPIPVQFS LLDGGADVLD
2010 2020 2030 2040 2050
KVRAQAVEHC KIPHEDIEDI YPATALQEGM MALTARTPGV YTTTLTCDLS
2060 2070 2080 2090 2100
EQVNLARLHY AWGKAAEAHP ILRTRIILTD NNMAVQVVQR AKGLPWDTYS
2110 2120 2130 2140 2150
LREGDVLPDL TSNMTSGSPL LRLAVVHRQS QPRMFLVAIH HALYDGWSMP
2160 2170 2180 2190 2200
LLKQAVEDAY HGRDLRPQLF TLFIKHLIAG KPAAQDFWTT HLDSFAGGVF
2210 2220 2230 2240 2250
PNLPSVDHQV QPKERRARSL TLPTATPRSQ YSMATKIQAA WALTVSRYAE
2260 2270 2280 2290 2300
ANDIVFGTVS TGRSAPVPAI DRMVGPTITT VPVRISLGDQ TERVISILQR
2310 2320 2330 2340 2350
VQENSWNIMD HEHLGLQHIR RLGESAAAAC SFQTLLVIQP REQTDTKYRY
2360 2370 2380 2390 2400
TLLSGLQDVA EFEGVDTYPL MLVCEPDGAR LHLTAVFDPA VLDGATLDRM
2410 2420 2430 2440 2450
LAHWELVLTQ LWNESDMAVI ELDTVSCTDK ETLMRWNTGQ TIPNACAHDA
2460 2470 2480 2490 2500
VYEWSVHTPH APAVCAWDGE WTYEEVERCS SLIAGHILAH GVSCGDSVAL
2510 2520 2530 2540 2550
YHEKSRWGAA GILAVFKAGA ILIALDPTHP TDRIKDILDQ ARPRLILTSQ
2560 2570 2580 2590 2600
FLLDEARNLE TSVLSVQFAA SQPLPEGCSP LPKINSTQAA YIPFTSGSTG
2610 2620 2630 2640 2650
RPKGIPLDHR GLAASTASIA RSCLLSPASR VLHFASFAFD ASMMEHLIAW
2660 2670 2680 2690 2700
HAGGCLCIPD ETARQTDLAK CIRDFNVTWA FLTPSCLRLI TPDDVPSLQA
2710 2720 2730 2740 2750
LGLGGESMTS EDIIIWGPRL RQIIQLYGPA ECCFVAALNE VTKPSENRLI
2760 2770 2780 2790 2800
GRPNACRCWV VDPRSPDRLA PIGAVGELII EGITVGRGYI NSPDRTTRAF
2810 2820 2830 2840 2850
IRPPNWLQTL YPDDHEPKRL YRTGDLVRYA GVDGKLAFIG RRDSQLKLHG
2860 2870 2880 2890 2900
QRIELADVEA HLRPLIHGTQ KMVVEMVHSA DNQNPILAAF LEEMSTSQNS
2910 2920 2930 2940 2950
AEREVGLLHP SQSQCALDVM AIHSALSRTV PHYMIPSMYL HISRLPLSAS
2960 2970 2980 2990 3000
GKLNRRHLRE MVAELPRQRL NEYAAGSSLS VPDRPKTSQE QEMQAIWARV
3010 3020 3030 3040 3050
LSLDPNTIGV NEDFFRIGGD SISGMQVATK CNAAGIHITS ADIFRYRTIE
3060 3070 3080 3090 3100
QLICHLNFIR ITDCASVLLP AEPVDEWVAL APIQQLFFEV APEGPNHFNQ
3110 3120 3130 3140 3150
SLLLRTSRRV SVGELAGGLD ILVGRHSMLR ARFCRKDSGQ WFQQVRSLDS
3160 3170 3180 3190 3200
EPASAFYRLA AHNQITRESL PTLFTAAQMA LSIEDGPLLT VDLVELEDGN
3210 3220 3230 3240 3250
QLVYLAAHHL IIDFVSWRIL HGDLEEYFQT GSLSSATGSV PFLTWTQLQA
3260 3270 3280 3290 3300
EYSAEHLPPL NDDFDVMRYW GISSESNTFG QTSISRFTLD RTVTDILFGS
3310 3320 3330 3340 3350
ANNVIDTRPV EILQAALWYS CNQALTDHPG PSIYVESHGR EPWTNSINVS
3360 3370 3380 3390 3400
GTVGWFTTMS PLVSTPWDHL SRKSMRDFVD VLSYIKDQRR RIPANGWAYF
3410 3420 3430 3440 3450
TSRYLNDEGR VAYGRTKPVV EVLFNYMGQY QEMKRDDAML QLAGDDIQSG
3460 3470 3480 3490 3500
TGASDIADNV PRFSLIDVTA FTANGCLTFE FTFPQLMQQD ARLEQCIKEC
3510 3520 3530 3540 3550
ERTLVAAASS LPAEGPRKTL TDFPLMSALT YDQLSQCLNY TLPSMGLRAQ
3560 3570 3580 3590 3600
DVWNIYPCCP VQQGMLLAQL RDRQAYQQRF RFQVMSRGPT DQLPLEKVKD
3610 3620 3630 3640 3650
AWTEVINRHE ILRTLLRPVS DHSHFDQVVM VPGSLQHLVR INAMNDNPTE
3660 3670 3680 3690 3700
GLPHTINITS DSTGTTICEW NVSHALVDAM SIAVIQREVN QVFEGALGQH
3710 3720 3730 3740 3750
RDVPQYVDYI QWLSLQDNTE AQAYWQNYLN GVEPCLFPKL TSSPDKVDSE
3760 3770 3780 3790 3800
GTISAIRATW SRDARMDELC LRHAITLTNL FHIVWAIVLG AYVGTDEVCF
3810 3820 3830 3840 3850
GYTALGRDVP VNRVETMVGP LVNVLATTVR HQEDETILNA LLVHQAHLTN
3860 3870 3880 3890 3900
SLQHQHYALA DVYASLGLVG SQLFNTIVSL QDTSHFDAPD EQRARLEMLP
3910 3920 3930 3940 3950
ANDVSEYDVA LNIGVDKSSI QLVCSYQSVS LSAEQADALL RTAFHVLGEI
3960 3970 3980 3990 4000
LRDPTQRFCE LEVISPKCKE QLVRWNAGML APTDEYIHEK IQGQCRIHNS
4010 4020 4030 4040 4050
RQAVCAWDGM FTYAEVDDLS SRLAARLIRI GVTFEDIIPI YSPKSRWTVI
4060 4070 4080 4090 4100
AILGVLKAGA AFTLLETSHP MARLHVICDQ IKAPMIIAPA SHAVPAANLI
4110 4120 4130 4140 4150
PILVVLDNIT SLTQEKSDLL PAVGIPPAGE ALAYLIFTSG STGNPKGVMV
4160 4170 4180 4190 4200
THQNLCSNAS IITTSVNMTS DSRVLQFASH AFDGCILELL GALIAGSCLI
4210 4220 4230 4240 4250
IPSESENKED LAGCIERMDV TWALLTPSVA RILEPETLPR LRNLVLGGEP
4260 4270 4280 4290 4300
IAASDLDMWR GHVQVVCAYG PTETTIIAST TSPSTFPTDG KDIGLPNGSS
4310 4320 4330 4340 4350
IWVVSRQNYQ KLAPLGATGE LLIEGPNVSL GYLGDPEKTK EAFPDSPRWL
4360 4370 4380 4390 4400
SQLRKSPPRV YRTGDLVRFD TTTGTIRFVG RKDNQIKFHG QRIELGEIEH
4410 4420 4430 4440 4450
HAQLAFPSAS MVIVDLITPE QPQQPYIVAF VHQSDATNET TDTTDSLLLP
4460 4470 4480 4490 4500
PSEAFRADAL AAQNKMHERL PHYMVPAVFL PLHRLPLSVT GKADRKHLRQ
4510 4520 4530 4540 4550
CALALSSPEL NTYRATASTK HTPSTAEERK MQELVATVLG RDPTEIGMDD
4560 4570 4580 4590 4600
SFFYLGGDSV QAMRLVAEGR QQGLALSLRA IFDSPRLRDL ADQARSPNAD
4610 4620 4630 4640 4650
NQRVSTASSA GPRDDCDQID RIVATNSLNK ADVADVLPTT SFQRHWLEAQ
4660 4670 4680 4690 4700
LKSYIVVDIS GPVDPARLLR AMHRVVEAHP ILRVSFVPYE TTTLQVILRT
4710 4720 4730 4740 4750
AVAITNADLS TTTVEEFCRR DVDAQMAPGV PYLRVILATQ DKADHKLIMR
4760 4770 4780 4790 4800
LSHAQYDAVS LSLLMNDLSH AYANEIHPLP STHFPRFNDY ITYQQAQRAD
4810 4820 4830 4840 4850
PTATTFWRHL LQDVSLTYLN LQPAESSASN GTPIILSRDI NIAAFPSLPS
4860 4870 4880 4890 4900
DITIATTIKA AWSLVLAQKT DFLAVIFGQV VHGRAIALPG VEGIVGPCAN
4910 4920 4930 4940 4950
VTPVVARLGL QTTGMELMQT LQDQHRSAMP YETVDLDDAL AYAKDSQAGR
4960 4970 4980 4990 5000
KGLQTIVQHQ NNVMVDDVEL SLGEVKCGVD ARAVDHLPKE VWVYSSVDEN
5010 5020 5030 5040
RPGMLEVKIM SSTLVMGEEV AKELMGLLVE KIVGLLRHPE IVCV
Length:5,044
Mass (Da):555,887
Last modified:October 10, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i97278B6BC3E2FB0A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
MSFU01000015 Genomic DNA Translation: PWY71312.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MSFU01000015 Genomic DNA Translation: PWY71312.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di1.10.1200.10, 4 hits
3.30.559.10, 5 hits
3.40.50.12780, 4 hits
InterProiView protein in InterPro
IPR010071 AA_adenyl_domain
IPR036736 ACP-like_sf
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501 AMP-binding, 4 hits
PF00668 Condensation, 5 hits
PF00550 PP-binding, 4 hits
SMARTiView protein in SMART
SM00823 PKS_PP, 4 hits
SUPFAMiSSF47336 SSF47336, 4 hits
TIGRFAMsiTIGR01733 AA-adenyl-dom, 4 hits
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 4 hits
PS50075 CARRIER, 4 hits
PS00012 PHOSPHOPANTETHEINE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMLFA_ASPEC
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A317VEE1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 10, 2019
Last sequence update: October 10, 2018
Last modified: July 3, 2019
This is version 6 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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