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Entry version 4 (13 Feb 2019)
Sequence version 1 (10 Oct 2018)
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Protein

Polyketide synthase-nonribosomal peptide synthetase hybrid himA

Gene

himA

Organism
Aspergillus japonicus
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Polyketide synthase-nonribosomal peptide synthetase hybrid; part of the him gene cluster that mediates the biosynthesis of himeic acid A, a ubiquitin-activating enzyme (E1) inhibitor (PubMed:29314577). First, himA, together with the trans-enoyl reductase himH, catalyzes the formation of apolyketide chain, which is then condensed with leucine by the NRPS activity of himA. Dieckmann cyclization and release from himA gives a tetramic acid intermediate as the product of himA PKS-NRPS (PubMed:29314577). HimG then catalyzes alpha-oxidation of the tetramic acid ring, with a subsequent rearrangement to yield apyrone intermediate (Probable). Two terminal methyl groups of polyketide and amide side chains are oxidized to carboxylic acids by himC cytochrome P450 monooxygenase to form himeic acid A (Probable). Himeic acid A is further converted to himeic acids B and C during culture growth. No gene responsible for pyrone to pyridone conversion was found in the him gene cluster and himeic acid A is non-enzymatically converted to himeic acid C by the incorporation of an ammonium nitrogen atom in a pH5 buffer, and to himeic acid B at a conversion ratio of 50% during incubation in MeOH for 5 days (PubMed:29486950).1 Publication2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Secondary metabolite biosynthesis

This protein is involved in Secondary metabolite biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in Secondary metabolite biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei181PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase, Multifunctional enzyme, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polyketide synthase-nonribosomal peptide synthetase hybrid himA1 Publication (EC:2.3.1.-1 Publication, EC:6.3.2.-1 Publication)
Short name:
PKS-NRPS hybrid synthetase himA1 Publication
Alternative name(s):
Himeic acid biosynthesis cluster protein A1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:himA1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAspergillus japonicus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri34381 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Completely abolishes the production of himeic acid A.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004459521 – 3970Polyketide synthase-nonribosomal peptide synthetase hybrid himAAdd BLAST3970

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2379O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3534O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2342 – 2419Carrier 1PROSITE-ProRule annotation1 PublicationAdd BLAST78
Domaini3496 – 3574Carrier 2PROSITE-ProRule annotation1 PublicationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni11 – 446Ketosynthase (KS) domainSequence analysis1 PublicationAdd BLAST436
Regioni561 – 876Malonyl-CoA:ACP transacylase (MAT) domainSequence analysis1 PublicationAdd BLAST316
Regioni949 – 1253Dehydratase (DH) domainSequence analysis1 PublicationAdd BLAST305
Regioni2060 – 2234Ketoreductase (KR) domainSequence analysis1 PublicationAdd BLAST175
Regioni2487 – 2919Condensation (C) domainSequence analysis1 PublicationAdd BLAST433
Regioni2974 – 3381Adenylation (A) domainSequence analysis1 PublicationAdd BLAST408
Regioni3633 – 3866Reductase (R) domainSequence analysis1 PublicationAdd BLAST234

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PKS-NRPS himA consists of nine catalytic domains including a ketoacyl synthase domain (KS), an acyl transferase domain (AT), a dehydratase domain (DH), a ketoreductase domaion (KR), an acyl carrier protein (ACP) domains, a condensation (C) domain, an adenylation (A) domain, a thiolation (T) domain, and a releasing or Dieckmann cyclization (R/D) domain. Because himA lacks a designated enoyl reductase (ER) domain, the required ER activity is likely to be provided by the free-standing ER himH.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRP synthase family.Curated

Keywords - Domaini

Repeat

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 2 hits
3.30.559.10, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR013120 Male_sterile_NAD-bd
IPR016036 Malonyl_transacylase_ACP-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR029063 SAM-dependent_MTases
IPR016039 Thiolase-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF00501 AMP-binding, 1 hit
PF00668 Condensation, 1 hit
PF16197 KAsynt_C_assoc, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PF08659 KR, 1 hit
PF07993 NAD_binding_4, 1 hit
PF00550 PP-binding, 2 hits
PF14765 PS-DH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00827 PKS_AT, 1 hit
SM00826 PKS_DH, 1 hit
SM00825 PKS_KS, 1 hit
SM00823 PKS_PP, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336 SSF47336, 2 hits
SSF51735 SSF51735, 2 hits
SSF52151 SSF52151, 1 hit
SSF53335 SSF53335, 1 hit
SSF53901 SSF53901, 1 hit
SSF55048 SSF55048, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455 AMP_BINDING, 1 hit
PS00606 B_KETOACYL_SYNTHASE, 1 hit
PS50075 CARRIER, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2Z5TM64-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYIPSSSEP IAIIGSACRF PGHSTSPSRL WELLRNPYDL TKQVPEGRFN
60 70 80 90 100
VDGFHHPDGE HHGTTNAPNG YWLEEDPRRF DSTFFNITPK EAEAIDPQGK
110 120 130 140 150
VLLEAVYEGL ESAGLTLEGC SGSQVGVYVG TMTADYDILT GKDELTFSQY
160 170 180 190 200
CATGTSRAII SNRVSYFFHW NGPSMTIDTA CSSSLVAMHQ AVLGLRSGES
210 220 230 240 250
TMACVAGANL MLSPEPFICE SSLHMLSPDG KSKMWDQSAD GYARGEGVGV
260 270 280 290 300
VFLKTLSRAL ADGDHIECIV RETGVNSDGR TKGITMPSSL AQAALIQDTY
310 320 330 340 350
RRSGLDALNP DHRCQYFEAH GTGTQAGDPT EAEAIYKAFF GEDEELQEDG
360 370 380 390 400
SILVGSIKTI IGHTEGAAGV AGVLKAALAL KHAQVPPNQH LKSMNPRVVP
410 420 430 440 450
FTRRLHVPNT LIPWPSVRPG HPLRASVNSF GFGGTNSHAI LESYVPAIHG
460 470 480 490 500
GHLAASIEKP IEHPPGFPLV LSANSAEALK DKVEQYIELL ESEPEIDLQD
510 520 530 540 550
LAWTLATRRS ELPYRVSFSP VAGRERLLQE MRERLQTTEG NSSLGVRSKT
560 570 580 590 600
VNHERGRILG IFTGQGAQWP QMGQQLIQRS PRFKEVIQSL DAVLRSCPDP
610 620 630 640 650
PAWSIAHELL APPTSSRLSE AALSQPLCTA VQIALVDILH EAGVELAAAV
660 670 680 690 700
GHSSGEIAAA YAAGILTAPD AILIAYYRGF HAGLAQGPEG CRGGMMAVGM
710 720 730 740 750
GVNEALEFCE QPAFLHHLHI AASNSPASVT ISGDLEPLKQ AKALLDERGT
760 770 780 790 800
FARLLKVDTA YHSHHMDRCA APYLQSLQAA NIAPLSLTRS CVWVSSVYGP
810 820 830 840 850
SGAPTLRELS GRYWKDNMVQ PVFFTEAVTR ALTEEGPFDM ALEIGPHPAL
860 870 880 890 900
QGPAVQTMQE VNGSALPYAG LLHRGRDDLA SVISTMGLIW SLLGSSSIDF
910 920 930 940 950
DALSVALGNE RSDCRVVKDL PSYPWDHTHM YHRQPRMAKQ YLNRPARPHE
960 970 980 990 1000
LLGVRTSDDT ESEWRWRNLL KPSTLPWLKD HRFQDQIIVP AAAYCVMAFE
1010 1020 1030 1040 1050
AARALTTKPV KLVEIQNLSI KRGITMSDDS QGVETIFMLR KEPTVPGEGV
1060 1070 1080 1090 1100
ISASFILDFV PGDADAQGTN AVKGMVHLHL GEPSAETLPR RSLPPPSGLN
1110 1120 1130 1140 1150
RVDLDEFYGS IKDIGLGYTG PFRAMTSLQR RLDFATGTLP KPHPAETSTL
1160 1170 1180 1190 1200
PVAPSLLDAC FQAAFAAYAA PGDGSLWTSF LPQEIQNIRF NLDLCPVNPG
1210 1220 1230 1240 1250
PAATVNVDAV ITQFSSASPE SPANFSGDIC VFNANGNMEV QVEGLTVVAL
1260 1270 1280 1290 1300
SSTGPANDCE LFIETVYKPD PYTGIVEART EGINEEYVAL QRACMRIADH
1310 1320 1330 1340 1350
FLHPNRTAGK PQQTPEAMQT GLADSPFRGY LELLISCGRT APSRLPTAIT
1360 1370 1380 1390 1400
EILMHFNEQS ALQSHIRASV SQISHRFPQL RVLEITLGEL QKYVTDAVVA
1410 1420 1430 1440 1450
GLAAPFHSYS HLFETTEKDA PSLLSAQTSI QDSRFRLLAF DKTALLSEQF
1460 1470 1480 1490 1500
PDETFDLVIL SDGNRKNATL TSQLDGVHQL LAPGGYVFCV HSTGIPLQDR
1510 1520 1530 1540 1550
LLNPQKHHQS LSLQTLLRAT PRVQGDFDLI SSWTSPLRTI ALSIRQSMSA
1560 1570 1580 1590 1600
DVRHLIMPLT ATDVSYMSDT VLLIGGETGE TAQLSYQLAA ILRDKSLEVV
1610 1620 1630 1640 1650
TAPRLEDVVS TSMGTVKAVI VLSDLDKPVL SSVNSSEFTA LKQILVPNMS
1660 1670 1680 1690 1700
VLWLTSGFRD DQPYHYGTVG LFRSIRTETP QLKLQILDVA HISGAETVIA
1710 1720 1730 1740 1750
ECFLRLITYL DSESTPLWTS EPELVWDGQH LLIPRVLPID DLNRRYNSTR
1760 1770 1780 1790 1800
RVVHNYQNAS LQVVQVVARW NGDRYTHHAV EATPSKASAP ADEHFVNLRV
1810 1820 1830 1840 1850
LYSSAWAIEI KKGFHAFVSV ATDSASRHLL ALSPTNSSLI TIPATHVHAL
1860 1870 1880 1890 1900
PATGLDLSAL LNRIVATLLA QSLLRQASPG GLLVHEADSF FADTLQRLND
1910 1920 1930 1940 1950
EVRLLCFSTT DLALDDNRFI RLHPLSTKDA TKAAVPSSRI SSVADFSLGL
1960 1970 1980 1990 2000
TPTALVGLKS STCMLIKAMD SLVKTEASIL DNGNALSTAQ DALLVVRWVV
2010 2020 2030 2040 2050
ETALEELGST RKPHTTTRVS DVLDKGLQPL GAVLDWTENV HVPLRVNRFD
2060 2070 2080 2090 2100
PGSQMRGNKT YVMIGLTGEL GQSLCQFMVS HGARHLVVAS RNPDKSPAWK
2110 2120 2130 2140 2150
TDLEKQGATI QVLSVDVTNV DAVRQLRVDL ETSMPPVGGI VNGAMVLSDG
2160 2170 2180 2190 2200
LFADMPVESL QKALAPKVLG SQNLHDVFSD VDLDFFVMFS SLTGVPGNQG
2210 2220 2230 2240 2250
QSNYTAANMF MAGLAAQRRK AGQAASVLDI GMVSGIGYIN RTDGAKIYAN
2260 2270 2280 2290 2300
LKRQGYMPIS ERDIHGMFIE AIHCGRPTST TGAQLTTGLQ RFGVEGEEPL
2310 2320 2330 2340 2350
YWHTDPRFSH HRVLRNAVHK STVSSSVESL KSRISEVQSQ TAIAAILTES
2360 2370 2380 2390 2400
FASHVEAMLH LDPGSLDKET AIINLGVDSL MAVEIRSWFL AEVEKDMPVL
2410 2420 2430 2440 2450
KVLGGSSVAT LAEEVAKELF EDRSTSAPPP MDLDKNSFDL GSVHGSSTDP
2460 2470 2480 2490 2500
SSNSDSKSGF DGFSSDDSSD IANDDSDPTA QCDQIEPMSL SQARMWLPYL
2510 2520 2530 2540 2550
MLQDKTAYNC TTSYRLIGQL DIPRFERALR SLLQSHQAFR TLFYTDHETG
2560 2570 2580 2590 2600
EAMQAIVPTS STFSLRKVGS ANDSSDVKVE HDRVAQHVYE LERGDSFIAT
2610 2620 2630 2640 2650
LVTHRPDYHT VIFGYHHIIL DGVSWQIFLQ ELDRFYADPQ RRPSLGVDFL
2660 2670 2680 2690 2700
DFSTRQHHDL TSIPSLSKRQ FWKMTFASGS LPESLPLFPF AKAPARMPLT
2710 2720 2730 2740 2750
QYRVTEYFVE LDRSLAAKIR SASTTNQTTA FHFYLSVFSV MMYRMLGVTD
2760 2770 2780 2790 2800
LCIGMTDANR NDQAFLETIG LLLDMLPLRF RLDKTPSDES AFADHLRATR
2810 2820 2830 2840 2850
DIVYSALGNS GVPLETILQD IGAESSATEL PLFQAVVNYR MGAIKHKSIG
2860 2870 2880 2890 2900
DLGLEYLSYE DAGHPFDFIL TIDEDEGRAG LTLSMQDYLY DRAGANIFLD
2910 2920 2930 2940 2950
SYIHLLEFFA TTPTERVATP PAFAPALERT AIELGTGPRL SDPWEEPTLV
2960 2970 2980 2990 3000
HRIDHMAAKY PSDVALGDER GSLSYKAMSD RVNAIATQLL AVGAQVSTRV
3010 3020 3030 3040 3050
AVFGTPSTDN ICSLLAILRI GAIYVPCDVR SADERLRTIL TESEATVVIV
3060 3070 3080 3090 3100
NRETSSRFAK FHPDTVQAVI QLATVPIQSS PVHNAATAAG LAFIMFTSGS
3110 3120 3130 3140 3150
TGTPKGIQLT HANFLTHVQA ASAYMQLGRE VVLQQSAASY DASLAQIFYA
3160 3170 3180 3190 3200
LANGGRLVVA DNLRDTVALA SILEKEAVTF TLMAPSEYLL LMEYTGDILA
3210 3220 3230 3240 3250
RCSEWKVAMC GGEAFPPRLK GDFGRLGHGE LSVYNAYGPT EIAVASNIGE
3260 3270 3280 3290 3300
VAIPRKEAAG ESNDGDESHV PIGSALPEYN VYLVNEDIEP VPLGCPGQIA
3310 3320 3330 3340 3350
VAGPAVSAGY LKNEPLTSDK FPLVGERFHP EKSTRVYLTG DLARMLSNGS
3360 3370 3380 3390 3400
MVYLGRIESD TQIKLRGIRV ELGDIANAIL KTSRGVIANA AVGVRNPGPD
3410 3420 3430 3440 3450
QFLVAYVVLS GEKGTKRPAN VRQYLDQLLV DLPLPQAMKP AVAVDVGSSL
3460 3470 3480 3490 3500
PMTSSGKLDM RALNARPLPA SGDEDGDEDT ETETGADADA DAGADTTLSD
3510 3520 3530 3540 3550
IHSKLREIWN RALGGHTSIP ITPSSNFFAV GGSSLSLLKM QALVQREFDL
3560 3570 3580 3590 3600
RIALPELFRT STFGAIAERI LRGVSAGFTE EEVEDTVPSS SPVDIIDWKK
3610 3620 3630 3640 3650
ETALSETLRS LASSSQSDTR SPPMRRRPLT VILTGATGFL GRAIARALQA
3660 3670 3680 3690 3700
RDDVLHIHCI AVRNPHSSAA LELERTCDKV ILHAGDLALP FLGMMEEEAR
3710 3720 3730 3740 3750
LVFEEADVIV HNGADVSFLK SYQTLRGPNL RATQTLVEMT AHRQVPFHFV
3760 3770 3780 3790 3800
STAGVATTLS EGSSPVIDEI SLANHPPPTS RTGDAVLIDG YVASKWASET
3810 3820 3830 3840 3850
FLEHVHAQLA LPVRIYRPSS ITGADAPALD VMHNVLNLSR RMRALPDLGT
3860 3870 3880 3890 3900
WTGYFDFIRV ETVAEEIAAG VTASPTPTAT TPTPSGVEFI HLSGEKLIPV
3910 3920 3930 3940 3950
AEARKHLERE TGYAFRTLEM AEWCREAAGY GLPALVAGYL ESLEGQALSF
3960 3970
PRLRSRIAEW GGGGREVVAV
Length:3,970
Mass (Da):431,760
Last modified:October 10, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF44F3AE8CF8389F2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
LC331673 Genomic DNA Translation: BBA91557.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LC331673 Genomic DNA Translation: BBA91557.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.1200.10, 2 hits
3.30.559.10, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit
InterProiView protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR013120 Male_sterile_NAD-bd
IPR016036 Malonyl_transacylase_ACP-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR029063 SAM-dependent_MTases
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF00501 AMP-binding, 1 hit
PF00668 Condensation, 1 hit
PF16197 KAsynt_C_assoc, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PF08659 KR, 1 hit
PF07993 NAD_binding_4, 1 hit
PF00550 PP-binding, 2 hits
PF14765 PS-DH, 1 hit
SMARTiView protein in SMART
SM00827 PKS_AT, 1 hit
SM00826 PKS_DH, 1 hit
SM00825 PKS_KS, 1 hit
SM00823 PKS_PP, 2 hits
SUPFAMiSSF47336 SSF47336, 2 hits
SSF51735 SSF51735, 2 hits
SSF52151 SSF52151, 1 hit
SSF53335 SSF53335, 1 hit
SSF53901 SSF53901, 1 hit
SSF55048 SSF55048, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit
PS00606 B_KETOACYL_SYNTHASE, 1 hit
PS50075 CARRIER, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHIMA_ASPJA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2Z5TM64
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2018
Last sequence update: October 10, 2018
Last modified: February 13, 2019
This is version 4 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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