UniProtKB - A0A2Z4LKS3 (A0A2Z4LKS3_HUMAN)
Protein
Submitted name:
MHC class II antigen
Gene
HLA-DRB5
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
Keywordsi
Biological process | Adaptive immunity, Immunity |
Names & Taxonomyi
Protein namesi | Submitted name: MHC class II antigenImported |
Gene namesi | Name:HLA-DRB5Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Endosome
- Endosome membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Lysosome
- Lysosome membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Endosome
- endosome membrane Source: UniProtKB-SubCell
Lysosome
- lysosomal membrane Source: UniProtKB-SubCell
Plasma Membrane
- MHC class II protein complex Source: UniProtKB-KW
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 228 – 250 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
EndosomeARBA annotation, LysosomeARBA annotation, Membrane, MHC IIARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | Sequence analysisAdd BLAST | 29 | |
ChainiPRO_5024571846 | 30 – 266 | Sequence analysisAdd BLAST | 237 |
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 126 – 214 | Ig-likeInterPro annotationAdd BLAST | 89 |
Keywords - Domaini
SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
OMAi | YFYNREE |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011162, MHC_I/II-like_Ag-recog IPR014745, MHC_II_a/b_N IPR000353, MHC_II_b_N |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00969, MHC_II_beta, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit SM00921, MHC_II_beta, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A2Z4LKS3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVCLKLPGGS YMAKLTVTLM VLSSPLALAG DTRPRFLQQD KYECHFFNGT
60 70 80 90 100
ERVRFLHRDI YNQEEDLRFD SDVGEYRAVT ELGRPDAEYW NSQKDFLEDR
110 120 130 140 150
RAAVDTYCRH NYGVGESFTV QRRVEPKVTV YPARTQTLQH HNLLVCSVNG
160 170 180 190 200
FYPGSIEVRW FRNSQEEKAG VVSTGLIQNG DWTFQTLVML ETVPRSGEVY
210 220 230 240 250
TCQVEHPSVT SPLTVEWRAQ SESAQSKMLS GVGGFVLGLL FLGAGLFIYF
260
KNQKGHSGLH PTGLVS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | MG571447 Genomic DNA Translation: AWX41771.1 MK680934 Genomic DNA Translation: QCY59264.1 MN565784 Genomic DNA Translation: QHD57371.1 MN565785 Genomic DNA Translation: QHD57372.1 MN565795 Genomic DNA Translation: QHD57373.1 |
RefSeqi | NP_002116.2, NM_002125.3 |
Genome annotation databases
GeneIDi | 3127 |
KEGGi | hsa:3127 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | MG571447 Genomic DNA Translation: AWX41771.1 MK680934 Genomic DNA Translation: QCY59264.1 MN565784 Genomic DNA Translation: QHD57371.1 MN565785 Genomic DNA Translation: QHD57372.1 MN565795 Genomic DNA Translation: QHD57373.1 |
RefSeqi | NP_002116.2, NM_002125.3 |
3D structure databases
SMRi | A0A2Z4LKS3 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 13708, 129 antibodies |
Genome annotation databases
GeneIDi | 3127 |
KEGGi | hsa:3127 |
Organism-specific databases
CTDi | 3127 |
Phylogenomic databases
OMAi | YFYNREE |
Miscellaneous databases
ChiTaRSi | HLA-DRB5, human |
Gene expression databases
ExpressionAtlasi | A0A2Z4LKS3, baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011162, MHC_I/II-like_Ag-recog IPR014745, MHC_II_a/b_N IPR000353, MHC_II_b_N |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00969, MHC_II_beta, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit SM00921, MHC_II_beta, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A2Z4LKS3_HUMAN | |
Accessioni | A0A2Z4LKS3Primary (citable) accession number: A0A2Z4LKS3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 10, 2018 |
Last sequence update: | October 10, 2018 | |
Last modified: | February 10, 2021 | |
This is version 19 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |