Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 9 (31 Jul 2019)
Sequence version 1 (12 Sep 2018)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Histone-lysine N-methyltransferase

Gene

KMT2A

Organism
Physeter macrocephalus (Sperm whale) (Physeter catodon)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methyltransferase.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei3875S-adenosyl-L-methionineUniRule annotation1
Binding sitei3877S-adenosyl-L-methionineUniRule annotation1
Binding sitei3919S-adenosyl-L-methionineUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi3945ZincUniRule annotation1
Metal bindingi3993ZincUniRule annotation1
Binding sitei3994S-adenosyl-L-methionineUniRule annotation1
Metal bindingi3995ZincUniRule annotation1
Metal bindingi4000ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1181 – 1229CXXC-typePROSITE-ProRule annotationAdd BLAST49

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationImported, Transferase
Biological processTranscription, Transcription regulationUniRule annotation
LigandMetal-binding, S-adenosyl-L-methionineUniRule annotationSAAS annotation, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseUniRule annotationSAAS annotation (EC:2.1.1.43UniRule annotationSAAS annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KMT2AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPhyseter macrocephalus (Sperm whale) (Physeter catodon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9755 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaOdontocetiPhyseteridaePhyseter
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000248484 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1181 – 1229CXXC-typeInterPro annotationAdd BLAST49
Domaini1465 – 1516PHD-typeInterPro annotationAdd BLAST52
Domaini1513 – 1567PHD-typeInterPro annotationAdd BLAST55
Domaini1600 – 1664PHD-typeInterPro annotationAdd BLAST65
Domaini1740 – 1785BromoInterPro annotationAdd BLAST46
Domaini1907 – 2015PHD-typeInterPro annotationAdd BLAST109
Domaini2055 – 2111FYR N-terminalInterPro annotationAdd BLAST57
Domaini3702 – 3783FYR C-terminalInterPro annotationAdd BLAST82
Domaini3865 – 3981SETInterPro annotationAdd BLAST117
Domaini3989 – 4005Post-SETInterPro annotationAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 70DisorderedSequence analysisAdd BLAST70
Regioni189 – 298DisorderedSequence analysisAdd BLAST110
Regioni357 – 378DisorderedSequence analysisAdd BLAST22
Regioni479 – 624DisorderedSequence analysisAdd BLAST146
Regioni747 – 979DisorderedSequence analysisAdd BLAST233
Regioni1072 – 1101DisorderedSequence analysisAdd BLAST30
Regioni1139 – 1200DisorderedSequence analysisAdd BLAST62
Regioni1234 – 1409DisorderedSequence analysisAdd BLAST176
Regioni1700 – 1750DisorderedSequence analysisAdd BLAST51
Regioni1843 – 1906DisorderedSequence analysisAdd BLAST64
Regioni2118 – 2170DisorderedSequence analysisAdd BLAST53
Regioni2183 – 2207DisorderedSequence analysisAdd BLAST25
Regioni2224 – 2243DisorderedSequence analysisAdd BLAST20
Regioni2313 – 2365DisorderedSequence analysisAdd BLAST53
Regioni2399 – 2469DisorderedSequence analysisAdd BLAST71
Regioni2517 – 2655DisorderedSequence analysisAdd BLAST139
Regioni2684 – 2712DisorderedSequence analysisAdd BLAST29
Regioni2750 – 2858DisorderedSequence analysisAdd BLAST109
Regioni2972 – 3095DisorderedSequence analysisAdd BLAST124
Regioni3169 – 3282DisorderedSequence analysisAdd BLAST114
Regioni3506 – 3643DisorderedSequence analysisAdd BLAST138
Regioni3655 – 3680DisorderedSequence analysisAdd BLAST26
Regioni3821 – 3844DisorderedSequence analysisAdd BLAST24
Regioni3942 – 3943S-adenosyl-L-methionine bindingUniRule annotation2

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili407 – 427Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi218 – 237PolarSequence analysisAdd BLAST20
Compositional biasi238 – 260PolyampholyteSequence analysisAdd BLAST23
Compositional biasi270 – 291PolyampholyteSequence analysisAdd BLAST22
Compositional biasi359 – 378PolyampholyteSequence analysisAdd BLAST20
Compositional biasi479 – 529PolarSequence analysisAdd BLAST51
Compositional biasi569 – 590PolarSequence analysisAdd BLAST22
Compositional biasi591 – 610Pro-richSequence analysisAdd BLAST20
Compositional biasi747 – 765PolarSequence analysisAdd BLAST19
Compositional biasi781 – 879PolarSequence analysisAdd BLAST99
Compositional biasi880 – 932PolyampholyteSequence analysisAdd BLAST53
Compositional biasi958 – 979PolarSequence analysisAdd BLAST22
Compositional biasi1080 – 1095PolarSequence analysisAdd BLAST16
Compositional biasi1268 – 1282PolarSequence analysisAdd BLAST15
Compositional biasi1283 – 1306PolyampholyteSequence analysisAdd BLAST24
Compositional biasi1315 – 1336PolarSequence analysisAdd BLAST22
Compositional biasi1337 – 1351Pro-richSequence analysisAdd BLAST15
Compositional biasi1859 – 1884Pro-richSequence analysisAdd BLAST26
Compositional biasi2133 – 2155PolarSequence analysisAdd BLAST23
Compositional biasi2226 – 2243PolarSequence analysisAdd BLAST18
Compositional biasi2313 – 2357PolarSequence analysisAdd BLAST45
Compositional biasi2418 – 2432PolarSequence analysisAdd BLAST15
Compositional biasi2439 – 2455PolarSequence analysisAdd BLAST17
Compositional biasi2565 – 2598PolarSequence analysisAdd BLAST34
Compositional biasi2608 – 2631PolarSequence analysisAdd BLAST24
Compositional biasi2758 – 2783PolarSequence analysisAdd BLAST26
Compositional biasi2784 – 2821PolyampholyteSequence analysisAdd BLAST38
Compositional biasi2822 – 2858PolarSequence analysisAdd BLAST37
Compositional biasi2972 – 2988PolarSequence analysisAdd BLAST17
Compositional biasi3048 – 3095PolarSequence analysisAdd BLAST48
Compositional biasi3169 – 3185PolarSequence analysisAdd BLAST17
Compositional biasi3201 – 3220PolarSequence analysisAdd BLAST20
Compositional biasi3233 – 3259PolarSequence analysisAdd BLAST27
Compositional biasi3267 – 3282PolarSequence analysisAdd BLAST16
Compositional biasi3506 – 3564PolarSequence analysisAdd BLAST59
Compositional biasi3597 – 3641PolarSequence analysisAdd BLAST45

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1181 – 1229CXXC-typePROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

BromodomainPROSITE-ProRule annotationSAAS annotation, Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15693 ePHD_KMT2A, 1 hit
cd15588 PHD1_KMT2A, 1 hit
cd15590 PHD2_KMT2A, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR034732 EPHD
IPR003889 FYrich_C
IPR003888 FYrich_N
IPR037927 KMT2A
IPR041958 KMT2A_ePHD
IPR042023 KMT2A_PHD1
IPR042025 KMT2A_PHD2
IPR016569 MeTrfase_trithorax
IPR003616 Post-SET_dom
IPR001214 SET_dom
IPR002857 Znf_CXXC
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR45838:SF2 PTHR45838:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05965 FYRC, 1 hit
PF05964 FYRN, 1 hit
PF00628 PHD, 2 hits
PF00856 SET, 1 hit
PF02008 zf-CXXC, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF010354 Methyltransferase_trithorax, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297 BROMO, 1 hit
SM00542 FYRC, 1 hit
SM00541 FYRN, 1 hit
SM00249 PHD, 4 hits
SM00508 PostSET, 1 hit
SM00317 SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50014 BROMODOMAIN_2, 1 hit
PS51805 EPHD, 1 hit
PS51543 FYRC, 1 hit
PS51542 FYRN, 1 hit
PS50868 POST_SET, 1 hit
PS50280 SET, 1 hit
PS51058 ZF_CXXC, 1 hit
PS50016 ZF_PHD_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

A0A2Y9TFU1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHSCRWRFP ARPGTTGGGG GGGRRGLGGA PRQRVPALLL PPGPLVGGGG
60 70 80 90 100
PGAPPSPPAV AAAAAAAAGS GGVGVPGGAA AASAASSSSA SSSSSSSSSA
110 120 130 140 150
SSGPALLRVG PGFDAALQVS AAIGTNLRRF RAVFGESGGG GGSGELTTQI
160 170 180 190 200
PCSWRTKGLI HDKKTEPFRL LAWSWCLNDE QFLGFGSDEE VRVRSPTRSP
210 220 230 240 250
SVKTSPRKPR GRPRSGSDRN SALLSDPSVF SPLNKSETKS GDKIKKKDSK
260 270 280 290 300
SIEKKRGRPP TFPGVKLKIT HGKDISELPK GNKEDSLKKM KRTPSATFQQ
310 320 330 340 350
ATKIKKLRAG KLSPLKSKFK TGKLQIGRKG VQIVRRRGRP PSTERIKTPS
360 370 380 390 400
GLLINSELEK PQKVRKDKEG TPPLTKEDKT VVRQSPRRIK PVRIIPSSKR
410 420 430 440 450
TDATIAKQLL QRAKKGAQKK IEKEAAQLQG RKVKTQVKNI RQFIMPVVSA
460 470 480 490 500
ISSRIIKTPR RFIEDEDYDP PIKIARLEST PNSRFSATSC GSSEKSSAAS
510 520 530 540 550
QHSSQMSSDS SRSSSPSVDT STDSQASEEI QVLPEERSDT PEVHTPLPIS
560 570 580 590 600
QSPENDSNDR RSRRYSVSER SFGSRTSKKL STLQSAPQQQ TSSSPPPPLL
610 620 630 640 650
TPPPPLQPAS SISDHTPWLM PPTIPLASPF LPTSAAPMQG KRKSILREPT
660 670 680 690 700
FRWTSLKHSR SEPQYFSSAK YAKEGLIRKP IFDNFRPPPL TPEDVGFASG
710 720 730 740 750
FSTSGTAASA RLFSPLHSGT RFDMHKRSPL LRAPRFTPSE AHSRIFESVT
760 770 780 790 800
LPSNRTSAGT SSSGVSNRKR KRKVFSPIRS EPRSPSHSMR TRSGRLSTSE
810 820 830 840 850
LSPLTPPSSV SSSLSISVSP LATSALNPTF TFPSHSLTQS GESAEKNQRP
860 870 880 890 900
RKQTSAPAEP FSSSSPTPLF PWFTPGSQTE RGRNKDKAPE ELSKERDADK
910 920 930 940 950
SVEKDKSRER DREREKENKR ESRKEKRKKG SEIQSSSALY PVGRVSKEKV
960 970 980 990 1000
VGEDVATSSS AKKATGRKKS SSLDSGTDIA SVTLGDTTAV KTKILIKKGR
1010 1020 1030 1040 1050
GNLEKTNLDL GPTAPSLEKE KTLCLSTPSS STVKHSTSSI GSMLAQADKL
1060 1070 1080 1090 1100
PMTDKRVASL LKKAKAQLCK IEKSKSLKQT DQPKAQGQES DSSETSVRGP
1110 1120 1130 1140 1150
RIKHVCRRAA VALGRKRAVF PDDMPTLSAL PWEEREKILS SMGNDDKSSI
1160 1170 1180 1190 1200
AGSEDAEPLA PPIKPIKPVT RNKAPQEPPV KKGRRSRRCG QCPGCQVPED
1210 1220 1230 1240 1250
CGVCTNCLDK PKFGGRNIKK QCCKMRKCQN LQWMPSKAYL QKQAKAVKKK
1260 1270 1280 1290 1300
EKKSKTSEKK ESKESSVVKS LADSSQKSTP SAREDPAPKK SNSEPPPRKP
1310 1320 1330 1340 1350
PEDKSEEGNA STPGPEAKQV ATPSSRKSSK QVSQPAPAIP LQPPSTAPPR
1360 1370 1380 1390 1400
KEVPKTTPSE PKKKQPPPPE SGPEQSKQKK VAPRPSIPVK QKPKEKEKPP
1410 1420 1430 1440 1450
PVSKQENAGT LNILSTLSNG NSSKQKVPAD GVHRIRVDFK EDCEAENVWE
1460 1470 1480 1490 1500
MGGLGILTSV PITPRVVCFL CASSGHVEFV YCQVCCEPFH KFCLEEHERP
1510 1520 1530 1540 1550
LEDQLENWCC RRCKFCHVCG RQHQATKQLL ECNKCRNSYH PECLGPNYPT
1560 1570 1580 1590 1600
KPTKKKKVWI CTKCVRCKSC GSTTPGKGWD AQWSHDFSLC HDCAKLFAKG
1610 1620 1630 1640 1650
NFCPLCDKCY DDDDYESKMM QCGKCDRWVH SKCENLSGTE DEMYEILSNL
1660 1670 1680 1690 1700
PESVAYTCVN CTERHPAEWR LALEKELQIS LKQVLTALLN SRTTSHLLRY
1710 1720 1730 1740 1750
RQAAKPPDLN PETEESIPSR SSPEGPDPPV LTEVSKQEDQ QPLDLEGVKR
1760 1770 1780 1790 1800
KMDQGNYTSV LEFSDDIVKI IQAAINSDGG QPEIKKANSM VKSFFIRQME
1810 1820 1830 1840 1850
RVFPWFSVKK SRFWEPNKVS SNSGMLPNAV LPPSLDHNYA QWQEREENSH
1860 1870 1880 1890 1900
TEQPPLMKKI IPAPKPKGPG EPDSPTPLHP PTPPILSTDR SREDSPELNP
1910 1920 1930 1940 1950
PPGIEDNRQC ALCLTYGDDS ANDAGRLLYI GQNEWTHVNC ALWSAEVFED
1960 1970 1980 1990 2000
DDGSLKNVHM AVIRGKQLRC EFCQKPGATV GCCLTSCTSN YHFMCSRAKN
2010 2020 2030 2040 2050
CVFLDDKKVY CQRHRDLIKG EVVPENGFEV FRRVFVDFEG ISLRRKFLNG
2060 2070 2080 2090 2100
LEPENIHMMI GSMTIDCLGI LNDLSDCEDK LFPIGYQCSR VYWSTTDARK
2110 2120 2130 2140 2150
RCVYTCKIVE CRPPVVEPDI NSTVEHDENR TIAHSPTSFA EISPKESQNT
2160 2170 2180 2190 2200
AEIVSPPSPD RPPHSQTSGS CFYHVISKVP RVRTPSYSPT QRSPGCRPLP
2210 2220 2230 2240 2250
SAGSPTPTTH EIVTVGDPLL SSGLRSIGSR RHSTSSLSPQ RSKLRIMSPA
2260 2270 2280 2290 2300
RTGSTYSRNS VSSVATVGTA ADLESSAKAV DHVLGPLNSN TNLGQNTPTS
2310 2320 2330 2340 2350
SHLQRTVVTM GTKTSHFDGS SSSEMKHSSA SDLTSKSSSS KGEKTKMPSS
2360 2370 2380 2390 2400
KNSEGSAHNV AYPGLPKLAP QVHNATAGEL NVSKTGTFAE LSSVPFSSKE
2410 2420 2430 2440 2450
ALPFPPLHLR GQRNDRDQQT DSNQSANSLP DEDTEVKTLK LSGVSNRSSI
2460 2470 2480 2490 2500
INEHVGSSSR DRRQKGKKSC KEMFKEKHSS KSFLEPGQVA TGEEGNLKPE
2510 2520 2530 2540 2550
FVDEVLPPEF MGQRPCNNVS SDKIGDKVHS VPGVPKAPSM QVEGSAKELQ
2560 2570 2580 2590 2600
TPRKRTVKVT LTPLKMEGES QSKNTLKESS PLSPLQIESA SPTEPVSTSE
2610 2620 2630 2640 2650
GPGDGPVAQA SPNNTSSQDS QSNNYQNLPV QDRNLMLPDG PKPQEDGSFK
2660 2670 2680 2690 2700
RRYPRRSARA RSNMFFGLTP LYGVRSYGEE DIPFYSSSTG KKRGKRSAEG
2710 2720 2730 2740 2750
QVDGADDLST SDEDDLYYYN FTRTVISSGG EERLTPHNLF REEEQCDLPK
2760 2770 2780 2790 2800
ISQLDGVDDG TESDTSVTAT TRKSSQIPKR NSKENGTENL KMDRPEDTGE
2810 2820 2830 2840 2850
KEHVIKSSVG HKNEPKMDNC HSVSRVKTQG QDSLEAQLSS LESSRRVHTS
2860 2870 2880 2890 2900
TPSDKNLLDT YNTELLKSDS DNNNSDDCGN ILPSDIMDFV LKNTPSMQAL
2910 2920 2930 2940 2950
GESPESSSSE LLNLGEGLGL DSNREKDMGL FEVFSQQLPT TEAVDSSVSS
2960 2970 2980 2990 3000
SISAEEQFEL PLELPSDLSV LTTRSPTVPS QNPSRLAVIS DSGEKRGTIP
3010 3020 3030 3040 3050
EKSVASSEGD SSLLSPGVDP SPEGHMTPDH FIQGHMDADH ISSPPCGSVE
3060 3070 3080 3090 3100
QGHGNNQDLT RNSSTPGLQV PVSPTVPIQN QKYVPNSTDS PGPSQISNAA
3110 3120 3130 3140 3150
VQTTPPHLKP ATEKLIVVNQ NMQPLYVLQT LPNGVTQKIQ LTSSVSSAPS
3160 3170 3180 3190 3200
VMETNTSVLG PMGSGLTLTT GLSPSLPTSQ SLFPPASKGL LPMPHHQHLH
3210 3220 3230 3240 3250
SFPAATQSSF PPNISSPPSG LLIGVQPPPD PQLLVSEASQ RTDLSTTVAT
3260 3270 3280 3290 3300
PSSGLKKRPI SRLQTRKNKK LAPSSTPSNI APSDVVSNMT LINFTPSQLP
3310 3320 3330 3340 3350
NHPNLLDLGS LNTSSHRTVP NIIKRSKSGI MYFEQAPLLP QNVGGTAAPA
3360 3370 3380 3390 3400
AGAATISQDT GHLTSGPVSG LASGSSVLNV VSMQTTTAPT SSASVPGHVA
3410 3420 3430 3440 3450
LTNPRLLGSP DIGSISNLLI KASQQSLGIQ DQPVALPPSS GMFPQLGTSQ
3460 3470 3480 3490 3500
TPSTAAMTAA SSICVLPSTQ TAGITAASPS GEAEEHYQLQ HVNQLLASKT
3510 3520 3530 3540 3550
GILSSQRDLD SAPGTQGSNF TQTVDAPNSM GLEQNKALSS AMQASSTSPG
3560 3570 3580 3590 3600
GSPSSGQQSA SPSVPGPMKP KPKIKRIQLP LDKGSGKKHK VSHLRTSSSE
3610 3620 3630 3640 3650
AHIPDQEANT TPLTSVTGTP GAEAEQQGIA NVEQSPQKEC GQPAGQVAVL
3660 3670 3680 3690 3700
PEVQTTQNPA DEQENSEPKT AEEEESNFSS PLMLWLQQEQ KRKESIAEKK
3710 3720 3730 3740 3750
PKKGLVFEIS SDDGFQICAE SIEDAWKSLT DKVQEARSNA RLKQLSFAGV
3760 3770 3780 3790 3800
NGLRMLGILH DAVVFLIEQL SGAKHCRNYK FRFHKPEEAN EPPLNPHGSA
3810 3820 3830 3840 3850
RAEVHLRKSA FDMFNFLASK HRQPPEYNPN DEEEEEVQLK SARRATSMDL
3860 3870 3880 3890 3900
PMPMRFRHLK KTSKEAVGVY RSPIHGRGLF CKRNIDAGEM VIEYAGNVIR
3910 3920 3930 3940 3950
SIQTDKREKY YDSKGIGCYM FRIDDSEVVD ATMHGNAARF INHSCEPNCY
3960 3970 3980 3990 4000
SRVINIDGQK HIVIFAMRKI YRGEELTYDY KFPIEDASNK LPCNCGAKKC

RKFLN
Length:4,005
Mass (Da):435,377
Last modified:September 12, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA9E239B91EBBE686
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2Y9T7Z9A0A2Y9T7Z9_PHYMC
Histone-lysine N-methyltransferase
KMT2A
3,969Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Y9TDY4A0A2Y9TDY4_PHYMC
Histone-lysine N-methyltransferase
KMT2A
3,972Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Y9FJC5A0A2Y9FJC5_PHYMC
Histone-lysine N-methyltransferase
KMT2A
3,101Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Y9FIP7A0A2Y9FIP7_PHYMC
Histone-lysine N-methyltransferase
KMT2A
2,993Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Y9T9Z2A0A2Y9T9Z2_PHYMC
Histone-lysine N-methyltransferase
KMT2A
3,560Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_023987049.1, XM_024131281.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_023987049.1, XM_024131281.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

CDDicd15693 ePHD_KMT2A, 1 hit
cd15588 PHD1_KMT2A, 1 hit
cd15590 PHD2_KMT2A, 1 hit
Gene3Di3.30.40.10, 3 hits
InterProiView protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR034732 EPHD
IPR003889 FYrich_C
IPR003888 FYrich_N
IPR037927 KMT2A
IPR041958 KMT2A_ePHD
IPR042023 KMT2A_PHD1
IPR042025 KMT2A_PHD2
IPR016569 MeTrfase_trithorax
IPR003616 Post-SET_dom
IPR001214 SET_dom
IPR002857 Znf_CXXC
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR45838:SF2 PTHR45838:SF2, 1 hit
PfamiView protein in Pfam
PF05965 FYRC, 1 hit
PF05964 FYRN, 1 hit
PF00628 PHD, 2 hits
PF00856 SET, 1 hit
PF02008 zf-CXXC, 1 hit
PIRSFiPIRSF010354 Methyltransferase_trithorax, 2 hits
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SM00542 FYRC, 1 hit
SM00541 FYRN, 1 hit
SM00249 PHD, 4 hits
SM00508 PostSET, 1 hit
SM00317 SET, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS50014 BROMODOMAIN_2, 1 hit
PS51805 EPHD, 1 hit
PS51543 FYRC, 1 hit
PS51542 FYRN, 1 hit
PS50868 POST_SET, 1 hit
PS50280 SET, 1 hit
PS51058 ZF_CXXC, 1 hit
PS50016 ZF_PHD_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2Y9TFU1_PHYMC
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2Y9TFU1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 12, 2018
Last sequence update: September 12, 2018
Last modified: July 31, 2019
This is version 9 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again