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Entry version 7 (31 Jul 2019)
Sequence version 1 (12 Sep 2018)
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Protein
Submitted name:

autophagy-related protein 2 homolog B isoform X1

Gene

ATG2B

Organism
Physeter macrocephalus (Sperm whale) (Physeter catodon)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
autophagy-related protein 2 homolog B isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATG2BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPhyseter macrocephalus (Sperm whale) (Physeter catodon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9755 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaOdontocetiPhyseteridaePhyseter
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000248484 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 107Chorein_NInterPro annotationAdd BLAST94
Domaini1992 – 2085ATG_CInterPro annotationAdd BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni868 – 892DisorderedSequence analysisAdd BLAST25
Regioni1389 – 1410DisorderedSequence analysisAdd BLAST22
Regioni1582 – 1603DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi878 – 892PolyampholyteSequence analysisAdd BLAST15

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026849 ATG2
IPR015412 Autophagy-rel_C
IPR026854 VPS13_N

The PANTHER Classification System

More...
PANTHERi
PTHR13190 PTHR13190, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09333 ATG_C, 1 hit
PF12624 Chorein_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

A0A2Y9T789-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPWPFSESIK KRACRYLLQR YLGHFLQEKL SLEQLSLDLY QGTGSLAQVP
60 70 80 90 100
LDKWCLNEIL ESADAPLEVT EGFIQSISLS VPWGSLLQDN CALEVKGLEL
110 120 130 140 150
VFRPRPRLAT GSEPMYWSSF MTSSMQLAKE CLSQKLTDEQ GEGSQPFEGL
160 170 180 190 200
EKFAETIETV LRRVKVTFID TVLRIEHVPE NSKTGTALEI RIERTMYCDE
210 220 230 240 250
TADESSGINV HQPTAFAHKL LQLSGVSLFW DEFSASAKSS PVCSTAPAEA
260 270 280 290 300
EPKLSPSWSP RIVYEPHPQL TRSLPEAAPS DPVQIGGLVG SLGLSLTLKQ
310 320 330 340 350
NEVLPGAKLD IDGQIDSVHL FLSPRQVHLL LDMLAAIAGP ENSSKIGLAN
360 370 380 390 400
KDRKNRPMQQ EDEYRIQMEL NRYYLRKDSL SAGVSSEQSF YETETARTPS
410 420 430 440 450
SREEEVFFSM ADMDMSHSLS SLPPLGEPPN MDLELSLTST YTNTPAGSPL
460 470 480 490 500
STTVLQPTWG DFLDHHKEQP VRGSALPSNL VHPASLQKTA LPSRSVSVDE
510 520 530 540 550
SRPEFIFRLA VGTFSISVLH IDPLSPPETS LNLNPLTPMA IAFFTCIEKI
560 570 580 590 600
DPARFSTEDF KSFRAVFAEA CSHDHLRFIG TGIKVSYEQR QRSASRYFST
610 620 630 640 650
DMSIGQMELL ECLFPTDFHS VPPHYTELLM FHSKEQTDSH PPVCLQLHYK
660 670 680 690 700
HSENKGPQGS QARLSSVPQK AELQVKLNPV FCELDISIVD RLNSLLQPQK
710 720 730 740 750
LTTVEVMASH MYTSYNKHIS LHKAFTEVFL DDSHNPANCR ISVQVATPVL
760 770 780 790 800
NLSVRFPIPD LRSDQERGPW FKKSLQKEIL HLAFTDLEFK TEFLGGSTPE
810 820 830 840 850
QVKLELTFRE LVGSFQEDKG EPSINFFHVT SGGDGDTASS DDFDWPRIVL
860 870 880 890 900
KVNPPAMHSI LERIAAEEAE ESDGHYQEEE EGGAHSLKDV CDLRRPAPSP
910 920 930 940 950
FSSRRVMFEN EQMVMPGDPV EMTEFQDKAI SNSHYVLELT LPNIHITLPN
960 970 980 990 1000
KSFYEKLYNR IFNDLLLWEP TAPSPVETFE NISYGIGLSV ASQLINTFNK
1010 1020 1030 1040 1050
DSFSPFKSTV HYDEESGSEE ETLQYFSTVD PNYRSRRKKK LDSQNKNSQS
1060 1070 1080 1090 1100
FLSVLLSINH GLMAVFTDVK QDNGDLLENK HGEFWLEFNS GSLFCVTKYE
1110 1120 1130 1140 1150
GFDDKHYICL HCSSFSLYHK GIVDGAIPST ETRLPSSTRP HWLEPTIYSS
1160 1170 1180 1190 1200
EEDGLSRASS DGVGGDTLNM LSVAVKILSD KSESNTKEFL IAVGLKGTTL
1210 1220 1230 1240 1250
QHRMLPSGLS WHEQILYFLN IADEPVLGYN PPASFTTFHV HLWSCALDYR
1260 1270 1280 1290 1300
PLYLPIRSLL TVETFSVSSS VALDKSSSTL RIILDEAALH LSDKCNTVTI
1310 1320 1330 1340 1350
NLNRDYVRVM DMGLLELTIT AVKSDSDGEQ TFLSFFPCPV QTEPHFELHC
1360 1370 1380 1390 1400
SSDVVHIRTC SDSCAALMNL IQYIASYGDL HAANKADVKP GAPQRKVKVD
1410 1420 1430 1440 1450
STGRSSSRCP VLPEADQQIL RDLMSDAMEE IDTQEAAASV KPQSNGVLDE
1460 1470 1480 1490 1500
KSQIQGPCCS DLFLFPDESG NVSQEPGPTY ASFTHHLMSD AVTGVPTEND
1510 1520 1530 1540 1550
DFCILFAPRA TIQEKEEEPV VKIMVDDAIV IRDNYFSLPV KKTDTSKAPL
1560 1570 1580 1590 1600
HFPIPVIRYL VKEVSLVWHL FGGKDFGTAP PASPAKSYIS PHSSPSHTPA
1610 1620 1630 1640 1650
RHGRNVVCGG KGRNHDFLME IQLSKVKFQH EVYPPCKPEC DSSLLEHPVS
1660 1670 1680 1690 1700
RQVFIVQDLE IRDRLATSQM NKFLYLYCSK EMPRKAHSNM LTVKALHVRP
1710 1720 1730 1740 1750
EPGRSPQECC LRVSLMPLRL NIDQDALFFL KDFFTSVSTE VELLMAPDPE
1760 1770 1780 1790 1800
VKKSPGADVT CSLPRHLSTS KEPNLVISFP GPKQPSPNGS ANSVQVVNGE
1810 1820 1830 1840 1850
EEKDFSAEEA SFSDQPVFFR EFRFTSEVPI RLDYHGKHVS MDQGTLAGIL
1860 1870 1880 1890 1900
IGLAQLNCSE LKLKRLFYRH GLLGVDKLFS YAITEWLTDI KKNQLPGILG
1910 1920 1930 1940 1950
GVGPMHSLVQ LVQGLKDLVW LPVEQYRKGG RIVRGFQRGA ASFGTSTAMA
1960 1970 1980 1990 2000
ALELTNRMVQ TIQAAAETAY DMVSPGTLSI EPKKIRRFPH HRLAHQPVDL
2010 2020 2030 2040 2050
REGVAKAYSV VKEGIADTAQ TIYETAAREH ESRGVTGAVG EVLRQIPPAV
2060 2070 2080
VKPLIVATEA TSNVLGGMRN QIRPDVRQDE SQKWRHGED
Length:2,089
Mass (Da):233,076
Last modified:September 12, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD93290B61ADEA30D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2Y9TAM2A0A2Y9TAM2_PHYMC
autophagy-related protein 2 homolog...
ATG2B
2,088Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Y9T939A0A2Y9T939_PHYMC
autophagy-related protein 2 homolog...
ATG2B
2,087Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Y9TD98A0A2Y9TD98_PHYMC
autophagy-related protein 2 homolog...
ATG2B
2,078Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Y9TAM9A0A2Y9TAM9_PHYMC
autophagy-related protein 2 homolog...
ATG2B
1,918Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Y9T794A0A2Y9T794_PHYMC
autophagy-related protein 2 homolog...
ATG2B
1,975Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A455BT51A0A455BT51_PHYMC
autophagy-related protein 2 homolog...
ATG2B
1,757Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A455C869A0A455C869_PHYMC
autophagy-related protein 2 homolog...
ATG2B
1,738Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_023986786.1, XM_024131018.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_023986786.1, XM_024131018.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR026849 ATG2
IPR015412 Autophagy-rel_C
IPR026854 VPS13_N
PANTHERiPTHR13190 PTHR13190, 1 hit
PfamiView protein in Pfam
PF09333 ATG_C, 1 hit
PF12624 Chorein_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2Y9T789_PHYMC
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2Y9T789
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 12, 2018
Last sequence update: September 12, 2018
Last modified: July 31, 2019
This is version 7 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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