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Entry version 8 (11 Dec 2019)
Sequence version 1 (12 Sep 2018)
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Protein
Submitted name:

NK-tumor recognition protein isoform X1

Gene

LOC101354876

Organism
Trichechus manatus latirostris (Florida manatee)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
NK-tumor recognition protein isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOC101354876Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTrichechus manatus latirostris (Florida manatee)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri127582 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaAfrotheriaSireniaTrichechidaeTrichechus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000248480 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 175PPIase cyclophilin-typeInterPro annotationAdd BLAST166

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni183 – 589DisorderedSequence analysisAdd BLAST407
Regioni607 – 1114DisorderedSequence analysisAdd BLAST508
Regioni1132 – 1206DisorderedSequence analysisAdd BLAST75
Regioni1251 – 1463DisorderedSequence analysisAdd BLAST213

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi183 – 197PolyampholyteSequence analysisAdd BLAST15
Compositional biasi221 – 238BasicSequence analysisAdd BLAST18
Compositional biasi239 – 285PolyampholyteSequence analysisAdd BLAST47
Compositional biasi347 – 403PolyampholyteSequence analysisAdd BLAST57
Compositional biasi404 – 419PolarSequence analysisAdd BLAST16
Compositional biasi425 – 457BasicSequence analysisAdd BLAST33
Compositional biasi461 – 475PolarSequence analysisAdd BLAST15
Compositional biasi476 – 525PolyampholyteSequence analysisAdd BLAST50
Compositional biasi526 – 541PolarSequence analysisAdd BLAST16
Compositional biasi542 – 556BasicSequence analysisAdd BLAST15
Compositional biasi557 – 579PolarSequence analysisAdd BLAST23
Compositional biasi640 – 660PolarSequence analysisAdd BLAST21
Compositional biasi661 – 694PolyampholyteSequence analysisAdd BLAST34
Compositional biasi695 – 721PolarSequence analysisAdd BLAST27
Compositional biasi768 – 782PolarSequence analysisAdd BLAST15
Compositional biasi783 – 797PolyampholyteSequence analysisAdd BLAST15
Compositional biasi798 – 824PolarSequence analysisAdd BLAST27
Compositional biasi825 – 913PolyampholyteSequence analysisAdd BLAST89
Compositional biasi931 – 970PolarSequence analysisAdd BLAST40
Compositional biasi975 – 1012BasicSequence analysisAdd BLAST38
Compositional biasi1030 – 1067PolyampholyteSequence analysisAdd BLAST38
Compositional biasi1092 – 1114PolarSequence analysisAdd BLAST23
Compositional biasi1265 – 1323PolyampholyteSequence analysisAdd BLAST59
Compositional biasi1324 – 1338BasicSequence analysisAdd BLAST15
Compositional biasi1339 – 1373PolarSequence analysisAdd BLAST35
Compositional biasi1374 – 1388BasicSequence analysisAdd BLAST15
Compositional biasi1389 – 1415PolarSequence analysisAdd BLAST27
Compositional biasi1416 – 1463PolyampholyteSequence analysisAdd BLAST48

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K12740

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00160 Pro_isomerase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00153 CSAPPISMRASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50891 SSF50891, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

A0A2Y9QEK7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAQDRPQCH FDIEINREPV GRIMFQLFSD ICPKTCKNFL CLCSGEKGLG
60 70 80 90 100
KTTGKKLCYK GSTFHRVVKN FMIQGGDFSE GNGKGGESIY GGYFKDENFI
110 120 130 140 150
LKHDRAFLLS MANRGKHTNG SQFFITTKPA PHLDGVHVVF GLVISGFEVI
160 170 180 190 200
EQIENLKTDA ASRPYADVRV IDCGVIATKS TKDVFEKKRK KPTHSEDSDS
210 220 230 240 250
SSSSSSSSES SSESEIEHER SRRRKHKRRP KVKHSKKRRK EASGSEEPRS
260 270 280 290 300
KHSLSPKGNS ERSDTNEKKS VDSNAKREKP VVRPEEIPPV PENRFLLRRD
310 320 330 340 350
MPVVTVEPEP KIPDVAPIVS DQKPSVSKSG RKIKGRGTIR YHTPPRSRSC
360 370 380 390 400
SESDDDDSSE TPPHWKEEMQ RLRAYRPPSG EKWSKGDKLS DPCSSRWDER
410 420 430 440 450
SLSQRSRSWS YNGYHSDLST ARHSDGHHKK RRKERKVKHK KKAKKQKHCR
460 470 480 490 500
RHKQTKKRTV IVPSDVESSK SSTRQTKFSC DRERRSRSSS LSSRHSSRRD
510 520 530 540 550
WSKSDKDNQS SSTHSSRDSY RSKSHSRSYS RGSSRSRTAS RSSSHSRSRS
560 570 580 590 600
KSRSSSKSGH QRTASKSPRT ASQLSENKPV KTEPLRVTVP QNENVVVQPV
610 620 630 640 650
VAENIPVIPL SDSPPPSRWK PGQKPWKPSY ERIQEMKAKT TDLLPTQSAY
660 670 680 690 700
SLANVKETGS SSSYHKREKH PESDRSAYSK YSDRSSESSP RSRSRSSRSR
710 720 730 740 750
SYSRSYTRSH SLVSSHSRSR SPSSRSHSRN KYSDHSEYSR SSSYSSVSSD
760 770 780 790 800
DRRLTKRRFR SSGKKNSTSG KRHSSSSEKT LGNKYVKGRD KSSYQRKYSE
810 820 830 840 850
GRSSLDYSSD SEQSSVQVVQ SAREKEKQVQ IEVTNNKQEK KRDEEKSKPE
860 870 880 890 900
RECPRSKKRT LKENFSDHLR NGNKPKRKNY AGSKWDSESN SERDVTKNSK
910 920 930 940 950
NDSRPSSDKE EGEATSDSES EFGEIHIKTK PTTKSLANTS LPDSNSVWKP
960 970 980 990 1000
SQPRSSTSDS GGSCSNSENN RGKLQKHKHG SKENLKREHT KKMKEKLKGK
1010 1020 1030 1040 1050
KDKKHKAPKR KQAFHWQPPL EFGEEEEEEI NEKQVTRESK EKKQVSENGE
1060 1070 1080 1090 1100
TIKDDTQKTE KSCEDGSVSG KHNAVNISSD LEQHTKDERK LSISPTVLNT
1110 1120 1130 1140 1150
EENVASSPPN IQHIEESVPS GVEDVLQTDD NMEICTPDRS SPAKVEEASP
1160 1170 1180 1190 1200
LGNSRFDPPD VSTVLKQDVQ TENPEAEVVK QESGVSESKM TGEVGKQDSG
1210 1220 1230 1240 1250
AAGLANAVES TVKREMAEKS QTSLVDNKWK PLQGVGNLAA PTLTSSGAVE
1260 1270 1280 1290 1300
VKTSTAVPEM KPQGLRIEIK SKNKVRPGSL FDEVRKTARL NQRPRNRESS
1310 1320 1330 1340 1350
SDEQTASRDG DSQSRSLSRS RSKSETKSRH RTRSVSYSHS RSRSRSSTSS
1360 1370 1380 1390 1400
YRSRSYSRSR SRGWYSRGRT RSRSSSYRSY KSHRSSSRSR SRSSSYDPHS
1410 1420 1430 1440 1450
RSSRSYTYDS YYSRSRSRSR SQRSDSYHRG RSYNRRSRSY GSDSESDRSY
1460
SHHRSPSESS RYS
Length:1,463
Mass (Da):165,666
Last modified:September 12, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i83987BD7622DEB35
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2Y9QQY2A0A2Y9QQY2_TRIMA
Peptidyl-prolyl cis-trans isomerase
LOC101354876
156Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Y9QRD9A0A2Y9QRD9_TRIMA
Peptidyl-prolyl cis-trans isomerase
LOC101354876
105Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Y9QIX7A0A2Y9QIX7_TRIMA
NK-tumor recognition protein isofor...
LOC101354876
1,462Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Y9QQW2A0A2Y9QQW2_TRIMA
NK-tumor recognition protein isofor...
LOC101354876
1,353Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Y9QEM6A0A2Y9QEM6_TRIMA
NK-tumor recognition protein isofor...
LOC101354876
1,163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_023581750.1, XM_023725982.1

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tmu:101354876

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_023581750.1, XM_023725982.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

KEGGitmu:101354876

Phylogenomic databases

KOiK12740

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2Y9QEK7_TRIMA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2Y9QEK7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 12, 2018
Last sequence update: September 12, 2018
Last modified: December 11, 2019
This is version 8 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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