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UniProtKB - A0A2Y9Q5U1 (A0A2Y9Q5U1_DELLE)

Entry version 13 (10 Feb 2021)
Sequence version 1 (12 Sep 2018)
Previous versions | rss
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Protein

Serine/threonine-protein kinase mTOR

Gene

MTOR

Organism
Delphinapterus leucas (Beluga whale)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotationARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase mTORUniRule annotation (EC:2.7.11.1UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MTORImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDelphinapterus leucas (Beluga whale)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9749 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Whippomorpha › Cetacea › Odontoceti › Monodontidae › Delphinapterus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000248483 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1305 – 1904FATInterPro annotationAdd BLAST600
Domaini2104 – 2471PI3K/PI4KInterPro annotationAdd BLAST368
Domaini2439 – 2471FATCInterPro annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1757 – 1789DisorderedSequence analysisAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili599 – 619Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.UniRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1070.11, 1 hit
1.20.120.150, 1 hit
1.25.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR024585, DUF3385_TOR
IPR003152, FATC_dom
IPR009076, FRB_dom
IPR036738, FRB_sf
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR003151, PIK-rel_kinase_FAT
IPR014009, PIK_FAT
IPR026683, TOR

The PANTHER Classification System

More...PANTHERi		PTHR11139:SF9, PTHR11139:SF9, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF11865, DUF3385, 1 hit
PF02259, FAT, 1 hit
PF02260, FATC, 1 hit
PF08771, FRB_dom, 1 hit
PF00454, PI3_PI4_kinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01346, DUF3385, 1 hit
SM01343, FATC, 1 hit
SM00146, PI3Kc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47212, SSF47212, 1 hit
SSF48371, SSF48371, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51189, FAT, 1 hit
PS51190, FATC, 1 hit
PS00915, PI3_4_KINASE_1, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A2Y9Q5U1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYPSSPFAFL SFPASLIGVE GGNATRIGRF ANYLRNLLPS NDPVVMEMAS 
        60         70         80         90        100
KAIGRLAMAG DTFTAEYVEF EVKRALEWLG ADRNEGRRHA AVLVLRELAI 
       110        120        130        140        150
SVPTFFFQQV QPFFDNIFVA VWDPKQAIRE GAVAALRACL ILTTQREPKE 
       160        170        180        190        200
MQKPQWYRHT FEEAEKGFDE TLAKEKGMNR DDRIHGALLI LNELVRISSM 
       210        220        230        240        250
EGERLREEME EITQQQLVHD KYCKDLMGFG TKPRHITPFT SFQAMQPQQS 
       260        270        280        290        300
NALVGLLGYS SHQGLMGFGA SPSPAKSTLV ESRCCRDLME EKFDQVCQWV 
       310        320        330        340        350
LKCRNSKNSL IQMTILNLLP RLAAFRPSAF TDTQYLQDTM NHVLSCVKKE 
       360        370        380        390        400
KERTAAFQAL GLLSVAVRSE FKVYLPRVLD IIRAALPPKD FAHKRQKAMQ 
       410        420        430        440        450
VDATVFTCIS MLARAMGPGI QQDIKELLEP MLAVGLSPAL TAVLYDLSRQ 
       460        470        480        490        500
IPQLKKDIQD GLLKMLSLVL MHKPLRHPGM PKGLAHQLAS PGLTTLPEAS 
       510        520        530        540        550
DVGSITLALR TLGSFEFEGH SLTQFVRHCA DHFLNSEHKE IRMEAARTCS 
       560        570        580        590        600
RLLTPSVHLI SGHAHVVSQT AVQVVADVLS KLLVVGITDP DPDIRYCVLA 
       610        620        630        640        650
SLDERFDAHL AQAENLQALF VALNDQVFEI RELAICTVGR LSSMNPAFVM 
       660        670        680        690        700
PFLRKMLIQI LTELEHSGIG RIKEQSARML GHLVSNAPRL IRPYMEPILK 
       710        720        730        740        750
ALILKLKDPD PDPNPGVINN VLATIGELAQ VSGLEMRKWV DELFIIIMDM 
       760        770        780        790        800
LQDSSLLAKR QVALWTLGQL VASTGYVVEP YRKYPTLLEV LLNFLKTEQN 
       810        820        830        840        850
QGTRREAIRV LGLLGALDPY KHKVNIGMID QSRDASAVSL SESKSSQDSS 
       860        870        880        890        900
DYSTSEMLVN MGNLPLDEFY PAVSMVALMR IFRDQSLSHH HTMVVQAITF 
       910        920        930        940        950
IFKSLGLKCV QFLPQVMPTF LNVIRVCDGA IREFLFQQLG MLVSFVKSHI 
       960        970        980        990       1000
RPYMDEIVTL MREFWVMNTS IQSTIILLIE QIVVALGGEF KLYLPQLIPH 
      1010       1020       1030       1040       1050
MLRVFMHDNS PGRIVSIKLL AAIQLFGANL DDYLHLLLPP IVKLFDAPEV 
      1060       1070       1080       1090       1100
PLPSRKAALE TVDRLTESLD FTDYASRIIH PIVRTLDQSP ELRPTAMDTL 
      1110       1120       1130       1140       1150
SSLVFQLGKK YQIFIPMVNK VLVRHRINHQ RYDVLICRIV KGYTLADEEE 
      1160       1170       1180       1190       1200
DPLIYQHRML RSGQGDALAS GPVETGPMKK LHVSTINLQK AWGAARRVSK 
      1210       1220       1230       1240       1250
DDWLEWLRRL SLELLKDSSS PSLRSCWALA QAYNPMARDL FNAAFVSCWS 
      1260       1270       1280       1290       1300
ELNEDQQDEL IRSIELALTS QDIAEVTQTL LNLAEFMEHS DKGPLPLRDD 
      1310       1320       1330       1340       1350
NGIVLLGERA AKCRAYAKAL HYKELEFQKG PTPAILESLI SINNKLQQPE 
      1360       1370       1380       1390       1400
AAAGVLEYAM KHFGELEIQA TWYEKLHEWE DALVAYDKKM DTNKDDPELM 
      1410       1420       1430       1440       1450
LGRMRCLEAL GEWGQLHQQC CEKWTLVNDE TQAKMARMAA AAAWGLGQWD 
      1460       1470       1480       1490       1500
SMEEYTCMIP RDTHDGAFYR AVLALHQDLF SLAQQCIDKA RDLLDAELTA 
      1510       1520       1530       1540       1550
MAGESYSRAY GAMVSCHMLS ELEEVIQYKL VPERREIIRQ IWWERLQGCQ 
      1560       1570       1580       1590       1600
RIVEDWQKIL MVRSLVVSPH EDMRTWLKYA SLCGKSGRLA LAHKTLVLLL 
      1610       1620       1630       1640       1650
GVDPSRQLDH PLPTVHPQVT YAYMKNMWKS ARKIDAFQHM QHFVQTVQQQ 
      1660       1670       1680       1690       1700
AQHAIATEDQ QHKQELHKLM ARCFLKLGEW QLNLQGINES TIPKVLQYYS 
      1710       1720       1730       1740       1750
AATEHDRSWY KAWHAWAVMN FEAVLHYKHQ NQARDEKKKL RHASGANITN 
      1760       1770       1780       1790       1800
VATAATTAAT ATATSTEGSN SESEAESTEN SPTPSPLQKK VTEDLSKTLL 
      1810       1820       1830       1840       1850
MYTVPAVQGF FRSISLSRGN NLQDTLRVLT LWFDYGHWPD VNEALVEGVK 
      1860       1870       1880       1890       1900
AIQIDTWLQV IPQLIARIDT PRPLVGRLIH QLLTDIGRYH PQALIYPLTV 
      1910       1920       1930       1940       1950
ASKSTTTARH NAANKILKNM CEHSNTLVQQ AMMVSEELIR VAILWHEMWH 
      1960       1970       1980       1990       2000
EGLEEASRLY FGERNVKGMF EVLEPLHAMM ERGPQTLKET SFNQAYGRDL 
      2010       2020       2030       2040       2050
MEAQEWCRKY MKSGNVKDLT QAWDLYYHVF RRISKQLPQL TSLELQYVSP 
      2060       2070       2080       2090       2100
KLLMCRDLEL AVPGTYDPNQ PIIRIQSIAP SLQVITSKQR PRKLTLMGSN 
      2110       2120       2130       2140       2150
GHEFVFLLKG HEDLRQDERV MQLFGLVNTL LANDPTSLRK NLSIQRYAVI 
      2160       2170       2180       2190       2200
PLSTNSGLIG WVPHCDTLHA LIRDYREKKK ILLNIEHRIM LRMAPDYDHL 
      2210       2220       2230       2240       2250
TLMQKVEVFE HAVNNTAGDD LARLLWLKSP SSEVWFDRRT NYTRSLAVMS 
      2260       2270       2280       2290       2300
MVGYILGLGD RHPSNLMLDR LSGKILHIDF GDCFEVAMTR EKFPEKIPFR 
      2310       2320       2330       2340       2350
LTRMLTNAME VTGLDGNYRI TCHTVMEVLR EHKDSVMAVL EAFVYDPLLN 
      2360       2370       2380       2390       2400
WRLMDTNTKG NKRSRTRTDS YSAGQSVEIL DGVELGEPAH KKTGTTVPES 
      2410       2420       2430       2440       2450
IHSFIGDGLV KPEALNKKAI QIINRVRDKL TGRDFSHDET LDVPTQVELL 
      2460       2470 
IKQATSHENL CQCYIGWCPF W
Length:2,471
Mass (Da):280,456
Last modified:September 12, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF0EE628BFBD839D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2Y9QA27A0A2Y9QA27_DELLE
Serine/threonine-protein kinase mTO...
MTOR
2,548Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...RefSeqi		XP_022454454.1, XM_022598746.1

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dle:111187265

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_022454454.1, XM_022598746.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

KEGGidle:111187265

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
1.20.120.150, 1 hit
1.25.10.10, 3 hits
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR024585, DUF3385_TOR
IPR003152, FATC_dom
IPR009076, FRB_dom
IPR036738, FRB_sf
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR003151, PIK-rel_kinase_FAT
IPR014009, PIK_FAT
IPR026683, TOR
PANTHERiPTHR11139:SF9, PTHR11139:SF9, 1 hit
PfamiView protein in Pfam
PF11865, DUF3385, 1 hit
PF02259, FAT, 1 hit
PF02260, FATC, 1 hit
PF08771, FRB_dom, 1 hit
PF00454, PI3_PI4_kinase, 1 hit
SMARTiView protein in SMART
SM01346, DUF3385, 1 hit
SM01343, FATC, 1 hit
SM00146, PI3Kc, 1 hit
SUPFAMiSSF47212, SSF47212, 1 hit
SSF48371, SSF48371, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51189, FAT, 1 hit
PS51190, FATC, 1 hit
PS00915, PI3_4_KINASE_1, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2Y9Q5U1_DELLE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2Y9Q5U1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 12, 2018
Last sequence update: September 12, 2018
Last modified: February 10, 2021
This is version 13 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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