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Entry version 13 (10 Feb 2021)
Sequence version 1 (12 Sep 2018)
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Protein

Serine/threonine-protein kinase mTOR

Gene

MTOR

Organism
Delphinapterus leucas (Beluga whale)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotationARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase mTORUniRule annotation (EC:2.7.11.1UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MTORImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDelphinapterus leucas (Beluga whale)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9749 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaWhippomorphaCetaceaOdontocetiMonodontidaeDelphinapterus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000248483 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1305 – 1904FATInterPro annotationAdd BLAST600
Domaini2104 – 2471PI3K/PI4KInterPro annotationAdd BLAST368
Domaini2439 – 2471FATCInterPro annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1757 – 1789DisorderedSequence analysisAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili599 – 619Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.UniRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1070.11, 1 hit
1.20.120.150, 1 hit
1.25.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR024585, DUF3385_TOR
IPR003152, FATC_dom
IPR009076, FRB_dom
IPR036738, FRB_sf
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR003151, PIK-rel_kinase_FAT
IPR014009, PIK_FAT
IPR026683, TOR

The PANTHER Classification System

More...
PANTHERi
PTHR11139:SF9, PTHR11139:SF9, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11865, DUF3385, 1 hit
PF02259, FAT, 1 hit
PF02260, FATC, 1 hit
PF08771, FRB_dom, 1 hit
PF00454, PI3_PI4_kinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01346, DUF3385, 1 hit
SM01343, FATC, 1 hit
SM00146, PI3Kc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47212, SSF47212, 1 hit
SSF48371, SSF48371, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51189, FAT, 1 hit
PS51190, FATC, 1 hit
PS00915, PI3_4_KINASE_1, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A2Y9Q5U1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYPSSPFAFL SFPASLIGVE GGNATRIGRF ANYLRNLLPS NDPVVMEMAS
60 70 80 90 100
KAIGRLAMAG DTFTAEYVEF EVKRALEWLG ADRNEGRRHA AVLVLRELAI
110 120 130 140 150
SVPTFFFQQV QPFFDNIFVA VWDPKQAIRE GAVAALRACL ILTTQREPKE
160 170 180 190 200
MQKPQWYRHT FEEAEKGFDE TLAKEKGMNR DDRIHGALLI LNELVRISSM
210 220 230 240 250
EGERLREEME EITQQQLVHD KYCKDLMGFG TKPRHITPFT SFQAMQPQQS
260 270 280 290 300
NALVGLLGYS SHQGLMGFGA SPSPAKSTLV ESRCCRDLME EKFDQVCQWV
310 320 330 340 350
LKCRNSKNSL IQMTILNLLP RLAAFRPSAF TDTQYLQDTM NHVLSCVKKE
360 370 380 390 400
KERTAAFQAL GLLSVAVRSE FKVYLPRVLD IIRAALPPKD FAHKRQKAMQ
410 420 430 440 450
VDATVFTCIS MLARAMGPGI QQDIKELLEP MLAVGLSPAL TAVLYDLSRQ
460 470 480 490 500
IPQLKKDIQD GLLKMLSLVL MHKPLRHPGM PKGLAHQLAS PGLTTLPEAS
510 520 530 540 550
DVGSITLALR TLGSFEFEGH SLTQFVRHCA DHFLNSEHKE IRMEAARTCS
560 570 580 590 600
RLLTPSVHLI SGHAHVVSQT AVQVVADVLS KLLVVGITDP DPDIRYCVLA
610 620 630 640 650
SLDERFDAHL AQAENLQALF VALNDQVFEI RELAICTVGR LSSMNPAFVM
660 670 680 690 700
PFLRKMLIQI LTELEHSGIG RIKEQSARML GHLVSNAPRL IRPYMEPILK
710 720 730 740 750
ALILKLKDPD PDPNPGVINN VLATIGELAQ VSGLEMRKWV DELFIIIMDM
760 770 780 790 800
LQDSSLLAKR QVALWTLGQL VASTGYVVEP YRKYPTLLEV LLNFLKTEQN
810 820 830 840 850
QGTRREAIRV LGLLGALDPY KHKVNIGMID QSRDASAVSL SESKSSQDSS
860 870 880 890 900
DYSTSEMLVN MGNLPLDEFY PAVSMVALMR IFRDQSLSHH HTMVVQAITF
910 920 930 940 950
IFKSLGLKCV QFLPQVMPTF LNVIRVCDGA IREFLFQQLG MLVSFVKSHI
960 970 980 990 1000
RPYMDEIVTL MREFWVMNTS IQSTIILLIE QIVVALGGEF KLYLPQLIPH
1010 1020 1030 1040 1050
MLRVFMHDNS PGRIVSIKLL AAIQLFGANL DDYLHLLLPP IVKLFDAPEV
1060 1070 1080 1090 1100
PLPSRKAALE TVDRLTESLD FTDYASRIIH PIVRTLDQSP ELRPTAMDTL
1110 1120 1130 1140 1150
SSLVFQLGKK YQIFIPMVNK VLVRHRINHQ RYDVLICRIV KGYTLADEEE
1160 1170 1180 1190 1200
DPLIYQHRML RSGQGDALAS GPVETGPMKK LHVSTINLQK AWGAARRVSK
1210 1220 1230 1240 1250
DDWLEWLRRL SLELLKDSSS PSLRSCWALA QAYNPMARDL FNAAFVSCWS
1260 1270 1280 1290 1300
ELNEDQQDEL IRSIELALTS QDIAEVTQTL LNLAEFMEHS DKGPLPLRDD
1310 1320 1330 1340 1350
NGIVLLGERA AKCRAYAKAL HYKELEFQKG PTPAILESLI SINNKLQQPE
1360 1370 1380 1390 1400
AAAGVLEYAM KHFGELEIQA TWYEKLHEWE DALVAYDKKM DTNKDDPELM
1410 1420 1430 1440 1450
LGRMRCLEAL GEWGQLHQQC CEKWTLVNDE TQAKMARMAA AAAWGLGQWD
1460 1470 1480 1490 1500
SMEEYTCMIP RDTHDGAFYR AVLALHQDLF SLAQQCIDKA RDLLDAELTA
1510 1520 1530 1540 1550
MAGESYSRAY GAMVSCHMLS ELEEVIQYKL VPERREIIRQ IWWERLQGCQ
1560 1570 1580 1590 1600
RIVEDWQKIL MVRSLVVSPH EDMRTWLKYA SLCGKSGRLA LAHKTLVLLL
1610 1620 1630 1640 1650
GVDPSRQLDH PLPTVHPQVT YAYMKNMWKS ARKIDAFQHM QHFVQTVQQQ
1660 1670 1680 1690 1700
AQHAIATEDQ QHKQELHKLM ARCFLKLGEW QLNLQGINES TIPKVLQYYS
1710 1720 1730 1740 1750
AATEHDRSWY KAWHAWAVMN FEAVLHYKHQ NQARDEKKKL RHASGANITN
1760 1770 1780 1790 1800
VATAATTAAT ATATSTEGSN SESEAESTEN SPTPSPLQKK VTEDLSKTLL
1810 1820 1830 1840 1850
MYTVPAVQGF FRSISLSRGN NLQDTLRVLT LWFDYGHWPD VNEALVEGVK
1860 1870 1880 1890 1900
AIQIDTWLQV IPQLIARIDT PRPLVGRLIH QLLTDIGRYH PQALIYPLTV
1910 1920 1930 1940 1950
ASKSTTTARH NAANKILKNM CEHSNTLVQQ AMMVSEELIR VAILWHEMWH
1960 1970 1980 1990 2000
EGLEEASRLY FGERNVKGMF EVLEPLHAMM ERGPQTLKET SFNQAYGRDL
2010 2020 2030 2040 2050
MEAQEWCRKY MKSGNVKDLT QAWDLYYHVF RRISKQLPQL TSLELQYVSP
2060 2070 2080 2090 2100
KLLMCRDLEL AVPGTYDPNQ PIIRIQSIAP SLQVITSKQR PRKLTLMGSN
2110 2120 2130 2140 2150
GHEFVFLLKG HEDLRQDERV MQLFGLVNTL LANDPTSLRK NLSIQRYAVI
2160 2170 2180 2190 2200
PLSTNSGLIG WVPHCDTLHA LIRDYREKKK ILLNIEHRIM LRMAPDYDHL
2210 2220 2230 2240 2250
TLMQKVEVFE HAVNNTAGDD LARLLWLKSP SSEVWFDRRT NYTRSLAVMS
2260 2270 2280 2290 2300
MVGYILGLGD RHPSNLMLDR LSGKILHIDF GDCFEVAMTR EKFPEKIPFR
2310 2320 2330 2340 2350
LTRMLTNAME VTGLDGNYRI TCHTVMEVLR EHKDSVMAVL EAFVYDPLLN
2360 2370 2380 2390 2400
WRLMDTNTKG NKRSRTRTDS YSAGQSVEIL DGVELGEPAH KKTGTTVPES
2410 2420 2430 2440 2450
IHSFIGDGLV KPEALNKKAI QIINRVRDKL TGRDFSHDET LDVPTQVELL
2460 2470
IKQATSHENL CQCYIGWCPF W
Length:2,471
Mass (Da):280,456
Last modified:September 12, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF0EE628BFBD839D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2Y9QA27A0A2Y9QA27_DELLE
Serine/threonine-protein kinase mTO...
MTOR
2,548Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_022454454.1, XM_022598746.1

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dle:111187265

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_022454454.1, XM_022598746.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

KEGGidle:111187265

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
1.20.120.150, 1 hit
1.25.10.10, 3 hits
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR024585, DUF3385_TOR
IPR003152, FATC_dom
IPR009076, FRB_dom
IPR036738, FRB_sf
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR003151, PIK-rel_kinase_FAT
IPR014009, PIK_FAT
IPR026683, TOR
PANTHERiPTHR11139:SF9, PTHR11139:SF9, 1 hit
PfamiView protein in Pfam
PF11865, DUF3385, 1 hit
PF02259, FAT, 1 hit
PF02260, FATC, 1 hit
PF08771, FRB_dom, 1 hit
PF00454, PI3_PI4_kinase, 1 hit
SMARTiView protein in SMART
SM01346, DUF3385, 1 hit
SM01343, FATC, 1 hit
SM00146, PI3Kc, 1 hit
SUPFAMiSSF47212, SSF47212, 1 hit
SSF48371, SSF48371, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51189, FAT, 1 hit
PS51190, FATC, 1 hit
PS00915, PI3_4_KINASE_1, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2Y9Q5U1_DELLE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2Y9Q5U1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 12, 2018
Last sequence update: September 12, 2018
Last modified: February 10, 2021
This is version 13 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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