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UniProtKB - A0A2Y9PYH3 (A0A2Y9PYH3_DELLE)

Entry version 11 (10 Feb 2021)
Sequence version 1 (12 Sep 2018)
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Protein

DNA polymerase kappa

Gene

POLK

Organism
Delphinapterus leucas (Beluga whale)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri628 – 658UBZ4-typePROSITE-ProRule annotationAdd BLAST31
Zinc fingeri784 – 814UBZ4-typePROSITE-ProRule annotationAdd BLAST31

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA repairPROSITE-ProRule annotationARBA annotation, DNA synthesisARBA annotation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase kappaARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POLKImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDelphinapterus leucas (Beluga whale)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9749 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Whippomorpha › Cetacea › Odontoceti › Monodontidae › Delphinapterus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000248483 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini110 – 365UmuCInterPro annotationAdd BLAST256
Domaini628 – 658UBZ4-typeInterPro annotationAdd BLAST31
Domaini784 – 814UBZ4-typeInterPro annotationAdd BLAST31

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni659 – 684DisorderedSequence analysisAdd BLAST26
Regioni821 – 851DisorderedSequence analysisAdd BLAST31
Regioni859 – 878DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1 – 21Sequence analysisAdd BLAST21
Coiled coili64 – 84Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi827 – 845PolarSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-Y family.ARBA annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri628 – 658UBZ4-typePROSITE-ProRule annotationAdd BLAST31
Zinc fingeri784 – 814UBZ4-typePROSITE-ProRule annotationAdd BLAST31

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Family and domain databases

Conserved Domains Database

More...CDDi		cd03586, PolY_Pol_IV_kappa, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.1490.100, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_01113, DNApol_IV, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR036775, DNA_pol_Y-fam_lit_finger_sf
IPR017961, DNA_pol_Y-fam_little_finger
IPR022880, DNApol_IV
IPR024728, PolY_HhH_motif
IPR006642, Rad18_UBZ4
IPR001126, UmuC

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00817, IMS, 1 hit
PF11799, IMS_C, 1 hit
PF11798, IMS_HHH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00734, ZnF_Rad18, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF100879, SSF100879, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50173, UMUC, 1 hit
PS51908, ZF_UBZ4, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2Y9PYH3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSTEEKNDS TKEKNDNYKD DLLLRVGLND NKAGMEGLDK EKINKIIMEA 
        60         70         80         90        100
TKGSRFYGNE LKKEKQVNQR IENMMQQKAQ ITSQQLRKAQ LQVDRFAMEL 
       110        120        130        140        150
EHSRDLNNTI VHIDMDAFYA AVEMRDNPEL KDKPIAVGSV SMLSTSNYHA 
       160        170        180        190        200
RRFGVRAAMP GFIAKRLCPQ LIIVPPNFDK YRAVSREVKE ILADYDPNFM 
       210        220        230        240        250
AMSLDEAYVN ITKHLEERQN WPEDKRKYFI KTGNSLENDK PGKEVNKLHE 
       260        270        280        290        300
QERSISPLLF EDSPPDLQSP GNPFQVNFEE LNNLQILQNS IVFGTSAEEV 
       310        320        330        340        350
VKEMRFRIEQ KTTLTASAGI APNTMLAKVC SDKNKPNGQY QILPNRQAVM 
       360        370        380        390        400
DFIKDLPIRK VSGIGKVTEK MLKALGIITC TELYQQRALL SLLFSETSWH 
       410        420        430        440        450
YFLHISLGLG STQLARDGER KSMSVERTFS EISKAEEQYS LCQELCSELA 
       460        470        480        490        500
QDLQKEGLKG RTVTIKLKNV NFEVKTRAST VSSVVSTAEE IFAIAKELLR 
       510        520        530        540        550
TEIDADFPHP LRLRLMGVRL SGFPNEEEKK CQQRSIIGFL QPGNQALSAT 
       560        570        580        590        600
RCIPEKTDKD QFLKPLEMSH KKSFFDKKRS ERNWSYQDTF KCETVDKQSL 
       610        620        630        640        650
QTSQFFQVLK KRMSENLETL ENSDNCHIFT CPVCFREQGS ISLEAFNKHV 
       660        670        680        690        700
DACLDGPSIS GNSKMSSRSH ASSTEVNEKE NVHDSVSVCE KQDCETHQKN 
       710        720        730        740        750
TVITSVDSVE LAETTGNPSN TEGVDALSNK HSEEECSSLP SKSFNMEHCP 
       760        770        780        790        800
QNCCTVPLEN EDVASLGRKE PLQPYLYEVI SDQVLVCPVC NLEQKTSDLT 
       810        820        830        840        850
LFNVHVDVCL NKGMIQELRK DKVNPVNQPK ESATSTDNSG KVQKIGTKAN 
       860        870 
RPRLMTKYSA SKKTKPNSPR HTLDIFFK
Length:878
Mass (Da):99,535
Last modified:September 12, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2E0503DE0C3C6F55
GO

Sequence databases

NCBI Reference Sequences

More...RefSeqi		XP_022450513.1, XM_022594805.1
XP_022450522.1, XM_022594814.1
XP_022450529.1, XM_022594821.1
XP_022450530.1, XM_022594822.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDLET00000012553; ENSDLEP00000011381; ENSDLEG00000008261

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dle:111185272

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_022450513.1, XM_022594805.1
XP_022450522.1, XM_022594814.1
XP_022450529.1, XM_022594821.1
XP_022450530.1, XM_022594822.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENSDLET00000012553; ENSDLEP00000011381; ENSDLEG00000008261
KEGGidle:111185272

Family and domain databases

CDDicd03586, PolY_Pol_IV_kappa, 1 hit
Gene3Di3.30.1490.100, 1 hit
HAMAPiMF_01113, DNApol_IV, 1 hit
InterProiView protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR036775, DNA_pol_Y-fam_lit_finger_sf
IPR017961, DNA_pol_Y-fam_little_finger
IPR022880, DNApol_IV
IPR024728, PolY_HhH_motif
IPR006642, Rad18_UBZ4
IPR001126, UmuC
PfamiView protein in Pfam
PF00817, IMS, 1 hit
PF11799, IMS_C, 1 hit
PF11798, IMS_HHH, 1 hit
SMARTiView protein in SMART
SM00734, ZnF_Rad18, 2 hits
SUPFAMiSSF100879, SSF100879, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS50173, UMUC, 1 hit
PS51908, ZF_UBZ4, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2Y9PYH3_DELLE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2Y9PYH3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 12, 2018
Last sequence update: September 12, 2018
Last modified: February 10, 2021
This is version 11 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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