CCND1

Functionⁱ

GO - Molecular functionⁱ

cyclin-dependent protein serine/threonine kinase regulator activity Source: Ensembl
histone deacetylase binding Source: Ensembl
proline-rich region binding Source: Ensembl
protein kinase activity Source: Ensembl
protein kinase binding Source: Ensembl
transcription corepressor activity Source: Ensembl
transcription factor binding Source: Ensembl

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

endoplasmic reticulum unfolded protein response Source: Ensembl
fat cell differentiation Source: Ensembl
G1/S transition of mitotic cell cycle Source: Ensembl
lactation Source: Ensembl
liver regeneration Source: Ensembl
mammary gland alveolus development Source: Ensembl
mammary gland epithelial cell proliferation Source: Ensembl
mitotic G1 DNA damage checkpoint Source: Ensembl
negative regulation of cell cycle arrest Source: Ensembl
negative regulation of epithelial cell differentiation Source: Ensembl
negative regulation of transcription by RNA polymerase II Source: Ensembl
positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
positive regulation of G2/M transition of mitotic cell cycle Source: Ensembl
positive regulation of mammary gland epithelial cell proliferation Source: Ensembl
re-entry into mitotic cell cycle Source: Ensembl
response to drug Source: Ensembl
response to leptin Source: Ensembl
response to UV-A Source: Ensembl
Wnt signaling pathway Source: Ensembl

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	CyclinUniRule annotationARBA annotation

Molecular function

CyclinUniRule annotationARBA annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: G1/S-specific cyclin-D1Imported
Gene namesⁱ	Name:CCND1Imported
Organismⁱ	Delphinapterus leucas (Beluga whale)Imported
Taxonomic identifierⁱ	9749 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Artiodactyla › Whippomorpha › Cetacea › Odontoceti › Monodontidae › Delphinapterus
Proteomesⁱ	UP000248483 Componentⁱ: Genome assembly

Interactionⁱ

GO - Molecular functionⁱ

histone deacetylase binding Source: Ensembl
proline-rich region binding Source: Ensembl
protein kinase binding Source: Ensembl
transcription factor binding Source: Ensembl

Complete GO annotation on QuickGO ...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	57 – 88	Cyclin N-terminalInterPro annotationAdd BLAST		32

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	264 – 295	DisorderedSequence analysisAdd BLAST		32

Sequence similaritiesⁱ

Belongs to the cyclin family.UniRule annotation

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00043, CYCLIN, 1 hit
InterProⁱ	View protein in InterPro IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR004367, Cyclin_C-dom IPR015451, Cyclin_D IPR006671, Cyclin_N
PANTHERⁱ	PTHR10177, PTHR10177, 1 hit PTHR10177:SF67, PTHR10177:SF67, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit
SMARTⁱ	View protein in SMART SM00385, CYCLIN, 1 hit SM01332, Cyclin_C, 1 hit
SUPFAMⁱ	SSF47954, SSF47954, 2 hits
PROSITEⁱ	View protein in PROSITE PS00292, CYCLINS, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A2Y9PNM2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAHQLLCCEM ETIRRAYPDA NLLNDRVLRA MLKAEETCAP SVSYFKCVQK 
        60         70         80         90        100
EILPSMRKIV ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS LEPVKKSRLQ 
       110        120        130        140        150
LLGATCMFVA SKMKETIPLT AEKLCIYTDN SIRPDELLQM ELVLVNKLKW 
       160        170        180        190        200
NLAATTPHDF IEHFLSKMPV VEESKQVIRK HAQTFVALCA TDVKFISNPP 
       210        220        230        240        250
SMVAAGSVVA AVQGLHLGSA NSFLSYHRLT RFLSKVIRCD PDCLRACQEQ 
       260        270        280        290 
IEALLESSLR QAQQQNLDPK AAEEGEEEEE ADLACTPTDV RDVDI

Length:295

Mass (Da):33,342

Last modified:September 12, 2018 - v1

Checksum:ⁱC6AB67B37BBED25A

GO

Sequence databases

NCBI Reference Sequences More...RefSeqⁱ	XP_022446856.1, XM_022591148.1

RefSeqⁱ

XP_022446856.1, XM_022591148.1

Genome annotation databases

Ensemblⁱ	ENSDLET00000009759; ENSDLEP00000008833; ENSDLEG00000006485
KEGGⁱ	dle:111183632

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A0A2Y9PNM2	G1/S-specific cyclin-D1		NEOAA		295	UniRef100_A0A341BS75
+1

Protein	Similar proteins		Species	Score	Length	Source
A0A2Y9PNM2	G1/S-specific cyclin-D1		LIPVE		295	UniRef90_A0A340Y332
CCND1 protein (Fragment)		CROCR		299
G1/S-specific cyclin-D1		NEOAA		295
G1/S-specific cyclin-D1		ACIJB		295
G1/S-specific cyclin-D1 isoform X2		TURTR		295
+2

Protein	Similar proteins		Species	Score	Length	Source
A0A2Y9PNM2	G1/S-specific cyclin-D1		RAT		295	UniRef50_P39948
G1/S-specific cyclin-D1		CHICK		292
G1/S-specific cyclin-D1		XENLA		291
CCND1		CRIGR		295
G1/S-specific cyclin-D1		MESAU		295
+369

Cross-referencesⁱ

Sequence databases

RefSeqⁱ	XP_022446856.1, XM_022591148.1

RefSeqⁱ

XP_022446856.1, XM_022591148.1

3D structure databases

ModBaseⁱ	Search...
SWISS-MODEL-Workspaceⁱ	Submit a new modelling project...

Genome annotation databases

Ensemblⁱ	ENSDLET00000009759; ENSDLEP00000008833; ENSDLEG00000006485
KEGGⁱ	dle:111183632

Family and domain databases

CDDⁱ	cd00043, CYCLIN, 1 hit
InterProⁱ	View protein in InterPro IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR004367, Cyclin_C-dom IPR015451, Cyclin_D IPR006671, Cyclin_N
PANTHERⁱ	PTHR10177, PTHR10177, 1 hit PTHR10177:SF67, PTHR10177:SF67, 1 hit
Pfamⁱ	View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit
SMARTⁱ	View protein in SMART SM00385, CYCLIN, 1 hit SM01332, Cyclin_C, 1 hit
SUPFAMⁱ	SSF47954, SSF47954, 2 hits
PROSITEⁱ	View protein in PROSITE PS00292, CYCLINS, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A2Y9PNM2_DELLE
Accessionⁱ	A0A2Y9PNM2Primary (citable) accession number: A0A2Y9PNM2
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	September 12, 2018
	Last sequence update:	September 12, 2018
	Last modified:	February 10, 2021
	This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteomeImported

UniProtKB - A0A2Y9PNM2 (A0A2Y9PNM2_DELLE)

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G1/S-specific cyclin-D1

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Other locations

Nucleus

Other locations

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Domains and Repeats

Region

Sequence similaritiesⁱ

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Genome annotation databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

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Supporting data

UniProtKB - A0A2Y9PNM2 (A0A2Y9PNM2_DELLE)

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G1/S-specific cyclin-D1

CCND1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Nucleus

Other locations

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Genome annotation databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ