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UniProtKB - A0A2Y9PJS0 (A0A2Y9PJS0_DELLE)

Entry version 11 (10 Feb 2021)
Sequence version 1 (12 Sep 2018)
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Protein
Submitted name:

axin-2 isoform X1

Gene

AXIN2

Organism
Delphinapterus leucas (Beluga whale)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processWnt signaling pathwayPROSITE-ProRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
axin-2 isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AXIN2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDelphinapterus leucas (Beluga whale)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9749 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Whippomorpha › Cetacea › Odontoceti › Monodontidae › Delphinapterus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000248483 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

ADP-ribosylationARBA annotation, PhosphoproteinARBA annotation, Ubl conjugationARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini81 – 200RGSInterPro annotationAdd BLAST120
Domaini761 – 843DIXInterPro annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 75DisorderedSequence analysisAdd BLAST75
Regioni297 – 335DisorderedSequence analysisAdd BLAST39
Regioni391 – 431DisorderedSequence analysisAdd BLAST41
Regioni561 – 618DisorderedSequence analysisAdd BLAST58
Regioni666 – 686DisorderedSequence analysisAdd BLAST21
Regioni718 – 748DisorderedSequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi297 – 315PolarSequence analysisAdd BLAST19
Compositional biasi391 – 407PolyampholyteSequence analysisAdd BLAST17
Compositional biasi722 – 742PolarSequence analysisAdd BLAST21

Family and domain databases

Conserved Domains Database

More...CDDi		cd11582, Axin_TNKS_binding, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.196.10, 1 hit
3.10.20.380, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR043581, Axin-like
IPR014936, Axin_b-cat-bd
IPR032101, Axin_TNKS-bd
IPR001158, DIX
IPR038207, DIX_dom_sf
IPR016137, RGS
IPR036305, RGS_sf
IPR024066, RGS_subdom1/3
IPR029071, Ubiquitin-like_domsf

The PANTHER Classification System

More...PANTHERi		PTHR46102, PTHR46102, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16646, AXIN1_TNKS_BD, 1 hit
PF08833, Axin_b-cat_bind, 1 hit
PF00778, DIX, 1 hit
PF00615, RGS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01301, RGSPROTEIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00021, DAX, 1 hit
SM00315, RGS, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48097, SSF48097, 1 hit
SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50841, DIX, 1 hit
PS50132, RGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A2Y9PJS0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSAVLVPRL PDPSSSFRED APRPPVPGEE GETPPCQPGV GKGPVAKPLP 
        60         70         80         90        100
VSSNARRNED GLGEPEGRAS PDSPLTRWTK SLHSLLGDQD GAYLFRTFLE 
       110        120        130        140        150
REKCVDTLDF WFACNGFRQM NLKDAKTLRV AKAIYKRYIE NNSIVSKQLK 
       160        170        180        190        200
PATKTYIRDG IKKQQIDSVM FDQAQTEIQA VMEDNAYQMF LTSDIYLEYV 
       210        220        230        240        250
RSGGENPACV GGGGLGSLKL VCGYLPTLNE EEEWTCADFK CKLSPSVVGL 
       260        270        280        290        300
SSKTLRATVG VRSTETVENG HRRSDPVNPY HVGSGCIFAP ATSANDSEIS 
       310        320        330        340        350
SDALTDDSMS MTDSSVDGIP PYLGGSKKQL QREMHRSVKA NGQVCLPHFP 
       360        370        380        390        400
RTHRLPKEMT PVEPAAFAAE LISRLEKLKL ELETRHSLEE RLQQIREDEE 
       410        420        430        440        450
KEGSELALSA REAGPTQHPL SLLPSGSYEE DPQTILDDHL SRVLKTPGCQ 
       460        470        480        490        500
SPGVGRYSPR ARSPDQHRRH HLLQHRAPPP PGGPLLPATA AAAGCPLLGA 
       510        520        530        540        550
RGFVSRQTTK HVHHHYIHHH AGPRTREEVE AEAAQRARCP CPVPTPGGSD 
       560        570        580        590        600
YPCCAKCKSH PGAPEPAAAA QAGGRGRGAV PPRRSGRGSE PGPAGPAREG 
       610        620        630        640        650
GAPGGAGPLQ PPGEEGDRAQ DVWQWVLESE RPGKPKPHSA QSTKRAYPLE 
       660        670        680        690        700
CARASPAGRH HLWVGSSGHP RATPRAHPFT QDPAVPPLTP PNTLAQLEEA 
       710        720        730        740        750
CRRLAEVSKP PKQRCCVASQ QRDRHHSATG QPGATPFSSP SLASEDHKEP 
       760        770        780        790        800
KKLAGVHALQ ASELVVTYFF CGEEIPYRRM LKAQSLTLGH FKEQLSKKGN 
       810        820        830        840 
YRYYFKKASN EFACGAVFEE VWDDEVVLPT YEGRILGKVE RID
Length:843
Mass (Da):91,905
Last modified:September 12, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i43B031FDBDE541E9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2Y9PIB2A0A2Y9PIB2_DELLE
axin-2 isoform X2
AXIN2
831Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...RefSeqi		XP_022445529.1, XM_022589821.1
XP_022445530.1, XM_022589822.1
XP_022445531.1, XM_022589823.1
XP_022445532.1, XM_022589824.1
XP_022445534.1, XM_022589826.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDLET00000015429; ENSDLEP00000013975; ENSDLEG00000010276

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dle:111182912

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_022445529.1, XM_022589821.1
XP_022445530.1, XM_022589822.1
XP_022445531.1, XM_022589823.1
XP_022445532.1, XM_022589824.1
XP_022445534.1, XM_022589826.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENSDLET00000015429; ENSDLEP00000013975; ENSDLEG00000010276
KEGGidle:111182912

Family and domain databases

CDDicd11582, Axin_TNKS_binding, 1 hit
Gene3Di1.10.196.10, 1 hit
3.10.20.380, 1 hit
InterProiView protein in InterPro
IPR043581, Axin-like
IPR014936, Axin_b-cat-bd
IPR032101, Axin_TNKS-bd
IPR001158, DIX
IPR038207, DIX_dom_sf
IPR016137, RGS
IPR036305, RGS_sf
IPR024066, RGS_subdom1/3
IPR029071, Ubiquitin-like_domsf
PANTHERiPTHR46102, PTHR46102, 1 hit
PfamiView protein in Pfam
PF16646, AXIN1_TNKS_BD, 1 hit
PF08833, Axin_b-cat_bind, 1 hit
PF00778, DIX, 1 hit
PF00615, RGS, 1 hit
PRINTSiPR01301, RGSPROTEIN
SMARTiView protein in SMART
SM00021, DAX, 1 hit
SM00315, RGS, 1 hit
SUPFAMiSSF48097, SSF48097, 1 hit
SSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50841, DIX, 1 hit
PS50132, RGS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2Y9PJS0_DELLE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2Y9PJS0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 12, 2018
Last sequence update: September 12, 2018
Last modified: February 10, 2021
This is version 11 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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