JUN

Functionⁱ

GO - Molecular functionⁱ

cAMP response element binding Source: Ensembl
DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
GTPase activator activity Source: Ensembl
identical protein binding Source: Ensembl
RNA polymerase II activating transcription factor binding Source: Ensembl
R-SMAD binding Source: Ensembl
ubiquitin protein ligase binding Source: Ensembl

GO - Biological processⁱ

cellular response to cadmium ion Source: Ensembl
cellular response to reactive oxygen species Source: Ensembl
negative regulation by host of viral transcription Source: Ensembl
negative regulation of DNA binding Source: Ensembl
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Source: Ensembl
positive regulation by host of viral transcription Source: Ensembl
positive regulation of apoptotic process Source: Ensembl
positive regulation of DNA-templated transcription, initiation Source: Ensembl
positive regulation of pri-miRNA transcription by RNA polymerase II Source: Ensembl
positive regulation of vascular associated smooth muscle cell proliferation Source: Ensembl
Ras protein signal transduction Source: Ensembl
SMAD protein signal transduction Source: Ensembl
transforming growth factor beta receptor signaling pathway Source: Ensembl

Keywordsⁱ

Molecular function	DNA-bindingARBA annotation
Biological process	Transcription, Transcription regulationARBA annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Activator protein 1ARBA annotation Alternative name(s): Proto-oncogene c-JunARBA annotation Transcription factor AP-1ARBA annotation V-jun avian sarcoma virus 17 oncogene homologARBA annotation
Gene namesⁱ	Name:JUNImported
Organismⁱ	Delphinapterus leucas (Beluga whale)Imported
Taxonomic identifierⁱ	9749 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Artiodactyla › Whippomorpha › Cetacea › Odontoceti › Monodontidae › Delphinapterus
Proteomesⁱ	UP000248483 Componentⁱ: Genome assembly

Interactionⁱ

GO - Molecular functionⁱ

identical protein binding Source: Ensembl
RNA polymerase II activating transcription factor binding Source: Ensembl
R-SMAD binding Source: Ensembl
ubiquitin protein ligase binding Source: Ensembl

Complete GO annotation on QuickGO ...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	264 – 327	BZIPInterPro annotationAdd BLAST		64

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	187 – 226	DisorderedSequence analysisAdd BLAST		40

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	269 – 330	Sequence analysisAdd BLAST		62

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	208 – 226	Pro-richSequence analysisAdd BLAST		19

Sequence similaritiesⁱ

Belongs to the bZIP family. Jun subfamily.ARBA annotation

Keywords - Domainⁱ

Coiled coilSequence analysis

Family and domain databases

InterProⁱ	View protein in InterPro IPR004827, bZIP IPR015558, C_Jun/v-Jun IPR005643, JNK IPR002112, Leuzip_Jun IPR008917, TF_DNA-bd_sf
PANTHERⁱ	PTHR11462:SF8, PTHR11462:SF8, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00170, bZIP_1, 1 hit PF03957, Jun, 1 hit
PRINTSⁱ	PR00043, LEUZIPPRJUN
SMARTⁱ	View protein in SMART SM00338, BRLZ, 1 hit
SUPFAMⁱ	SSF47454, SSF47454, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A2Y9NBA9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTAKMETTFY DDALNASFLQ SESGAYGYSN PKILKQSMTL NLADPVGSLK 
        60         70         80         90        100
PHLRAKNSDL LTSPDVGLLK LASPELERLI IQSSNGHITT TPTPTQFLCP 
       110        120        130        140        150
KNVTDEQEGF AEGFVRALAE LHSQNTLPSV TSAAQPVSGA GLVAPAVASV 
       160        170        180        190        200
AGGGGGGGGG GGFGASLHSE PPVYANLSNF NPGALSGGGG GGGAPSYGAA 
       210        220        230        240        250
GLAFPAQPQQ QQPPPPPPPP HHLPQQIPVQ HPRLQALKEE PQTVPEMPGE 
       260        270        280        290        300
TPPLSPIDME SQERIKAERK RMRNRIAASK CRKRKLERIA RLEEKVKTLK 
       310        320        330        340 
AQNSELASTA NMLREQVAQL KQKVMNHVNS GCQLMLTQQL QTF

Length:343

Mass (Da):36,351

Last modified:September 12, 2018 - v1

Checksum:ⁱ2D3DDD2DFB4B2307

GO

Sequence databases

NCBI Reference Sequences More...RefSeqⁱ	XP_022431510.1, XM_022575802.1

RefSeqⁱ

XP_022431510.1, XM_022575802.1

Genome annotation databases

Ensemblⁱ	ENSDLET00000029816; ENSDLEP00000027128; ENSDLEG00000019588
KEGGⁱ	dle:111175871

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A0A2Y9NBA9	Activator protein 1		TURTR		345	UniRef90_A0A2Y9NBA9
Activator protein 1		MONMO		341
Activator protein 1		LIPVE		337
Activator protein 1		OCTDE		322
Jun oncogene (Fragment)		MOUSE		14
+10

Protein	Similar proteins		Species	Score	Length	Source
A0A2Y9NBA9	Viral jun-transforming protein	)	AVIS1		287	UniRef50_P05411
Proto-oncogene c-Jun		ALLMI		320
Proto-oncogene c-Jun (Fragment)		OPIHO		303
Proto-oncogene c-Jun (Fragment)		MERNU		290
Proto-oncogene c-Jun		ALLSI		282
+400

Cross-referencesⁱ

Sequence databases

RefSeqⁱ	XP_022431510.1, XM_022575802.1

RefSeqⁱ

XP_022431510.1, XM_022575802.1

3D structure databases

ModBaseⁱ	Search...
SWISS-MODEL-Workspaceⁱ	Submit a new modelling project...

Genome annotation databases

Ensemblⁱ	ENSDLET00000029816; ENSDLEP00000027128; ENSDLEG00000019588
KEGGⁱ	dle:111175871

Family and domain databases

InterProⁱ	View protein in InterPro IPR004827, bZIP IPR015558, C_Jun/v-Jun IPR005643, JNK IPR002112, Leuzip_Jun IPR008917, TF_DNA-bd_sf
PANTHERⁱ	PTHR11462:SF8, PTHR11462:SF8, 1 hit
Pfamⁱ	View protein in Pfam PF00170, bZIP_1, 1 hit PF03957, Jun, 1 hit
PRINTSⁱ	PR00043, LEUZIPPRJUN
SMARTⁱ	View protein in SMART SM00338, BRLZ, 1 hit
SUPFAMⁱ	SSF47454, SSF47454, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A2Y9NBA9_DELLE
Accessionⁱ	A0A2Y9NBA9Primary (citable) accession number: A0A2Y9NBA9
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	September 12, 2018
	Last sequence update:	September 12, 2018
	Last modified:	February 10, 2021
	This is version 11 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteomeImported

UniProtKB - A0A2Y9NBA9 (A0A2Y9NBA9_DELLE)

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Activator protein 1

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Nucleus

Nucleus

Other locations

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Domains and Repeats

Region

Coiled coil

Compositional bias

Sequence similaritiesⁱ

Keywords - Domainⁱ

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Genome annotation databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProt is an ELIXIR core data resource

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Proteomes

Annotation systems

Supporting data

UniProtKB - A0A2Y9NBA9 (A0A2Y9NBA9_DELLE)

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Activator protein 1

JUN

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Genome annotation databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ